{"id":"https://openalex.org/W2804853658","doi":"https://doi.org/10.1200/edbk_201421","title":"Neoadjuvant Chemotherapy, Concurrent Chemoradiation, and Adjuvant Chemotherapy for High-Risk Extremity Soft Tissue Sarcoma","display_name":"Neoadjuvant Chemotherapy, Concurrent Chemoradiation, and Adjuvant Chemotherapy for High-Risk Extremity Soft Tissue Sarcoma","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2804853658","doi":"https://doi.org/10.1200/edbk_201421","mag":"2804853658","pmid":"https://pubmed.ncbi.nlm.nih.gov/30231383"},"language":"en","primary_location":{"id":"doi:10.1200/edbk_201421","doi":"https://doi.org/10.1200/edbk_201421","is_oa":false,"landing_page_url":"https://doi.org/10.1200/edbk_201421","pdf_url":null,"source":{"id":"https://openalex.org/S4210215109","display_name":"American Society of Clinical Oncology Educational Book","issn_l":"1548-8748","issn":["1548-8748","1548-8756","1930-7020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Society of Clinical Oncology Educational Book","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106483495","display_name":"Elizabeth Healey Baldini","orcid":"https://orcid.org/0000-0003-3609-9834","observed_orcids":["https://orcid.org/0000-0003-3609-9834"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Elizabeth H. Baldini","raw_affiliation_strings":["From the Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women\u2019s Hospital, Boston, MA; Department of Adult Medicine, Gustave Roussy, Villejuif, France; Division of Medical Oncology, Sarcoma Program, Sylvester Comprehensive Cancer Center, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women\u2019s Hospital, Boston, MA; Department of Adult Medicine, Gustave Roussy, Villejuif, France; Division of Medical Oncology, Sarcoma Program, Sylvester Comprehensive Cancer Center, Miami, FL","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I2801843802","https://openalex.org/I4210117453","https://openalex.org/I4210157065","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090103193","display_name":"Axel Le Cesne","orcid":"https://orcid.org/0000-0002-8006-8659","observed_orcids":["https://orcid.org/0000-0002-8006-8659"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Axel Le Cesne","raw_affiliation_strings":["From the Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women\u2019s Hospital, Boston, MA; Department of Adult Medicine, Gustave Roussy, Villejuif, France; Division of Medical Oncology, Sarcoma Program, Sylvester Comprehensive Cancer Center, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women\u2019s Hospital, Boston, MA; Department of Adult Medicine, Gustave Roussy, Villejuif, France; Division of Medical Oncology, Sarcoma Program, Sylvester Comprehensive Cancer Center, Miami, FL","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I2801843802","https://openalex.org/I4210117453","https://openalex.org/I4210157065","https://openalex.org/I4210161994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004418792","display_name":"Jonathan C. Trent","orcid":"https://orcid.org/0000-0001-6169-5238","observed_orcids":["https://orcid.org/0000-0001-6169-5238"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Jonathan C. Trent","raw_affiliation_strings":["From the Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women\u2019s Hospital, Boston, MA; Department of Adult Medicine, Gustave Roussy, Villejuif, France; Division of Medical Oncology, Sarcoma Program, Sylvester Comprehensive Cancer Center, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women\u2019s Hospital, Boston, MA; Department of Adult Medicine, Gustave Roussy, Villejuif, France; Division of Medical Oncology, Sarcoma Program, Sylvester Comprehensive Cancer Center, Miami, FL","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I2801843802","https://openalex.org/I4210117453","https://openalex.org/I4210157065","https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6549,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.56462001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"38","issue":"38","first_page":"910","last_page":"915"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extremity-soft-tissue-sarcoma","display_name":"extremity soft tissue sarcoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/concurrent-chemoradiotherapy","display_name":"concurrent chemoradiotherapy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":1.0},{"id":"https://openalex.org/keywords/distant-recurrence","display_name":"distant