{"id":"https://openalex.org/W2804565607","doi":"https://doi.org/10.1111/1348-0421.12602","title":"Degradation of amyloid \u03b2 peptide by neprilysin expressed from Borna disease virus vector","display_name":"Degradation of amyloid \u03b2 peptide by neprilysin expressed from Borna disease virus vector","publication_year":2018,"publication_date":"2018-05-17","ids":{"openalex":"https://openalex.org/W2804565607","doi":"https://doi.org/10.1111/1348-0421.12602","mag":"2804565607","pmid":"https://pubmed.ncbi.nlm.nih.gov/29771464"},"language":"en","primary_location":{"id":"doi:10.1111/1348-0421.12602","doi":"https://doi.org/10.1111/1348-0421.12602","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1348-0421.12602","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1348-0421.12602","source":{"id":"https://openalex.org/S149171590","display_name":"Microbiology and Immunology","issn_l":"0385-5600","issn":["0385-5600","1348-0421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1348-0421.12602","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062005446","display_name":"Madoka Sakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Madoka Sakai","raw_affiliation_strings":["Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042111900","display_name":"Sakiho Ueda","orcid":"https://orcid.org/0000-0001-9198-0419","observed_orcids":["https://orcid.org/0000-0001-9198-0419"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sakiho Ueda","raw_affiliation_strings":["Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","School of Health Sciences, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"School of Health Sciences, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053550841","display_name":"Takuji Daito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405287359","display_name":"Hokkaido University International Institute for Zoonosis Control","ror":"https://ror.org/04z6qv748","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405287359"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuji Daito","raw_affiliation_strings":["Research Center for Zoonosis Control, Biologics Development, Hokkaido University, North 20, West 10 Kita-ku, Sapporo 001-0020, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Zoonosis Control, Biologics Development, Hokkaido University, North 20, West 10 Kita-ku, Sapporo 001-0020, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405287359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018849839","display_name":"Megumi Asada\u2010Utsugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Megumi Asada\u2010Utsugi","raw_affiliation_strings":["School of Health Sciences, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Sciences, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103040752","display_name":"Yumiko Komatsu","orcid":"https://orcid.org/0000-0002-4090-5889","observed_orcids":["https://orcid.org/0000-0002-4090-5889"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumiko Komatsu","raw_affiliation_strings":["Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research (K-CONNEX), Kyoto University, Kyoto, Japan","Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research (K-CONNEX), Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044809052","display_name":"Ayae Kinoshita","orcid":"https://orcid.org/0009-0000-9017-3754","observed_orcids":["https://orcid.org/0009-0000-9017-3754"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayae Kinoshita","raw_affiliation_strings":["School of Health Sciences, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Sciences, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009335165","display_name":"Takakuni Maki","orcid":"https://orcid.org/0000-0001-9826-0203","observed_orcids":["https://orcid.org/0000-0001-9826-0203"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takakuni Maki","raw_affiliation_strings":["Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022475345","display_name":"Akira Kuzuya","orcid":"https://orcid.org/0009-0003-4925-9099","observed_orcids":["https://orcid.org/0009-0003-4925-9099"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Kuzuya","raw_affiliation_strings":["Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100724728","display_name":"Ry\u014dsuke Takahashi","orcid":"https://orcid.org/0000-0002-1407-9640","observed_orcids":["https://orcid.org/0000-0002-1407-9640"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Takahashi","raw_affiliation_strings":["Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054250729","display_name":"Akiko Makino","orcid":"https://orcid.org/0000-0001-9628-2126","observed_orcids":["https://orcid.org/0000-0001-9628-2126"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akiko Makino","raw_affiliation_strings":["Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019725294","display_name":"Keiz\u014d Tomonaga","orcid":"https://orcid.org/0000-0003-0405-7103","observed_orcids":["https://orcid.org/0000-0003-0405-7103"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keizo Tomonaga","raw_affiliation_strings":["Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","Department of Molecular Virology, Graduate School of Medicine, Kyoto University, Kyoto, Japan","Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Molecular Virology, Graduate School of Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054250729"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":null,"fwci":0.7821,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.62412533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"62","issue":"7","first_page":"467","last_page":"472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7699999809265137},{"id":"https://openalex.org/keywords/neprilysin","display_name":"neprilysin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/amyloid-beta-40","display_name":"A\u03b240","score":0.8880000114440918},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":1.0},{"id":"https://openalex.org/keywords/enzyme-delivery","display_name":"enzyme