{"id":"https://openalex.org/W2805329012","doi":"https://doi.org/10.1038/s41598-018-21799-8","title":"Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain","display_name":"Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain","publication_year":2018,"publication_date":"2018-02-16","ids":{"openalex":"https://openalex.org/W2805329012","doi":"https://doi.org/10.1038/s41598-018-21799-8","mag":"2805329012","pmid":"https://pubmed.ncbi.nlm.nih.gov/29472575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5823904"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-21799-8","doi":"https://doi.org/10.1038/s41598-018-21799-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-21799-8","pdf_url":"https://www.nature.com/articles/s41598-018-21799-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-21799-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021473803","display_name":"Korn\u00e9l P Kir\u00e1ly","orcid":"https://orcid.org/0000-0002-7252-0422","observed_orcids":["https://orcid.org/0000-0002-7252-0422"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Korn\u00e9l Kir\u00e1ly","raw_affiliation_strings":["Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065327267","display_name":"M\u00e1rk Kozsurek","orcid":"https://orcid.org/0000-0001-5465-2803","observed_orcids":["https://orcid.org/0000-0001-5465-2803"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"M\u00e1rk Kozsurek","raw_affiliation_strings":["Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0001-5465-2803","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039033176","display_name":"Erika Luk\u00e1csi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Erika Luk\u00e1csi","raw_affiliation_strings":["Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080511874","display_name":"Benjamin Barta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Benjamin Barta","raw_affiliation_strings":["Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019972655","display_name":"Al\u00e1n Alp\u00e1r","orcid":"https://orcid.org/0000-0003-4810-0820","observed_orcids":["https://orcid.org/0000-0003-4810-0820"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Al\u00e1n Alp\u00e1r","raw_affiliation_strings":["Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080344528","display_name":"Tam\u00e1s Bal\u00e1zsa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Tam\u00e1s Bal\u00e1zsa","raw_affiliation_strings":["Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001902256","display_name":"Csaba Fekete","orcid":"https://orcid.org/0000-0002-8206-562X","observed_orcids":["https://orcid.org/0000-0002-8206-562X"]},"institutions":[{"id":"https://openalex.org/I4210106880","display_name":"HUN-REN Institute of Experimental Medicine","ror":"https://ror.org/01jsgmp44","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210106880","https://openalex.org/I4387152226"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Csaba Fekete","raw_affiliation_strings":["\"Lend\u00fclet\" Laboratory of Integrative Neurobiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, H-1083, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"Lend\u00fclet\" Laboratory of Integrative Neurobiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, H-1083, Budapest, Hungary","institution_ids":["https://openalex.org/I4210106880","https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045096741","display_name":"Judit Szabon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106880","display_name":"HUN-REN Institute of Experimental Medicine","ror":"https://ror.org/01jsgmp44","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210106880","https://openalex.org/I4387152226"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Judit Szabon","raw_affiliation_strings":["\"Lend\u00fclet\" Laboratory of Integrative Neurobiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, H-1083, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"Lend\u00fclet\" Laboratory of Integrative Neurobiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, H-1083, Budapest, Hungary","institution_ids":["https://openalex.org/I4210106880","https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037712558","display_name":"Zsuzsanna Helyes","orcid":"https://orcid.org/0000-0003-2435-4367","observed_orcids":["https://orcid.org/0000-0003-2435-4367"]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsuzsanna Helyes","raw_affiliation_strings":["Department of Pharmacology and Pharmacotherapy, Medical School & Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624, P\u00e9cs, Hungary","MTA-PTE NAP B Chronic Pain Research Group, University of P\u00e9cs, H-7624, P\u00e9cs, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacotherapy, Medical School & Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]},{"raw_affiliation_string":"MTA-PTE NAP B Chronic Pain Research Group, University of P\u00e9cs, H-7624, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086614566","display_name":"Kata B\u00f6lcskei","orcid":"https://orcid.org/0000-0002-3008-4538","observed_orcids":["https://orcid.org/0000-0002-3008-4538"]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Kata B\u00f6lcskei","raw_affiliation_strings":["Department of Pharmacology and Pharmacotherapy, Medical School & Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624, P\u00e9cs, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacotherapy, Medical School & Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082025917","display_name":"Val\u00e9ria T\u00e9kus","orcid":"https://orcid.org/0000-0003-2918-4475","observed_orcids":["https://orcid.org/0000-0003-2918-4475"]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Val\u00e9ria T\u00e9kus","raw_affiliation_strings":["Department of Pharmacology and Pharmacotherapy, Medical School & Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624, P\u00e9cs, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacotherapy, Medical School & Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101614541","display_name":"Zsuzsanna