{"id":"https://openalex.org/W2805252124","doi":"https://doi.org/10.1097/01.hjh.0000539312.55033.aa","title":"LEVELS OF ENDOCAN, ANGIOPOIETIN-2 AND HIF-1A IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE AND DIFFERENT LEVELS OF RENAL FUNCTION","display_name":"LEVELS OF ENDOCAN, ANGIOPOIETIN-2 AND HIF-1A IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE AND DIFFERENT LEVELS OF RENAL FUNCTION","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2805252124","doi":"https://doi.org/10.1097/01.hjh.0000539312.55033.aa","mag":"2805252124"},"language":"en","primary_location":{"id":"doi:10.1097/01.hjh.0000539312.55033.aa","doi":"https://doi.org/10.1097/01.hjh.0000539312.55033.aa","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.hjh.0000539312.55033.aa","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061730396","display_name":"Charalampos Loutradis","orcid":"https://orcid.org/0000-0001-6387-4176","observed_orcids":["https://orcid.org/0000-0001-6387-4176"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C. Loutradis","raw_affiliation_strings":["Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052189864","display_name":"Vasileios Raptis","orcid":"https://orcid.org/0000-0002-1203-2582","observed_orcids":["https://orcid.org/0000-0002-1203-2582"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"V. Raptis","raw_affiliation_strings":["Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]},{"raw_affiliation_string":"Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036118949","display_name":"Constantinos Bakogiannis","orcid":"https://orcid.org/0000-0002-1132-9835","observed_orcids":["https://orcid.org/0000-0002-1132-9835"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C. Bakogiannis","raw_affiliation_strings":["rd Department of Cardiology Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","3rd Department of Cardiology Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"rd Department of Cardiology Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"3rd Department of Cardiology Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087629460","display_name":"Afroditi Boutou","orcid":"https://orcid.org/0000-0001-7366-2038","observed_orcids":["https://orcid.org/0000-0001-7366-2038"]},"institutions":[{"id":"https://openalex.org/I4210157387","display_name":"G. Papanikolaou General Hospital","ror":"https://ror.org/0463dsf87","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210157387"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A.K. Boutou","raw_affiliation_strings":["Department of Respiratory Medicine, Papanikolaou General Hospital, Thessaloniki, Thessaloniki, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Papanikolaou General Hospital, Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I4210157387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036204499","display_name":"Ioanna Lampropoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I. Lampropoulou","raw_affiliation_strings":["Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065804663","display_name":"Elena Intzevidou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. Intzevidou","raw_affiliation_strings":["Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088402193","display_name":"Athanasios Sioulis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Sioulis","raw_affiliation_strings":["Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035933837","display_name":"Elias V. Balaskas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. Balaskas","raw_affiliation_strings":["Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028159985","display_name":"Pantelis A. Sarafidis","orcid":"https://orcid.org/0000-0002-9174-4018","observed_orcids":["https://orcid.org/0000-0002-9174-4018"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210116665","display_name":"Ippokrateio General Hospital of Thessaloniki","ror":"https://ror.org/02kpyrm37","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210116665"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"P.A. Sarafidis","raw_affiliation_strings":["Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GREECE","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210116665"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"Supplement 1","first_page":"e120","last_page":"e120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/endocan","display_name":"endocan","score":0.9670000076293945},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.7540000081062317},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9819999933242798},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8790000081062317},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7120000123977661},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.628000020980835},{"id":"https://openalex.org/keywords/renal-ischemia","display_name":"renal ischemia","score":0.5529999732971191},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.5659999847412109},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.4099999964237213},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.46700000762939453},{"id":"https://openalex.org/keywords/renal-tubular-epithelial-cells","display_name":"renal tubular epithelial cells","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8802837133407593},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7343863844871521},{"id":"https://openalex.org/C2776266639","wikidata":"https://www.wikidata.org/wiki/Q2732398","display_name":"Autosomal dominant polycystic kidney