{"id":"https://openalex.org/W2805043421","doi":"https://doi.org/10.1146/annurev-genom-083117-021632","title":"Editing the Epigenome: Reshaping the Genomic Landscape","display_name":"Editing the Epigenome: Reshaping the Genomic Landscape","publication_year":2018,"publication_date":"2018-05-31","ids":{"openalex":"https://openalex.org/W2805043421","doi":"https://doi.org/10.1146/annurev-genom-083117-021632","mag":"2805043421","pmid":"https://pubmed.ncbi.nlm.nih.gov/29852072"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-genom-083117-021632","doi":"https://doi.org/10.1146/annurev-genom-083117-021632","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-genom-083117-021632","pdf_url":null,"source":{"id":"https://openalex.org/S8095556","display_name":"Annual Review of Genomics and Human Genetics","issn_l":"1527-8204","issn":["1527-8204","1545-293X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Genomics and Human Genetics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028836470","display_name":"Liad Holtzman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liad Holtzman","raw_affiliation_strings":["Department of Biomedical Engineering and Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708, USA;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708, USA;,","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076902342","display_name":"Charles A. Gersbach","orcid":"https://orcid.org/0000-0003-1478-4013","observed_orcids":["https://orcid.org/0000-0003-1478-4013"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Gersbach","raw_affiliation_strings":["Department of Biomedical Engineering and Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708, USA;,","Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708, USA;,","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4758,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.83401166,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"43","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.2720000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenome-editing","display_name":"epigenome editing","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-structure","display_name":"DNA structure","score":0.7820000052452087},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.6290000081062317},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cell-identity","display_name":"cell identity","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.959026575088501},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8420801162719727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6965766549110413},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6885048151016235},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.6743934154510498},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6529151201248169},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5377533435821533},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5243121385574341},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46987229585647583},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.46392592787742615},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.31527361273765564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2647227644920349},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15802723169326782}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042421","descriptor_name":"Histone Code","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev-genom-083117-021632","doi":"https://doi.org/10.1146/annurev-genom-083117-021632","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-genom-083117-021632","pdf_url":null,"source":{"id":"https://openalex.org/S8095556","display_name":"Annual Review of Genomics and Human Genetics","issn_l":"1527-8204","issn":["1527-8204","1545-293X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Genomics and Human Genetics","raw_type":"journal-article"},{"id":"pmid:29852072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29852072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of genomics and human genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2762090281","display_name":"In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic Mice","funder_award_id":"R21DA041878","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2784745079","display_name":"Decoding and Reprogramming the Corticosteroid Transcriptional Regulatory Network","funder_award_id":"U01HG007900","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2930773470","display_name":"Enhancing Neuronal Reprogramming with Epigenome Editing","funder_award_id":"R21NS103007","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5131175428","display_name":"Duke Skin Disease Research Core Center","funder_award_id":"P30AR066527","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6204546280","display_name":"Engineering Targeted Epigenetic Modifiers for Precise Control of Gene Regulation","funder_award_id":"R01DA036865","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7188780935","display_name":"Regulatory Mechanisms of CD4+ T Cell Differentiation","funder_award_id":"UM1HG009428","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G7952319182","display_name":"A Platform Technology for High-Throughput Screening of Gene Regulatory Elements","funder_award_id":"R41GM119914","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320317068","display_name":"Paul G. Allen Frontiers Group","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":184,"referenced_works":["https://openalex.org/W1171540079","https://openalex.org/W1523117612","https://openalex.org/W1558348929","https://openalex.org/W1669374546","https://openalex.org/W1941076503","https://openalex.org/W1965423091","https://openalex.org/W1965469784","https://openalex.org/W1967588153","https://openalex.org/W1967841068","https://openalex.org/W1968931043","https://openalex.org/W1969331670","https://openalex.org/W1969670934","https://openalex.org/W1973062929","https://openalex.org/W1975459355","https://openalex.org/W1976125136","https://openalex.org/W1977621555","https://openalex.org/W1981354816","https://openalex.org/W1981516407","https://openalex.org/W1982881824","https://openalex.org/W1984173288","https://openalex.org/W1984562049","https://openalex.org/W1984807040","https://openalex.org/W1985706594","https://openalex.org/W1986947784","https://openalex.org/W1987825638","https://openalex.org/W1991244004","https://openalex.org/W1992858116","https://openalex.org/W1995143570","https://openalex.org/W1996487270","https://openalex.org/W2000875293","https://openalex.org/W2001971523","https://openalex.org/W2004608668","https://openalex.org/W2004966039","https://openalex.org/W2006995958","https://openalex.org/W2007086697","https://openalex.org/W2009949436","https://openalex.org/W2010232809","https://openalex.org/W2012974517","https://openalex.org/W2013250198","https://openalex.org/W2014799921","https://openalex.org/W2017840637","https://openalex.org/W2019197788","https://openalex.org/W2028823361","https://openalex.org/W2030043909","https://openalex.org/W2030483280","https://openalex.org/W2031190145","https://openalex.org/W2033160626","https://openalex.org/W2036211082","https://openalex.org/W2036636377","https://openalex.org/W2036777838","https://openalex.org/W2038774969","https://openalex.org/W2041686632","https://openalex.org/W2042087070","https://openalex.org/W2042789810","https://openalex.org/W2044826047","https://openalex.org/W2046691617","https://openalex.org/W2048613921","https://openalex.org/W2049855310","https://openalex.org/W2050880607","https://openalex.org/W2055327776","https://openalex.org/W2055790209","https://openalex.org/W2056198580","https://openalex.org/W2059099579","https://openalex.org/W2059244281","https://openalex.org/W2060712252","https://openalex.org/W2061650108","https://openalex.org/W2061846271","https://openalex.org/W2062927905","https://openalex.org/W2064261519","https://openalex.org/W2064886170","https://openalex.org/W2065498897","https://openalex.org/W2066783444","https://openalex.org/W2069328568","https://openalex.org/W2069918359","https://openalex.org/W2074656730","https://openalex.org/W2074750860","https://openalex.org/W2076154138","https://openalex.org/W2078616374","https://openalex.org/W2079212177","https://openalex.org/W2084191969","https://openalex.org/W2086239585","https://openalex.org/W2090714945","https://openalex.org/W2091208410","https://openalex.org/W2091232875","https://openalex.org/W2092015664","https://openalex.org/W2095008765","https://openalex.org/W2098356010","https://openalex.org/W2100365251","https://openalex.org/W2101749257","https://openalex.org/W2102560467","https://openalex.org/W2102663142","https://openalex.org/W2103177465","https://openalex.org/W2106391833","https://openalex.org/W2110199196","https://openalex.org/W2111801210","https://openalex.org/W2112444085","https://openalex.org/W2114866946","https://openalex.org/W2117446594","https://openalex.org/W2117792884","https://openalex.org/W2121091193","https://openalex.org/W2121659981","https://openalex.org/W2123032740","https://openalex.org/W2125572458","https://openalex.org/W2127862779","https://openalex.org/W2127993547","https://openalex.org/W2128663764","https://openalex.org/W2133938268","https://openalex.org/W2134087142","https://openalex.org/W2134868027","https://openalex.org/W2135185213","https://openalex.org/W2136691282","https://openalex.org/W2137065828","https://openalex.org/W2140