T\u00f3th","orcid":"https://orcid.org/0000-0002-0628-1320","observed_orcids":["https://orcid.org/0000-0002-0628-1320"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsuzsanna E. T\u00f3th","raw_affiliation_strings":["Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053507683","display_name":"K\u00e1roly Pap","orcid":"https://orcid.org/0000-0003-1063-4026","observed_orcids":["https://orcid.org/0000-0003-1063-4026"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I4210125476","display_name":"Uzsoki Hospital","ror":"https://ror.org/030pj1w51","country_code":"HU","type":"healthcare","lineage":["https://openalex.org/I4210125476"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"K\u00e1roly Pap","raw_affiliation_strings":["Department of Traumatology, Semmelweis University, H-1113 Budapest, Hungary & Department of Orthopaedics and Traumatology, Uzsoki Hospital, H-1145, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traumatology, Semmelweis University, H-1113 Budapest, Hungary & Department of Orthopaedics and Traumatology, Uzsoki Hospital, H-1145, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996","https://openalex.org/I4210125476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035476284","display_name":"G\u00e1bor Gerber","orcid":"https://orcid.org/0000-0003-0256-2608","observed_orcids":["https://orcid.org/0000-0003-0256-2608"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G\u00e1bor Gerber","raw_affiliation_strings":["Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008139231","display_name":"Zita Pusk\u00e1r","orcid":"https://orcid.org/0000-0003-0096-2018","observed_orcids":["https://orcid.org/0000-0003-0096-2018"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Zita Pusk\u00e1r","raw_affiliation_strings":["Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary. puskar.zita@med.semmelweis-univ.hu","Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary. puskar.zita@med.semmelweis-univ.hu","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Department of Anatomy, Histology and Embryology, Semmelweis University, H-1094, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008139231"],"corresponding_institution_ids":["https://openalex.org/I101202996"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":3.2569,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.92250227,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"3490","last_page":"3490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dipeptidyl-peptidase-4","display_name":"dipeptidyl peptidase IV","score":0.996999979019165},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.6769999861717224},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9419999718666077},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":1.0},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.902999997138977},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.996999979019165},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/allodynia","display_name":"allodynia","score":0.9419999718666077},{"id":"https://openalex.org/keywords/vildagliptin","display_name":"vildagliptin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ipi","display_name":"IPI","score":0.5759999752044678},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.9769999980926514},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/endogenous-opioid-system","display_name":"endogenous opioid system","score":0.6340000033378601},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.7996116876602173},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.6897264122962952},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.638995885848999},{"id":"https://openalex.org/C2776453732","wikidata":"https://www.wikidata.org/wiki/Q421042","display_name":"Vildagliptin","level":4,"score":0.5874714851379395},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5858535766601562},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5612255930900574},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.5464972853660583},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.5167738199234009},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.5001544952392578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49589380621910095},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48708510398864746},{"id":"https://openalex.org/C2781469919","wikidata":"https://www.wikidata.org/wiki/Q5279728","display_name":"Dipeptidyl peptidase","level":3,"score":0.46665024757385254},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44588154554367065},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.44022274017333984},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.37648385763168335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3072676658630371},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23540985584259033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22441908717155457},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.14652365446090698},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.13568115234375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06880205869674683},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05874603986740112},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018819","descriptor_name":"Dipeptidyl Peptidase 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-018-21799-8","doi":"https://doi.org/10.1038/s41598-018-21799-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-21799-8","pdf_url":"https://www.nature.com/articles/s41598-018-21799-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4732048","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5823904","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5823904","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5823904","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:29472575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29472575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:24d74c8afb4446d58b71a3a0eb302c9f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/24d74c8afb4446d58b71a3a0eb302c9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)","raw_type":"article"},{"id":"pmh:oai:repo.lib.semmelweis.hu:123456789/5998","doi":null,"is_oa":false,"landing_page_url":"http://repo.lib.semmelweis.hu//handle/123456789/5998","pdf_url":null,"source":{"id":"https://openalex.org/S4306402199","display_name":"Semmelweis