{"id":"https://openalex.org/W2805388317","doi":"https://doi.org/10.3389/fimmu.2018.01395","title":"\u03b3\u03b4 T Cells and Tumor Microenvironment: From Immunosurveillance to Tumor Evasion","display_name":"\u03b3\u03b4 T Cells and Tumor Microenvironment: From Immunosurveillance to Tumor Evasion","publication_year":2018,"publication_date":"2018-06-15","ids":{"openalex":"https://openalex.org/W2805388317","doi":"https://doi.org/10.3389/fimmu.2018.01395","mag":"2805388317","pmid":"https://pubmed.ncbi.nlm.nih.gov/29963061","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6013569"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2018.01395","doi":"https://doi.org/10.3389/fimmu.2018.01395","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.01395","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.01395/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2805388317"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.01395/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080411648","display_name":"Elena Lo Presti","orcid":"https://orcid.org/0000-0001-5401-4545","observed_orcids":["https://orcid.org/0000-0001-5401-4545"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Lo Presti","raw_affiliation_strings":["Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064442801","display_name":"Gabriele Pizzolato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele Pizzolato","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas Universit\u00e0, Rozzano, Italy","Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas Universit\u00e0, Rozzano, Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038857342","display_name":"Anna Maria Corsale","orcid":"https://orcid.org/0000-0002-2541-4619","observed_orcids":["https://orcid.org/0000-0002-2541-4619"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Maria Corsale","raw_affiliation_strings":["Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086599840","display_name":"Nadia Caccamo","orcid":"https://orcid.org/0000-0002-1018-5710","observed_orcids":["https://orcid.org/0000-0002-1018-5710"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nadia Caccamo","raw_affiliation_strings":["Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039175745","display_name":"Guido Sireci","orcid":"https://orcid.org/0000-0002-3969-0155","observed_orcids":["https://orcid.org/0000-0002-3969-0155"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guido Sireci","raw_affiliation_strings":["Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010991352","display_name":"Francesco Dieli","orcid":"https://orcid.org/0000-0002-6685-352X","observed_orcids":["https://orcid.org/0000-0002-6685-352X"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Dieli","raw_affiliation_strings":["Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041560313","display_name":"Serena Meraviglia","orcid":"https://orcid.org/0000-0002-0383-5818","observed_orcids":["https://orcid.org/0000-0002-0383-5818"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Serena Meraviglia","raw_affiliation_strings":["Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopathology, Universit\u00e0 degli Studi di Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041560313"],"corresponding_institution_ids":["https://openalex.org/I900890020"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.2657,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.80157539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"1395","last_page":"1395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2791000008583069,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9620000123977661},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7229999899864197},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5649999976158142},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7937755584716797},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7874693274497986},{"id":"https://openalex.org/C2776885095","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immunosurveillance","level":3,"score":0.7255772352218628},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5923327207565308},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5390142798423767},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49328869581222534},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46747517585754395},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.43959158658981323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4389439523220062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3234923779964447},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19889068603515625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2018.01395","doi":"https://doi.org/10.3389/fimmu.2018.01395","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.01395","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.01395/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4971635","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6013569","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29963061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29963061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6013569","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6013569/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e66b063ec96141b98e0298a5381ed1e0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e66b063ec96141b98e0298a5381ed1e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 9 (2018)","raw_type":"article"},{"id":"pmh:oai:iris.unipa.it:10447/356640","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10447/356640","pdf_url":null,"source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2018.01395","doi":"https://doi.org/10.3389/fimmu.2018.01395","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.01395","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.01395/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805388317.pdf","grobid_xml":"https://content.openalex.org/works/W2805388317.grobid-xml"},"referenced_works_count":127,"referenced_works":["https://openalex.org/W52273448","https://openalex.org/W960289126","https://openalex.org/W1107917109","https://openalex.org/W1512693074","https://openalex.org/W1528231659","https://openalex.org/W1535243328","https://openalex.org/W1642448589","https://openalex.org/W1674967027","https://openalex.org/W1764179577","https://openalex.org/W1821802349","https://openalex.org/W1830478373","https://openalex.org/W1838472703","https://openalex.org/W1944454646","https://openalex.org/W1959606306","