{"id":"https://openalex.org/W2804604879","doi":"https://doi.org/10.1016/b978-0-12-812512-0.00009-9","title":"Can Early Clinical Trials Help Deliver More Precise Cancer Care?","display_name":"Can Early Clinical Trials Help Deliver More Precise Cancer Care?","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2804604879","doi":"https://doi.org/10.1016/b978-0-12-812512-0.00009-9","mag":"2804604879"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-812512-0.00009-9","doi":"https://doi.org/10.1016/b978-0-12-812512-0.00009-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-812512-0.00009-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Novel Designs of Early Phase Trials for Cancer Therapeutics","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W3156448708","display_name":"Novel Designs of Early Phase Trials for Cancer Therapeutics"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027873167","display_name":"Joline S.J. Lim","orcid":"https://orcid.org/0000-0001-8979-8597","observed_orcids":["https://orcid.org/0000-0001-8979-8597"]},"institutions":[{"id":"https://openalex.org/I4210103786","display_name":"National University Cancer Institute, Singapore","ror":"https://ror.org/025yypj46","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210103786","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Joline S.J. Lim","raw_affiliation_strings":["National University Cancer Institute of Singapore, Singapore, Singapore","Royal Marsden Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University Cancer Institute of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I4210103786"]},{"raw_affiliation_string":"Royal Marsden Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053239232","display_name":"Jessica S. Brown","orcid":"https://orcid.org/0000-0002-9278-0598","observed_orcids":["https://orcid.org/0000-0002-9278-0598"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jessica S. Brown","raw_affiliation_strings":["Royal Marsden Hospital, London, United Kingdom","The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I4210121186"]},{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Johann S. De Bono","raw_affiliation_strings":["Royal Marsden Hospital, London, United Kingdom","The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I4210121186"]},{"raw_affiliation_string":"The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3172,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57348703,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"115","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-phase-trials","display_name":"early clinical trials","score":0.8650000095367432},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.8420000076293945},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.6299999952316284},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.9620000123977661},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9520000219345093},{"id":"https://openalex.org/keywords/omics","display_name":"omics","score":0.718999981880188},{"id":"https://openalex.org/keywords/trial-selection","display_name":"trial selection","score":0.7699999809265137},{"id":"https://openalex.org/keywords/molecularly-targeted-agents","display_name":"molecularly targeted agents","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.7079070210456848},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.6281528472900391},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5987622737884521},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5880879163742065},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.46582716703414917},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.46398380398750305},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4585734009742737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4175289273262024},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41394972801208496},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3605028986930847},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.34762731194496155},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33046382665634155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.211515873670578},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11647486686706543},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-12-812512-0.00009-9","doi":"https://doi.org/10.1016/b978-0-12-812512-0.00009-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-812512-0.00009-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Novel Designs of Early Phase Trials for Cancer Therapeutics","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1893269340","https://openalex.org/W1967304777","https://openalex.org/W1980721628","https://openalex.org/W1990371568","https://openalex.org/W2002437466","https://openalex.org/W2012034410","https://openalex.org/W2025183726","https://openalex.org/W2028846884","https://openalex.org/W2030566540","https://openalex.org/W2034269086","https://openalex.org/W2038622031","https://openalex.org/W2061680337","https://openalex.org/W2065477010","https://openalex.org/W2071433038","https://openalex.org/W2103146352","https://openalex.org/W2103724490","https://openalex.org/W2104287359","https://openalex.org/W2106410630","https://openalex.org/W2108701193","https://openalex.org/W2111429259","https://openalex.org/W2117692326","https://openalex.org/W2118462057","https://openalex.org/W2118526609","https://openalex.org/W2119335520","https://openalex.org/W2121906867","https://openalex.org/W2123303153","https://openalex.org/W2125792957","https://openalex.org/W2127832858","https://openalex.org/W2128542677","https://openalex.org/W2135536328","https://openalex.org/W2136652669","https://openalex.org/W2138270253","https://openalex.org/W2140587309","https://openalex.org/W2144246281","https://openalex.org/W2144510519","https://openalex.org/W2146448515","https://openalex.org/W2150575159","https://openalex.org/W2152454229","https://openalex.org/W2154523488","https://openalex.org/W2155244882","https://openalex.org/W2158485828","https://openalex.org/W2161375781","https://openalex.org/W2165786425","https://openalex.org/W2166074036","https://openalex.org/W2166259976","https://openalex.org/W2193403647","https://openalex.org/W2197170290","https://openalex.org/W2200963198","https://openalex.org/W2221570229","https://openalex.org/W2235405584","https://openalex.org/W2235602583","https://openalex.org/W2239287815","https://openalex.org/W2313395946","https://openalex.org/W2553042679","https://openalex.org/W2573450018","https://openalex.org/W6680119109"],"related_works":["https://openalex.org/W1550200871","https://openalex.org/W2134834078","https://openalex.org/W2898417657","https://openalex.org/W2179599855","https://openalex.org/W2064512018","https://openalex.org/W4293767654","https://openalex.org/W2178240174","https://openalex.org/W1997885998","https://openalex.org/W2589745280","https://openalex.org/W2197328337"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2018-06-01T00:00:00"}