University Repository (Semmelweis University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I101202996","host_organization_name":"Semmelweis University","host_organization_lineage":["https://openalex.org/I101202996"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-21799-8","doi":"https://doi.org/10.1038/s41598-018-21799-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-21799-8","pdf_url":"https://www.nature.com/articles/s41598-018-21799-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G489963656","display_name":null,"funder_award_id":"115422","funder_id":"https://openalex.org/F4320326762","funder_display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal"}],"funders":[{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"},{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"},{"id":"https://openalex.org/F4320326762","display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805329012.pdf","grobid_xml":"https://content.openalex.org/works/W2805329012.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W32619398","https://openalex.org/W1496412423","https://openalex.org/W1497393946","https://openalex.org/W1507910610","https://openalex.org/W1552127247","https://openalex.org/W1581333439","https://openalex.org/W1839798074","https://openalex.org/W1906452216","https://openalex.org/W1945915564","https://openalex.org/W1963536010","https://openalex.org/W1969751124","https://openalex.org/W1972681397","https://openalex.org/W1985443889","https://openalex.org/W1998186208","https://openalex.org/W2006445520","https://openalex.org/W2009845088","https://openalex.org/W2027236524","https://openalex.org/W2028568649","https://openalex.org/W2031468509","https://openalex.org/W2038910860","https://openalex.org/W2047730645","https://openalex.org/W2047961059","https://openalex.org/W2051755650","https://openalex.org/W2054602840","https://openalex.org/W2055419442","https://openalex.org/W2055665437","https://openalex.org/W2056262623","https://openalex.org/W2058830778","https://openalex.org/W2059903872","https://openalex.org/W2065458147","https://openalex.org/W2067924690","https://openalex.org/W2068938067","https://openalex.org/W2071539369","https://openalex.org/W2071700706","https://openalex.org/W2072380789","https://openalex.org/W2076808452","https://openalex.org/W2087458050","https://openalex.org/W2087809119","https://openalex.org/W2087901606","https://openalex.org/W2089259173","https://openalex.org/W2091099236","https://openalex.org/W2091212902","https://openalex.org/W2094758439","https://openalex.org/W2099030247","https://openalex.org/W2111631879","https://openalex.org/W2120031987","https://openalex.org/W2120967846","https://openalex.org/W2128635872","https://openalex.org/W2128692107","https://openalex.org/W2149760207","https://openalex.org/W2163660677","https://openalex.org/W2256167805","https://openalex.org/W2330263046","https://openalex.org/W2404552601","https://openalex.org/W2547811689","https://openalex.org/W2609684457","https://openalex.org/W2939844444","https://openalex.org/W3192892652"],"related_works":["https://openalex.org/W7070006884","https://openalex.org/W2911351633","https://openalex.org/W4313588193","https://openalex.org/W2087809119","https://openalex.org/W4229061103","https://openalex.org/W1988210084","https://openalex.org/W4213153571","https://openalex.org/W4378781626","https://openalex.org/W2003028048","https://openalex.org/W2026881175"],"abstract_inverted_index":{"Altered":[0],"pain":[1,13],"sensations":[2],"such":[3],"as":[4],"hyperalgesia":[5,193],"and":[6,15,78,85,101,115,128,159,174,190,194],"allodynia":[7],"are":[8],"characteristic":[9],"features":[10],"of":[11,27,47,88,108,143,165,178,192],"various":[12],"states,":[14],"remain":[16],"difficult":[17],"to":[18,148,187],"treat.":[19],"We":[20],"have":[21],"shown":[22],"previously":[23],"that":[24],"spinal":[25,53,183],"application":[26,107],"dipeptidyl":[28],"peptidase":[29],"4":[30],"(DPP4)":[31],"inhibitors":[32,111,167],"induces":[33],"strong":[34],"antihyperalgesic":[35,124,133,141],"effect":[36,125,142],"during":[37,99,126],"inflammatory":[38,67],"pain.":[39],"In":[40,74],"this":[41],"study":[42],"we":[43],"observed":[44],"low":[45],"level":[46],"DPP4":[48,81,94,110,179],"mRNA":[49],"in":[50,56,65,97,102,104,121,135,181],"the":[51,116,136,166,182,188],"rat":[52],"dorsal":[54],"horn":[55],"physiological":[57],"conditions,":[58],"which":[59,185],"did":[60],"not":[61],"change":[62],"significantly":[63,95],"either":[64],"carrageenan-induced":[66],"or":[68],"partial":[69],"nerve":[70],"ligation-generated":[71],"neuropathic":[72,137],"states.":[73],"na\u00efve":[75],"animals,":[76],"microglia":[77,103],"astrocytes":[79,98],"expressed":[80],"protein":[82],"with":[83,196],"one":[84],"two":[86,109],"orders":[87],"magnitude":[89],"higher":[90],"than":[91],"neurons,":[92],"respectively.":[93],"increased":[96],"inflammation":[100],"neuropathy.":[105],"Intrathecal":[106],"tripeptide":[112],"isoleucin-prolin-isoleucin":[113],"(IPI)":[114],"antidiabetic":[117],"drug":[118],"vildagliptin":[119,152],"resulted":[120],"robust":[122],"opioid-dependent":[123],"inflammation,":[127],"milder":[129],"but":[130],"significant":[131],"opioid-independent":[132],"action":[134],"model.":[138],"The":[139],"opioid-mediated":[140],"IPI":[144],"was":[145],"exclusively":[146],"related":[147],"mu-opioid":[149],"receptors,":[150],"while":[151],"affected":[153],"mainly":[154],"delta-receptor":[155],"activity,":[156],"although":[157],"mu-":[158],"kappa-receptors":[160],"were":[161],"also":[162],"involved.":[163],"None":[164],"influenced":[168],"allodynia.":[169],"Our":[170],"results":[171],"suggest":[172],"pathology":[173],"glia-type":[175],"specific":[176],"changes":[177],"activity":[180],"cord,":[184],"contribute":[186],"development":[189],"maintenance":[191],"interact":[195],"endogenous":[197],"opioid":[198],"systems.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}