{"id":"https://openalex.org/W2804676460","doi":"https://doi.org/10.1038/s41419-018-0651-5","title":"RNF25 promotes gefitinib resistance in EGFR-mutant NSCLC cells by inducing NF-\u03baB-mediated ERK reactivation","display_name":"RNF25 promotes gefitinib resistance in EGFR-mutant NSCLC cells by inducing NF-\u03baB-mediated ERK reactivation","publication_year":2018,"publication_date":"2018-05-22","ids":{"openalex":"https://openalex.org/W2804676460","doi":"https://doi.org/10.1038/s41419-018-0651-5","mag":"2804676460","pmid":"https://pubmed.ncbi.nlm.nih.gov/29789542","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5964247"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-018-0651-5","doi":"https://doi.org/10.1038/s41419-018-0651-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-018-0651-5","pdf_url":"https://www.nature.com/articles/s41419-018-0651-5.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-018-0651-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050237530","display_name":"Jung Hee Cho","orcid":"https://orcid.org/0000-0002-6147-7473","observed_orcids":["https://orcid.org/0000-0002-6147-7473"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Hee Cho","raw_affiliation_strings":["Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061234731","display_name":"Yeon-Mi You","orcid":"https://orcid.org/0000-0002-3157-5216","observed_orcids":["https://orcid.org/0000-0002-3157-5216"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeon-Mi You","raw_affiliation_strings":["Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","institution_ids":["https://openalex.org/I88761825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066139777","display_name":"Young Il Yeom","orcid":"https://orcid.org/0000-0003-4279-805X","observed_orcids":["https://orcid.org/0000-0003-4279-805X"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Y I Yeom","raw_affiliation_strings":["Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","institution_ids":["https://openalex.org/I88761825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087990317","display_name":"Dong Chul Lee","orcid":"https://orcid.org/0000-0003-4211-6901","observed_orcids":["https://orcid.org/0000-0003-4211-6901"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Chul Lee","raw_affiliation_strings":["Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638470","display_name":"Bo\u2010Kyung Kim","orcid":"https://orcid.org/0000-0003-0863-3008","observed_orcids":["https://orcid.org/0000-0003-0863-3008"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Bo-Kyung Kim","raw_affiliation_strings":["Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026175736","display_name":"Misun Won","orcid":"https://orcid.org/0000-0001-6626-0647","observed_orcids":["https://orcid.org/0000-0001-6626-0647"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Misun Won","raw_affiliation_strings":["Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064697305","display_name":"Byoung Chul Cho","orcid":"https://orcid.org/0000-0002-5562-270X","observed_orcids":["https://orcid.org/0000-0002-5562-270X"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4405258038","display_name":"Yonsei Cancer Hospital","ror":"https://ror.org/0005vby86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung Chul Cho","raw_affiliation_strings":["Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, 03722, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, 03722, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791","https://openalex.org/I4405258038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101411667","display_name":"Minho Kang","orcid":"https://orcid.org/0000-0003-0069-026X","observed_orcids":["https://orcid.org/0000-0003-0069-026X"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minho Kang","raw_affiliation_strings":["Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078915948","display_name":"Seulki Park","orcid":"https://orcid.org/0000-0002-4304-5247","observed_orcids":["https://orcid.org/0000-0002-4304-5247","https://orcid.org/0009-0006-5679-3718"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seulki Park","raw_affiliation_strings":["Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110292778","display_name":"Suk-Jin Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suk-Jin Yang","raw_affiliation_strings":["Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110063287","display_name":"Jang-Seong Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jang Seong Kim","raw_affiliation_strings":["Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea. jungaekim@kribb.re.kr","Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea. jungaekim@kribb.re.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea. jungaekim@kribb.re.kr","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea. jungaekim@kribb.re.kr","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101774712","display_name":"Jung\u2010Ae Kim","orcid":"https://orcid.org/0000-0001-5485-4843","observed_orcids":["https://orcid.org/0000-0001-5485-4843"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Ae Kim","raw_affiliation_strings":["Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea. jungaekim@kribb.re.kr","Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea. jungaekim@kribb.re.