{"id":"https://openalex.org/W2804966566","doi":"https://doi.org/10.2217/pme-2017-0092","title":"Pharmacogenetics of Novel Oral Anticoagulants: A Review of Identified Gene Variants & Future Perspectives","display_name":"Pharmacogenetics of Novel Oral Anticoagulants: A Review of Identified Gene Variants & Future Perspectives","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2804966566","doi":"https://doi.org/10.2217/pme-2017-0092","mag":"2804966566","pmid":"https://pubmed.ncbi.nlm.nih.gov/29767545"},"language":"en","primary_location":{"id":"doi:10.2217/pme-2017-0092","doi":"https://doi.org/10.2217/pme-2017-0092","is_oa":false,"landing_page_url":"https://doi.org/10.2217/pme-2017-0092","pdf_url":null,"source":{"id":"https://openalex.org/S134466978","display_name":"Personalized Medicine","issn_l":"1741-0541","issn":["1741-0541","1744-828X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Personalized Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037186551","display_name":"Adna A\u0161i\u0107","orcid":"https://orcid.org/0000-0001-6197-9572","observed_orcids":["https://orcid.org/0000-0001-6197-9572"]},"institutions":[{"id":"https://openalex.org/I51716468","display_name":"International Burch University","ror":"https://ror.org/040cm8d21","country_code":"BA","type":"education","lineage":["https://openalex.org/I51716468"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Adna A\u0161i\u0107","raw_affiliation_strings":["Department of Genetics & Bioengineering, International Burch University, Francuske revolucije bb, 71210Ilid\u017ea, Sarajevo, Bosnia & Herzegovina","Fax: +387 33 944 500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics & Bioengineering, International Burch University, Francuske revolucije bb, 71210Ilid\u017ea, Sarajevo, Bosnia & Herzegovina","institution_ids":["https://openalex.org/I51716468"]},{"raw_affiliation_string":"Fax: +387 33 944 500","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014960976","display_name":"Damir Marjanovi\u0107","orcid":"https://orcid.org/0000-0002-7472-4525","observed_orcids":["https://orcid.org/0000-0002-7472-4525"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]},{"id":"https://openalex.org/I4210088013","display_name":"Institute for Anthropological Research","ror":"https://ror.org/001xj8m36","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4210088013"]},{"id":"https://openalex.org/I51716468","display_name":"International Burch University","ror":"https://ror.org/040cm8d21","country_code":"BA","type":"education","lineage":["https://openalex.org/I51716468"]}],"countries":["BA","HR"],"is_corresponding":false,"raw_author_name":"Damir Marjanovi\u0107","raw_affiliation_strings":["Department of Genetics & Bioengineering, International Burch University, Francuske revolucije bb, 71210Ilid\u017ea, Sarajevo, Bosnia & Herzegovina","Institute for Anthropological Research, University of Zagreb, Ljudevita Gaja 32, 10000Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics & Bioengineering, International Burch University, Francuske revolucije bb, 71210Ilid\u017ea, Sarajevo, Bosnia & Herzegovina","institution_ids":["https://openalex.org/I51716468"]},{"raw_affiliation_string":"Institute for Anthropological Research, University of Zagreb, Ljudevita Gaja 32, 10000Zagreb, Croatia","institution_ids":["https://openalex.org/I181343428","https://openalex.org/I4210088013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082500612","display_name":"Jure Mirat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jure Mirat","raw_affiliation_strings":["Polyclinic Kardioton, Kaptol 26, 10000Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polyclinic Kardioton, Kaptol 26, 10000Zagreb, Croatia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017159217","display_name":"Dragan Primorac","orcid":"https://orcid.org/0000-0001-5565-080X","observed_orcids":["https://orcid.org/0000-0001-5565-080X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I4210089068","display_name":"Children's Hospital Srebrnjak","ror":"https://ror.org/008sqe405","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210089068"]},{"id":"https://openalex.org/I4405267329","display_name":"Specijalna bolnica Sv. Katarina","ror":"https://ror.org/027ef7e21","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4405267329"]},{"id":"https://openalex.org/I51314090","display_name":"University of Osijek","ror":"https://ror.org/05sw4wc49","country_code":"HR","type":"education","lineage":["https://openalex.org/I51314090"]},{"id":"https://openalex.org/I92251255","display_name":"University of