delivery","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C104826730","wikidata":"https://www.wikidata.org/wiki/Q414232","display_name":"Neprilysin","level":3,"score":0.9482218623161316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6912350654602051},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.6184190511703491},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.5639073252677917},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4872194826602936},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4794003963470459},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.47366055846214294},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.46593135595321655},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4440135657787323},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4206477105617523},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.413875013589859},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38508331775665283},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.34723788499832153},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18996065855026245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13705554604530334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12120908498764038},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0865071713924408},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/1348-0421.12602","doi":"https://doi.org/10.1111/1348-0421.12602","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1348-0421.12602","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1348-0421.12602","source":{"id":"https://openalex.org/S149171590","display_name":"Microbiology and Immunology","issn_l":"0385-5600","issn":["0385-5600","1348-0421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and Immunology","raw_type":"journal-article"},{"id":"pmid:29771464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29771464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/1348-0421.12602","doi":"https://doi.org/10.1111/1348-0421.12602","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1348-0421.12602","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1348-0421.12602","source":{"id":"https://openalex.org/S149171590","display_name":"Microbiology and Immunology","issn_l":"0385-5600","issn":["0385-5600","1348-0421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G163335109","display_name":null,"funder_award_id":"JP16H06429","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G1649966974","display_name":null,"funder_award_id":"JP17H04083","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2241728962","display_name":null,"funder_award_id":"JP16H06430","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2889425227","display_name":"Generation of episomal RNA viral vector for stem cell gene therapy","funder_award_id":"16K19069","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6104434301","display_name":null,"funder_award_id":"JP16K21723","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6802760042","display_name":null,"funder_award_id":"JP17fm0208014","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G7219106078","display_name":"Study on DNA damage responses for regulation of intranuclear RNA viruses","funder_award_id":"17H04083","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7257929133","display_name":null,"funder_award_id":"JP16H06429","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8728950419","display_name":null,"funder_award_id":"JP17am0301015","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G8769996592","display_name":null,"funder_award_id":"JP16H06430","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8873078592","display_name":null,"funder_award_id":"JP16K21723","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804565607.pdf","grobid_xml":"https://content.openalex.org/works/W2804565607.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1131579344","https://openalex.org/W1480972367","https://openalex.org/W1538232203","https://openalex.org/W1584834830","https://openalex.org/W1725557059","https://openalex.org/W1729585270","https://openalex.org/W1967408430","https://openalex.org/W1969810313","https://openalex.org/W1971836287","https://openalex.org/W1979660154","https://openalex.org/W1980906872","https://openalex.org/W1987624864","https://openalex.org/W1990670176","https://openalex.org/W2014356856","https://openalex.org/W2030641075","https://openalex.org/W2039481158","https://openalex.org/W2044546031","https://openalex.org/W2046209489","https://openalex.org/W2052825194","https://openalex.org/W2058723245","https://openalex.org/W2067675520","https://openalex.org/W2072203507","https://openalex.org/W2072435649","https://openalex.org/W2073100533","https://openalex.org/W2073364218","https://openalex.org/W2083252334","https://openalex.org/W2083633251","https://openalex.org/W2090150925","https://openalex.org/W2095727654","https://openalex.org/W2095845810","https://openalex.org/W2096410114","https://openalex.org/W2105743184","https://openalex.org/W2122320288","https://openalex.org/W2124097986","https://openalex.org/W2129337589","https://openalex.org/W2130953797","https://openalex.org/W2131819352","https://openalex.org/W2138559742","https://openalex.org/W2142386529","https://openalex.org/W2162929058","https://openalex.org/W2183820563","https://openalex.org/W2232237847","https://openalex.org/W2232674046","https://openalex.org/W2265799967","https://openalex.org/W2323101848","https://openalex.org/W2399674695","https://openalex.org/W2405724104","https://openalex.org/W2734929066","https://openalex.org/W2742701562","https://openalex.org/W2745901391"],"related_works":["https://openalex.org/W1999461142","https://openalex.org/W1813590465","https://openalex.org/W1734002875","https://openalex.org/W1995801084","https://openalex.org/W2155133303","https://openalex.org/W1967408430","https://openalex.org/W2087986459","https://openalex.org/W7097309848","https://openalex.org/W2079891381","https://openalex.org/W7046557693"],"abstract_inverted_index":{"Accumulation":[0],"of":[1,13,45,59,71],"amyloid":[2],"\u03b2":[3],"(A\u03b240":[4],"and":[5,66,73],"A\u03b242)":[6],"in":[7,27,48],"the":[8,28,49,56,63,69,83],"brain":[9,29],"is":[10,20,30,86],"a":[11,21,31],"characteristic":[12],"Alzheimer's":[14],"disease":[15,38],"(AD).":[16],"Because":[17],"neprilysin":[18],"(NEP)":[19],"major":[22],"A\u03b2-degrading":[23],"enzyme,":[24],"NEP":[25,60,80],"delivery":[26],"promising":[32],"gene":[33],"therapy":[34],"for":[35],"AD.":[36],"Borna":[37],"virus":[39],"(BoDV)":[40],"vector":[41,65,85],"enables":[42],"long-term":[43],"transduction":[44],"foreign":[46],"genes":[47],"central":[50],"nerve":[51],"system.":[52],"Here,":[53],"we":[54],"evaluated":[55],"proteolytic":[57],"ability":[58],"transduced":[61],"by":[62],"BoDV":[64,84],"found":[67],"that":[68,79],"amounts":[70],"A\u03b240":[72],"A\u03b242":[74],"significantly":[75],"decreased,":[76],"which":[77],"suggests":[78],"expressed":[81],"from":[82],"functional":[87],"to":[88],"degrade":[89],"A\u03b2.":[90]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}