disease","level":3,"score":0.6378841400146484},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5542256832122803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.533876895904541},{"id":"https://openalex.org/C2780145431","wikidata":"https://www.wikidata.org/wiki/Q15443105","display_name":"Polycystic kidney disease","level":3,"score":0.5223656296730042},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5029723048210144},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.49257713556289673},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48657166957855225},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48322781920433044},{"id":"https://openalex.org/C2779094623","wikidata":"https://www.wikidata.org/wiki/Q539710","display_name":"Angiopoietin","level":4,"score":0.47529590129852295},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.45507705211639404},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4472080171108246},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.41108086705207825},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3645564317703247},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.3490801453590393},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.11099579930305481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.056900858879089355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.hjh.0000539312.55033.aa","doi":"https://doi.org/10.1097/01.hjh.0000539312.55033.aa","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.hjh.0000539312.55033.aa","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2804457706","https://openalex.org/W2795110896","https://openalex.org/W2804925550","https://openalex.org/W3131050773","https://openalex.org/W2803538177","https://openalex.org/W2955025283","https://openalex.org/W3087148967","https://openalex.org/W2923289005","https://openalex.org/W2996402731","https://openalex.org/W2804271665"],"abstract_inverted_index":{"Objective:":[0],"Endothelial":[1],"dysfunction":[2],"leading":[3],"to":[4,145,205,297,303],"unbalanced":[5],"vasoconstriction":[6],"and":[7,48,58,90,93,111,138,245,253,293,318,330],"ischemia":[8],"of":[9,19,31,41,44,64,100,105,128,201,225,280,286,316,327],"renal":[10,20,55,72,84,101,213],"parenchyma":[11],"is":[12],"increasingly":[13],"proposed":[14],"as":[15],"an":[16],"additional":[17],"pathway":[18],"damage":[21],"in":[22,50,121,147,194,295,313],"autosomal-dominant-polycystic-kidney-disease":[23],"(ADPKD).":[24],"However,":[25],"human":[26],"studies":[27],"investigating":[28],"the":[29,39,281,304,314],"evolution":[30],"such":[32],"phenomena":[33],"are":[34],"limited.":[35],"This":[36],"study":[37,61,265],"investigated":[38],"levels":[40,104,127,200],"emerging":[42],"biomarkers":[43],"endothelial":[45,290],"function,":[46],"angiogenesis":[47,292],"hypoxia,":[49],"ADPKD":[51,68,80,219,282,317],"patients":[52,69,81,146,193,270],"with":[53,70,82,97,229,259,271],"different":[54],"function.":[56,214],"Design":[57],"method:":[59],"The":[60],"population":[62],"consisted":[63],"three":[65],"groups:":[66],"26":[67,79,91],"impaired":[71],"function":[73,85],"(Group":[74,86],"A)":[75],"(eGFR":[76],"45\u201370":[77],"ml/min/1.73m2),":[78,89],"preserved":[83],"B)":[87],"(eGFR>70":[88],"age-":[92],"sex-":[94],"matched":[95],"controls":[96,172,206],"no":[98],"history":[99],"disease.":[102],"Circulating":[103],"endocan":[106,129],"(endothelial":[107],"cell-specific":[108],"molecule-1)":[109],"angiopoietin-2,":[110],"hypoxia-induced-factor-1a":[112],"(HIF-1a)":[113],"were":[114],"determined":[115],"by":[116],"ELISA":[117],"techniques.":[118],"Results:":[119],"Patients":[120],"Group":[122,148,195],"A":[123],"had":[124,197,283],"significantly":[125],"higher":[126,199,284],"(7.17":[130],"\u00b1":[131,136,141,151,158,164,174,178,182],"0.43":[132],"ng/ml),":[133],"angiopoietin-2":[134],"(5,595.43":[135],"3,390)":[137],"HIF-1a":[139,246],"(163.68":[140],"37.84":[142],"pg/ml)":[143],"compared":[144,204],"B":[149,196],"(6.86":[150],"0.59":[152],"ng/ml,":[153,176],"p":[154,160,167,185,235,242,250],"=":[155,161,168,233,240,248],"0.017,":[156],"3,854.41":[157],"3,014.30,":[159],"0.018,":[162],"136.84":[163],"42.10":[165],"pg/ml,":[166,180,184],"0.019,":[169],"respectively)":[170],"or":[171,256],"(4.83":[173],"0.69":[175],"1,069":[177],"427.88":[179],"70.20":[181],"17.49":[183],"<":[186,208,236,243,251],"0.001":[187,244],"for":[188,289],"all":[189,202,226],"comparisons).":[190],"Of":[191],"note,":[192],"also":[198,275],"markers":[203,228,287],"(p":[207],"0.001),":[209,252],"despite":[210],"having":[211],"similar":[212],"In":[215,262],"correlation":[216],"analyses":[217],"within":[218],"patients,":[220],"we":[221],"noted":[222],"strong":[223],"correlations":[224,258],"studied":[227],"ADMA":[230],"(endocan":[231],"r":[232,239,247],"0.908,":[234],"0.001,":[237],"angiopoietin2":[238],"0.983,":[241],"0.998,":[249],"only":[254,269],"weak":[255],"modest":[257],"eGFR.":[260],"Conclusions:":[261],"conclusion,":[263],"this":[264],"suggests":[266],"that":[267,306],"not":[268],"low":[272],"eGFR,":[273],"but":[274],"those":[276],"at":[277],"early":[278,312],"stages":[279],"expression":[285],"indicative":[288],"dysfunction,":[291],"hypoxia":[294],"comparison":[296],"controls.":[298],"These":[299],"results":[300],"could":[301,319],"lead":[302],"hypothesis":[305],"local":[307],"microcirculatory":[308],"changes":[309],"may":[310],"come":[311],"course":[315],"be":[320],"a":[321,325],"cause":[322],"rather":[323],"than":[324],"result":[326],"disease":[328],"progression":[329],"eGFR":[331],"decline.":[332]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-06-13T00:00:00"}