{"id":"https://openalex.org/W2804526675","doi":"https://doi.org/10.1016/j.jcyt.2018.05.003","title":"Centralised versus decentralised manufacturing and the delivery of healthcare products: A United Kingdom exemplar","display_name":"Centralised versus decentralised manufacturing and the delivery of healthcare products: A United Kingdom exemplar","publication_year":2018,"publication_date":"2018-05-25","ids":{"openalex":"https://openalex.org/W2804526675","doi":"https://doi.org/10.1016/j.jcyt.2018.05.003","mag":"2804526675","pmid":"https://pubmed.ncbi.nlm.nih.gov/29807726"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcyt.2018.05.003","doi":"https://doi.org/10.1016/j.jcyt.2018.05.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2018.05.003","pdf_url":"http://www.isct-cytotherapy.org/article/S1465324918305140/pdf","source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.isct-cytotherapy.org/article/S1465324918305140/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082336772","display_name":"Richard P. Harrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I143804889","display_name":"Loughborough University","ror":"https://ror.org/04vg4w365","country_code":"GB","type":"education","lineage":["https://openalex.org/I143804889"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard P. Harrison","raw_affiliation_strings":["Centre for Biological Engineering, Holywell Park, Loughborough University, Loughborough, United Kingdom; Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), School of Medicine, Nottingham, United Kingdom. Electronic address: r.p.harrison@lboro.ac.uk","Centre for Biological Engineering, Holywell Park, Loughborough University, Loughborough, United Kingdom","Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), School of Medicine, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biological Engineering, Holywell Park, Loughborough University, Loughborough, United Kingdom; Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), School of Medicine, Nottingham, United Kingdom. Electronic address: r.p.harrison@lboro.ac.uk","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I143804889"]},{"raw_affiliation_string":"Centre for Biological Engineering, Holywell Park, Loughborough University, Loughborough, United Kingdom","institution_ids":["https://openalex.org/I143804889"]},{"raw_affiliation_string":"Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), School of Medicine, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003693586","display_name":"Qasim A. Rafiq","orcid":"https://orcid.org/0000-0003-4400-9106","observed_orcids":["https://orcid.org/0000-0003-4400-9106"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Qasim A. Rafiq","raw_affiliation_strings":["Department of Biochemical Engineering, Faculty of Engineering Science, University College London, Gower Street, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Engineering, Faculty of Engineering Science, University College London, Gower Street, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006368070","display_name":"Nicholas Medcalf","orcid":"https://orcid.org/0000-0001-8173-1961","observed_orcids":["https://orcid.org/0000-0001-8173-1961"]},"institutions":[{"id":"https://openalex.org/I143804889","display_name":"Loughborough University","ror":"https://ror.org/04vg4w365","country_code":"GB","type":"education","lineage":["https://openalex.org/I143804889"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas Medcalf","raw_affiliation_strings":["Centre for Biological Engineering, Holywell Park, Loughborough University, Loughborough, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biological Engineering, Holywell Park, Loughborough University, Loughborough, United Kingdom","institution_ids":["https://openalex.org/I143804889"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082336772"],"corresponding_institution_ids":["https://openalex.org/I142263535","https://openalex.org/I143804889"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":2614,"currency":"EUR","value_usd":2819},"fwci":5.4392,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.95546478,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"6","first_page":"873","last_page":"890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.4950999915599823,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.4950999915599823,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.1648000031709671,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-and-gene-therapy-manufacturing","display_name":"cell and gene therapy manufacturing","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/patient-specific-therapy","display_name":"patient-specific therapy","score":0.621999979019165},{"id":"https://openalex.org/keywords/production-capacity","display_name":"production capacity","score":0.46299999952316284},{"id":"https://openalex.org/keywords/united-kingdom","display_name":"United