{"id":"https://openalex.org/W2805038712","doi":"https://doi.org/10.2174/1573395514666180528081204","title":"Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond","display_name":"Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond","publication_year":2018,"publication_date":"2018-05-28","ids":{"openalex":"https://openalex.org/W2805038712","doi":"https://doi.org/10.2174/1573395514666180528081204","mag":"2805038712","pmid":"https://pubmed.ncbi.nlm.nih.gov/31327960","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6640863"},"language":"en","primary_location":{"id":"doi:10.2174/1573395514666180528081204","doi":"https://doi.org/10.2174/1573395514666180528081204","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573395514666180528081204","pdf_url":null,"source":{"id":"https://openalex.org/S175109673","display_name":"Current Immunology Reviews","issn_l":"1573-3955","issn":["1573-3955","1875-631X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Immunology Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6640863","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069221243","display_name":"Barbara L. Shacklett","orcid":"https://orcid.org/0000-0002-7067-732X","observed_orcids":["https://orcid.org/0000-0002-7067-732X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barbara L. Shacklett","raw_affiliation_strings":["Department of Medical Microbiology and Immunology and Division of Infectious Diseases, Department of Medicine, School of Medicine, University of California, Davis, CA 95616, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology and Division of Infectious Diseases, Department of Medicine, School of Medicine, University of California, Davis, CA 95616, United States","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069221243"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":0.9167,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.69441341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"63","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.8880000114440918},{"id":"https://openalex.org/keywords/sivmac","display_name":"SIVmac","score":0.9120000004768372},{"id":"https://openalex.org/keywords/female-reproductive-tract","display_name":"female reproductive tract","score":0.9390000104904175},{"id":"https://openalex.org/keywords/gastrointestinal-tract","display_name":"gastrointestinal tract","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tissue-resident-memory-t-cells","display_name":"tissue-resident memory T cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/th22-cells","display_name":"Th22 cells","score":1.0},{"id":"https://openalex.org/keywords/innate-lymphoid-cells","display_name":"innate lymphoid cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/commensal-microbiota","display_name":"commensal microbiota","score":0.9330000281333923},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/barrier-integrity","display_name":"barrier integrity","score":0.6010000109672546},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.7012029886245728},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6574331521987915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6466883420944214},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6384989619255066},{"id":"https://openalex.org/C3018462044","wikidata":"https://www.wikidata.org/wiki/Q6931261","display_name":"Mucosal immunity","level":4,"score":0.6050574779510498},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.577630341053009},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5532537698745728},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5514814853668213},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5193044543266296},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4911465346813202},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33950358629226685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2174/1573395514666180528081204","doi":"https://doi.org/10.2174/1573395514666180528081204","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573395514666180528081204","pdf_url":null,"source":{"id":"https://openalex.org/S175109673","display_name":"Current Immunology Reviews","issn_l":"1573-3955","issn":["1573-3955","1875-631X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Immunology Reviews","raw_type":"journal-article"},{"id":"pmid:31327960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31327960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current immunology reviews","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6640863","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6640863","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Immunol Rev","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt47w1n386","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/47w1n386","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Immunology Reviews, vol 15, iss 