https://openalex.org/W1965794095","https://openalex.org/W1967856594","https://openalex.org/W1971761379","https://openalex.org/W1977179270","https://openalex.org/W1978029914","https://openalex.org/W1982611882","https://openalex.org/W1986242326","https://openalex.org/W1986369171","https://openalex.org/W1991827918","https://openalex.org/W1993142403","https://openalex.org/W1993786192","https://openalex.org/W1996802288","https://openalex.org/W2001114440","https://openalex.org/W2004151829","https://openalex.org/W2006382856","https://openalex.org/W2013781127","https://openalex.org/W2019609336","https://openalex.org/W2019822903","https://openalex.org/W2025859745","https://openalex.org/W2030611121","https://openalex.org/W2030994367","https://openalex.org/W2032760352","https://openalex.org/W2037099316","https://openalex.org/W2040154148","https://openalex.org/W2041127810","https://openalex.org/W2041909243","https://openalex.org/W2042856504","https://openalex.org/W2046829925","https://openalex.org/W2049553585","https://openalex.org/W2052313621","https://openalex.org/W2053798613","https://openalex.org/W2061581062","https://openalex.org/W2064037601","https://openalex.org/W2065434106","https://openalex.org/W2069592230","https://openalex.org/W2070855360","https://openalex.org/W2071754406","https://openalex.org/W2072112559","https://openalex.org/W2073606915","https://openalex.org/W2081827243","https://openalex.org/W2084177213","https://openalex.org/W2084335237","https://openalex.org/W2089576694","https://openalex.org/W2092868870","https://openalex.org/W2093833484","https://openalex.org/W2096151993","https://openalex.org/W2098983864","https://openalex.org/W2101653483","https://openalex.org/W2102089901","https://openalex.org/W2105055793","https://openalex.org/W2107972965","https://openalex.org/W2108933323","https://openalex.org/W2109077280","https://openalex.org/W2111329034","https://openalex.org/W2111762872","https://openalex.org/W2112135890","https://openalex.org/W2113313714","https://openalex.org/W2114951959","https://openalex.org/W2115373139","https://openalex.org/W2121803603","https://openalex.org/W2123469465","https://openalex.org/W2126108715","https://openalex.org/W2127107746","https://openalex.org/W2130978174","https://openalex.org/W2134108915","https://openalex.org/W2134401635","https://openalex.org/W2142300779","https://openalex.org/W2150060394","https://openalex.org/W2152488336","https://openalex.org/W2152514732","https://openalex.org/W2154108455","https://openalex.org/W2155755553","https://openalex.org/W2160245658","https://openalex.org/W2160975857","https://openalex.org/W2163242247","https://openalex.org/W2163616598","https://openalex.org/W2165064029","https://openalex.org/W2166609587","https://openalex.org/W2166738731","https://openalex.org/W2169435545","https://openalex.org/W2170952917","https://openalex.org/W2288921756","https://openalex.org/W2340194153","https://openalex.org/W2407490762","https://openalex.org/W2462185002","https://openalex.org/W2464231245","https://openalex.org/W2512931560","https://openalex.org/W2517571287","https://openalex.org/W2519107733","https://openalex.org/W2531967896","https://openalex.org/W2560367415","https://openalex.org/W2566137755","https://openalex.org/W2570468264","https://openalex.org/W2571138221","https://openalex.org/W2586932252","https://openalex.org/W2597510015","https://openalex.org/W2603154053","https://openalex.org/W2605918054","https://openalex.org/W2724769065","https://openalex.org/W2727871530","https://openalex.org/W2734735597","https://openalex.org/W2736150987","https://openalex.org/W2747774814","https://openalex.org/W2754901959","https://openalex.org/W2766751225","https://openalex.org/W2771342962","https://openalex.org/W2775161773","https://openalex.org/W2792530328","https://openalex.org/W2792593720","https://openalex.org/W2802789880","https://openalex.org/W2995442355","https://openalex.org/W4243879036","https://openalex.org/W7036447705"],"related_works":["https://openalex.org/W3096807217","https://openalex.org/W4415164579","https://openalex.org/W2735300967","https://openalex.org/W4404977720","https://openalex.org/W2950477675","https://openalex.org/W4213262343","https://openalex.org/W2792593720","https://openalex.org/W3135560592","https://openalex.org/W2042552886","https://openalex.org/W2058222130"],"abstract_inverted_index":{"gamma":[0,39,47,61,93,130,156,181],"delta":[1,40,48,62,94,131,157,182],"T":[2,41,49,63,95,132,158,183],"cells":[3,50,64,96,119,133,159,184],"possess":[4],"cytotoxic":[5,15,178],"anti-tumor":[6],"activity":[7,16],"mediated":[8],"by":[9,75,140],"production":[10],"of":[11,19,23,34,69,78,84,180],"pro-inflammatory":[12],"cytokines,":[13],"direct":[14],"and":[17,80,108,116,126,129,160,163,175],"regulation":[18],"the":[20,32,98,106,145,152,165,172,177,187],"biological":[21],"functions":[22,134],"other":[24],"cell":[25],"types.":[26],"Hence,":[27],"these":[28],"features":[29],"have":[30,58],"prompted":[31],"development":[33],"therapeutic":[35],"strategies":[36,168],"in":[37,72,121,194],"which":[38],"cells-":[42],"agonists":[43],"or":[44,138],"ex":[45],"vivo-expanded":[46],"are":[51,65,135],"administered":[52],"to":[53,170,190],"tumor":[54,112,114,146,195],"patients.":[55],"Several":[56],"studies":[57],"shown":[59],"that":[60,167],"an":[66],"important":[67],"component":[68],"tumor-infiltrating":[70,92,117],"lymphocytes":[71],"patients":[73],"affected":[74],"different":[76],"types":[77],"cancer":[79],"a":[81,122],"recent":[82],"analysis":[83],"~18,000":[85],"transcriptomes":[86],"from":[87,144],"39":[88],"human":[89],"tumors":[90],"identified":[91],"as":[97],"most":[99],"significant":[100],"favourable":[101],"cancer-wide":[102],"prognostic":[103],"signature.":[104],"However,":[105],"complex":[107],"intricate":[109],"interactions":[110],"between":[111,124,155],"cells,":[113],"microenvironment":[115],"immune":[118],"results":[120],"balance":[123],"tumor-promoting":[125],"tumor-controlling":[127],"effects":[128],"often":[136],"diverted":[137],"impaired":[139],"immunosuppressive":[141,173],"signals":[142],"originating":[143],"microenvironment.":[147],"This":[148],"review":[149],"focuses":[150],"on":[151],"dangerous":[153],"liason":[154],"tumoral":[161],"microenviroment":[162],"raises":[164],"possibility":[166],"capable":[169],"reduce":[171],"environment":[174],"increase":[176],"ability":[179],"may":[185],"be":[186],"key":[188],"factor":[189],"improve":[191],"their":[192],"utilization":[193],"immunotherapy.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-06-13T00:00:00"}