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea. jungaekim@kribb.re.kr","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea. jungaekim@kribb.re.kr","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000122352","display_name":"Kyung Chan Park","orcid":"https://orcid.org/0000-0002-7730-9466","observed_orcids":["https://orcid.org/0000-0002-7730-9466"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyung Chan Park","raw_affiliation_strings":["Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea. kpark@kribb.re.kr","Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea. kpark@kribb.re.kr","Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea. kpark@kribb.re.kr","institution_ids":["https://openalex.org/I88761825"]},{"raw_affiliation_string":"Personal Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea. kpark@kribb.re.kr","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Department of Functional Genomics, University of Science and Technology, Daejeon, 34113, South Korea","institution_ids":["https://openalex.org/I88761825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000122352","https://openalex.org/A5100638470","https://openalex.org/A5110063287"],"corresponding_institution_ids":["https://openalex.org/I73616290","https://openalex.org/I88761825"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":2.8493,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91066503,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"6","first_page":"587","last_page":"587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gefitinib-resistance","display_name":"gefitinib resistance","score":1.0},{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.921999990940094},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8679999709129333},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.906000018119812},{"id":"https://openalex.org/keywords/rnai-screen","display_name":"RNAi screen","score":0.5960000157356262},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.5609999895095825},{"id":"https://openalex.org/keywords/combination-therapy-targets","display_name":"combination therapy targets","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.9738026261329651},{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.7570475339889526},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6693089008331299},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6469094753265381},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5355185270309448},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.46868398785591125},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.46653109788894653},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4652441740036011},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.4458784759044647},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.43821483850479126},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4334127604961395},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43273818492889404},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.430787056684494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3984096646308899},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3425416946411133},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3287569284439087},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.179611474275589},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17880025506019592},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.13878178596496582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09741586446762085},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41419-018-0651-5","doi":"https://doi.org/10.1038/s41419-018-0651-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-018-0651-5","pdf_url":"https://www.nature.com/articles/s41419-018-0651-5.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4921133","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5964247","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29789542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29789542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5964247","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5964247/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:27fa7eb48fa540719c77acfe0f4debdd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/27fa7eb48fa540719c77acfe0f4debdd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 9, Iss 6, Pp 1-13 (2018)","raw_type":"article"},{"id":"pmh:oai:http://repository.kribb.re.kr:201005/17891","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1038/s41419-018-0651-5","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/15774.pdf","raw_type":"Article"},{"id":"pmh:oai:https://repository.kribb.re.kr:201005/17891","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1038/s41419-018-0651-5","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/15774.pdf","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/s41419-018-0651-5","doi":"https://doi.org/10.1038/s41419-018-0651-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-018-0651-5","pdf_url":"https://www.nature.com/articles/s41419-018-0651-5.