{"id":"https://openalex.org/W2804669840","doi":null,"title":"The mut-2 mutator of Caenorhabditis elegans","display_name":"The mut-2 mutator of Caenorhabditis elegans","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2804669840","mag":"2804669840"},"language":"en","primary_location":{"id":"pmh:oai:scholars.unh.edu:dissertation-3102","doi":null,"is_oa":false,"landing_page_url":"https://scholars.unh.edu/dissertation/2103","pdf_url":null,"source":{"id":"https://openalex.org/S4377196362","display_name":"University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179093154","host_organization_name":"University of New Hampshire at Manchester","host_organization_lineage":["https://openalex.org/I179093154"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016627959","display_name":"K.F. Boese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kathrine Queta Flint Boese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016627959"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mutator-genes","display_name":"mutator genes","score":0.6470000147819519},{"id":"https://openalex.org/keywords/transposable-elements","display_name":"transposable elements","score":0.7680000066757202},{"id":"https://openalex.org/keywords/meiotic-chromosome-segregation","display_name":"meiotic chromosome segregation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gametogenesis","display_name":"gametogenesis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/chd1","display_name":"CHD1","score":0.6499999761581421},{"id":"https://openalex.org/keywords/swi-snf-chromatin-remodeling","display_name":"SWI/SNF chromatin remodeling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.40700000524520874},{"id":"https://openalex.org/keywords/chromodomain","display_name":"chromodomain","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8497465252876282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7866074442863464},{"id":"https://openalex.org/C2776687438","wikidata":"https://www.wikidata.org/wiki/Q3749492","display_name":"Sterility","level":2,"score":0.7119277715682983},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.706743597984314},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.600715696811676},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.5681694149971008},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5630661845207214},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.4996504783630371},{"id":"https://openalex.org/C2776496032","wikidata":"https://www.wikidata.org/wiki/Q1904768","display_name":"Caenorhabditis","level":4,"score":0.47055721282958984},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.42617443203926086},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4255126714706421},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.420484334230423}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholars.unh.edu:dissertation-3102","doi":null,"is_oa":false,"landing_page_url":"https://scholars.unh.edu/dissertation/2103","pdf_url":null,"source":{"id":"https://openalex.org/S4377196362","display_name":"University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179093154","host_organization_name":"University of New Hampshire at Manchester","host_organization_lineage":["https://openalex.org/I179093154"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:2804669840","doi":null,"is_oa":false,"landing_page_url":"https://scholars.unh.edu/cgi/viewcontent.cgi?article=3102&context=dissertation","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W959762504","https://openalex.org/W1531671305","https://openalex.org/W1552396478","https://openalex.org/W1738249403","https://openalex.org/W1777520221","https://openalex.org/W1845343606","https://openalex.org/W1911331852","https://openalex.org/W1923953773","https://openalex.org/W1944127002","https://openalex.org/W1952527981","https://openalex.org/W1963730017","https://openalex.org/W1965769301","https://openalex.org/W1972181955","https://openalex.org/W1972812440","https://openalex.org/W1972937465","https://openalex.org/W1981773006","https://openalex.org/W1982073044","https://openalex.org/W1983019299","https://openalex.org/W1986201324","https://openalex.org/W1987734333","https://openalex.org/W1989322815","https://openalex.org/W1989728485","https://openalex.org/W1990747646","https://openalex.org/W1993097572","https://openalex.org/W1994528729","https://openalex.org/W2000254114","https://openalex.org/W2009207290","https://openalex.org/W2014565441","https://openalex.org/W2015152309","https://openalex.org/W2016603998","https://openalex.org/W2019421777","https://openalex.org/W2020038980","https://openalex.org/W2027120933","https://openalex.org/W2029880048","https://openalex.org/W2032093562","https://openalex.org/W2033553593","https://openalex.org/W2035075034","https://openalex.org/W2035726721","https://openalex.org/W2036795266","https://openalex.org/W2039785559","https://openalex.org/W2043009942","https://openalex.org/W2044251005","https://openalex.org/W2045025978","https://openalex.org/W2053130764","https://openalex.org/W2055793572","https://openalex.org/W2062361778","https://openalex.org/W2064168721","https://openalex.org/W2064644532","https://openalex.org/W2067826134","https://openalex.org/W2068591005","https://openalex.org/W2069333095","https://openalex.org/W2070358486","https://openalex.org/W2077214743","https://openalex.org/W2083116426","https://openalex.org/W2086689509","https://openalex.org/W2089036016","https://openalex.org/W2089689942","https://openalex.org/W2090437002","https://openalex.org/W2090689099","https://openalex.org/W2091814259","https://openalex.org/W2092026879","https://openalex.org/W2092955450","https://openalex.org/W2094764721","https://openalex.org/W2102161874","https://openalex.org/W2103080800","https://openalex.org/W2106742994","https://openalex.org/W2106949927","https://openalex.org/W2110582366","https://openalex.org/W2110925400","https://openalex.org/W2114224136","https://openalex.org/W2117775489","https://openalex.org/W2122163057","https://openalex.org/W2126385398","https://openalex.org/W2130578722","https://openalex.org/W2132019913","https://openalex.org/W2138085830","https://openalex.org/W2144666203","https://openalex.org/W2149633773","https://openalex.org/W2152128037","https://openalex.org/W2157261001","https://openalex.org/W2159686532","https://openalex.org/W2168656510","https://openalex.org/W2169441235","https://openalex.org/W2169831229","https://openalex.org/W2206338784","https://openalex.org/W2212128169","https://openalex.org/W2281754086","https://openalex.org/W2289057249","https://openalex.org/W2576734941","https://openalex.org/W2760576933","https://openalex.org/W2806926254","https://openalex.org/W4301248260"],"related_works":["https://openalex.org/W2126385398","https://openalex.org/W2092955450","https://openalex.org/W2340869525","https://openalex.org/W2012756922","https://openalex.org/W96852892","https://openalex.org/W2132449943","https://openalex.org/W917212500","https://openalex.org/W2204070455","https://openalex.org/W1978674159","https://openalex.org/W2081686348"],"abstract_inverted_index":{"The":[0,203,215,314,405],"mut-2":[1,33,43,121,184,293,368,372,419],"mutator":[2,44],"plays":[3,373],"multiple":[4,378],"regulatory":[5],"roles":[6],"in":[7,36,61,201,317,376,384,435],"the":[8,42,68,76,79,93,98,113,119,133,167,178,245,277,282,286,292,310,326,338,367,393,399,418,422,431,450,458],"germ":[9,18],"line":[10,19],"of":[11,21,51,58,92,117,147,166,205,244,281,337,341,398,424,441,457],"C.":[12,436],"elegans.":[13],"In":[14],"addition":[15],"to":[16,78,87,111,138,188,218,223,232,248,295,325,414],"regulating":[17,377,433],"transposition":[20,434],"at":[22,126,159,208,229],"least":[23],"four":[24],"distinct":[25],"transposon":[26],"families":[27],"(Tc1,":[28],"Tc3,":[29],"Tc4":[30],"and":[31,153,170,185,251,259,303,344,382,387,396,416,427,446,455],"Tc5)":[32],"is":[34,124,142,157,163,186,334],"implicated":[35],"chromosome":[37,63,385],"segregation.":[38],"Animals":[39],"that":[40,132,177,195,354,371,407,452],"harbor":[41],"produce":[45,233],"broods":[46],"with":[47,183,225,262,323,348],"a":[48,56,89,145,199,253,263,296,321,335,346,363,374],"higher":[49],"incidence":[50],"males":[52],"phenotype":[53,70,181,247],"(Him)":[54],"as":[55,443],"result":[57],"an":[59],"increase":[60],"X":[62],"non-disjunction":[64],"during":[65],"meiosis.":[66],"Using":[67,270],"Him":[69],"conferred":[71],"by":[72,299,352,357,392],"mut-2(r459),":[73],"I":[74,241,256,275,408],"mapped":[75],"gene":[77,94,322,333,369,395],"dpy-14":[80,287],"sem-4":[81,288],"interval":[82,289,294],"on":[83],"LGI.":[84],"However,":[85],"efforts":[86],"identify":[88,252],"molecular":[90,400,444],"clone":[91],"were":[95,101],"hampered":[96],"because":[97],"available":[99],"phenotypes":[100],"unsuitable":[102],"for":[103,366,403],"standard":[104,271],"transformation":[105,273],"rescue":[106,250,258,391],"approaches.":[107],"This":[108,237,332],"lead":[109],"me":[110],"re-examine":[112],"temperature":[114],"sensitive":[115],"behavior":[116,135],"mut-2(r459);":[118],"original":[120],"isolate,":[122],"TR674,":[123],"sterile":[125,180,312],"25\u00b0C.":[127],"Previously":[128],"it":[129],"was":[130,136],"assumed":[131],"ts":[134,179,246,311],"related":[137],"its":[139,189],"heritage.":[140],"TR674":[141],"derived":[143,172],"from":[144,173,198],"hybrid":[146],"two":[148,300],"common":[149],"laboratory":[150],"strains,":[151],"N2":[152,156],"Bergerac":[154],"(BO).":[155],"fertile":[158],"25\u00b0C":[160,209,230],"but":[161,221],"BO":[162,190],"sterile.":[164],"Analysis":[165],"immediate":[168],"ancestors":[169],"recombinants":[171],"mut-2-bearing":[174],"strains":[175],"demonstrated":[176,257],"cosegregates":[182],"unrelated":[187],"ancestry.":[191],"Closer":[192],"inspection":[193],"revealed":[194],"sterility":[196],"results":[197],"defect":[200],"gametogenesis.":[202,388],"gonads":[204],"animals":[206],"raised":[207],"have":[210,409],"few,":[211],"morphologically":[212],"abnormal":[213],"sperm.":[214],"oocytes":[216],"appear":[217],"be":[219],"normal":[220],"attempts":[222],"cross-fertilize":[224],"wild":[226],"type":[227],"sperm":[228],"failed":[231],"any":[234],"viable":[235],"progeny.":[236],"thesis":[238],"describes":[239],"how":[240],"took":[242],"advantage":[243],"achieve":[249],"candidate":[254,365],"gene.":[255,420],"restored":[260],"fertility":[261],"small,":[264],"genetically":[265],"defined":[266,276],"free":[267],"duplication,":[268],"hDp65.":[269],"DNA":[272],"techniques,":[274],"relative":[278],"physical":[279],"position":[280],"duplication":[283],"endpoint":[284],"within":[285],"thereby":[290],"reducing":[291],"region":[297],"spanned":[298],"cosmids,":[301],"C30F12":[302],"H06O01.":[304],"Of":[305],"these":[306],"two,":[307],"H06O01":[308],"rescued":[309],"phenotype.":[313],"sequence":[315],"represented":[316],"this":[318],"cosmid":[319],"includes":[320],"similarity":[324],"chromo":[327],"domain-helicase-DNA":[328],"binding":[329],"protein,":[330],"CHD1.":[331],"member":[336],"SWI/SNF":[339],"superfamily":[340],"transcriptional":[342],"regulators":[343],"encodes":[345],"protein":[347],"several":[349],"motifs":[350],"shared":[351],"factors":[353],"regulate":[355],"transcription":[356],"remodeling":[358],"chromatin":[359],"architecture.":[360],"CHD1":[361,394],"represents":[362],"compelling":[364],"given":[370],"role":[375],"transposons":[379,442],"genome":[380,459],"wide":[381],"participates":[383],"segregation":[386],"Confirmation":[389],"awaits":[390],"sequencing":[397],"lesion":[401],"responsible":[402],"mut-2(r459).":[404],"work":[406],"described":[410],"moves":[411],"us":[412],"closer":[413],"identifying":[415],"cloning":[417],"Ultimately,":[421],"characterization":[423],"mut-2's":[425],"structure":[426],"function":[428],"will":[429],"elucidate":[430],"mechanisms":[432],"elegans,":[437],"allow":[438],"better":[439],"use":[440],"tools":[445],"provide":[447],"insight":[448],"into":[449],"processes":[451],"maintain":[453],"integrity":[454],"plasticity":[456],"throughout":[460],"life.":[461]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}