Kingdom","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C136810230","wikidata":"https://www.wikidata.org/wiki/Q188961","display_name":"Decentralization","level":2,"score":0.6652036905288696},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.58713698387146},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.5611577033996582},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.510144054889679},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.4306493401527405},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.37785226106643677},{"id":"https://openalex.org/C195094911","wikidata":"https://www.wikidata.org/wiki/Q14167904","display_name":"Process management","level":1,"score":0.33120930194854736},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14557769894599915},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.14357390999794006},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.13802188634872437},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D003132","descriptor_name":"Commerce","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":false},{"descriptor_ui":"D003365","descriptor_name":"Costs and Cost Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011057","descriptor_name":"Politics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014015","descriptor_name":"Tissue Banks","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D014015","descriptor_name":"Tissue Banks","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D014186","descriptor_name":"Transportation","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":true},{"descriptor_ui":"D014186","descriptor_name":"Transportation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014186","descriptor_name":"Transportation","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D014507","descriptor_name":"Urbanization","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D017146","descriptor_name":"Models, Organizational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060846","descriptor_name":"Cell Engineering","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D060846","descriptor_name":"Cell Engineering","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":true},{"descriptor_ui":"D060846","descriptor_name":"Cell Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D060846","descriptor_name":"Cell Engineering","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jcyt.2018.05.003","doi":"https://doi.org/10.1016/j.jcyt.2018.05.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2018.05.003","pdf_url":"http://www.isct-cytotherapy.org/article/S1465324918305140/pdf","source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"},{"id":"pmid:29807726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29807726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.lboro.ac.uk:2134/34023","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/34023","pdf_url":null,"source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10050318","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10050318/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cytotherapy , 20 (6) pp. 873-890. (2018)","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/9561074","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Centralised_versus_decentralised_manufacturing_and_the_delivery_of_healthcare_products_A_United_Kingdom_exemplar/9561074","pdf_url":null,"source":{"id":"https://openalex.org/S4306402585","display_name":"Loughborough University Research Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jcyt.2018.05.003","doi":"https://doi.org/10.1016/j.jcyt.2018.05.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcyt.2018.05.003","pdf_url":"http://www.isct-cytotherapy.org/article/S1465324918305140/pdf","source":{"id":"https://openalex.org/S36838616","display_name":"Cytotherapy","issn_l":"1465-3249","issn":["1465-3249","1477-2566"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037},{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.4943999946117401}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2021376508","display_name":"E-TERM, Engineering Tissue Engineering and Regenerative Medicine","funder_award_id":"EP/I017801/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6411983584","display_name":"FUTURE TARGETED HEALTHCARE MANUFACTURING HUB","funder_award_id":"EP/P006485/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6654411751","display_name":"EPSRC Fellowships in Manufacturing - Regenerative Medicine Manufacture: A Systems Based Research Platform","funder_award_id":"EP/K037099/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8126271770","display_name":"RDM Healthcare Research Network","funder_award_id":"EP/M017559/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804526675.pdf","grobid_xml":"https://content.openalex.org/works/W2804526675.