{"id":"https://openalex.org/W2805304147","doi":"https://doi.org/10.1038/s41598-018-27165-y","title":"Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes","display_name":"Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes","publication_year":2018,"publication_date":"2018-06-08","ids":{"openalex":"https://openalex.org/W2805304147","doi":"https://doi.org/10.1038/s41598-018-27165-y","mag":"2805304147","pmid":"https://pubmed.ncbi.nlm.nih.gov/29904107","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6002548"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-27165-y","doi":"https://doi.org/10.1038/s41598-018-27165-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-27165-y","pdf_url":"https://www.nature.com/articles/s41598-018-27165-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-27165-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053354430","display_name":"Alessandra Lo Cicero","orcid":"https://orcid.org/0000-0001-6525-4480","observed_orcids":["https://orcid.org/0000-0001-6525-4480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandra Lo Cicero","raw_affiliation_strings":["CECS, I-Stem, Corbeil-Essonnes, 91100, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CECS, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017804811","display_name":"Manoubia Saidani","orcid":"https://orcid.org/0000-0002-2805-4639","observed_orcids":["https://orcid.org/0000-0002-2805-4639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manoubia Saidani","raw_affiliation_strings":["CECS, I-Stem, Corbeil-Essonnes, 91100, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CECS, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034670110","display_name":"Jennifer Allouche","orcid":"https://orcid.org/0000-0002-2379-0979","observed_orcids":["https://orcid.org/0000-0002-2379-0979"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I88467170","display_name":"Universit\u00e9 d'\u00c9vry Val-d'Essonne","ror":"https://ror.org/00e96v939","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954","https://openalex.org/I88467170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jennifer Allouche","raw_affiliation_strings":["INSERM U861, I-Stem, Corbeil-Essonnes, 91100, France","UEVE U861, I-Stem, Corbeil-Essonnes, 91100, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U861, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UEVE U861, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":["https://openalex.org/I88467170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113913772","display_name":"Anne-Laure Egesipe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Laure Egesipe","raw_affiliation_strings":["CECS, I-Stem, Corbeil-Essonnes, 91100, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CECS, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013054320","display_name":"Lucile Hoch","orcid":"https://orcid.org/0000-0002-7264-9031","observed_orcids":["https://orcid.org/0000-0002-7264-9031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucile Hoch","raw_affiliation_strings":["CECS, I-Stem, Corbeil-Essonnes, 91100, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CECS, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072836432","display_name":"C\u00e9line Bruge","orcid":"https://orcid.org/0000-0002-9505-5527","observed_orcids":["https://orcid.org/0000-0002-9505-5527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Celine Bruge","raw_affiliation_strings":["CECS, I-Stem, Corbeil-Essonnes, 91100, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CECS, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030858407","display_name":"Sabine Sigaudy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sabine Sigaudy","raw_affiliation_strings":["Aix Marseille Univ, INSERM, MMG, Marseille, France","Department of Medical Genetics, Children's Hospital La Timone, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, INSERM, MMG, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767"]},{"raw_affiliation_string":"Department of Medical Genetics, Children's Hospital La Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038169437","display_name":"Annachiara De Sandre\u2010Giovannoli","orcid":"https://orcid.org/0000-0002-2324-2462","observed_orcids":["https://orcid.org/0000-0002-2324-2462"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Annachiara De Sandre-Giovannoli","raw_affiliation_strings":["Aix Marseille Univ, INSERM, MMG, Marseille, France","Department of Medical Genetics, Children's Hospital La Timone, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, INSERM, MMG, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767"]},{"raw_affiliation_string":"Department of Medical Genetics, Children's Hospital La Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063671279","display_name":"Nicolas L\u00e9vy","orcid":"https://orcid.org/0000-0001-5171-6365","observed_orcids":["https://orcid.org/0000-0001-5171-6365"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Levy","raw_affiliation_strings":["Aix Marseille Univ, INSERM, MMG, Marseille, France","Department of Medical Genetics, Children's Hospital La Timone, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, INSERM, MMG, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767"]},{"raw_affiliation_string":"Department of Medical Genetics, Children's Hospital La Timone, Marseille, France","institution_ids":["https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032744232","display_name":"Christine