471643","https://openalex.org/W2140977526","https://openalex.org/W2141215651","https://openalex.org/W2144328273","https://openalex.org/W2144792857","https://openalex.org/W2145760956","https://openalex.org/W2149142532","https://openalex.org/W2152505144","https://openalex.org/W2154240028","https://openalex.org/W2154294588","https://openalex.org/W2156626022","https://openalex.org/W2157668741","https://openalex.org/W2163173465","https://openalex.org/W2169373177","https://openalex.org/W2170210082","https://openalex.org/W2192789229","https://openalex.org/W2235496227","https://openalex.org/W2237361299","https://openalex.org/W2239511084","https://openalex.org/W2259938310","https://openalex.org/W2267962174","https://openalex.org/W2270544154","https://openalex.org/W2273050936","https://openalex.org/W2279123229","https://openalex.org/W2294327742","https://openalex.org/W2336828812","https://openalex.org/W2340540054","https://openalex.org/W2346829986","https://openalex.org/W2351565907","https://openalex.org/W2400411104","https://openalex.org/W2402793322","https://openalex.org/W2462631977","https://openalex.org/W2465336312","https://openalex.org/W2500498803","https://openalex.org/W2501443726","https://openalex.org/W2508292514","https://openalex.org/W2517955921","https://openalex.org/W2521981506","https://openalex.org/W2522031854","https://openalex.org/W2523099503","https://openalex.org/W2524507363","https://openalex.org/W2536055301","https://openalex.org/W2565920386","https://openalex.org/W2566892327","https://openalex.org/W2570462922","https://openalex.org/W2593014410","https://openalex.org/W2604130415","https://openalex.org/W2606412267","https://openalex.org/W2607585298","https://openalex.org/W2610903912","https://openalex.org/W2611717200","https://openalex.org/W2612830428","https://openalex.org/W2619632075","https://openalex.org/W2736242246","https://openalex.org/W2747710600","https://openalex.org/W2748423437","https://openalex.org/W2755284555","https://openalex.org/W2756293223","https://openalex.org/W2757387674","https://openalex.org/W2761461280","https://openalex.org/W2763478649","https://openalex.org/W2765567136","https://openalex.org/W2765770174","https://openalex.org/W2765782410","https://openalex.org/W2766599608","https://openalex.org/W2772697618","https://openalex.org/W2783322400","https://openalex.org/W2783807303","https://openalex.org/W2784154277","https://openalex.org/W2789402965","https://openalex.org/W2803895514","https://openalex.org/W2950415340"],"related_works":["https://openalex.org/W7222724795","https://openalex.org/W4401091940","https://openalex.org/W7154264165","https://openalex.org/W2515130998","https://openalex.org/W7167685426","https://openalex.org/W7166326838","https://openalex.org/W2526246975","https://openalex.org/W4220764172","https://openalex.org/W4401512124","https://openalex.org/W7130842754"],"abstract_inverted_index":{"The":[0,46],"eukaryotic":[1],"epigenome":[2,52,94,127],"has":[3],"an":[4],"instrumental":[5],"role":[6],"in":[7,40,88],"determining":[8],"and":[9,13,26,44,64,102,114,117,120,138],"maintaining":[10],"cell":[11,68],"identity":[12],"function.":[14],"Epigenetic":[15],"components":[16,113],"such":[17,134],"as":[18,135],"DNA":[19,27],"methylation,":[20],"histone":[21],"tail":[22],"modifications,":[23],"chromatin":[24],"accessibility,":[25],"architecture":[28],"are":[29],"tightly":[30],"correlated":[31],"with":[32],"central":[33],"cellular":[34],"processes,":[35],"while":[36],"their":[37],"dysregulation":[38],"manifests":[39],"aberrant":[41],"gene":[42,115],"expression":[43],"disease.":[45],"ability":[47],"to":[48,83],"specifically":[49],"edit":[50],"the":[51,54,108,123],"holds":[53],"promise":[55],"of":[56,59,67,122,126],"enhancing":[57],"understanding":[58],"how":[60],"epigenetic":[61,86,112,136],"modifications":[62],"function":[63],"enabling":[65],"manipulation":[66],"phenotype":[69],"for":[70,131],"research":[71],"or":[72],"therapeutic":[73],"purposes.":[74],"Genome":[75],"engineering":[76],"technologies":[77,101],"use":[78],"highly":[79],"specific":[80],"DNA-targeting":[81],"tools":[82],"precisely":[84],"deposit":[85],"changes":[87],"a":[89],"locus-specific":[90],"manner,":[91],"creating":[92],"diverse":[93],"editing":[95],"platforms.":[96],"This":[97],"review":[98],"summarizes":[99],"these":[100],"insights":[103],"from":[104],"recent":[105],"studies,":[106],"describes":[107],"complex":[109],"relationship":[110],"between":[111],"regulation,":[116],"highlights":[118],"caveats":[119],"promises":[121],"emerging":[124],"field":[125],"editing,":[128],"including":[129],"applications":[130],"translational":[132],"purposes,":[133],"therapy":[137],"regenerative":[139],"medicine.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}