Split","ror":"https://ror.org/00m31ft63","country_code":"HR","type":"education","lineage":["https://openalex.org/I92251255"]}],"countries":["HR","US"],"is_corresponding":false,"raw_author_name":"Dragan Primorac","raw_affiliation_strings":["Children\u2019s Hospital Srebrnjak, Srebrnjak 100, 10000Zagreb, Croatia","Eberly College of Science, 517 Thomas St, State College, Penn State University, PA16803, USA","School of Medicine, University of Osijek, Ulica cara Hadrijana 10, 31000Osijek, Croatia","School of Medicine, University of Split, \u0160oltanska 2, 21000Split, Croatia","St. Catherine Specialty Hospital, Zagreb & Zabok, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Srebrnjak, Srebrnjak 100, 10000Zagreb, Croatia","institution_ids":["https://openalex.org/I4210089068"]},{"raw_affiliation_string":"Eberly College of Science, 517 Thomas St, State College, Penn State University, PA16803, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"School of Medicine, University of Osijek, Ulica cara Hadrijana 10, 31000Osijek, Croatia","institution_ids":["https://openalex.org/I51314090"]},{"raw_affiliation_string":"School of Medicine, University of Split, \u0160oltanska 2, 21000Split, Croatia","institution_ids":["https://openalex.org/I92251255"]},{"raw_affiliation_string":"St. Catherine Specialty Hospital, Zagreb & Zabok, Croatia","institution_ids":["https://openalex.org/I4405267329"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4251,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.28033473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"3","first_page":"209","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dabigatran","display_name":"dabigatran","score":0.9480000138282776},{"id":"https://openalex.org/keywords/rivaroxaban","display_name":"rivaroxaban","score":1.0},{"id":"https://openalex.org/keywords/apixaban","display_name":"apixaban","score":1.0},{"id":"https://openalex.org/keywords/edoxaban","display_name":"edoxaban","score":1.0},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.7910000085830688},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9810000061988831},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.6579999923706055},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8230000138282776},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.5950000286102295},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2780290652","wikidata":"https://www.wikidata.org/wiki/Q21011234","display_name":"Edoxaban","level":5,"score":0.9359830617904663},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.8714057207107544},{"id":"https://openalex.org/C2778810321","wikidata":"https://www.wikidata.org/wiki/Q419345","display_name":"Dabigatran","level":4,"score":0.8458191156387329},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.8345986604690552},{"id":"https://openalex.org/C2780638905","wikidata":"https://www.wikidata.org/wiki/Q414462","display_name":"Apixaban","level":5,"score":0.7799504995346069},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7639479041099548},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.5354089736938477},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5176220536231995},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5066155195236206},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49564898014068604},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.4646925628185272},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4413120448589325},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3388512134552002},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17485439777374268},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15522584319114685},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11625877022743225},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.11356565356254578},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10112938284873962},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.083437979221344}],"mesh":[{"descriptor_ui":"D000069552","descriptor_name":"Rivaroxaban","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069552","descriptor_name":"Rivaroxaban","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000069604","descriptor_name":"Dabigatran","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069604","descriptor_name":"Dabigatran","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000071184","descriptor_name":"Pharmacogenomic Variants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2217/pme-2017-0092","doi":"https://doi.org/10.2217/pme-2017-0092","is_oa":false,"landing_page_url":"https://doi.org/10.2217/pme-2017-0092","pdf_url":null,"source":{"id":"https://openalex.org/S134466978","display_name":"Personalized