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1479790796","https://openalex.org/W1513417733","https://openalex.org/W1529732115","https://openalex.org/W1582450268","https://openalex.org/W1966713323","https://openalex.org/W1968268217","https://openalex.org/W1985481249","https://openalex.org/W1989665064","https://openalex.org/W1998430092","https://openalex.org/W2013575587","https://openalex.org/W2028353755","https://openalex.org/W2028719871","https://openalex.org/W2090896098","https://openalex.org/W2095405984","https://openalex.org/W2103959341","https://openalex.org/W2118287786","https://openalex.org/W2138843012","https://openalex.org/W2145301346","https://openalex.org/W2155825917","https://openalex.org/W2164733956","https://openalex.org/W2218303276","https://openalex.org/W2289870196","https://openalex.org/W2356433343","https://openalex.org/W2414554054","https://openalex.org/W2491602957","https://openalex.org/W2514334597","https://openalex.org/W2540117757","https://openalex.org/W2544376078","https://openalex.org/W2557034149","https://openalex.org/W2557684868","https://openalex.org/W2596179513","https://openalex.org/W2622750667","https://openalex.org/W2742829995","https://openalex.org/W2781105157","https://openalex.org/W2880177077","https://openalex.org/W3144628837","https://openalex.org/W3148988894","https://openalex.org/W4241893026","https://openalex.org/W6728634660","https://openalex.org/W6730226545"],"related_works":["https://openalex.org/W2781105157","https://openalex.org/W2766464354","https://openalex.org/W2742829995","https://openalex.org/W2414554054","https://openalex.org/W7160179080","https://openalex.org/W7155063128","https://openalex.org/W4412994943","https://openalex.org/W4402015924","https://openalex.org/W7214774807","https://openalex.org/W7214221759"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,91],"cell":[2,125],"and":[3,53,88,116,193],"gene":[4],"therapy":[5,85],"(CGT)":[6],"field":[7],"is":[8,54],"at":[9],"a":[10,98,122,240],"critical":[11],"juncture.":[12],"Clinical":[13],"successes":[14],"have":[15,216],"underpinned":[16],"the":[17,30,50,62,105,129,156,209,217,221,230,236],"requirement":[18],"for":[19,197],"developing":[20],"manufacturing":[21,37,39,64,87,168,214],"capacity":[22,40],"suited":[23],"to":[24,49,58,96,111,170,176,189,219,242],"patient-specific":[25],"therapies":[26],"that":[27,103,207,215],"can":[28],"satisfy":[29],"eventual":[31],"demand":[32],"post-launch.":[33],"Decentralised":[34,173],"or":[35,165],"'redistributed'":[36],"divides":[38],"across":[41,248],"geographic":[42],"regions,":[43],"promising":[44,226],"local,":[45],"responsive":[46],"manufacturing,":[47],"customised":[48],"end":[51],"user,":[52],"an":[55,133,194,234],"attractive":[56,195],"solution":[57],"overcome":[59],"challenges":[60,206],"facing":[61],"CGT":[63],"chain.":[65],"METHODS:":[66],"A":[67],"study":[68],"was":[69,180,187],"undertaken":[70],"building":[71],"on":[72],"previous,":[73],"so":[74],"far":[75],"unpublished,":[76],"semi-structured":[77],"interviews":[78],"with":[79,114],"key":[80],"opinion":[81],"leaders":[82],"in":[83],"advanced":[84],"research,":[86],"clinical":[89],"practice.":[90],"qualitative":[92],"findings":[93],"were":[94,139,150],"applied":[95],"construct":[97],"cost":[99,106,135],"of":[100,108,119,121,145,159,184,212,224],"goods":[101],"model":[102],"permitted":[104],"impact":[107],"regional":[109,245],"siting":[110],"be":[112,171,190],"combined":[113],"variable":[115],"fixed":[117],"costs":[118,144],"manufacture":[120],"mesenchymal":[123],"stromal":[124],"product.":[126],"RESULTS:":[127],"Using":[128],"United":[130,231],"Kingdom":[131,232],"as":[132,233],"exemplar,":[134,235],"disparities":[136],"between":[137],"regions":[138],"examined.":[140,181],"Per":[141],"patient":[142],"dose":[143],"~\u00a31,800":[146],"per":[147],"75,000,000":[148],"cells":[149],"observed.":[151],"Financial":[152],"savings":[153],"from":[154],"situating":[155],"facility":[157],"outside":[158],"London":[160],"allow":[161],"25-41":[162],"additional":[163],"staff":[164],"24-35":[166],"extra":[167],"vessels":[169],"employed.":[172],"quality":[174,185],"control":[175,186],"mitigate":[177],"site-to-site":[178],"variation":[179],"Partial":[182],"decentralisation":[183],"observed":[188],"financially":[191],"possible":[192],"option":[196],"facilitating":[198],"release":[199],"'at":[200],"risk'.":[201],"DISCUSSION:":[202],"There":[203],"are":[204],"important":[205],"obstruct":[208],"easy":[210],"adoption":[211],"decentralised":[213],"potential":[218],"undermine":[220],"market":[222],"success":[223],"otherwise":[225],"products.":[227],"By":[228],"using":[229],"modelled":[237],"data":[238],"provide":[239],"framework":[241],"inform":[243],"similar":[244],"policy":[246],"considerations":[247],"other":[249],"global":[250],"territories.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-01T00:00:00"}
