{"id":"https://openalex.org/W2805111780","doi":"https://doi.org/10.1387/ijdb.170218yt","title":"Migration of lymphatic endothelial cells and lymphatic vascular development in the craniofacial region of embryonic mice","display_name":"Migration of lymphatic endothelial cells and lymphatic vascular development in the craniofacial region of embryonic mice","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2805111780","doi":"https://doi.org/10.1387/ijdb.170218yt","mag":"2805111780","pmid":"https://pubmed.ncbi.nlm.nih.gov/29877568"},"language":"en","primary_location":{"id":"doi:10.1387/ijdb.170218yt","doi":"https://doi.org/10.1387/ijdb.170218yt","is_oa":false,"landing_page_url":"https://doi.org/10.1387/ijdb.170218yt","pdf_url":null,"source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2805111780"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008362441","display_name":"Yuji Taya","orcid":"https://orcid.org/0000-0001-5663-0835","observed_orcids":["https://orcid.org/0000-0001-5663-0835"]},"institutions":[{"id":"https://openalex.org/I35552710","display_name":"Nippon Dental University","ror":"https://ror.org/01s1hm369","country_code":"JP","type":"education","lineage":["https://openalex.org/I35552710"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuji Taya","raw_affiliation_strings":["Department of Pathology, The Nippon Dental University School of Life Dentistry at Tokyo, Tokyo, Japan. taya-yu@tky.ndu.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Nippon Dental University School of Life Dentistry at Tokyo, Tokyo, Japan. taya-yu@tky.ndu.ac.jp","institution_ids":["https://openalex.org/I35552710"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kaori Sato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaori Sato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048522798","display_name":"Youichi Shirako","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youichi Shirako","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067647425","display_name":"Yuuichi Soeno","orcid":"https://orcid.org/0000-0001-8466-6376","observed_orcids":["https://orcid.org/0000-0001-8466-6376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuuichi Soeno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008362441"],"corresponding_institution_ids":["https://openalex.org/I35552710"],"apc_list":null,"apc_paid":null,"fwci":0.2087,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53362615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"4-5","first_page":"293","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphatic-endothelial-cells","display_name":"lymphatic endothelial cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lymphatic-endothelial-cell-migration","display_name":"lymphatic endothelial cell migration","score":0.824999988079071},{"id":"https://openalex.org/keywords/cardinal-vein","display_name":"cardinal vein","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mandibular-arch","display_name":"mandibular arch","score":0.8349999785423279},{"id":"https://openalex.org/keywords/prox1","display_name":"Prox1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/vegfr-3","display_name":"VEGFR-3","score":0.875},{"id":"https://openalex.org/keywords/lyve-1","display_name":"LYVE-1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ccl21","display_name":"CCL21","score":0.996999979019165},{"id":"https://openalex.org/keywords/venous-endothelial-cells","display_name":"venous endothelial cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.8569036722183228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7430022954940796},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.6986275315284729},{"id":"https://openalex.org/C2910366181","wikidata":"https://www.wikidata.org/wiki/Q6708239","display_name":"Lymphatic Endothelium","level":3,"score":0.5957934260368347},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.541445791721344},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.47297942638397217},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.47138816118240356},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.4218893051147461},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4199643135070801},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.4179891347885132},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35943353176116943},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.283855676651001},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2701929807662964},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.23964831233024597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11751306056976318},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08931830525398254},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07199552655220032},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.06690046191215515},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000098551","descriptor_name":"Prospero-Related Homeobox 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040321","descriptor_name":"Vascular Endothelial Growth Factor Receptor-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1387/ijdb.170218yt","doi":"https://doi.org/10.1387/ijdb.170218yt","is_oa":false,"landing_page_url":"https://doi.org/10.1387/ijdb.170218yt","pdf_url":null,"source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},{"id":"pmid:29877568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29877568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of