{"id":"https://openalex.org/W2805145040","doi":null,"title":"A novel role for macrophages in peripheral nerve regeneration","display_name":"A novel role for macrophages in peripheral nerve regeneration","publication_year":2018,"publication_date":"2018-05-28","ids":{"openalex":"https://openalex.org/W2805145040","mag":"2805145040"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10049387","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/10049387/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077052532","display_name":"Lucie Van Emmenis","orcid":"https://orcid.org/0000-0002-6207-6946","observed_orcids":["https://orcid.org/0000-0002-6207-6946"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lucie Van Emmenis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6207-6946","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5077052532"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8479999899864197},{"id":"https://openalex.org/keywords/peripheral-nerve-regeneration","display_name":"peripheral nerve regeneration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nerve-injury","display_name":"nerve injury","score":0.8709999918937683},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/schwann-cell-migration","display_name":"Schwann cell migration","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ccl3","display_name":"CCL3","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.843999981880188},{"id":"https://openalex.org/keywords/cx3cr1","display_name":"CX3CR1","score":0.875},{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.8899999856948853},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.7919999957084656},{"id":"https://openalex.org/keywords/macrophage-heterogeneity","display_name":"macrophage heterogeneity","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6894097924232483},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6364314556121826},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5777978301048279},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.5725246071815491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5674839615821838},{"id":"https://openalex.org/C2777004073","wikidata":"https://www.wikidata.org/wiki/Q465621","display_name":"Schwann cell","level":2,"score":0.5621572732925415},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.5191947221755981},{"id":"https://openalex.org/C100776233","wikidata":"https://www.wikidata.org/wiki/Q2532492","display_name":"Bridge (graph theory)","level":2,"score":0.4346555471420288},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.41548633575439453},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4119148254394531},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35743939876556396},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3025335669517517},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2695739269256592},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18012818694114685},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08991566300392151},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10049387","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/10049387/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:2805145040","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/id/eprint/10049387/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":249,"referenced_works":["https://openalex.org/W51843776","https://openalex.org/W86358223","https://openalex.org/W169304000","https://openalex.org/W186197308","https://openalex.org/W882470887","https://openalex.org/W904058290","https://openalex.org/W1034388696","https://openalex.org/W1518835034","https://openalex.org/W1532654778","https://openalex.org/W1539046700","https://openalex.org/W1568448898","https://openalex.org/W1578383688","https://openalex.org/W1588935895","https://openalex.org/W1615683666","https://openalex.org/W1650902214","https://openalex.org/W1655540037","https://openalex.org/W1758604915","https://openalex.org/W1768356346","https://openalex.org