{"id":"https://openalex.org/W2804878738","doi":"https://doi.org/10.2166/wst.2004.0326","title":"Assessing the elimination of estrogenic activity in advanced wastewater treatment with a reporter gene-based bioassay","display_name":"Assessing the elimination of estrogenic activity in advanced wastewater treatment with a reporter gene-based bioassay","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2804878738","doi":"https://doi.org/10.2166/wst.2004.0326","mag":"2804878738","pmid":"https://pubmed.ncbi.nlm.nih.gov/15497846"},"language":"en","primary_location":{"id":"doi:10.2166/wst.2004.0326","doi":"https://doi.org/10.2166/wst.2004.0326","is_oa":false,"landing_page_url":"https://doi.org/10.2166/wst.2004.0326","pdf_url":null,"source":{"id":"https://openalex.org/S53450646","display_name":"Water Science & Technology","issn_l":"0273-1223","issn":["0273-1223","1996-9732"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Water Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086796272","display_name":"Anja Coors","orcid":"https://orcid.org/0000-0002-9224-2917","observed_orcids":["https://orcid.org/0000-0002-9224-2917"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"A. Coors","raw_affiliation_strings":["Department of Biology V (Ecology, Ecotoxicology, Ecochemistry), Aachen University, Worringerweg 1, 52056 Aachen, Germany (E-mail: anja.coors@bio5.rwth-aachen.de; toni.ratte@bio5.rwth-aachen.de)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology V (Ecology, Ecotoxicology, Ecochemistry), Aachen University, Worringerweg 1, 52056 Aachen, Germany (E-mail: anja.coors@bio5.rwth-aachen.de; toni.ratte@bio5.rwth-aachen.de)","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006354670","display_name":"Paul D. Jones","orcid":"https://orcid.org/0000-0002-7483-5380","observed_orcids":["https://orcid.org/0000-0002-7483-5380"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.D. Jones","raw_affiliation_strings":["Zoology Department, Institute for Environmental Toxicology and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA (E-mail: jonespa7@msu.edu; jgiesy@aol.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Institute for Environmental Toxicology and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA (E-mail: jonespa7@msu.edu; jgiesy@aol.com)","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009044499","display_name":"John Paul Giesy","orcid":"https://orcid.org/0000-0003-1931-9962","observed_orcids":["https://orcid.org/0000-0003-1931-9962"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.P. Giesy","raw_affiliation_strings":["Zoology Department, Institute for Environmental Toxicology and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA (E-mail: jonespa7@msu.edu; jgiesy@aol.com)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Institute for Environmental Toxicology and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA (E-mail: jonespa7@msu.edu; jgiesy@aol.com)","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113694068","display_name":"Hans\u2010Toni Ratte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H.T. Ratte","raw_affiliation_strings":["Department of Biology V (Ecology, Ecotoxicology, Ecochemistry), Aachen University, Worringerweg 1, 52056 Aachen, Germany (E-mail: anja.coors@bio5.rwth-aachen.de; toni.ratte@bio5.rwth-aachen.de)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology V (Ecology, Ecotoxicology, Ecochemistry), Aachen University, Worringerweg 1, 52056 Aachen, Germany (E-mail: anja.coors@bio5.rwth-aachen.de; toni.ratte@bio5.rwth-aachen.de)","institution_ids":["https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086796272"],"corresponding_institution_ids":["https://openalex.org/I887968799"],"apc_list":null,"apc_paid":null,"fwci":1.302,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.78016653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"50","issue":"5","first_page":"181","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.3303000032901764,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenoestrogens","display_name":"xenoestrogens","score":0.9380000233650208},{"id":"https://openalex.org/keywords/estrogenic-activity","display_name":"estrogenic