{"id":"https://openalex.org/W2804880164","doi":"https://doi.org/10.3389/fpsyt.2018.00242","title":"Neuromarkers for Mental Disorders: Harnessing Population Neuroscience","display_name":"Neuromarkers for Mental Disorders: Harnessing Population Neuroscience","publication_year":2018,"publication_date":"2018-06-06","ids":{"openalex":"https://openalex.org/W2804880164","doi":"https://doi.org/10.3389/fpsyt.2018.00242","mag":"2804880164","pmid":"https://pubmed.ncbi.nlm.nih.gov/29928237","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5998767"},"language":"en","primary_location":{"id":"doi:10.3389/fpsyt.2018.00242","doi":"https://doi.org/10.3389/fpsyt.2018.00242","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2018.00242","pdf_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00242/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00242/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045756776","display_name":"Lee Jollans","orcid":"https://orcid.org/0000-0003-4254-5159","observed_orcids":["https://orcid.org/0000-0003-4254-5159"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Lee Jollans","raw_affiliation_strings":["School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050499058","display_name":"Robert Whelan","orcid":"https://orcid.org/0000-0002-2790-7281","observed_orcids":["https://orcid.org/0000-0002-2790-7281"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Robert Whelan","raw_affiliation_strings":["School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050499058"],"corresponding_institution_ids":["https://openalex.org/I205274468"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.0625,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.703125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"242","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.4246000051498413,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.4246000051498413,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":0.18230000138282776,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.1143999993801117,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromarkers","display_name":"neuromarkers","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neuroimaging-biomarkers","display_name":"neuroimaging biomarkers","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.9629999995231628},{"id":"https://openalex.org/keywords/psychiatric-classification","display_name":"psychiatric classification","score":0.9079999923706055},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.7250000238418579},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"multivariate analysis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/generalizability","display_name":"generalizability","score":0.859000027179718},{"id":"https://openalex.org/keywords/construct-validity","display_name":"construct validity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/psychiatric-diagnosis","display_name":"psychiatric diagnosis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/psychiatric-treatment","display_name":"psychiatric treatment","score":0.7129999995231628},{"id":"https://openalex.org/keywords/research-collaboration","display_name":"research collaboration","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.721255898475647},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.5594971179962158},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5503336191177368},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4941923916339874},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4920308291912079},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4403674900531769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30555301904678345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06987357139587402},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fpsyt.2018.00242","doi":"https://doi.org/10.3389/fpsyt.2018.00242","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2018.00242","pdf_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00242/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4960962","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5998767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5998767","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5998767","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Psychiatry","raw_type":"Text"},{"id":"pmid:29928237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29928237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0e3fc6cf88bf41f2a245cb26e27dc04f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0e3fc6cf88bf41f2a245cb26e27dc04f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Psychiatry, Vol 9 (2018)","raw_type":"article"},{"id":"pmh:oai:tara.tcd.ie:2262/83989","doi":null,"is_oa":false,"landing_page_url":"http://people.tcd.ie/whelanr3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3389/fpsyt.2018.00242","doi":"https://doi.org/10.3389/fpsyt.2018.00242","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fpsyt.2018.00242","pdf_url":"https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00242/pdf","source":{"id":"https://openalex.org/S92766711","display_name":"Frontiers in Psychiatry","issn_l":"1664-0640","issn":["1664-0640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2215071536","display_name":null,"funder_award_id":"GOIPG/2014/418","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"}],"funders":[{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804880164.pdf","grobid_xml":"https://content.openalex.org/works/W2804880164.