/W1778576079","https://openalex.org/W1784352764","https://openalex.org/W1815693934","https://openalex.org/W1817666133","https://openalex.org/W1851526054","https://openalex.org/W1914125466","https://openalex.org/W1935201742","https://openalex.org/W1949425569","https://openalex.org/W1959055352","https://openalex.org/W1960355435","https://openalex.org/W1963739427","https://openalex.org/W1965571714","https://openalex.org/W1965932992","https://openalex.org/W1966476265","https://openalex.org/W1969552240","https://openalex.org/W1970570245","https://openalex.org/W1971393286","https://openalex.org/W1971817487","https://openalex.org/W1972170345","https://openalex.org/W1972286844","https://openalex.org/W1973409138","https://openalex.org/W1973433801","https://openalex.org/W1974640915","https://openalex.org/W1976096075","https://openalex.org/W1976719807","https://openalex.org/W1976821656","https://openalex.org/W1977536320","https://openalex.org/W1980745289","https://openalex.org/W1981410259","https://openalex.org/W1982242924","https://openalex.org/W1982542580","https://openalex.org/W1983458178","https://openalex.org/W1985940938","https://openalex.org/W1988692680","https://openalex.org/W1991755057","https://openalex.org/W1991923928","https://openalex.org/W1993006648","https://openalex.org/W1993412993","https://openalex.org/W1995717532","https://openalex.org/W1996479070","https://openalex.org/W1996861581","https://openalex.org/W1997230083","https://openalex.org/W1997343220","https://openalex.org/W1997349847","https://openalex.org/W1998279268","https://openalex.org/W1998420703","https://openalex.org/W2000601562","https://openalex.org/W2000814289","https://openalex.org/W2001341519","https://openalex.org/W2002408287","https://openalex.org/W2004538934","https://openalex.org/W2005448587","https://openalex.org/W2006557479","https://openalex.org/W2006773314","https://openalex.org/W2008431619","https://openalex.org/W2008488746","https://openalex.org/W2011780078","https://openalex.org/W2011965919","https://openalex.org/W2011984976","https://openalex.org/W2013204606","https://openalex.org/W2015479943","https://openalex.org/W2016518845","https://openalex.org/W2016717347","https://openalex.org/W2019922483","https://openalex.org/W2020164587","https://openalex.org/W2021218920","https://openalex.org/W2022308075","https://openalex.org/W2022369905","https://openalex.org/W2022971724","https://openalex.org/W2023164440","https://openalex.org/W2027685865","https://openalex.org/W2028862487","https://openalex.org/W2028934778","https://openalex.org/W2029416405","https://openalex.org/W2029427164","https://openalex.org/W2030691946","https://openalex.org/W2034670933","https://openalex.org/W2035538295","https://openalex.org/W2039942900","https://openalex.org/W2040610114","https://openalex.org/W2042769704","https://openalex.org/W2048340704","https://openalex.org/W2048502950","https://openalex.org/W2048672935","https://openalex.org/W2049959255","https://openalex.org/W2050935187","https://openalex.org/W2051013988","https://openalex.org/W2052259025","https://openalex.org/W2052316576","https://openalex.org/W2052730253","https://openalex.org/W2053199336","https://openalex.org/W2053583666","https://openalex.org/W2053632281","https://openalex.org/W2054540776","https://openalex.org/W2055348159","https://openalex.org/W2055620105","https://openalex.org/W2056909536","https://openalex.org/W2058264719","https://openalex.org/W2058401539","https://openalex.org/W2058648826","https://openalex.org/W2062035900","https://openalex.org/W2063063761","https://openalex.org/W2065577291","https://openalex.org/W2066278568","https://openalex.org/W2066318475","https://openalex.org/W2066796908","https://openalex.org/W2066943555","https://openalex.org/W2067701233","https://openalex.org/W2071867803","https://openalex.org/W2072041004","https://openalex.org/W2072462631","https://openalex.org/W2073998405","https://openalex.org/W2077885131","https://openalex.org/W2079659068","https://openalex.org/W2080074351","https://openalex.org