Baldeschi","orcid":"https://orcid.org/0000-0001-6624-0507","observed_orcids":["https://orcid.org/0000-0001-6624-0507"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I88467170","display_name":"Universit\u00e9 d'\u00c9vry Val-d'Essonne","ror":"https://ror.org/00e96v939","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954","https://openalex.org/I88467170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Baldeschi","raw_affiliation_strings":["INSERM U861, I-Stem, Corbeil-Essonnes, 91100, France","UEVE U861, I-Stem, Corbeil-Essonnes, 91100, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U861, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UEVE U861, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":["https://openalex.org/I88467170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069115438","display_name":"Xavier Nissan","orcid":"https://orcid.org/0000-0003-3374-6274","observed_orcids":["https://orcid.org/0000-0003-3374-6274"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xavier Nissan","raw_affiliation_strings":["CECS, I-Stem, Corbeil-Essonnes, 91100, France. xnissan@istem.fr","CECS, I-Stem, Corbeil-Essonnes, 91100, France"],"raw_orcid":"https://orcid.org/0000-0003-3374-6274","affiliations":[{"raw_affiliation_string":"CECS, I-Stem, Corbeil-Essonnes, 91100, France. xnissan@istem.fr","institution_ids":[]},{"raw_affiliation_string":"CECS, I-Stem, Corbeil-Essonnes, 91100, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069115438"],"corresponding_institution_ids":[],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.1954,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.41485728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"1","first_page":"9112","last_page":"9112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hutchinson-gilford-progeria-syndrome","display_name":"Hutchinson-Gilford progeria syndrome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hypopigmentation","display_name":"hypopigmentation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.8159999847412109},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/progerin","display_name":"progerin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/melanosome-maturation","display_name":"melanosome maturation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2778465436","wikidata":"https://www.wikidata.org/wiki/Q213098","display_name":"Progeria","level":3,"score":0.9530484676361084},{"id":"https://openalex.org/C94435474","wikidata":"https://www.wikidata.org/wiki/Q1065756","display_name":"Melanosome","level":3,"score":0.7803994417190552},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.6021460890769958},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5819559097290039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5747460722923279},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.5645817518234253},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5499182343482971},{"id":"https://openalex.org/C2776291823","wikidata":"https://www.wikidata.org/wiki/Q1291366","display_name":"Hypopigmentation","level":2,"score":0.5006043910980225},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4848857820034027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3078761696815491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2608744502067566},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.1385866105556488},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010859","descriptor_name":"Pigmentation Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010859","descriptor_name":"Pigmentation Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011371","descriptor_name":"Progeria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011371","descriptor_name":"Progeria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020460","descriptor_name":"Melanosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020460","descriptor_name":"Melanosomes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-018-27165-y","doi":"https://doi.org/10.1038/s41598-018-27165-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-27165-y","pdf_url":"https://www.nature.com/articles/s41598-018-27165-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4967365","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6002548","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29904107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29904107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6002548","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6002548/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-01991357v1","doi":null,"is_oa":true,"landing_page_url":"https://amu.hal.science/hal-01991357","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-27165-y⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:df5141673b6845d895286483aed51c1d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/df5141673b6845d895286483aed51c1d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)","raw_type":"article"},{"id":"pmh:oai:iris.unipa.it:10447/585155","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10447/585155","pdf_url":null,"source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-27165-y","doi":"https://doi.org/10.1038/s41598-018-27165-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-27165-y","pdf_url":"https://www.nature.com/articles/s41598-018-27165-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G120131529","display_name":null,"funder_award_id":"ANR-10\u2013INSB\u201304","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G175125242","display_name":null,"funder_award_id":"ANR-10-LABX73","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5188301940","display_name":null,"funder_award_id":"ANR-10-INSB-04","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5529810614","display_name":"INFRASTRUCTURE