{"id":"https://openalex.org/W2804888047","doi":"https://doi.org/10.1134/s1990747818020071","title":"Bile Acid-Induced Ca2+ Efflux from Liver Mitochondria as a Factor Preventing the Formation of Mitochondrial Pores","display_name":"Bile Acid-Induced Ca2+ Efflux from Liver Mitochondria as a Factor Preventing the Formation of Mitochondrial Pores","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2804888047","doi":"https://doi.org/10.1134/s1990747818020071","mag":"2804888047"},"language":"en","primary_location":{"id":"doi:10.1134/s1990747818020071","doi":"https://doi.org/10.1134/s1990747818020071","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1990747818020071","pdf_url":null,"source":{"id":"https://openalex.org/S4210232935","display_name":"Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology","issn_l":"1990-7478","issn":["1990-7478","1990-7494"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033616879","display_name":"Ekaterina I. Khoroshavina","orcid":"https://orcid.org/0000-0002-1498-7518","observed_orcids":["https://orcid.org/0000-0002-1498-7518"]},"institutions":[{"id":"https://openalex.org/I3132405765","display_name":"Mari State University","ror":"https://ror.org/01yjw8d43","country_code":"RU","type":"education","lineage":["https://openalex.org/I3132405765"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. I. Khoroshavina","raw_affiliation_strings":["Mari State University, Yoshkar-Ola, 424001, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mari State University, Yoshkar-Ola, 424001, Russia","institution_ids":["https://openalex.org/I3132405765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037236045","display_name":"Mikhail V. Dubinin","orcid":"https://orcid.org/0000-0002-7453-3390","observed_orcids":["https://orcid.org/0000-0002-7453-3390"]},"institutions":[{"id":"https://openalex.org/I3132405765","display_name":"Mari State University","ror":"https://ror.org/01yjw8d43","country_code":"RU","type":"education","lineage":["https://openalex.org/I3132405765"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"M. V. Dubinin","raw_affiliation_strings":["Mari State University, Yoshkar-Ola, 424001, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mari State University, Yoshkar-Ola, 424001, Russia","institution_ids":["https://openalex.org/I3132405765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087160339","display_name":"A. V. Khokhlov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3132405765","display_name":"Mari State University","ror":"https://ror.org/01yjw8d43","country_code":"RU","type":"education","lineage":["https://openalex.org/I3132405765"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Khokhlov","raw_affiliation_strings":["Mari State University, Yoshkar-Ola, 424001, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mari State University, Yoshkar-Ola, 424001, Russia","institution_ids":["https://openalex.org/I3132405765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037465425","display_name":"Victor N. Samartsev","orcid":"https://orcid.org/0000-0003-0673-7305","observed_orcids":["https://orcid.org/0000-0003-0673-7305"]},"institutions":[{"id":"https://openalex.org/I3132405765","display_name":"Mari State University","ror":"https://ror.org/01yjw8d43","country_code":"RU","type":"education","lineage":["https://openalex.org/I3132405765"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. N. Samartsev","raw_affiliation_strings":["Mari State University, Yoshkar-Ola, 424001, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mari State University, Yoshkar-Ola, 424001, Russia","institution_ids":["https://openalex.org/I3132405765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037236045"],"corresponding_institution_ids":["https://openalex.org/I3132405765"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"2","first_page":"128","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":1.0},{"id":"https://openalex.org/keywords/calcium-efflux","display_name":"calcium efflux","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mitochondrial-matrix","display_name":"mitochondrial matrix","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.8240000009536743},{"id":"https://openalex.org/keywords/ruthenium-red","display_name":"ruthenium red","score":0.7699999809265137},{"id":"https://openalex.org/keywords/calcium-uniporter","display_name":"calcium uniporter","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lithocholic-acid","display_name":"lithocholic acid","score":0.8560000061988831},{"id":"https://openalex.org/keywords/chenodeoxycholic-acid","display_name":"chenodeoxycholic acid","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cholic-acid","display_name":"cholic acid","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.6850000023841858},{"id":"https://openalex.org/keywords/liver-mitochondria","display_name":"liver mitochondria","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2779657890","wikidata":"https://www.wikidata.org/wiki/Q424006","display_name":"Ruthenium red","level":3,"score":0.8334170579910278},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.6821617484092712},{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.6651567816734314},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.6569675803184509},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.6385236382484436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.621125340461731},{"id":"https://openalex.org/C35341161","wikidata":"https://www.wikidata.org/wiki/Q289992","display_name":"Uniporter","level":4,"score":0.6203388571739197},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.597676694393158},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.5866583585739136},{"id":"https://openalex.org/C2781089062","wikidata":"https://www.wikidata.org/wiki/Q419028","display_name":"Chenodeoxycholic