/W2081304354","https://openalex.org/W2085695854","https://openalex.org/W2086534450","https://openalex.org/W2089836937","https://openalex.org/W2089846619","https://openalex.org/W2089985513","https://openalex.org/W2090177945","https://openalex.org/W2091363184","https://openalex.org/W2091487793","https://openalex.org/W2091562888","https://openalex.org/W2092322285","https://openalex.org/W2092857773","https://openalex.org/W2096179876","https://openalex.org/W2103256993","https://openalex.org/W2103698298","https://openalex.org/W2105925708","https://openalex.org/W2107567947","https://openalex.org/W2107826905","https://openalex.org/W2110179483","https://openalex.org/W2113774043","https://openalex.org/W2114504843","https://openalex.org/W2118655588","https://openalex.org/W2120231073","https://openalex.org/W2120421863","https://openalex.org/W2120442017","https://openalex.org/W2121294918","https://openalex.org/W2122144410","https://openalex.org/W2123950558","https://openalex.org/W2124403328","https://openalex.org/W2126811287","https://openalex.org/W2127845947","https://openalex.org/W2129927864","https://openalex.org/W2131020789","https://openalex.org/W2132924600","https://openalex.org/W2133054656","https://openalex.org/W2133793569","https://openalex.org/W2135007468","https://openalex.org/W2136016462","https://openalex.org/W2136188258","https://openalex.org/W2139154500","https://openalex.org/W2140380746","https://openalex.org/W2141291709","https://openalex.org/W2142254746","https://openalex.org/W2147932294","https://openalex.org/W2148898943","https://openalex.org/W2149053153","https://openalex.org/W2149599746","https://openalex.org/W2150761291","https://openalex.org/W2150907996","https://openalex.org/W2151399165","https://openalex.org/W2153406260","https://openalex.org/W2156750162","https://openalex.org/W2158070898","https://openalex.org/W2159560463","https://openalex.org/W2161057248","https://openalex.org/W2162631036","https://openalex.org/W2163590547","https://openalex.org/W2163987689","https://openalex.org/W2164036959","https://openalex.org/W2165078107","https://openalex.org/W2165230539","https://openalex.org/W2168254795","https://openalex.org/W2169622652","https://openalex.org/W2169956387","https://openalex.org/W2172103539","https://openalex.org/W2178578592","https://openalex.org/W2225115505","https://openalex.org/W2240326522","https://openalex.org/W2265779583","https://openalex.org/W2268619028","https://openalex.org/W2276651706","https://openalex.org/W2277951273","https://openalex.org/W2294088168","https://openalex.org/W2299806323","https://openalex.org/W2300114742","https://openalex.org/W2301038687","https://openalex.org/W2306715392","https://openalex.org/W2314634699","https://openalex.org/W2339391327","https://openalex.org/W2343063221","https://openalex.org/W2344661736","https://openalex.org/W2345128728","https://openalex.org/W2346820190","https://openalex.org/W2396814975","https://openalex.org/W2411386874","https://openalex.org/W2443001171","https://openalex.org/W2464410938","https://openalex.org/W2467426346","https://openalex.org/W2488623684","https://openalex.org/W2492998259","https://openalex.org/W2496428480","https://openalex.org/W2502245595","https://openalex.org/W2506892818","https://openalex.org/W2506944489","https://openalex.org/W2511868650","https://openalex.org/W2516515961","https://openalex.org/W2517088590","https://openalex.org/W2529168807","https://openalex.org/W2530303858","https://openalex.org/W2551905860","https://openalex.org/W2554700856","https://openalex.org/W2558137541","https://openalex.org/W2565655079","https://openalex.org/W2581219109","https://openalex.org/W2582686270","https://openalex.org/W2588198821","https://openalex.org/W2590477501","https://openalex.org/W2593338143","https://openalex.org/W2594459336","https://openalex.org/W2597060258","https://openalex.org/W2597734448","https://openalex.org/W2599822883","https://openalex.org/W2625298747","https://openalex.org/W2626120438","https://openalex.org/W2745295358","https://openalex