recurrence","score":0.652999997138977},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7424229979515076},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7035689353942871},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.6446000933647156},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.587240993976593},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5665935277938843},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5643388032913208},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.48530715703964233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4200098514556885},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15146154165267944}],"mesh":[{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059248","descriptor_name":"Chemoradiotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059248","descriptor_name":"Chemoradiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/edbk_201421","doi":"https://doi.org/10.1200/edbk_201421","is_oa":false,"landing_page_url":"https://doi.org/10.1200/edbk_201421","pdf_url":null,"source":{"id":"https://openalex.org/S4210215109","display_name":"American Society of Clinical Oncology Educational Book","issn_l":"1548-8748","issn":["1548-8748","1548-8756","1930-7020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Society of Clinical Oncology Educational Book","raw_type":"journal-article"},{"id":"pmid:30231383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30231383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1598058107","https://openalex.org/W1845127980","https://openalex.org/W1862666273","https://openalex.org/W1878715328","https://openalex.org/W1893251984","https://openalex.org/W1907859928","https://openalex.org/W1912227677","https://openalex.org/W1979119159","https://openalex.org/W1991663900","https://openalex.org/W2050917665","https://openalex.org/W2051346698","https://openalex.org/W2057962602","https://openalex.org/W2059931397","https://openalex.org/W2067787818","https://openalex.org/W2069325265","https://openalex.org/W2080349967","https://openalex.org/W2096577727","https://openalex.org/W2096854366","https://openalex.org/W2100339026","https://openalex.org/W2104213181","https://openalex.org/W2104336706","https://openalex.org/W2113855026","https://openalex.org/W2126836474","https://openalex.org/W2134901403","https://openalex.org/W2144461653","https://openalex.org/W2145199918","https://openalex.org/W2147965643","https://openalex.org/W2148565300","https://openalex.org/W2275599683","https://openalex.org/W2302390567","https://openalex.org/W2312262713","https://openalex.org/W2416231602","https://openalex.org/W2589359707","https://openalex.org/W2613892444","https://openalex.org/W2989800034","https://openalex.org/W4237253263","https://openalex.org/W4248877280"],"related_works":["https://openalex.org/W4323294209","https://openalex.org/W2972091406","https://openalex.org/W4389612248","https://openalex.org/W3000348884","https://openalex.org/W4392880595","https://openalex.org/W1983586273","https://openalex.org/W1989655793","https://openalex.org/W2971100188","https://openalex.org/W2095696542","https://openalex.org/W4399280294"],"abstract_inverted_index":{"Standard":[0],"treatment":[1,113],"of":[2,67,96],"large":[3],"intermediate-":[4],"and":[5,16,52,89,101,126],"high-grade":[6],"extremity":[7],"soft":[8],"tissue":[9],"sarcoma":[10,124],"(ESTS)":[11],"typically":[12],"includes":[13],"wide":[14],"excision":[15],"radiation":[17],"therapy.":[18],"Many":[19],"patients":[20,58,71],"do":[21],"well":[22],"with":[23,29,72],"this":[24],"approach,":[25],"but":[26],"for":[27,33,55,70,92],"those":[28],"unfavorable":[30],"features,":[31],"risk":[32,134],"distant":[34],"recurrence":[35],"and,":[36],"ultimately,":[37],"mortality":[38],"can":[39],"exceed":[40],"50%.":[41],"Unfortunately,":[42],"universally":[43],"accepted":[44],"data":[45],"elucidating":[46],"effective":[47],"treatments":[48],"to":[49,84,103,108,130],"prevent":[50],"recurrences":[51],"improve":[53],"survival":[54],"such":[56],"high-risk":[57,73,93],"are":[59,99],"lacking.":[60],"Accordingly,":[61],"opinions":[62],"about":[63],"the":[64,80,106,112,131],"appropriate":[65],"role":[66],"systemic":[68],"therapy":[69],"localized":[74],"ESTS":[75],"vary.":[76],"This":[77],"article":[78],"reviews":[79],"current":[81],"literature":[82],"pertaining":[83],"neoadjuvant":[85],"chemotherapy,":[86],"concurrent":[87],"chemoradiation,":[88],"adjuvant":[90],"chemotherapy":[91,110],"ESTS.":[94],"All":[95],"these":[97],"approaches":[98],"feasible":[100],"reasonable":[102],"consider.":[104],"Ultimately,":[105],"decision":[107],"incorporate":[109],"into":[111],"regimen":[114],"is":[115],"best":[116],"reached":[117],"by":[118],"discussion":[119],"among":[120],"an":[121],"experienced":[122],"multidisciplinary":[123],"team":[125],"should":[127],"be":[128],"tailored":[129],"individual":[132],"patient":[133],"profile.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}