1","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6640863","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6640863","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Immunol Rev","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2606761766","display_name":null,"funder_award_id":"R01 AI057020","funder_id":"https://openalex.org/F4320309123","funder_display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3094992243","display_name":"Intestinal MAIT Cells in HIV Infection","funder_award_id":"R01DK108350","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6897957043","display_name":"HIV-Specific T Cell Responses in Rectal Mucosa","funder_award_id":"R01AI057020","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":197,"referenced_works":["https://openalex.org/W1164997755","https://openalex.org/W1187448213","https://openalex.org/W1203070212","https://openalex.org/W1470384648","https://openalex.org/W1496700409","https://openalex.org/W1500518582","https://openalex.org/W1511974199","https://openalex.org/W1542749101","https://openalex.org/W1548246322","https://openalex.org/W1581564829","https://openalex.org/W1632859538","https://openalex.org/W1645781049","https://openalex.org/W1825956709","https://openalex.org/W1833987578","https://openalex.org/W1848970261","https://openalex.org/W1855758394","https://openalex.org/W1924959793","https://openalex.org/W1960008687","https://openalex.org/W1967493382","https://openalex.org/W1968201178","https://openalex.org/W1972989279","https://openalex.org/W1975586435","https://openalex.org/W1975929837","https://openalex.org/W1976212425","https://openalex.org/W1977761329","https://openalex.org/W1978667884","https://openalex.org/W1980233833","https://openalex.org/W1980803239","https://openalex.org/W1981347969","https://openalex.org/W1982891648","https://openalex.org/W1984999783","https://openalex.org/W1985725340","https://openalex.org/W1987039284","https://openalex.org/W1987678152","https://openalex.org/W1991249702","https://openalex.org/W1994087084","https://openalex.org/W1994287107","https://openalex.org/W1994569436","https://openalex.org/W1995930566","https://openalex.org/W1996229570","https://openalex.org/W1996770717","https://openalex.org/W1999022079","https://openalex.org/W1999396723","https://openalex.org/W1999988675","https://openalex.org/W2000408898","https://openalex.org/W2001452004","https://openalex.org/W2001805788","https://openalex.org/W2002987322","https://openalex.org/W2003412654","https://openalex.org/W2003664178","https://openalex.org/W2004348278","https://openalex.org/W2004986685","https://openalex.org/W2005280169","https://openalex.org/W2008994596","https://openalex.org/W2013386415","https://openalex.org/W2013899807","https://openalex.org/W2017520700","https://openalex.org/W2020122175","https://openalex.org/W2020317149","https://openalex.org/W2020418416","https://openalex.org/W2021963193","https://openalex.org/W2024361090","https://openalex.org/W2026340875","https://openalex.org/W2029329186","https://openalex.org/W2032475342","https://openalex.org/W2036685063","https://openalex.org/W2038904455","https://openalex.org/W2038954578","https://openalex.org/W2040367910","https://openalex.org/W2040793589","https://openalex.org/W2041918949","https://openalex.org/W2042074909","https://openalex.org/W2044087049","https://openalex.org/W2046833861","https://openalex.org/W2047455387","https://openalex.org/W2048893909","https://openalex.org/W2051465794","https://openalex.org/W2051623708","https://openalex.org/W2052275203","https://openalex.org/W2055522639","https://openalex.org/W2055694058","https://openalex.org/W2056204715","https://openalex.org/W2057023184","https://openalex.org/W2057899448","https://openalex.org/W2058983339","https://openalex.org/W2059449393","https://openalex.org/W2061202914","https://openalex.org/W2062207606","https://openalex.org/W2064187617","https://openalex.org/W2065252029","https://openalex.org/W2065958240","https://openalex.org/W2066506853","https://openalex.org/W2074620757","https://openalex.org/W2076120354","https://openalex.org/W2076363780","https://openalex.org/W2078546233","https://openalex.org/W2078897402","https://openalex.org/W2079429316","https://openalex.org/W2080384507","https://openalex.org/W2080697998","https://openalex.org/W2082414958","https://openalex.org/W2082450021","https://openalex.org/W2087463086","https://openalex.org/W2087693617","https://openalex.org/W2088102919","https://openalex.org/W2089077748","https://openalex.org/W2090996688","https://openalex.org/W2092570071","https://openalex.org/W2092917323","https://openalex.org/W2093555020","https://openalex.org/W2093704069","https://openalex.org/W2098381125","https://openalex.org/W2099149517","https://openalex.org/W2099331224","https://openalex.org/W2102009960","https://openalex.org/W2102118600","https://openalex.org/W2103846516","https://openalex.org/W2106464597","https://openalex.org/W2106750237