.org/W2755983607"],"related_works":["https://openalex.org/W2337789130","https://openalex.org/W1935201742","https://openalex.org/W4407611349","https://openalex.org/W4411115225","https://openalex.org/W7011913476","https://openalex.org/W4313199819","https://openalex.org/W3044394245","https://openalex.org/W2333893582","https://openalex.org/W2130333176","https://openalex.org/W4399044230"],"abstract_inverted_index":{"Peripheral":[0],"nerves":[1],"are":[2,201,247],"one":[3],"of":[4,65,115,182,193,206,299,308,332],"the":[5,33,40,60,63,86,101,116,139,175,178,191,196,259,282,297,330],"few":[6],"adult":[7],"tissues":[8],"which":[9,36,69,164],"can":[10,165],"regenerate":[11],"following":[12,301],"injury,":[13,26,302,323],"and":[14,44,99,127,171,180,198,254,275,336],"macrophages":[15,58,90,111,143,194,231,246],"have":[16,210],"many":[17],"important":[18],"roles":[19],"in":[20,59,195,232,238,272,293,306,320,329],"this":[21],"multicellular":[22],"process.":[23],"Following":[24],"nerve":[25,41,124,142,161,309,322,334],"regrowing":[27],"axons":[28,82],"must":[29],"traverse":[30],"tissue":[31,51],"termed":[32],"\u2018nerve":[34],"bridge\u2019,":[35],"forms":[37],"spontaneously":[38],"between":[39],"stumps":[42],"(proximal":[43],"distal),":[45],"to":[46,78,96,103,122,128,151,215,223,249,267],"reconnect":[47],"with":[48,83,92],"their":[49],"original":[50],"target.":[52],"Previously,":[53],"we":[54,157,209,220,242],"found":[55,158,243],"that":[56,190,244,279],"hypoxic":[57,229,245,287],"bridge":[61,197,207,230],"induce":[62,250,268],"formation":[64],"a":[66,76,133,145,225],"polarised":[67],"vasculature":[68],"dedifferentiated":[70],"Schwann":[71,93,135,234,251,269,312],"cells":[72,94],"subsequently":[73],"use":[74],"as":[75,262,303,305,324,326],"scaffold":[77],"migrate":[79],"along,":[80],"taking":[81],"them":[84],"into":[85],"distal":[87,199],"stump.":[88],"Here,":[89],"together":[91],"function":[95],"clear":[97],"debris":[98],"remodel":[100],"environment":[102],"facilitate":[104],"axonal":[105],"regeneration,":[106],"demonstrating":[107],"distinct":[108,146,160],"functions":[109],"for":[110,228],"within":[112,138],"discrete":[113],"areas":[114],"regenerating":[117],"nerve.":[118],"This":[119],"thesis":[120],"aims":[121],"characterise":[123],"macrophage":[125,154,183],"populations":[126,163,184],"determine":[129],"whether":[130],"there":[131],"is":[132,185,265,281],"specific":[134],"cell":[136,235,252,270,313],"chemoattractant":[137,260,284,314],"bridge.":[140],"Resident":[141],"displayed":[144],"gene":[147],"expression":[148,170],"pattern":[149],"compared":[150],"other":[152],"resident":[153,162],"populations.":[155],"Moreover,":[156],"two":[159],"be":[166],"distinguished":[167],"by":[168,286],"CX3CR1":[169],"physiological":[172],"location.":[173],"In":[174,203],"injured":[176],"nerve,":[177],"origin":[179],"phenotype":[181],"currently":[186],"unknown.":[187],"We":[188,289],"determined":[189],"majority":[192],"stump":[200],"monocyte-derived.":[202],"further":[204],"characterisation":[205],"macrophages,":[208],"identified":[211,258],"an":[212,255],"intrinsic":[213],"ability":[214],"differentially":[216],"sense":[217],"hypoxia.":[218],"Here":[219],"show":[221],"data":[222],"support":[224],"novel":[226],"role":[227,298],"promoting":[233],"migration.":[236],"Using":[237],"vitro":[239],"chemotaxis":[240],"assays,":[241,274],"able":[248,266],"migration":[253,271],"unbiased":[256],"screen":[257],"factor":[261,315],"CCL3.":[263],"CCL3":[264,280,300],"chemotactic":[273],"knockdown":[276],"studies":[277],"showed":[278],"primary":[283],"secreted":[285],"macrophages.":[288],"also":[290],"present":[291],"preliminary":[292],"vivo":[294],"experiments":[295],"investigating":[296],"well":[304,325],"models":[307],"repair.":[310],"A":[311],"has":[316],"wide":[317],"therapeutic":[318],"implications":[319],"peripheral":[321],"potential":[327],"uses":[328],"treatment":[331],"aberrant":[333],"growth":[335],"tumour":[337],"spread.":[338]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}