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W1097741600","https://openalex.org/W1518888592","https://openalex.org/W1731053727","https://openalex.org/W1804828504","https://openalex.org/W1943522337","https://openalex.org/W1965445933","https://openalex.org/W1970684162","https://openalex.org/W1970727058","https://openalex.org/W1971179749","https://openalex.org/W1977465442","https://openalex.org/W1979450493","https://openalex.org/W1981830992","https://openalex.org/W1982352919","https://openalex.org/W1984615306","https://openalex.org/W1993400322","https://openalex.org/W2000099664","https://openalex.org/W2003955778","https://openalex.org/W2005305137","https://openalex.org/W2006591500","https://openalex.org/W2007307305","https://openalex.org/W2009110843","https://openalex.org/W2012066625","https://openalex.org/W2016205856","https://openalex.org/W2017337590","https://openalex.org/W2017854344","https://openalex.org/W2020519533","https://openalex.org/W2032752029","https://openalex.org/W2036439084","https://openalex.org/W2046146277","https://openalex.org/W2049577872","https://openalex.org/W2063166582","https://openalex.org/W2078524519","https://openalex.org/W2079187454","https://openalex.org/W2079484785","https://openalex.org/W2081983998","https://openalex.org/W2093918468","https://openalex.org/W2102508963","https://openalex.org/W2105824687","https://openalex.org/W2107493662","https://openalex.org/W2117004913","https://openalex.org/W2118164359","https://openalex.org/W2118540296","https://openalex.org/W2119910794","https://openalex.org/W2121049815","https://openalex.org/W2122825543","https://openalex.org/W2126415088","https://openalex.org/W2128368278","https://openalex.org/W2128667519","https://openalex.org/W2131786905","https://openalex.org/W2132449499","https://openalex.org/W2135264137","https://openalex.org/W2137559366","https://openalex.org/W2139870060","https://openalex.org/W2144269887","https://openalex.org/W2144903814","https://openalex.org/W2145680887","https://openalex.org/W2146404132","https://openalex.org/W2146739527","https://openalex.org/W2148601182","https://openalex.org/W2151056789","https://openalex.org/W2151480498","https://openalex.org/W2152723280","https://openalex.org/W2154776925","https://openalex.org/W2155607477","https://openalex.org/W2155624710","https://openalex.org/W2162381025","https://openalex.org/W2167101736","https://openalex.org/W2168106919","https://openalex.org/W2168463527","https://openalex.org/W2178154174","https://openalex.org/W2193791265","https://openalex.org/W2196404391","https://openalex.org/W2205424056","https://openalex.org/W2232639819","https://openalex.org/W2257438637","https://openalex.org/W2283026346","https://openalex.org/W2283383139","https://openalex.org/W2302532339","https://openalex.org/W2310177520","https://openalex.org/W2344945222","https://openalex.org/W2345845789","https://openalex.org/W2346273735","https://openalex.org/W2399385044","https://openalex.org/W2468051497","https://openalex.org/W2517195842","https://openalex.org/W2528004326","https://openalex.org/W2550484220","https://openalex.org/W2550495677","https://openalex.org/W2551056916","https://openalex.org/W2555699120","https://openalex.org/W2559184870","https://openalex.org/W2560565629","https://openalex.org/W2565817028","https://openalex.org/W2566424235","https://openalex.org/W2572683392","https://openalex.org/W2584830124","https://openalex.org/W2587272693","https://openalex.org/W2590328111","https://openalex.org/W2738873788"],"related_works":["https://openalex.org/W7160651387","https://openalex.org/W2809971085","https://openalex.org/W2158775170","https://openalex.org/W38227877","https://openalex.org/W4376131758","https://openalex.org/W4410194723","https://openalex.org/W6668765","https://openalex.org/W3118731442","https://openalex.org/W2566424235","https://openalex.org/W2019141334"],"abstract_inverted_index":{"Despite":[0],"abundant":[1],"research":[2,152],"into":[3],"the":[4,29,48,58,65,133,140,160],"neurobiology":[5],"of":[6,47,60,102,115,131,135,144],"mental":[7,34,103,116],"disorders,":[8,104],"to":[9,81],"date":[10],"neurobiological":[11],"insights":[12],"have":[13],"had":[14],"very":[15],"little":[16],"impact":[17],"on":[18,124],"psychiatric":[19,43,53,121,167],"diagnosis":[20],"or":[21],"treatment.":[22],"In":[23],"this":[24],"review,":[25],"we":[26,63,155],"contend":[27],"that":[28,91],"search":[30],"for":[31,52,57,67,71,84,99,142,150],"neuroimaging":[32,54,87],"biomarkers-neuromarkers-of":[33],"disorders":[35],"is":[36],"a":[37,108,112],"highly":[38],"promising":[39],"avenue":[40],"toward":[41,120],"improved":[42],"healthcare.":[44,168],"However,":[45],"many":[46],"traditional":[49],"tools":[50],"used":[51],"are":[55,79],"inadequate":[56],"identification":[59],"neuromarkers.":[61],"Specifically,":[62],"highlight":[64,156],"need":[66,141],"larger":[68],"samples":[69],"and":[70,105,119,146,149,162],"multivariate":[72],"analysis.":[73],"Approaches":[74],"such":[75],"as":[76],"machine":[77],"learning":[78],"likely":[80],"be":[82,97],"beneficial":[83],"interrogating":[85],"high-dimensional":[86],"data.":[88],"We":[89,127],"suggest":[90],"broad,":[92],"population-based":[93],"study":[94],"designs":[95],"will":[96,106],"important":[98],"developing":[100],"neuromarkers":[101,136,165],"facilitate":[107],"move":[109],"away":[110],"from":[111],"phenomenological":[113],"definition":[114],"disorder":[117],"categories":[118],"nosology":[122],"based":[123],"biological":[125],"evidence.":[126],"provide":[128],"an":[129],"outline":[130],"how":[132],"development":[134],"should":[137],"occur,":[138],"emphasizing":[139],"tests":[143],"external":[145],"construct":[147],"validity,":[148],"collaborative":[151],"efforts.":[153],"Finally,":[154],"some":[157],"concerns":[158],"regarding":[159],"development,":[161],"use":[163],"of,":[164],"in":[166]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-01T00:00:00"}