{"id":"https://openalex.org/W2804773765","doi":"https://doi.org/10.1093/ndt/gfy104.fp302","title":"FP302HYPOXIA INDUCEDHE4 IN TUBULAR EPITHELIAL CELLS PROMOTES THE ACCUMULATION OF ECM AND RENAL FIBROSIS THROUGH NF- \u03baB SIGNALS","display_name":"FP302HYPOXIA INDUCEDHE4 IN TUBULAR EPITHELIAL CELLS PROMOTES THE ACCUMULATION OF ECM AND RENAL FIBROSIS THROUGH NF- \u03baB SIGNALS","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2804773765","doi":"https://doi.org/10.1093/ndt/gfy104.fp302","mag":"2804773765"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfy104.fp302","doi":"https://doi.org/10.1093/ndt/gfy104.fp302","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfy104.fp302","pdf_url":"https://academic.oup.com/ndt/article-pdf/33/suppl_1/i133/24822058/gfy104.fp302.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ndt/article-pdf/33/suppl_1/i133/24822058/gfy104.fp302.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101526528","display_name":"Shiren Sun","orcid":"https://orcid.org/0000-0001-5322-1454","observed_orcids":["https://orcid.org/0000-0001-5322-1454"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I4391767982","display_name":"State Key Laboratory of Cancer Biology","ror":"https://ror.org/01b280561","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767982","https://openalex.org/I9916479"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiren Sun","raw_affiliation_strings":["Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I4391767982","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611811","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0003-3536-8692","observed_orcids":["https://orcid.org/0000-0003-3536-8692","https://orcid.org/0009-0003-7274-0446"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I4391767982","display_name":"State Key Laboratory of Cancer Biology","ror":"https://ror.org/01b280561","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767982","https://openalex.org/I9916479"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I4391767982","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388544","display_name":"Limin Liu","orcid":"https://orcid.org/0000-0003-2527-7201","observed_orcids":["https://orcid.org/0000-0003-2527-7201"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I4391767982","display_name":"State Key Laboratory of Cancer Biology","ror":"https://ror.org/01b280561","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767982","https://openalex.org/I9916479"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Limin Liu","raw_affiliation_strings":["Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I4391767982","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014953889","display_name":"Minna Liu","orcid":"https://orcid.org/0000-0002-1566-6759","observed_orcids":["https://orcid.org/0000-0002-1566-6759"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I4391767982","display_name":"State Key Laboratory of Cancer Biology","ror":"https://ror.org/01b280561","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767982","https://openalex.org/I9916479"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minna Liu","raw_affiliation_strings":["Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I4391767982","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026834273","display_name":"Zhen Lu Yang","orcid":"https://orcid.org/0000-0002-9895-4771","observed_orcids":["https://orcid.org/0000-0002-9895-4771"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I4391767982","display_name":"State Key Laboratory of Cancer Biology","ror":"https://ror.org/01b280561","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767982","https://openalex.org/I9916479"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Yang","raw_affiliation_strings":["Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I4391767982","https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014042979","display_name":"Menglu Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I4391767982","display_name":"State Key Laboratory of Cancer Biology","ror":"https://ror.org/01b280561","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391767982","https://openalex.org/I9916479"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menglu Duan","raw_affiliation_strings":["Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi&#146;an, China","an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology, State Key Laboratory of Cancer Biology, Xijing Hospital, the Fourth Military Medical University, Xi&#146;an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I4391767982","https://openalex.org/I9916479"]},{"raw_affiliation_string":"an, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"suppl_1","first_page":"i133","last_page":"i133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/he4","display_name":"HE4","score":0.8999999761581421},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8519999980926514},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tubular-epithelial-cells","display_name":"tubular