activity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/wastewater-treatment-plants","display_name":"wastewater treatment plants","score":0.8420000076293945},{"id":"https://openalex.org/keywords/activated-sludge","display_name":"activated sludge","score":0.6940000057220459},{"id":"https://openalex.org/keywords/nitrification-denitrification","display_name":"nitrification-denitrification","score":0.8960000276565552},{"id":"https://openalex.org/keywords/advanced-wastewater-treatment","display_name":"advanced wastewater treatment","score":0.9879999756813049},{"id":"https://openalex.org/keywords/estradiol-equivalents","display_name":"estradiol equivalents","score":0.9570000171661377},{"id":"https://openalex.org/keywords/process-water","display_name":"process water","score":0.5289999842643738},{"id":"https://openalex.org/keywords/effluent-quality","display_name":"effluent quality","score":0.503000020980835},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.9031435251235962},{"id":"https://openalex.org/C147455438","wikidata":"https://www.wikidata.org/wiki/Q1057706","display_name":"Effluent","level":2,"score":0.8834061622619629},{"id":"https://openalex.org/C57442070","wikidata":"https://www.wikidata.org/wiki/Q221275","display_name":"Sewage treatment","level":2,"score":0.7373331189155579},{"id":"https://openalex.org/C2777730692","wikidata":"https://www.wikidata.org/wiki/Q815353","display_name":"Activated sludge","level":3,"score":0.7346879839897156},{"id":"https://openalex.org/C58790150","wikidata":"https://www.wikidata.org/wiki/Q10966166","display_name":"Sewage","level":2,"score":0.672904372215271},{"id":"https://openalex.org/C164752452","wikidata":"https://www.wikidata.org/wiki/Q668677","display_name":"Nitrification","level":3,"score":0.6051039695739746},{"id":"https://openalex.org/C94061648","wikidata":"https://www.wikidata.org/wiki/Q336191","display_name":"Wastewater","level":2,"score":0.5806130766868591},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.5625715255737305},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.44739145040512085},{"id":"https://openalex.org/C73593433","wikidata":"https://www.wikidata.org/wiki/Q742637","display_name":"Denitrification","level":3,"score":0.4384397864341736},{"id":"https://openalex.org/C2776849215","wikidata":"https://www.wikidata.org/wiki/Q5102910","display_name":"Chloramination","level":4,"score":0.4147692024707794},{"id":"https://openalex.org/C173764188","wikidata":"https://www.wikidata.org/wiki/Q4915238","display_name":"Bioreporter","level":5,"score":0.4134131073951721},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3981379270553589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3461172580718994},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.3386029601097107},{"id":"https://openalex.org/C87717796","wikidata":"https://www.wikidata.org/wiki/Q146326","display_name":"Environmental engineering","level":1,"score":0.3309495151042938},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1838858425617218},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07312759757041931},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07290342450141907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05783960223197937},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.05758020281791687},{"id":"https://openalex.org/C2779488458","wikidata":"https://www.wikidata.org/wiki/Q9189940","display_name":"Chloramine","level":3,"score":0.0564020574092865},{"id":"https://openalex.org/C505241676","wikidata":"https://www.wikidata.org/wiki/Q688","display_name":"Chlorine","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014865","descriptor_name":"Waste Disposal, Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2166/wst.2004.0326","doi":"https://doi.org/10.2166/wst.2004.0326","is_oa":false,"landing_page_url":"https://doi.org/10.2166/wst.2004.0326","pdf_url":null,"source":{"id":"https://openalex.org/S53450646","display_name":"Water Science & Technology","issn_l":"0273-1223","issn":["0273-1223","1996-9732"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Water