{"id":"https://openalex.org/W2805048671","doi":"https://doi.org/10.1038/s42003-018-0062-2","title":"Selective cold pain inhibition by targeted block of TRPM8-expressing neurons with quaternary lidocaine derivative QX-314","display_name":"Selective cold pain inhibition by targeted block of TRPM8-expressing neurons with quaternary lidocaine derivative QX-314","publication_year":2018,"publication_date":"2018-05-16","ids":{"openalex":"https://openalex.org/W2805048671","doi":"https://doi.org/10.1038/s42003-018-0062-2","mag":"2805048671","pmid":"https://pubmed.ncbi.nlm.nih.gov/30271936","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6123689"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-018-0062-2","doi":"https://doi.org/10.1038/s42003-018-0062-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-018-0062-2","pdf_url":"https://www.nature.com/articles/s42003-018-0062-2.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-018-0062-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061136357","display_name":"Serra Ongun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serra Ongun","raw_affiliation_strings":["Molecular and Computational Biology Graduate Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA","Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Computational Biology Graduate Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041467257","display_name":"Angela Sarkisian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Sarkisian","raw_affiliation_strings":["Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014749115","display_name":"David D. McKemy","orcid":"https://orcid.org/0000-0002-5583-5983","observed_orcids":["https://orcid.org/0000-0002-5583-5983"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David D. McKemy","raw_affiliation_strings":["Molecular and Computational Biology Graduate Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA. mckemy@dornsife.usc.edu","Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA. mckemy@dornsife.usc.edu","Molecular and Computational Biology Graduate Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Computational Biology Graduate Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA. mckemy@dornsife.usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA. mckemy@dornsife.usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Molecular and Computational Biology Graduate Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014749115"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.5457,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.78630266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"53","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/qx-314","display_name":"QX-314","score":0.9380000233650208},{"id":"https://openalex.org/keywords/lidocaine-derivatives","display_name":"lidocaine derivatives","score":0.8240000009536743},{"id":"https://openalex.org/keywords/trpm8","display_name":"TRPM8","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cold-pain","display_name":"cold pain","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cold-allodynia","display_name":"cold allodynia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cold-hyperalgesia","display_name":"cold hyperalgesia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nociceptors","display_name":"nociceptors","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ligand-gated-cation-channels","display_name":"ligand-gated cation channels","score":0.796999990940094},{"id":"https://openalex.org/keywords/cold-sensation","display_name":"cold sensation","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C163146387","wikidata":"https://www.wikidata.org/wiki/Q15324395","display_name":"TRPM8","level":5,"score":0.9061408042907715},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.7860034704208374},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.7308944463729858},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.5713515877723694},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5449009537696838},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.47829681634902954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4591718018054962},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.44872209429740906},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4399726986885071},{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.4379061460494995},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43496376276016235},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38454556465148926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34770864248275757},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.3134384751319885},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21720841526985168},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1156524121761322},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.102903813123703}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1038/s42003-018-0062-2","doi":"https://doi.org/10.1038/s42003-018-0062-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-018-0062-2","pdf_url":"https://www.nature.com/articles/s42003-018-0062-2.