{"id":"https://openalex.org/W2804833713","doi":"https://doi.org/10.1021/acs.jmedchem.8b00173","title":"Factor XIa Inhibitors as New Anticoagulants","display_name":"Factor XIa Inhibitors as New Anticoagulants","publication_year":2018,"publication_date":"2018-05-18","ids":{"openalex":"https://openalex.org/W2804833713","doi":"https://doi.org/10.1021/acs.jmedchem.8b00173","mag":"2804833713","pmid":"https://pubmed.ncbi.nlm.nih.gov/29775297"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.8b00173","doi":"https://doi.org/10.1021/acs.jmedchem.8b00173","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.8b00173","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030883249","display_name":"Mimi L. C. Quan","orcid":"https://orcid.org/0000-0001-5866-0114","observed_orcids":["https://orcid.org/0000-0001-5866-0114"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mimi L. Quan","raw_affiliation_strings":["Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States"],"raw_orcid":"https://orcid.org/0000-0001-5866-0114","affiliations":[{"raw_affiliation_string":"Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062012797","display_name":"Donald J. P. Pinto","orcid":"https://orcid.org/0000-0003-4356-5979","observed_orcids":["https://orcid.org/0000-0003-4356-5979"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald J. P. Pinto","raw_affiliation_strings":["Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States"],"raw_orcid":"https://orcid.org/0000-0003-4356-5979","affiliations":[{"raw_affiliation_string":"Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073847679","display_name":"Joanne M. Smallheer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne M. Smallheer","raw_affiliation_strings":["Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054457818","display_name":"William R. Ewing","orcid":"https://orcid.org/0000-0002-9434-8053","observed_orcids":["https://orcid.org/0000-0002-9434-8053"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Ewing","raw_affiliation_strings":["Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054179990","display_name":"Karen A. Rossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen A. Rossi","raw_affiliation_strings":["Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046070580","display_name":"Joseph M. Luettgen","orcid":"https://orcid.org/0000-0002-5067-8819","observed_orcids":["https://orcid.org/0000-0002-5067-8819"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Luettgen","raw_affiliation_strings":["Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026463840","display_name":"Dietmar Seiffert","orcid":"https://orcid.org/0009-0006-4818-2407","observed_orcids":["https://orcid.org/0009-0006-4818-2407"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dietmar A. Seiffert","raw_affiliation_strings":["Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003421053","display_name":"Ruth R. Wexler","orcid":"https://orcid.org/0000-0001-5514-5053","observed_orcids":["https://orcid.org/0000-0001-5514-5053"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth R. Wexler","raw_affiliation_strings":["Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543, United States","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030883249"],"corresponding_institution_ids":["https://openalex.org/I4210091812"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.3255,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.79008746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"61","issue":"17","first_page":"7425","last_page":"7447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.26829999685287476,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-xia-inhibitors","display_name":"factor XIa inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.9589999914169312},{"id":"https://openalex.org/keywords/antithrombotic-agents","display_name":"antithrombotic agents","score":0.8399999737739563},{"id":"https://openalex.org/keywords/factor-xa-inhibitors","display_name":"factor Xa inhibitors","score":0.746999979019165},{"id":"https://openalex.org/keywords/thrombin-inhibitors","display_name":"thrombin inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oral-anticoagulants","display_name":"oral anticoagulants","score":0.902999997138977},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.7179999947547913},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.7411847114562988},{"id":"https://openalex.org/C57002609","wikidata":"https://www.wikidata.org/wiki/Q5281999","display_name":"Discovery and development of direct thrombin