Medicine","issn_l":"1741-0541","issn":["1741-0541","1744-828X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Personalized Medicine","raw_type":"journal-article"},{"id":"pmid:29767545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29767545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Personalized medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W92746139","https://openalex.org/W1518470197","https://openalex.org/W1534687747","https://openalex.org/W1780454865","https://openalex.org/W1786021016","https://openalex.org/W1967129589","https://openalex.org/W1973743170","https://openalex.org/W1984967682","https://openalex.org/W1985788916","https://openalex.org/W2000438765","https://openalex.org/W2006321544","https://openalex.org/W2008955498","https://openalex.org/W2017582897","https://openalex.org/W2023158584","https://openalex.org/W2027008828","https://openalex.org/W2046882767","https://openalex.org/W2073493628","https://openalex.org/W2093049209","https://openalex.org/W2097854437","https://openalex.org/W2114189419","https://openalex.org/W2114992089","https://openalex.org/W2118092611","https://openalex.org/W2120203545","https://openalex.org/W2122667952","https://openalex.org/W2122732537","https://openalex.org/W2127435768","https://openalex.org/W2129500914","https://openalex.org/W2130199362","https://openalex.org/W2133088218","https://openalex.org/W2133686162","https://openalex.org/W2144540237","https://openalex.org/W2150819692","https://openalex.org/W2161876144","https://openalex.org/W2162349494","https://openalex.org/W2162508946","https://openalex.org/W2166402206","https://openalex.org/W2174386486","https://openalex.org/W2213987403","https://openalex.org/W2280164428","https://openalex.org/W2282667685","https://openalex.org/W2285010763","https://openalex.org/W2288949058","https://openalex.org/W2312567072","https://openalex.org/W2332034563","https://openalex.org/W2345197321","https://openalex.org/W2399437025","https://openalex.org/W2416524516","https://openalex.org/W2467616965","https://openalex.org/W2518583188","https://openalex.org/W2529526902","https://openalex.org/W2559528249","https://openalex.org/W2562806729","https://openalex.org/W2588625607","https://openalex.org/W2591050574","https://openalex.org/W2596305759","https://openalex.org/W2605578961","https://openalex.org/W2621404381","https://openalex.org/W2728110284","https://openalex.org/W3004050106","https://openalex.org/W3020968218","https://openalex.org/W4210659358","https://openalex.org/W4253084136","https://openalex.org/W7075647632"],"related_works":["https://openalex.org/W4405619639","https://openalex.org/W2945146681","https://openalex.org/W3119634521","https://openalex.org/W2909073103","https://openalex.org/W3156563987","https://openalex.org/W2066327183","https://openalex.org/W7040160647","https://openalex.org/W3083841860","https://openalex.org/W2063223800","https://openalex.org/W2809903455"],"abstract_inverted_index":{"Novel":[0],"oral":[1],"anticoagulants":[2,36],"(NOACs)":[3],"are":[4,81,113],"becoming":[5],"a":[6],"therapy":[7],"of":[8,32,59,75,101,115],"choice":[9],"in":[10,57,73,107],"everyday":[11],"clinical":[12],"practice":[13],"after":[14],"almost":[15],"50":[16],"years":[17],"during":[18],"which":[19],"warfarin":[20],"and":[21,41,46,49,79,105],"related":[22],"coumarin":[23],"derivatives":[24],"were":[25],"used":[26],"as":[27,61],"the":[28],"main":[29],"anticoagulants.":[30],"Advantages":[31],"NOACs":[33],"over":[34],"standard":[35],"include":[37,99],"their":[38],"predictable":[39],"pharmacodynamics":[40],"pharmacokinetics,":[42],"stable":[43],"plasma":[44],"concentrations":[45],"less":[47],"drug-drug":[48],"food-drug":[50],"interactions.":[51],"However,":[52],"pharmacogenetics":[53,74],"has":[54],"its":[55],"place":[56],"administration":[58],"NOACs,":[60],"considerable":[62],"interindividual":[63],"variations":[64],"have":[65],"been":[66],"detected.":[67],"In":[68],"this":[69],"review,":[70],"previous":[71],"findings":[72],"dabigatran,":[76],"rivaroxaban,":[77],"apixaban":[78],"edoxaban":[80],"summarized,":[82],"along":[83],"with":[84],"recommendations":[85],"for":[86,93,110],"studying":[87],"genes":[88],"encoding":[89],"metabolically":[90],"important":[91],"enzymes":[92],"four":[94],"selected":[95],"NOACs.":[96],"Future":[97],"directions":[98],"identification":[100],"clinically":[102],"relevant":[103],"SNPs,":[104],"change":[106],"optimum":[108],"dosage":[109],"patients":[111],"who":[112],"carriers":[114],"significant":[116],"variants.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-01T00:00:00"}