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5104488","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6123689","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30271936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30271936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6123689","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6123689/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Commun Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b4243c97717a417f88740bb4634e22b3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b4243c97717a417f88740bb4634e22b3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Biology, Vol 1, Iss 1, Pp 1-10 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s42003-018-0062-2","doi":"https://doi.org/10.1038/s42003-018-0062-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-018-0062-2","pdf_url":"https://www.nature.com/articles/s42003-018-0062-2.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2970335544","display_name":"Nerve conduction block in cold-responsive sensory neurons","funder_award_id":"R01NS087542","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2805048671.pdf","grobid_xml":"https://content.openalex.org/works/W2805048671.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W84808320","https://openalex.org/W1511198581","https://openalex.org/W1585790473","https://openalex.org/W1843071464","https://openalex.org/W1968935630","https://openalex.org/W1974195039","https://openalex.org/W1975332997","https://openalex.org/W1975391411","https://openalex.org/W1975875514","https://openalex.org/W1977871353","https://openalex.org/W1983037105","https://openalex.org/W1987879958","https://openalex.org/W1992594817","https://openalex.org/W1995166803","https://openalex.org/W1995330222","https://openalex.org/W2005505879","https://openalex.org/W2008902622","https://openalex.org/W2020016202","https://openalex.org/W2023872394","https://openalex.org/W2032916625","https://openalex.org/W2039463240","https://openalex.org/W2043088091","https://openalex.org/W2049321527","https://openalex.org/W2058775148","https://openalex.org/W2069183005","https://openalex.org/W2080382070","https://openalex.org/W2087665027","https://openalex.org/W2092166214","https://openalex.org/W2093791660","https://openalex.org/W2095679461","https://openalex.org/W2106186035","https://openalex.org/W2106871219","https://openalex.org/W2107057154","https://openalex.org/W2113278451","https://openalex.org/W2116411564","https://openalex.org/W2118897180","https://openalex.org/W2122097870","https://openalex.org/W2126229620","https://openalex.org/W2127001240","https://openalex.org/W2131100809","https://openalex.org/W2144832875","https://openalex.org/W2168210103","https://openalex.org/W2170754929","https://openalex.org/W2331016958","https://openalex.org/W2334908740","https://openalex.org/W2561370551","https://openalex.org/W6647322692"],"related_works":["https://openalex.org/W1585790473","https://openalex.org/W2168210103","https://openalex.org/W6908050969","https://openalex.org/W4409867178","https://openalex.org/W3081172038","https://openalex.org/W2161006864","https://openalex.org/W2020016202","https://openalex.org/W7098568646","https://openalex.org/W4405525517","https://openalex.org/W2087665027"],"abstract_inverted_index":{"Treatment":[0],"of":[1,20,55,82,101,108],"pain":[2,22,121],"with":[3,57],"local":[4],"anesthetics":[5],"leads":[6],"to":[7,16,40,89,117],"an":[8,114],"unfavorable":[9],"decrease":[10],"in":[11,68],"general":[12,124],"sensory":[13],"acuity":[14],"due":[15],"their":[17],"indiscriminate":[18],"block":[19,90],"both":[21,102],"sensing":[23,27],"(nociceptors)":[24],"and":[25,73,85,104],"non-pain":[26],"nerves.":[28],"However,":[29],"the":[30,60],"cell":[31],"impermeant":[32],"lidocaine":[33],"derivative":[34],"QX-314":[35,56,109],"can":[36,86],"be":[37,87],"selectively":[38],"targeted":[39],"only":[41],"nociceptors":[42],"by":[43],"permeation":[44],"through":[45],"ligand-gated":[46],"cation":[47],"channels.":[48],"Here":[49],"we":[50],"show":[51],"that":[52],"localized":[53,119],"injection":[54],"agonists":[58],"for":[59],"menthol":[61],"receptor":[62],"TRPM8":[63],"specifically":[64],"blocks":[65],"cold-evoked":[66],"behaviors":[67],"mice,":[69],"including":[70],"cold":[71,83,91,97,120],"allodynia":[72],"hyperalgesia.":[74],"Remarkably,":[75],"cooling":[76],"stimuli":[77],"also":[78],"promotes":[79],"QX-314-mediated":[80],"inhibition":[81],"behaviors,":[84],"used":[88],"allodynia,":[92],"while":[93],"retaining":[94],"relatively":[95],"normal":[96],"sensation.":[98],"The":[99],"effects":[100],"agonist":[103],"thermally":[105],"evoked":[106],"uptake":[107],"are":[110],"TRPM8-dependent,":[111],"results":[112],"demonstrating":[113],"effective":[115],"approach":[116],"treat":[118],"without":[122],"altering":[123],"somatosensation.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-13T00:00:00"}