NATIONALE D'INGENIERIE DES CELLULES SOUCHES PLURIPOTENTES","funder_award_id":"ANR-11-INBS-0009","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5802621812","display_name":null,"funder_award_id":"ANR-11-INBS","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5852100077","display_name":null,"funder_award_id":"ANR-10-LABX-73","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G720919035","display_name":"Infrastructure de Recherche Translationnelle pour les Bioth\u00e9rapies en Neurosciences","funder_award_id":"ANR-11-INBS-0011","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7376787254","display_name":null,"funder_award_id":"ANR-10-LABX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8197154694","display_name":null,"funder_award_id":"ANR-10-LABX-73","funder_id":"https://openalex.org/F4320322892","funder_display_name":"Centre National de la Recherche Scientifique"},{"id":"https://openalex.org/G8447172698","display_name":"D\u00e9veloppment d'une infrastructure fran\u00e7aise distribu\u00e9e coordonn\u00e9e","funder_award_id":"ANR-10-INBS-0004","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8987543086","display_name":"Stem Cells in Regenerative Biology and Medicine","funder_award_id":"ANR-10-LABX-0073","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320315862","display_name":"Infrastructures en Biologie Sant\u00e9 et Agronomie","ror":"https://ror.org/054q97b08"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805304147.pdf","grobid_xml":"https://content.openalex.org/works/W2805304147.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W190255315","https://openalex.org/W1224195541","https://openalex.org/W1602375218","https://openalex.org/W1783158084","https://openalex.org/W1954901000","https://openalex.org/W1964551999","https://openalex.org/W1972207344","https://openalex.org/W1974449792","https://openalex.org/W1976506286","https://openalex.org/W1992900610","https://openalex.org/W2009842965","https://openalex.org/W2011024729","https://openalex.org/W2016268789","https://openalex.org/W2024153799","https://openalex.org/W2048445712","https://openalex.org/W2054521968","https://openalex.org/W2057084831","https://openalex.org/W2062203555","https://openalex.org/W2066442023","https://openalex.org/W2066816830","https://openalex.org/W2069910674","https://openalex.org/W2072810104","https://openalex.org/W2073460054","https://openalex.org/W2073610802","https://openalex.org/W2073720872","https://openalex.org/W2073853835","https://openalex.org/W2096905898","https://openalex.org/W2106782182","https://openalex.org/W2109196816","https://openalex.org/W2111819985","https://openalex.org/W2122132943","https://openalex.org/W2122983246","https://openalex.org/W2126525177","https://openalex.org/W2127680780","https://openalex.org/W2128353741","https://openalex.org/W2131116166","https://openalex.org/W2138977668","https://openalex.org/W2143185290","https://openalex.org/W2146079271","https://openalex.org/W2158608461","https://openalex.org/W2166403801","https://openalex.org/W2531202570","https://openalex.org/W2553410755","https://openalex.org/W2725323001","https://openalex.org/W2745145572","https://openalex.org/W4366456675","https://openalex.org/W7096805262"],"related_works":["https://openalex.org/W2073610802","https://openalex.org/W2128353741","https://openalex.org/W2077856475","https://openalex.org/W2160591443","https://openalex.org/W2116862648","https://openalex.org/W2334230058","https://openalex.org/W4414444844","https://openalex.org/W7166939046","https://openalex.org/W1794604032","https://openalex.org/W1752290721"],"abstract_inverted_index":{"Hutchinson-Gilford":[0],"Progeria":[1],"Syndrome":[2],"(HGPS)":[3],"is":[4],"a":[5,54,77,86,105],"rare":[6],"genetic":[7],"disorder":[8],"that":[9,122],"leads":[10],"to":[11,23,64],"premature":[12],"aging.":[13,129],"In":[14],"this":[15],"study,":[16],"we":[17],"used":[18],"induced":[19],"pluripotent":[20],"stem":[21],"cells":[22,41],"investigate":[24],"the":[25,69,91,97,117],"hypopigmentation":[26],"phenotypes":[27,121],"observed":[28],"in":[29,59,96,109,116],"patients":[30,44],"with":[31,125],"progeria.":[32],"Accordingly,":[33],"two":[34],"iPS":[35],"cell":[36],"lines":[37],"were":[38],"derived":[39],"from":[40,42],"HGPS":[43,60,110],"and":[45,111,127],"differentiated":[46],"into":[47],"melanocytes.":[48],"Measurements":[49],"of":[50,57,68,80,94,99,119],"melanin":[51,58],"content":[52],"revealed":[53,76,90],"lower":[55,78],"synthesis":[56],"melanocytes":[61],"as":[62],"compared":[63],"non-pathologic":[65],"cells.":[66],"Analysis":[67],"melanosome":[70],"maturation":[71],"process":[72],"by":[73],"electron":[74],"microscopy":[75],"percentage":[79],"mature,":[81],"fully":[82],"pigmented":[83],"melanosomes.":[84],"Finally,":[85],"functional":[87],"rescue":[88],"experiment":[89],"direct":[92],"role":[93],"progerin":[95],"regulation":[98],"melanogenesis.":[100],"Overall,":[101],"these":[102],"results":[103],"report":[104],"new":[106],"dysregulated":[107],"pathway":[108],"open":[112],"up":[113],"novel":[114],"perspectives":[115],"study":[118],"pigmentation":[120],"are":[123],"associated":[124],"normal":[126],"pathological":[128]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-13T00:00:00"}