{"id":"https://openalex.org/W2804589802","doi":"https://doi.org/10.5958/2321-5836.2017.00038.6","title":"Pancreatic Polypeptide: Biologically Active Neuropeptide and their Clinical Significance","display_name":"Pancreatic Polypeptide: Biologically Active Neuropeptide and their Clinical Significance","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2804589802","doi":"https://doi.org/10.5958/2321-5836.2017.00038.6","mag":"2804589802"},"language":"en","primary_location":{"id":"doi:10.5958/2321-5836.2017.00038.6","doi":"https://doi.org/10.5958/2321-5836.2017.00038.6","is_oa":true,"landing_page_url":"https://doi.org/10.5958/2321-5836.2017.00038.6","pdf_url":null,"source":{"id":"https://openalex.org/S2764385673","display_name":"Research Journal of Pharmacology and Pharmacodynamics","issn_l":"0975-4407","issn":["0975-4407","2321-5836"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacology and Pharmacodynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.5958/2321-5836.2017.00038.6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031301845","display_name":"Hemlata Dewangan","orcid":"https://orcid.org/0009-0004-1414-6649","observed_orcids":["https://orcid.org/0009-0004-1414-6649"]},"institutions":[{"id":"https://openalex.org/I4405287660","display_name":"Columbia Institute of Pharmacy","ror":"https://ror.org/05t525t18","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405287660"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hemlata Dewangan","raw_affiliation_strings":["Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, Pin-493111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, Pin-493111","institution_ids":["https://openalex.org/I4405287660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080173737","display_name":"J. S. R. Prasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287660","display_name":"Columbia Institute of Pharmacy","ror":"https://ror.org/05t525t18","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405287660"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jhakeshwar Prasad","raw_affiliation_strings":["Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, Pin-493111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, Pin-493111","institution_ids":["https://openalex.org/I4405287660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085679408","display_name":"Trilochan Satapathy","orcid":"https://orcid.org/0000-0001-6871-1288","observed_orcids":["https://orcid.org/0000-0001-6871-1288"]},"institutions":[{"id":"https://openalex.org/I4405287660","display_name":"Columbia Institute of Pharmacy","ror":"https://ror.org/05t525t18","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405287660"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Trilochan Satapathy","raw_affiliation_strings":["Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, Pin-493111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, Pin-493111","institution_ids":["https://openalex.org/I4405287660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405287660"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"9","issue":"4","first_page":"211","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-polypeptide","display_name":"pancreatic polypeptide","score":1.0},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.9269999861717224},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/anorexigenic-hormones","display_name":"anorexigenic hormones","score":0.8370000123977661},{"id":"https://openalex.org/keywords/peptide-yy","display_name":"peptide YY","score":0.6690000295639038},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hypothalamic-arcuate-nucleus","display_name":"hypothalamic arcuate nucleus","score":0.8159999847412109},{"id":"https://openalex.org/keywords/dorsal-vagal-complex","display_name":"dorsal vagal complex","score":0.9610000252723694},{"id":"https://openalex.org/keywords/vagus-nerve-stimulation","display_name":"vagus nerve stimulation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/anti-obesity-drugs","display_name":"anti-obesity drugs","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.6457401514053345},{"id":"https://openalex.org/C2778108375","wikidata":"https://www.wikidata.org/wiki/Q246978","display_name":"Pancreatic polypeptide","level":4,"score":0.6051452159881592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41092410683631897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.386435329914093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3708057403564453},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.3571292757987976},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05797094106674194},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.0},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5958/2321-5836.2017.00038.6","doi":"https://doi.org/10.5958/2321-5836.2017.00038.6","is_oa":true,"landing_page_url":"https://doi.org/10.5958/2321-5836.2017.00038.6","pdf_url":null,"source":{"id":"https://openalex.org/S2764385673","display_name":"Research Journal of Pharmacology and Pharmacodynamics","issn_l":"0975-4407","issn":["0975-4407","2321-5836"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacology and Pharmacodynamics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5958/2321-5836.2017.00038.6","doi":"https://doi.org/10.5958/2321-5836.2017.00038.6","is_oa":true,"landing_page_url":"https://doi.org/10.5958/2321-5836.2017.00038.6","pdf_url":null,"source":{"id":"https://openalex.org/S2764385673","display_name":"Research Journal of Pharmacology and Pharmacodynamics","issn_l":"0975-4407","issn":["0975-4407","2321-5836"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacology and Pharmacodynamics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W835887328","https://openalex.org/W2111347392","https://openalex.org/W2055471579","https://openalex.org/W3023796856","https://openalex.org/W1990651463","https://openalex.org/W2087301276","https://openalex.org/W2072112475","https://openalex.org/W2073753029","https://openalex.org/W1970442841","https://openalex.org/W2061878801"],"abstract_inverted_index":{"Imbalances":[0],"in":[1,43,74,94],"normal":[2],"regulation":[3],"of":[4,65,90,97,111],"food":[5,30],"intake":[6,31],"can":[7],"cause":[8],"obesity":[9],"and":[10,32,55,62,80,107,118,139],"related":[11],"disorders.":[12],"Pancreatic":[13],"polypeptide":[14,136],"(PP)":[15],"share":[16],"considerable":[17],"amino":[18],"acid":[19],"sequence":[20],"homology":[21],"act":[22],"as":[23],"a":[24],"robust":[25],"anorexigenic":[26],"hormone":[27],"effectively":[28],"modulates":[29],"energy":[33,116],"homeostasis,":[34],"thus":[35],"potentially":[36],"aiding":[37],"anti-obesity":[38],"therapeutics.":[39],"They":[40],"are":[41],"found":[42],"widely":[44],"disparate":[45],"locations,":[46],"including":[47],"the":[48,51,56,71,85,98,112,131,134],"pancreas":[49],"(PP),":[50],"distal":[52],"gut":[53],"(PYY),":[54],"central":[57],"nervous":[58],"system":[59],"(NPY).":[60],"Intra-gastric":[61],"intra-intestinal":[63],"infusion":[64],"nutrients":[66],"stimulate":[67],"PP":[68],"secretion":[69],"from":[70],"gastrointestinal":[72],"tract,":[73],"turn":[75],"that":[76],"causes":[77],"vagal":[78,109],"stimulation":[79],"exerts":[81],"complex":[82,110],"actions":[83],"via":[84],"neuropeptide":[86],"Y4":[87],"receptor":[88],"(Family":[89],"G-protein":[91],"coupled":[92],"Receptors)":[93],"arcuate":[95],"nucleus":[96],"hypothalamus,":[99],"there":[100],"by":[101],"subsequently":[102],"activating":[103],"key":[104],"hypothalamic":[105],"nuclei":[106],"dorsal":[108],"brainstem":[113],"to":[114,129],"influence":[115],"homeostasis":[117],"body":[119],"composition.":[120],"In":[121],"this":[122],"review":[123],"our":[124],"efforts":[125],"have":[126],"been":[127],"devoted":[128],"summarize":[130],"detail":[132],"about":[133],"pancreatic":[135],"their":[137],"functions":[138],"mechanisms.":[140]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2018-06-01T00:00:00"}