acid","level":3,"score":0.561122715473175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4894517958164215},{"id":"https://openalex.org/C2775900799","wikidata":"https://www.wikidata.org/wiki/Q287415","display_name":"Cholic acid","level":3,"score":0.46736451983451843},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4616687595844269},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36641281843185425},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.22467467188835144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20297124981880188},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06772074103355408},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s1990747818020071","doi":"https://doi.org/10.1134/s1990747818020071","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1990747818020071","pdf_url":null,"source":{"id":"https://openalex.org/S4210232935","display_name":"Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology","issn_l":"1990-7478","issn":["1990-7478","1990-7494"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308590","display_name":"University of California","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1581717960","https://openalex.org/W1875161787","https://openalex.org/W1920479129","https://openalex.org/W1978641306","https://openalex.org/W1990769348","https://openalex.org/W1995629494","https://openalex.org/W2005641666","https://openalex.org/W2020178087","https://openalex.org/W2023915559","https://openalex.org/W2041167465","https://openalex.org/W2044126226","https://openalex.org/W2047819722","https://openalex.org/W2076598575","https://openalex.org/W2082944347","https://openalex.org/W2086067198","https://openalex.org/W2093686699","https://openalex.org/W2110060107","https://openalex.org/W2133244994","https://openalex.org/W2151766741","https://openalex.org/W2171898438","https://openalex.org/W2184631836","https://openalex.org/W2199978366","https://openalex.org/W2202366653","https://openalex.org/W2321435102","https://openalex.org/W2330902317","https://openalex.org/W2342263753","https://openalex.org/W2562509778","https://openalex.org/W2747539490"],"related_works":["https://openalex.org/W2562509778","https://openalex.org/W2747539490","https://openalex.org/W2321435102","https://openalex.org/W4367310859","https://openalex.org/W1891300354","https://openalex.org/W2133244994","https://openalex.org/W1533597003","https://openalex.org/W2403874908","https://openalex.org/W2079720564","https://openalex.org/W2093686699"],"abstract_inverted_index":{"The":[0],"effect":[1,198,212],"of":[2,7,25,42,68,84,101,109,124,129,140,151,189,199,205,213,219,222,233,254,262],"bile":[3,61,76,115,146,247],"acids":[4,62,77,147,248],"as":[5,202,216,252,260],"inducers":[6,261],"Ca":[8,36,88,181,239,264],"2+":[9,37,89,166,171,182,240,265],"efflux":[10,90,100,142,241],"from":[11,91,143,242],"the":[12,23,40,43,92,99,110,122,127,130,144,158,187,193,197,206,211,223,231,234,243,255,263],"matrix":[13,194,244],"was":[14,54,174],"studied":[15],"on":[16],"isolated":[17],"rat":[18],"liver":[19],"mitochondria.":[20,274],"Mitochondria":[21],"in":[22,157,230,273],"presence":[24],"cyclosporin":[26],"A":[27],"(CsA)":[28],"were":[29,49],"energized":[30,184],"by":[31,51,114,121,246],"succinate,":[32],"then":[33],"loaded":[34],"with":[35,107,138],"and":[38,64,70,74,79,154,167,195,210,269],"after":[39],"addition":[41],"calcium":[44,141,235],"uniporter":[45,236],"inhibitor":[46],"ruthenium":[47,177],"red":[48,178],"de-energized":[50],"malonate.":[52],"It":[53,95,133,173],"shown":[55],"that":[56,98,136,176,229],"under":[57],"these":[58,102,190],"conditions":[59,232],"hydrophobic":[60],"lithocholic":[63],"chenodeoxycholic":[65,200],"at":[66,81],"concentrations":[67],"10":[69],"30":[71],"\u03bcM":[72,86],"respectively":[73],"hydrophilic":[75],"ursodeoxycholic":[78,214],"cholic":[80],"a":[82],"concentration":[83],"400":[85],"induce":[87],"mitochondrial":[93,112,208,225],"matrix.":[94],"is":[96,104,119,134],"noted":[97],"ions":[103,156,191],"not":[105],"associated":[106],"damage":[108],"inner":[111,224],"membrane":[113],"acids,":[116],"since":[117],"it":[118],"accompanied":[120],"generation":[123],"\u0394\u03c8,":[125],"i.e.,":[126,161],"formation":[128],"diffusion":[131],"potential.":[132],"assumed":[135],"along":[137],"induction":[139],"matrix,":[145],"are":[148],"also":[149],"capable":[150],"transporting":[152],"hydrogen":[153],"potassium":[155],"opposite":[159],"direction,":[160],"perform":[162],"H":[163],"+":[164,169],"/Ca":[165,170],"K":[168],"exchange.":[172],"found":[175],"added":[179],"to":[180,192],"-loaded":[183],"mitochondria":[185],"prevents":[186],"return":[188],"weakens":[196],"acid":[201,215],"an":[203,217],"inducer":[204,218],"CsA-sensitive":[207,267],"pore":[209,268],"CsA-insensitive":[220,270],"permeability":[221,271],"membrane.":[226],"We":[227],"conclude":[228],"activity":[237],"decrease,":[238],"induced":[245],"can":[249],"be":[250],"considered":[251],"one":[253],"mechanisms":[256],"reducing":[257],"their":[258],"effectiveness":[259],"-dependent":[266],"transition":[272]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-06-01T00:00:00"}
