{"id":"https://openalex.org/W2805063718","doi":"https://doi.org/10.1128/msystems.00020-18","title":"Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome","display_name":"Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome","publication_year":2018,"publication_date":"2018-06-04","ids":{"openalex":"https://openalex.org/W2805063718","doi":"https://doi.org/10.1128/msystems.00020-18","mag":"2805063718","pmid":"https://pubmed.ncbi.nlm.nih.gov/29896566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5989129"},"language":"en","primary_location":{"id":"doi:10.1128/msystems.00020-18","doi":"https://doi.org/10.1128/msystems.00020-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00020-18","pdf_url":"https://msystems.asm.org/content/msys/3/3/e00020-18.full.pdf","source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://msystems.asm.org/content/msys/3/3/e00020-18.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060283036","display_name":"Anupriya Tripathi","orcid":"https://orcid.org/0000-0001-8912-9684","observed_orcids":["https://orcid.org/0000-0001-8912-9684"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anupriya Tripathi","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, San Diego, California, USA","Division of Biological Sciences, University of California, San Diego, San Diego, California, USA","Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Biological Sciences, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011189475","display_name":"Alexey V. Melnik","orcid":"https://orcid.org/0000-0002-4645-8880","observed_orcids":["https://orcid.org/0000-0002-4645-8880"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexey V. Melnik","raw_affiliation_strings":["Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113724424","display_name":"Jin Xue","orcid":"https://orcid.org/0000-0002-1219-0441","observed_orcids":["https://orcid.org/0000-0002-1219-0441"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Xue","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038648389","display_name":"Orit Poulsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orit Poulsen","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075504716","display_name":"Michael J. Meehan","orcid":"https://orcid.org/0000-0002-6836-0294","observed_orcids":["https://orcid.org/0000-0002-6836-0294"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Meehan","raw_affiliation_strings":["Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082559708","display_name":"Gregory Humphrey","orcid":"https://orcid.org/0000-0003-3930-1663","observed_orcids":["https://orcid.org/0000-0003-3930-1663"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Humphrey","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066665482","display_name":"Lingjing Jiang","orcid":"https://orcid.org/0000-0001-8706-2850","observed_orcids":["https://orcid.org/0000-0001-8706-2850"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lingjing Jiang","raw_affiliation_strings":["Department of Family Medicine and Public Health, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine and Public Health, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077137639","display_name":"Gail L. Ackermann","orcid":"https://orcid.org/0000-0002-3901-4931","observed_orcids":["https://orcid.org/0000-0002-3901-4931"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gail Ackermann","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022461817","display_name":"Daniel T. McDonald","orcid":"https://orcid.org/0000-0003-0876-9060","observed_orcids":["https://orcid.org/0000-0003-0876-9060"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel McDonald","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002092179","display_name":"Dan Zhou","orcid":"https://orcid.org/0000-0001-6401-9040","observed_orcids":["https://orcid.org/0000-0001-6401-9040"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Zhou","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033881627","display_name":"Rob D. Knight","orcid":"https://orcid.org/0000-0002-0975-9019","observed_orcids":["https://orcid.org/0000-0002-0975-9019","https://orcid.org/0000-0001-7531-0087"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rob Knight","raw_affiliation_strings":["Center for Microbiome Innovation, University of California, San Diego, San Diego, California, USA","Department of Computer Science and Engineering, University of California, San Diego, San Diego, California, USA","Department of Pediatrics, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082720301","display_name":"Pieter C. Dorrestein","orcid":"https://orcid.org/0000-0002-3003-1030","observed_orcids":["https://orcid.org/0000-0002-3003-1030"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pieter C. Dorrestein","raw_affiliation_strings":["Center for Computational Mass Spectrometry, University of California, San Diego, San Diego, California, USA","Center for Microbiome Innovation, University of California, San Diego, San Diego, California, USA","Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Mass Spectrometry, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Center for Microbiome Innovation, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102775655","display_name":"Gabriel G. Haddad","orcid":"https://orcid.org/0000-0003-2462-6668","observed_orcids":["https://orcid.org/0000-0003-2462-6668"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabriel G. Haddad","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, San Diego, California, USA","Department of Pediatrics, University of California, San Diego, San Diego, California, USA","Rady\u2019s Children\u2019s Hospital, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Rady\u2019s Children\u2019s Hospital, San Diego, California, USA","institution_ids":["https://openalex.org/I4210087384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033881627","https://openalex.org/A5082720301","https://openalex.org/A5102775655"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":4.6016,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.96521867,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"3","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9629999995231628},{"id":"https://openalex.org/keywords/intermittent-hypoxia","display_name":"intermittent hypoxia","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hypercapnia","display_name":"hypercapnia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9449999928474426},{"id":"https://openalex.org/keywords/gut-metabolome","display_name":"gut metabolome","score":0.8190000057220459},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cardiovascular-comorbidity","display_name":"cardiovascular comorbidity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/metabolic-comorbidities","display_name":"metabolic comorbidities","score":0.8870000243186951},{"id":"https://openalex.org/keywords/microbial-metabolites","display_name":"microbial