","https://openalex.org/W2107031485","https://openalex.org/W2107938435","https://openalex.org/W2108064918","https://openalex.org/W2109130469","https://openalex.org/W2110395460","https://openalex.org/W2111666869","https://openalex.org/W2112112221","https://openalex.org/W2112361824","https://openalex.org/W2112418007","https://openalex.org/W2113628320","https://openalex.org/W2114937185","https://openalex.org/W2119524073","https://openalex.org/W2121449768","https://openalex.org/W2121477549","https://openalex.org/W2122483069","https://openalex.org/W2123832762","https://openalex.org/W2124605791","https://openalex.org/W2125218508","https://openalex.org/W2125967520","https://openalex.org/W2127027832","https://openalex.org/W2127936550","https://openalex.org/W2128536797","https://openalex.org/W2133212359","https://openalex.org/W2134717682","https://openalex.org/W2135332303","https://openalex.org/W2136921311","https://openalex.org/W2137894872","https://openalex.org/W2137901778","https://openalex.org/W2138293866","https://openalex.org/W2138652626","https://openalex.org/W2139982503","https://openalex.org/W2141638714","https://openalex.org/W2143709477","https://openalex.org/W2146208066","https://openalex.org/W2149317992","https://openalex.org/W2149492547","https://openalex.org/W2151519597","https://openalex.org/W2153778605","https://openalex.org/W2157654243","https://openalex.org/W2159046231","https://openalex.org/W2159740872","https://openalex.org/W2161713835","https://openalex.org/W2162703129","https://openalex.org/W2162952070","https://openalex.org/W2163953271","https://openalex.org/W2165613244","https://openalex.org/W2165996538","https://openalex.org/W2172412199","https://openalex.org/W2179834311","https://openalex.org/W2181033391","https://openalex.org/W2212811500","https://openalex.org/W2215044127","https://openalex.org/W2216450681","https://openalex.org/W2232375730","https://openalex.org/W2256158981","https://openalex.org/W2258220506","https://openalex.org/W2273021913","https://openalex.org/W2274972818","https://openalex.org/W2284415085","https://openalex.org/W2286807773","https://openalex.org/W2314047676","https://openalex.org/W2319153630","https://openalex.org/W2320679796","https://openalex.org/W2336017858","https://openalex.org/W2342345222","https://openalex.org/W2417497667","https://openalex.org/W2427560245","https://openalex.org/W2462036387","https://openalex.org/W2471154607","https://openalex.org/W2517479804","https://openalex.org/W2518506318","https://openalex.org/W2552551254","https://openalex.org/W2554913814","https://openalex.org/W2559909402","https://openalex.org/W2566527653","https://openalex.org/W2570519144","https://openalex.org/W2606263154","https://openalex.org/W4234715488"],"related_works":["https://openalex.org/W1990525123","https://openalex.org/W2907679558","https://openalex.org/W2166795408","https://openalex.org/W2004508080","https://openalex.org/W2799013204","https://openalex.org/W7163062708","https://openalex.org/W78320112","https://openalex.org/W2041424225","https://openalex.org/W2769328785","https://openalex.org/W2137852056"],"abstract_inverted_index":{"As":[0],"our":[1],"understanding":[2],"of":[3,33,69,88,100],"mucosal":[4,26,98],"immunity":[5,92],"increases,":[6],"it":[7],"is":[8,17,28],"becoming":[9],"clear":[10],"that":[11,133],"the":[12,101,106,139],"host":[13,77],"response":[14],"to":[15,93],"HIV-1":[16,94],"more":[18,66],"complex":[19],"and":[20,50,62,73,95,105,115,128],"nuanced":[21],"than":[22,79],"originally":[23],"believed.":[24],"The":[25],"landscape":[27],"populated":[29],"with":[30],"a":[31],"variety":[32],"specialized":[34],"cell":[35,71,113],"types":[36,72],"whose":[37],"functions":[38],"include":[39],"combating":[40],"infectious":[41],"agents":[42],"while":[43],"preserving":[44],"commensal":[45],"microbiota,":[46],"maintaining":[47],"barrier":[48],"integrity,":[49],"ensuring":[51],"immune":[52],"homeostasis.":[53],"Advances":[54],"in":[55,76,97,138],"multiparameter":[56],"flow":[57],"cytometry,":[58],"gene":[59],"expression":[60],"analysis":[61],"bioinformatics":[63],"have":[64,134],"allowed":[65],"detailed":[67],"characterization":[68],"these":[70],"their":[74],"roles":[75],"defense":[78],"was":[80],"previously":[81],"possible.":[82],"This":[83],"review":[84],"provides":[85],"an":[86],"overview":[87],"existing":[89],"literature":[90],"on":[91,110,120],"SIVmac":[96],"tissues":[99],"female":[102],"reproductive":[103],"tract":[104],"gastrointestinal":[107,140],"tract,":[108],"focusing":[109],"major":[111],"effector":[112],"populations":[114],"briefly":[116],"summarizing":[117],"new":[118],"information":[119],"tissue-resident":[121],"memory":[122],"T":[123],"cells,":[124],"Treg,":[125],"Th17,":[126],"Th22":[127],"innate":[129],"lymphocytes":[130],"(ILC),":[131],"subsets":[132],"been":[135],"studied":[136],"primarily":[137],"mucosa.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-06-13T00:00:00"}