epithelial cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.6850000023841858},{"id":"https://openalex.org/keywords/ureteral-reimplantation","display_name":"ureteral reimplantation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8635257482528687},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6712445616722107},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.540891170501709},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44216176867485046},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38158589601516724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24907034635543823},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.09921804070472717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.050926774740219116}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ndt/gfy104.fp302","doi":"https://doi.org/10.1093/ndt/gfy104.fp302","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfy104.fp302","pdf_url":"https://academic.oup.com/ndt/article-pdf/33/suppl_1/i133/24822058/gfy104.fp302.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ndt/gfy104.fp302","doi":"https://doi.org/10.1093/ndt/gfy104.fp302","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfy104.fp302","pdf_url":"https://academic.oup.com/ndt/article-pdf/33/suppl_1/i133/24822058/gfy104.fp302.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804773765.pdf","grobid_xml":"https://content.openalex.org/works/W2804773765.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2995619852","https://openalex.org/W1983244976","https://openalex.org/W2053470746","https://openalex.org/W2108760251","https://openalex.org/W2953040678","https://openalex.org/W2085943887","https://openalex.org/W2579804224","https://openalex.org/W2777402864","https://openalex.org/W2803671366","https://openalex.org/W2386581392"],"abstract_inverted_index":{"INTRODUCTION":[0],"AND":[1],"AIMS:":[2],"Hypoxia-induced":[3],"extracellular":[4],"matrix":[5],"(ECM)":[6],"deposition":[7,21,61],"is":[8,22,25],"an":[9],"important":[10,257],"cause":[11,33],"of":[12,17,78,105,114,119,152,165,171,191,202,229,236],"renal":[13,63,139,206,225,254,261],"fibrosis.":[14,64,187],"The":[15,103],"mechanism":[16,38,55,248],"hypoxia":[18,85,145,223],"triggering":[19],"ECM":[20,34,60,166,237],"unclear.":[23],"HE4":[24,57,79,89,106,120,134,153,192,250],"a":[26,50,176,243],"newly":[27],"discovered":[28],"key":[29],"molecule":[30],"that":[31],"can":[32,154],"deposition.":[35],"But":[36],"the":[37,48,76,112,169,179,186,189,195,200,234],"still":[39],"remains":[40],"largely":[41],"unknown.":[42],"This":[43],"study":[44],"was":[45,92,107,123,135],"to":[46,74,158],"determin":[47],"uncovering":[49],"novel":[51,244],"function":[52,245],"and":[53,68,86,99,146,209,246,263],"molecular":[54,247],"for":[56,249],"in":[58,62,80,111,121,128,138,194,205,252],"hypoxia-induced":[59,253],"METHODS:":[65],"Western":[66],"blot":[67],"quantitative":[69],"Real-Time":[70],"PCR":[71],"were":[72],"used":[73],"examine":[75],"expression":[77,190],"HK2":[81],"cells":[82,142],"induced":[83,143],"by":[84,94,109,144,167],"UUO":[87,147,183],"models.":[88,148],"binding":[90],"site":[91],"analysed":[93],"dual-luciferase":[95],"reporter":[96],"gene":[97],"assay":[98],"chromatin":[100],"immunoprecipitation":[101],"assay.":[102],"abundance":[104],"measured":[108],"ELISA":[110],"serum":[113,210],"patients":[115],"with":[116,125,131,175,199],"CKD.":[117],"Therole":[118],"vivo":[122],"explored":[124],"lentivirus":[126],"injection":[127],"C57":[129,180],"mice":[130,181],"UUO.":[132],"RESULTS:":[133],"significantly":[136],"increased":[137],"tubular":[140],"epithelial":[141],"In":[149,173],"addition,":[150],"overexpression":[151,251],"activate":[155],"NF-\u03baB":[156,239],"pathway":[157],"upregulate":[159],"TIMP1":[160],"which":[161,231],"could":[162,184,232],"inhibit":[163],"degradation":[164],"inhibiting":[168],"activity":[170],"MMP2.":[172],"vivo,":[174],"Lv-HE4":[177],"treat":[178],"before":[182],"reverse":[185],"Meanwhile,":[188],"proteins":[193],"tubulointerstitiumwas":[196],"positively":[197],"correlated":[198],"percentage":[201],"tubulointerstitial":[203],"fibrosis":[204,226,255,262],"tissue":[207],"samples":[208],"from":[211],"chronic":[212],"kidney":[213],"disease":[214],"patients.":[215],"CONCLUSIONS:":[216],"Our":[217],"findings":[218],"provide":[219],"mechanistic":[220],"insight":[221,258],"into":[222,259],"induction":[224],"via":[227],"up-regulation":[228],"HE4,":[230],"increase":[233],"accumulation":[235],"through":[238],"signal":[240],"pathway.":[241],"Uncovering":[242],"provides":[256],"understanding":[260],"antifbrogenesis":[264],"strategies":[265],".":[266]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-06-01T00:00:00"}