metabolites","score":0.6029999852180481},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.671999990940094},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.9419692754745483},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.71781325340271},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6827881336212158},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6651068329811096},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.643762469291687},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.6411488056182861},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5102198123931885},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.49255213141441345},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.48099884390830994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46173107624053955},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.44577622413635254},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4205087423324585},{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.4163203537464142},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.4144021272659302},{"id":"https://openalex.org/C2780241833","wikidata":"https://www.wikidata.org/wiki/Q6556375","display_name":"Lipidome","level":3,"score":0.41227155923843384},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.41020309925079346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.388355016708374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26559799909591675},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19542410969734192},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.13877791166305542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C117437137","wikidata":"https://www.wikidata.org/wiki/Q5038720","display_name":"Cardiorespiratory fitness","level":2,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1128/msystems.00020-18","doi":"https://doi.org/10.1128/msystems.00020-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00020-18","pdf_url":"https://msystems.asm.org/content/msys/3/3/e00020-18.full.pdf","source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4949316","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5989129","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5989129","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5989129","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"Text"},{"id":"pmid:29896566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29896566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0944137470fc475baa145681bfd232f2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0944137470fc475baa145681bfd232f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mSystems, Vol 3, Iss 3, p e00020-18 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c01326f5b4b0417ba6d9d3532c83605c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c01326f5b4b0417ba6d9d3532c83605c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mSystems, Vol 3, Iss 3 (2018)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3fn376j6","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3fn376j6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mSystems, vol 3, iss 3","raw_type":"article"},{"id":"pmh:qt3fn376j6","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/3fn376j6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tripathi, A; Melnik, AV; Xue, J; Poulsen, O; Meehan, MJ; Humphrey, G; \u00c2\u00a0et al.(2018). Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome. MSYSTEMS, 3(3). doi: 10.1128/mSystems.00020-18. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3fn376j6","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/msystems.00020-18","doi":"https://doi.org/10.1128/msystems.00020-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00020-18","pdf_url":"https://msystems.asm.org/content/msys/3/3/e00020-18.full.pdf","source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3508513410","display_name":"Synapt ion mobility mass spectrometer","funder_award_id":"S10RR029121","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5259231185","display_name":"Center for Computational Mass Spectrometry","funder_award_id":"P41GM103484","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G670806520","display_name":null,"funder_award_id":"S10-RR029121","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805063718.pdf"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1538670268","https://openalex.org/W1611854178","https://openalex.org/W1789164482","https://openalex.org/W1973742381","https://openalex.org/W1989299822","https://openalex.org/W2027974246","https://openalex.org/W2032618685","https://openalex.org/W2033900229","https://openalex.org/W2056884786","https://openalex.org/W2058683100","https://openalex.org/W2072970694","https://openalex.org/W2076728075","https://openalex.org/W2083637865","https://openalex.org/W2086275477","https://openalex.org/W2102161788","https://openalex.org/W2121353895","https://openalex.org/W2126971215","https://openalex.org/W2130731460","https://openalex.org/W2136552678","https://openalex.org/W2144655743","https://openalex.org/W2147259528","https://openalex.org/W2159675211","https://openalex.org/W2166171121","https://openalex.org/W2166562121","https://openalex.org/W2168249366","https://openalex.org/W2170024099","https://openalex.org/W2342464149","https://openalex.org/W2342540743","https://openalex.org/W2394516948","https://openalex.org/W2504691963","https://openalex.org/W2515118094","https://openalex.org/W2575979318","https://openalex.org/W2586644082","https://openalex.org/W2586959160","https://openalex.org/W2592244930","https://openalex.org/W2593591803","https://openalex.org/W2594502506","https://openalex.org/W2612416997","https://openalex.org/W2729454705","https://openalex.org/W2763590288","https://openalex.org/W2765519733","https://openalex.org/W2767808924","https://openalex.org/W2768716840","https://openalex.org/W2903337602","https://openalex.org/W2955504961","https://openalex.org/W3001290322","https://openalex.org/W3194266802"],"related_works":["https://openalex.org/W4213262106","https://openalex.org/W7203478044","https://openalex.org/W4413335045","https://openalex.org/W3173687967","https://openalex.org/W2933708335","https://openalex.org/W7017382428","https://openalex.org/W7135017703","https://openalex.org/W3154924840","https://openalex.org/W7165790770","https://openalex.org/W4324135646"],"abstract_inverted_index":{"Intestinal":[0],"dysbiosis":[1,14],"mediates":[2],"various":[3],"cardiovascular":[4,16,107],"diseases":[5],"comorbid":[6],"with":[7],"OSA.":[8,97],"To":[9],"understand":[10],"the":[11,26,55,61,65,79],"role":[12],"of":[13,28,45,67,96],"in":[15,38,60,72,78],"and":[17,50,57,94,102,108],"metabolic":[18,109],"disease":[19],"caused":[20],"by":[21],"OSA,":[22],"we":[23,99],"systematically":[24],"study":[25,48],"effect":[27],"intermittent":[29],"hypoxic/hypercapnic":[30],"stress":[31],"(IHH,":[32],"mimicking":[33],"OSA)":[34],"on":[35,69,87],"gut":[36,62,80,92],"microbes":[37,68,93],"an":[39],"animal":[40],"model.":[41],"We":[42,74],"take":[43],"advantage":[44],"a":[46],"longitudinal":[47],"design":[49],"paired":[51],"omics":[52],"to":[53,63],"investigate":[54],"microbial":[56],"molecular":[58],"dynamics":[59],"ascertain":[64],"contribution":[66],"intestinal":[70],"metabolism":[71],"IHH.":[73],"observe":[75],"microbe-dependent":[76],"changes":[77],"metabolome":[81],"that":[82],"will":[83],"guide":[84],"future":[85],"research":[86],"unrecognized":[88],"mechanistic":[89],"links":[90],"between":[91],"comorbidities":[95],"Additionally,":[98],"highlight":[100],"novel":[101],"noninvasive":[103],"biomarkers":[104],"for":[105],"OSA-linked":[106],"disorders.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-06-13T00:00:00"}