{"id":"https://openalex.org/W2805370680","doi":"https://doi.org/10.1093/molbev/msy113","title":"Genome-Wide Mapping of Gene\u2013Phenotype Relationships in Experimentally Evolved Populations","display_name":"Genome-Wide Mapping of Gene\u2013Phenotype Relationships in Experimentally Evolved Populations","publication_year":2018,"publication_date":"2018-05-29","ids":{"openalex":"https://openalex.org/W2805370680","doi":"https://doi.org/10.1093/molbev/msy113","mag":"2805370680","pmid":"https://pubmed.ncbi.nlm.nih.gov/29860403"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/msy113","doi":"https://doi.org/10.1093/molbev/msy113","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msy113","pdf_url":"https://academic.oup.com/mbe/article-pdf/35/8/2085/25231606/msy113.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mbe/article-pdf/35/8/2085/25231606/msy113.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040590971","display_name":"Laurence D. Mueller","orcid":"https://orcid.org/0000-0003-4192-2549","observed_orcids":["https://orcid.org/0000-0003-4192-2549"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laurence D Mueller","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058763315","display_name":"Mark Phillips","orcid":"https://orcid.org/0000-0002-2319-7913","observed_orcids":["https://orcid.org/0000-0002-2319-7913"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A Phillips","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas T Barter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas T Barter","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110627126","display_name":"Zachary S. Greenspan","orcid":"https://orcid.org/0009-0002-0843-7779","observed_orcids":["https://orcid.org/0009-0002-0843-7779"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary S Greenspan","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060496544","display_name":"Michael R. Rose","orcid":"https://orcid.org/0000-0002-7766-0731","observed_orcids":["https://orcid.org/0000-0002-7766-0731"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R Rose","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040590971"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":null,"fwci":0.9058,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72498465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"35","issue":"8","first_page":"2085","last_page":"2095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"experimental evolution","score":0.8830000162124634},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.5170000195503235},{"id":"https://openalex.org/keywords/phenotypic-differentiation","display_name":"phenotypic differentiation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.6940000057220459},{"id":"https://openalex.org/keywords/snp-variation","display_name":"SNP variation","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9218589067459106},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7950452566146851},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6545771360397339},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5880900025367737},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5332103967666626},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5311214923858643},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5099238157272339},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.4558606743812561},{"id":"https://openalex.org/C130073038","wikidata":"https://www.wikidata.org/wiki/Q1211967","display_name":"Phenotypic trait","level":4,"score":0.4525134861469269},{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.4336540102958679},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068618","descriptor_name":"Selective Breeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049750","descriptor_name":"Genome, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/molbev/msy113","doi":"https://doi.org/10.1093/molbev/msy113","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msy113","pdf_url":"https://academic.oup.com/mbe/article-pdf/35/8/2085/25231606/msy113.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:29860403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29860403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Evaluation Study"}],"best_oa_location":{"id":"doi:10.1093/molbev/msy113","doi":"https://doi.org/10.1093/molbev/msy113","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msy113","pdf_url":"https://academic.oup.com/mbe/article-pdf/35/8/2085/25231606/msy113.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805370680.pdf","grobid_xml":"https://content.openalex.org/works/W2805370680.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1547248981","https://openalex.org/W1596493414","https://openalex.org/W1928998639","https://openalex.org/W1991656070","https://openalex.org/W1992140675","https://openalex.org/W2016903449","https://openalex.org/W2056636001","https://openalex.org/W2084289989","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2110065044","https://openalex.org/W2128343509","https://openalex.org/W2148985208","https://openalex.org/W2161950199","https://openalex.org/W2163285329","https://openalex.org/W2417874262","https://openalex.org/W2424097553","https://openalex.org/W2478753681","https://openalex.org/W2563093404","https://openalex.org/W2572522185","https://openalex.org/W2582743722","https://openalex.org/W4246178267"],"related_works":["https://openalex.org/W4322718288","https://openalex.org/W3092954956","https://openalex.org/W2566187461","https://openalex.org/W3095515011","https://openalex.org/W2072201802","https://openalex.org/W7098106161","https://openalex.org/W4390940821","https://openalex.org/W7099176170","https://openalex.org/W2908303872","https://openalex.org/W2139776178"],"abstract_inverted_index":{"Model":[0],"organisms":[1],"subjected":[2,146],"to":[3,32,72,134,147,151],"sustained":[4],"experimental":[5],"evolution":[6],"often":[7],"show":[8],"levels":[9],"of":[10,25,42,53,70,100,113,120,144,155],"phenotypic":[11,17,44,124],"differentiation":[12],"that":[13,38],"dramatically":[14],"exceed":[15],"the":[16,30,36,40,51,59,68,92,153,156],"differences":[18],"observed":[19],"in":[20,109,138],"natural":[21],"populations.":[22],"Genome-wide":[23],"sequencing":[24],"pooled":[26],"populations":[27],"then":[28],"offers":[29],"opportunity":[31],"make":[33],"inferences":[34],"about":[35],"genes":[37,75,86,101],"are":[39,77],"cause":[41],"these":[43,97],"differences.":[45],"We":[46,65],"tested,":[47],"through":[48],"computer":[49],"simulations,":[50],"efficacy":[52,112],"a":[54,82],"statistical":[55],"learning":[56],"technique":[57],"called":[58],"\"fused":[60],"lasso":[61],"additive":[62],"model\"":[63],"(FLAM).":[64],"focused":[66],"on":[67,91],"ability":[69],"FLAM":[71,94,114,131],"distinguish":[73],"between":[74],"which":[76,87],"differentiated":[78,85],"and":[79,126,141],"directly":[80],"affect":[81],"phenotype":[83],"from":[84],"have":[88],"no":[89],"effect":[90],"phenotype.":[93],"can":[95],"separate":[96],"two":[98],"classes":[99],"even":[102],"with":[103,117],"relatively":[104],"small":[105],"samples":[106],"(10":[107],"populations,":[108,121],"total).":[110],"The":[111],"is":[115],"improved":[116],"increased":[118,127],"number":[119],"reduced":[122],"environmental":[123],"variation,":[125],"within-treatment":[128],"among-replicate":[129],"variation.":[130],"was":[132],"applied":[133],"SNP":[135],"variation":[136],"measured":[137],"both":[139],"twenty-population":[140],"thirty-population":[142],"studies":[143],"Drosophila":[145],"selection":[148],"for":[149],"age-at-reproduction,":[150],"illustrate":[152],"application":[154],"method.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}