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1418689810","display_name":null,"funder_award_id":"NRF-2016M3A9E4947789","funder_id":"https://openalex.org/F4320322110","funder_display_name":"Korea Research Institute of Bioscience and Biotechnology"},{"id":"https://openalex.org/G1671617503","display_name":null,"funder_award_id":"NRF\u20102016R1A5A2012284","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G1974277813","display_name":null,"funder_award_id":"2016R1A5A2012284","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3323352893","display_name":null,"funder_award_id":"NRF- 2013M3A9B5076422","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4345041756","display_name":null,"funder_award_id":"NRF-2016M3A9E4947789","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G525064073","display_name":null,"funder_award_id":"NRF-2017M3A9F9030565","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8912662338","display_name":null,"funder_award_id":"NRF-2017M3A9F9030565","funder_id":"https://openalex.org/F4320322110","funder_display_name":"Korea Research Institute of Bioscience and Biotechnology"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322110","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804676460.pdf","grobid_xml":"https://content.openalex.org/works/W2804676460.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1525027209","https://openalex.org/W1831549537","https://openalex.org/W1936571436","https://openalex.org/W1967249248","https://openalex.org/W1980497534","https://openalex.org/W1998971866","https://openalex.org/W2011563647","https://openalex.org/W2017180421","https://openalex.org/W2027977034","https://openalex.org/W2036374416","https://openalex.org/W2037139573","https://openalex.org/W2040362887","https://openalex.org/W2043458577","https://openalex.org/W2044246917","https://openalex.org/W2044596369","https://openalex.org/W2047263793","https://openalex.org/W2052705131","https://openalex.org/W2052871311","https://openalex.org/W2054020870","https://openalex.org/W2056451421","https://openalex.org/W2061439410","https://openalex.org/W2068244265","https://openalex.org/W2086840459","https://openalex.org/W2087955215","https://openalex.org/W2090029719","https://openalex.org/W2096322101","https://openalex.org/W2097017740","https://openalex.org/W2106787323","https://openalex.org/W2110218677","https://openalex.org/W2110463517","https://openalex.org/W2111662961","https://openalex.org/W2113508099","https://openalex.org/W2122442582","https://openalex.org/W2127618977","https://openalex.org/W2133488997","https://openalex.org/W2133982451","https://openalex.org/W2134386348","https://openalex.org/W2134887638","https://openalex.org/W2142868310","https://openalex.org/W2147699387","https://openalex.org/W2152905269","https://openalex.org/W2169460814","https://openalex.org/W2272802268","https://openalex.org/W2352491315","https://openalex.org/W2566863750","https://openalex.org/W2578736186","https://openalex.org/W2917837889"],"related_works":["https://openalex.org/W2327029117","https://openalex.org/W2339036191","https://openalex.org/W2757796401","https://openalex.org/W2806658823","https://openalex.org/W2122442582","https://openalex.org/W7098937731","https://openalex.org/W4410305010","https://openalex.org/W2114843158","https://openalex.org/W2479876202","https://openalex.org/W2616916186"],"abstract_inverted_index":{"Non-small":[0],"cell":[1],"lung":[2],"cancer":[3],"(NSCLC)":[4],"patients":[5,54],"with":[6,77],"EGFR":[7,13,35],"mutations":[8],"initially":[9],"respond":[10],"well":[11],"to":[12,25,30,66,97,108,140,204],"tyrosine":[14],"kinase":[15],"inhibitors":[16],"(TKIs)":[17],"but":[18],"eventually":[19],"exhibit":[20],"acquired":[21],"or":[22,38],"innate":[23],"resistance":[24,57,118,184,207],"the":[26,43,68,142,148,153,201],"therapies":[27],"typically":[28],"due":[29],"gene":[31],"mutations,":[32],"such":[33,157],"as":[34,92,158],"T790M":[36],"mutation":[37,41],"a":[39,49,74,80,93,166,197],"second":[40],"in":[42,84,119,129,133,165,182],"downstream":[44],"pathways":[45],"of":[46,52,101,114,137,155,185,208],"EGFR.":[47],"Importantly,":[48],"significant":[50],"portion":[51],"NSCLC":[53,87,106,186],"shows":[55],"TKI":[56,206],"without":[58],"any":[59],"known":[60],"mechanisms,":[61],"calling":[62],"more":[63],"comprehensive":[64],"studies":[65],"reveal":[67],"underlying":[69],"mechanisms.":[70],"Here,":[71],"we":[72],"investigated":[73],"synthetic":[75],"lethality":[76],"gefitinib":[78,98,109,117,183],"using":[79],"genome-wide":[81],"RNAi":[82],"screen":[83],"TKI-resistant":[85],"EGFR-mutant":[86],"cells,":[88,131],"and":[89,192,195],"identified":[90,146],"RNF25":[91,102,115,125,177],"novel":[94,198],"factor":[95],"related":[96],"resistance.":[99,144],"Depletion":[100],"expression":[103,113,161],"substantially":[104],"sensitized":[105],"cells":[107],"treatment,":[110],"while":[111],"forced":[112],"augmented":[116],"sensitive":[120],"cells.":[121],"We":[122,145],"demonstrated":[123],"that":[124,147,176],"mediates":[126],"NF-\u03baB":[127,171,191],"activation":[128],"gefitinib-treated":[130],"which,":[132],"turn,":[134],"induces":[135],"reactivation":[136,150],"ERK":[138,149,193],"signal":[139],"cause":[141],"drug":[143],"occurs":[151],"via":[152],"function":[154],"cytokines,":[156],"IL-6,":[159],"whose":[160],"is":[162],"transcriptionally":[163],"induced":[164],"gefitinib-dependent":[167],"manner":[168],"by":[169,187],"RNF25-mediated":[170],"signals.":[172],"These":[173],"results":[174],"suggest":[175],"plays":[178],"an":[179],"essential":[180],"role":[181],"mediating":[188],"cross-talk":[189],"between":[190],"pathways,":[194],"provide":[196],"target":[199],"for":[200],"combination":[202],"therapy":[203],"overcome":[205],"NSCLC.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-01T00:00:00"}