{"id":"https://openalex.org/W2805437692","doi":null,"title":"Effects of age -related ultra-structural level changes in bone on microdamage mechanisms.","display_name":"Effects of age -related ultra-structural level changes in bone on microdamage mechanisms.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2805437692","mag":"2805437692"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/123678","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstreams/652556b3-3463-444f-a1a0-4dd486139332/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058651182","display_name":"Rupak M. Rajachar","orcid":"https://orcid.org/0000-0001-6233-9307","observed_orcids":["https://orcid.org/0000-0001-6233-9307"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rupak M. Rajachar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6233-9307","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058651182"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10396","display_name":"Fatigue and fracture mechanics","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-microdamage","display_name":"bone microdamage","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cortical-bone","display_name":"cortical bone","score":0.7760000228881836},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8709999918937683},{"id":"https://openalex.org/keywords/femoral-bone","display_name":"femoral bone","score":0.6759999990463257},{"id":"https://openalex.org/keywords/fatigue-material","display_name":"fatigue (material)","score":0.4189999997615814},{"id":"https://openalex.org/keywords/microcracks","display_name":"microcracks","score":0.6499999761581421},{"id":"https://openalex.org/keywords/carbonation","display_name":"carbonation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/mineral-orientation","display_name":"mineral orientation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.39899998903274536},{"id":"https://openalex.org/keywords/raman-spectroscopy","display_name":"Raman spectroscopy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/x-ray-diffraction","display_name":"X-ray diffraction","score":0.6510000228881836},{"id":"https://openalex.org/keywords/confocal-laser-scanning-microscopy","display_name":"confocal laser scanning microscopy","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.3305560350418091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29128021001815796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18941521644592285}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/123678","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstreams/652556b3-3463-444f-a1a0-4dd486139332/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2805437692","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/123678","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2119170231","https://openalex.org/W2170302666","https://openalex.org/W2017568962","https://openalex.org/W1991094026","https://openalex.org/W2151437118","https://openalex.org/W2086447636","https://openalex.org/W1998455566","https://openalex.org/W2123097481","https://openalex.org/W2125296797","https://openalex.org/W2057811175"],"abstract_inverted_index":{"The":[0,95,176,278],"objective":[1],"of":[2,10,27,83,115,127,168,178,197,206,252,281,287,326],"this":[3,179,282],"thesis":[4],"was":[5,255,273],"to":[6,51,59,72,91,147,164,192,245,322],"study":[7],"the":[8,62,81,165,193,204,250,285,295,324],"effect":[9],"age-related":[11,92,307,327],"changes":[12,60,141,158,308],"in":[13,22,30,61,80,105,142,159,298,309],"microstructure":[14],"and":[15,20,38,69,86,102,119,130,145,155,162,195,220,236,269,314],"composition":[16,68,313],"on":[17],"microdamage":[18,28,84,104,128],"formation":[19,85,129,194],"growth":[21,87,131,196],"cortical":[23,107],"bone.":[24],"A":[25],"continuum":[26],"exists":[29],"bone":[31,108],"between":[32],"diffuse":[33,45,186,221],"ultra-structural":[34,46,76,187,296],"level":[35,47,297],"damage":[36,48,143,160,183,188,222,290,301],"(<10mum)":[37],"microcracking":[39],"(>10mum).":[40],"It":[41],"is":[42,189,284],"hypothesized":[43],"that":[44,249,263,292],"zones":[49],"contributing":[50],"fatigue":[52,73,218],"processes":[53],"are":[54,320],"reduced":[55],"with":[56,110,214,267,275],"age":[57,113,268],"due":[58],"mechanism":[63,82],"by":[64,257,306],"which":[65],"mineral":[66,149,170,208,234,242,264,312,316],"phase":[67,211],"distribution":[70,146,163,167],"respond":[71],"at":[74,294],"an":[75],"level.":[77],"Ultimately,":[78],"alterations":[79],"could":[88],"contribute":[89],"significantly":[90,270],"skeletal":[93,328],"fragility.":[94,329],"specific":[96],"aims":[97],"were":[98],"to:":[99],"(1)":[100],"quantify":[101],"compare":[103],"femoral":[106],"associated":[109,213,274],"2":[111],"different":[112],"groups":[114],"mice":[116],"(3--4":[117],"month":[118,121],"22--24":[120],"C57BL6);":[122],"(2)":[123],"determine":[124],"predominant":[125],"locations":[126],"using":[132,151,171],"laser":[133],"scanning":[134],"confocal":[135],"microscopy":[136],"(LSCM)":[137],"techniques;":[138,154],"(3)":[139],"relate":[140,157],"mode":[144,161],"local":[148,169,311],"content":[150],"Raman":[152,200],"spectroscopic":[153,201],"(4)":[156],"spatial":[166],"quantitative":[172],"x-ray":[173],"scattering":[174],"techniques.":[175],"results":[177],"research":[180],"established":[181],"a":[182,190,288],"mechanism,":[184],"where":[185,300],"precursor":[191],"linear":[198],"microcracks.":[199],"analyses":[202],"showed":[203,262],"presence":[205],"distinct":[207],"species":[209,235,243],"(i.e.":[210],"transformations)":[212],"damage.":[215],"Regions":[216],"surrounding":[217],"microcracks":[219],"contained":[223,231,239],"less-carbonated":[224],"apatite.":[225],"With":[226],"monotonic":[227,276],"loading,":[228],"older":[229],"specimens":[230,238],"one":[232],"unique":[233,241],"younger":[237],"two":[240],"localized":[244],"fracture":[246],"sites,":[247],"suggesting":[248],"dissipation":[251],"mechanical":[253],"energy":[254],"achieved":[256],"age-dependent":[258],"mechanisms.":[259],"X-ray":[260],"data":[261],"orientation":[265],"increased":[266],"greater":[271],"disorientation":[272],"loading.":[277],"primary":[279],"result":[280],"work":[283],"characterization":[286],"dynamic":[289],"process":[291],"occurs":[293],"bone,":[299],"can":[302],"be":[303],"characterized":[304],"collectively":[305],"morphology,":[310],"regional":[315],"orientation.":[317],"These":[318],"findings":[319],"important":[321],"understanding":[323],"evolution":[325]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2018-06-13T00:00:00"}