Science and Technology","raw_type":"journal-article"},{"id":"pmid:15497846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15497846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Water science and technology : a journal of the International Association on Water Pollution Research","raw_type":"Journal Article"},{"id":"pmh:oai:publications.rwth-aachen.de:152961","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-031429%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"4. IWA Specialized Conference on Assessment and Control of Hazardous Substances in Water, Aachen, Germany, 2003-09-14-2003-09-17","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","score":1.0,"display_name":"Clean water and sanitation"},{"id":"https://metadata.un.org/sdg/12","score":0.5925999879837036,"display_name":"Responsible consumption and production"},{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W78692487","https://openalex.org/W1973402545","https://openalex.org/W1986289302","https://openalex.org/W2023666759","https://openalex.org/W2024925996","https://openalex.org/W2025260655","https://openalex.org/W2052856379","https://openalex.org/W2126289236","https://openalex.org/W2137480282","https://openalex.org/W2153907510","https://openalex.org/W2249397753","https://openalex.org/W2256866970","https://openalex.org/W2264899144","https://openalex.org/W2307575554","https://openalex.org/W2340275545"],"related_works":["https://openalex.org/W155587928","https://openalex.org/W3003114243","https://openalex.org/W7096296532","https://openalex.org/W4391734816","https://openalex.org/W2082938373","https://openalex.org/W1980368019","https://openalex.org/W2006910114","https://openalex.org/W2066778333","https://openalex.org/W2092988417","https://openalex.org/W1964690188"],"abstract_inverted_index":{"Estrogen-like":[0],"chemicals,":[1],"so-called":[2],"xenoestrogens,":[3],"have":[4],"become":[5],"a":[6,63,149],"topic":[7],"of":[8,15,20,25,35,57,62,88,126,133,138,151,168],"concern":[9],"because":[10],"they":[11],"are":[12,30],"potentially":[13],"capable":[14],"disturbing":[16],"the":[17,32,38,86,89,124,131,134,165,169,174,192],"hormonal":[18],"balance":[19],"wildlife":[21],"and":[22,55,75,94,108,156,173],"humans.":[23],"Effluents":[24],"wastewater":[26],"treatment":[27,72,77,172],"plants":[28,103],"(WWTPs)":[29],"presumably":[31],"major":[33],"source":[34,132],"xenoestrogens":[36],"in":[37,85,102,109,112,123,154,159,191],"aquatic":[39],"environment.":[40],"In":[41],"this":[42],"study,":[43],"we":[44],"investigated":[45],"eight":[46],"WWTPs":[47,68,90],"with":[48,73],"respect":[49],"to":[50,148],"their":[51],"input,":[52],"elimination":[53,166],"efficiency,":[54],"output":[56],"estrogenic":[58,119,189],"activity":[59,120],"by":[60,177],"means":[61],"reporter":[64],"gene-based":[65],"bioassay.":[66,193],"All":[67],"employed":[69],"activated":[70,170],"sludge":[71,171],"nitrification/denitrification":[74],"tertiary":[76,160,179],"(second":[78],"nitrification":[79],"and/or":[80],"filtration).":[81],"Estradiol":[82],"equivalents":[83],"(EEQs)":[84],"influents":[87],"were":[91,100],"between":[92],"5.7":[93],"65.8":[95],"ng/L.":[96],"The":[97],"greatest":[98],"inputs":[99],"found":[101],"treating":[104],"pure":[105],"domestic":[106],"sewage":[107],"samples":[110],"collected":[111],"winter.":[113],"Process":[114],"waters":[115],"either":[116],"had":[117],"no":[118],"or":[121],"EEQs":[122,137],"range":[125],"raw":[127],"sewage,":[128],"depending":[129],"on":[130],"process":[135],"water.":[136],"effluents":[139,184],"ranged":[140],"from":[141],"mostly":[142],"below":[143],"quantification":[144],"limit":[145],"(0.8":[146],"ng/L)":[147],"maximum":[150],"5.4":[152],"ng/L":[153,158],"secondary":[155],"1.4":[157],"effluents.":[161],"These":[162],"findings":[163],"demonstrate":[164],"efficiency":[167],"further":[175],"improvement":[176],"additional":[178],"treatment.":[180],"However,":[181],"several":[182],"concentrated":[183],"elicited":[185],"little,":[186],"but":[187],"detectable":[188],"responses":[190]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-01T00:00:00"}