inhibitors","level":4,"score":0.5541936159133911},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5327890515327454},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4898812174797058},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4718256890773773},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.459205687046051},{"id":"https://openalex.org/C2776654903","wikidata":"https://www.wikidata.org/wiki/Q2601463","display_name":"SAFER","level":2,"score":0.43538710474967957},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3622922897338867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19340002536773682},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15281271934509277},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1168312132358551},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.09331637620925903},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015945","descriptor_name":"Factor XIa","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015945","descriptor_name":"Factor XIa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015945","descriptor_name":"Factor XIa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jmedchem.8b00173","doi":"https://doi.org/10.1021/acs.jmedchem.8b00173","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.8b00173","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:29775297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29775297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1593430977","https://openalex.org/W1819699650","https://openalex.org/W1966458033","https://openalex.org/W1968944648","https://openalex.org/W1981300426","https://openalex.org/W1985416926","https://openalex.org/W1985469117","https://openalex.org/W1985828707","https://openalex.org/W1987596051","https://openalex.org/W1988714638","https://openalex.org/W1989009158","https://openalex.org/W1989883128","https://openalex.org/W1996076154","https://openalex.org/W1997568232","https://openalex.org/W1998233841","https://openalex.org/W2004091546","https://openalex.org/W2014347434","https://openalex.org/W2023018411","https://openalex.org/W2029829519","https://openalex.org/W2034968703","https://openalex.org/W2038299059","https://openalex.org/W2040948537","https://openalex.org/W2042434678","https://openalex.org/W2047107573","https://openalex.org/W2047153261","https://openalex.org/W2056457196","https://openalex.org/W2063706685","https://openalex.org/W2067893808","https://openalex.org/W2069812802","https://openalex.org/W2072757169","https://openalex.org/W2074808135","https://openalex.org/W2077608534","https://openalex.org/W2084544867","https://openalex.org/W2084923285","https://openalex.org/W2087368295","https://openalex.org/W2097888801","https://openalex.org/W2102719739","https://openalex.org/W2103573619","https://openalex.org/W2106156338","https://openalex.org/W2107361996","https://openalex.org/W2108114253","https://openalex.org/W2115570439","https://openalex.org/W2129781476","https://openalex.org/W2131424070","https://openalex.org/W2134282223","https://openalex.org/W2143461406","https://openalex.org/W2152623033","https://openalex.org/W2153580867","https://openalex.org/W2171857763","https://openalex.org/W2176997392","https://openalex.org/W2282129983","https://openalex.org/W2316939698","https://openalex.org/W2320376837","https://openalex.org/W2510277784","https://openalex.org/W2547601331","https://openalex.org/W2547782348","https://openalex.org/W2557845780","https://openalex.org/W2561128455","https://openalex.org/W2561678715","https://openalex.org/W2572688079","https://openalex.org/W2580792129","https://openalex.org/W2589393452","https://openalex.org/W2602516229","https://openalex.org/W2611735159","https://openalex.org/W2612915091","https://openalex.org/W2618557602","https://openalex.org/W2624114580","https://openalex.org/W2710402301","https://openalex.org/W2755672336","https://openalex.org/W2766752605","https://openalex.org/W2785116040","https://openalex.org/W2790890902","https://openalex.org/W3146582863"],"related_works":["https://openalex.org/W7167506453","https://openalex.org/W4321371060","https://openalex.org/W2995799310","https://openalex.org/W4380373717","https://openalex.org/W4408026196","https://openalex.org/W7171919270","https://openalex.org/W4367056731","https://openalex.org/W3081789922","https://openalex.org/W2282129983","https://openalex.org/W4306871090"],"abstract_inverted_index":{"With":[0],"the":[1,10,58],"introduction":[2],"of":[3,32,52,57,62,64],"thrombin":[4],"and":[5,19,26,55,60],"factor":[6,33,65],"Xa":[7],"inhibitors":[8,31,63],"to":[9],"oral":[11],"anticoagulant":[12],"market,":[13],"significant":[14],"improvements":[15],"in":[16],"both":[17],"efficacy":[18,43],"safety":[20],"have":[21],"been":[22],"achieved.":[23],"Early":[24],"clinical":[25],"preclinical":[27],"data":[28],"suggest":[29],"that":[30],"XIa":[34,66],"can":[35],"provide":[36],"a":[37],"still":[38],"safer":[39],"alternative,":[40],"with":[41],"expanded":[42],"for":[44],"arterial":[45],"indications.":[46],"This":[47],"Perspective":[48],"provides":[49],"an":[50],"overview":[51],"target":[53],"rationale":[54],"details":[56],"discovery":[59],"development":[61],"as":[67],"next":[68],"generation":[69],"antithrombotic":[70],"agents.":[71]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}