developmental biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2148372609","display_name":"Development of micro-biopsy array system toward early detection of oral mucosal lesions","funder_award_id":"18K09778","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2219607621","display_name":"Molecular regulation of directed migration of lymphatic endothelial cells to the craniofacial region in lymphatic vascular development","funder_award_id":"17K11631","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7468255441","display_name":"Reorganization of blood/lymphatic vessel networks by irradiation under the presence/absence of cancer cells in mouse tongue xenograft model","funder_award_id":"17K17111","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8397290037","display_name":"Nerve/tumor interaction during perineural invasion of human oral carcinoma cells in mouse tongue xenograft model","funder_award_id":"16K11529","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G913438355","display_name":"Molecular mechanism governing the axon guidance of hypoglossal nerves associated with development of mouse tongue","funder_award_id":"18K09530","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W195244493","https://openalex.org/W1568237782","https://openalex.org/W1757033803","https://openalex.org/W1986411159","https://openalex.org/W1988203596","https://openalex.org/W1991298929","https://openalex.org/W1991927700","https://openalex.org/W1994638693","https://openalex.org/W2001524010","https://openalex.org/W2002925249","https://openalex.org/W2006433494","https://openalex.org/W2058607872","https://openalex.org/W2066212925","https://openalex.org/W2076462567","https://openalex.org/W2077358124","https://openalex.org/W2093406696","https://openalex.org/W2094286495","https://openalex.org/W2097731330","https://openalex.org/W2099703857","https://openalex.org/W2120413309","https://openalex.org/W2130685621","https://openalex.org/W2160167323","https://openalex.org/W2202905887","https://openalex.org/W2317488771","https://openalex.org/W2554888829","https://openalex.org/W7099405366"],"related_works":["https://openalex.org/W3176393826","https://openalex.org/W4301600587","https://openalex.org/W2160167323","https://openalex.org/W4200518765","https://openalex.org/W4392390273","https://openalex.org/W2006433494","https://openalex.org/W2095116552","https://openalex.org/W2103705636","https://openalex.org/W2020651710","https://openalex.org/W2060628162"],"abstract_inverted_index":{"Lymphatic":[0],"development":[1],"in":[2,6,34,104,125,154,203],"mice":[3],"is":[4],"initiated":[5],"the":[7,19,28,35,128,155,167,170,178,196,222,227],"trunk":[8,168,223],"at":[9,45,135,173,192],"embryonic":[10],"day":[11],"(E)":[12],"9.5.":[13],"This":[14],"study":[15],"aimed":[16],"to":[17,149,169,240],"examine":[18],"origin":[20],"of":[21,31,127,131,195,221,242],"craniofacial":[22,37,207,216,234],"lymphatic":[23,32,72,120,190,208,235],"endothelial":[24,53,66,74],"cells":[25,107],"(LECs)":[26],"and":[27,51,79,87,93,115,151,164,184,188,201,224],"developmental":[29],"process":[30],"vessels":[33,191,236],"mouse":[36,43],"region.":[38],"Serial":[39],"sections":[40],"from":[41,166,219,247],"ICR":[42],"embryos":[44],"E9.5-E14.5":[46],"were":[47,99,139,152],"immunolabeled":[48],"with":[49],"LEC":[50,142,197],"venous":[52],"cell":[54],"(VEC)":[55],"markers.":[56],"These":[57,137],"markers":[58],"included":[59],"prospero":[60],"homeobox":[61],"protein":[62],"1":[63,77],"(Prox1),":[64],"vascular":[65,121,209],"growth":[67],"factor":[68,90],"receptor":[69,76],"3":[70],"(Vegfr3),":[71],"vessel":[73],"hyaluronan":[75],"(Lyve1),":[78],"C-C":[80],"motif":[81],"chemokine":[82],"2":[83,91],"(Ccl21)":[84],"for":[85,96],"LEC,":[86],"COUP":[88],"transcription":[89],"(CoupTF2)":[92],"endomucin":[94],"(Emcn)":[95],"VEC.":[97],"LECs":[98,112,123,138,160,182,204,217,244],"monitored":[100],"as":[101],"an":[102],"index":[103],"Prox1/Vegfr3":[105],"double-positive":[106],"using":[108],"three-dimensional":[109],"analysis":[110],"because":[111],"express":[113],"Prox1":[114],"Vegfr3":[116],"ab":[117],"initio":[118],"during":[119,206],"development.":[122,210],"appeared":[124],"VECs":[126],"lateral":[129],"walls":[130],"cardinal":[132],"veins":[133],"(CVs)":[134],"E9.5.":[136],"dichotomized":[140],"into":[141,226],"populations":[143],"that":[144,215,233,245],"formed":[145,161,185,238],"lymph":[146,186],"sacs":[147,187],"close":[148],"CVs":[150,220],"scattered":[153,159],"surrounding":[156],"CVs.":[157,248],"The":[158],"cellular":[162],"streams":[163],"extended":[165],"mandibular":[171,179,228],"arches":[172],"E10.5":[174],"-":[175],"E11.5.":[176],"In":[177],"arches,":[180],"individual":[181,243],"aggregated,":[183],"tubular":[189],"E11.5-E14.5.":[193],"Expression":[194],"marker":[198],"proteins":[199],"Lyve1":[200],"Ccl21":[202],"changed":[205],"Collectively,":[211],"these":[212],"findings":[213],"suggest":[214],"originate":[218],"migrate":[225,246],"arches.":[229],"Additionally,":[230],"we":[231],"found":[232],"are":[237],"according":[239],"morphogenesis":[241]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-13T00:00:00"}