{"id":"https://openalex.org/W2804501763","doi":"https://doi.org/10.18632/oncotarget.25429","title":"Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia","display_name":"Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia","publication_year":2018,"publication_date":"2018-05-19","ids":{"openalex":"https://openalex.org/W2804501763","doi":"https://doi.org/10.18632/oncotarget.25429","mag":"2804501763","pmid":"https://pubmed.ncbi.nlm.nih.gov/29876014","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986653"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.25429","doi":"https://doi.org/10.18632/oncotarget.25429","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25429","pdf_url":"https://www.oncotarget.com/article/25429/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.oncotarget.com/article/25429/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055976006","display_name":"Abhishek A. Singh","orcid":"https://orcid.org/0000-0003-0577-3451","observed_orcids":["https://orcid.org/0000-0003-0577-3451"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Abhishek A. Singh","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110147","display_name":"Francesca Petraglia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesca Petraglia","raw_affiliation_strings":["Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023140151","display_name":"Angela Nebbioso","orcid":"https://orcid.org/0000-0001-5374-3527","observed_orcids":["https://orcid.org/0000-0001-5374-3527"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Nebbioso","raw_affiliation_strings":["Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017585756","display_name":"Guoqiang Yi","orcid":"https://orcid.org/0000-0001-8248-9126","observed_orcids":["https://orcid.org/0000-0001-8248-9126"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Guoqiang Yi","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078908851","display_name":"Mariarosaria Conte","orcid":"https://orcid.org/0000-0002-3622-1476","observed_orcids":["https://orcid.org/0000-0002-3622-1476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariarosaria Conte","raw_affiliation_strings":["IRCCS SDN, Napoli Via E. Gianturco, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS SDN, Napoli Via E. Gianturco, Napoli, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084101516","display_name":"S\u00e9rgio Valente","orcid":"https://orcid.org/0000-0002-2241-607X","observed_orcids":["https://orcid.org/0000-0002-2241-607X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sergio Valente","raw_affiliation_strings":["Dipartimento di Chimica e Tecnologie del Farmaco \u2018Sapienza\u2019 Universit\u00e0, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica e Tecnologie del Farmaco \u2018Sapienza\u2019 Universit\u00e0, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105003689","display_name":"Amit Mandoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Amit Mandoli","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084385725","display_name":"Lucia Scisciola","orcid":"https://orcid.org/0000-0003-3636-4298","observed_orcids":["https://orcid.org/0000-0003-3636-4298"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Scisciola","raw_affiliation_strings":["Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035630262","display_name":"Rik G.H. Lindeboom","orcid":"https://orcid.org/0000-0002-3660-504X","observed_orcids":["https://orcid.org/0000-0002-3660-504X"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rik Lindeboom","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088001893","display_name":"Hinri H. D. Kerstens","orcid":"https://orcid.org/0000-0003-2289-4108","observed_orcids":["https://orcid.org/0000-0003-2289-4108"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hinri Kerstens","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083852130","display_name":"Eva M. Janssen\u2010Megens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eva M. Janssen-Megens","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081603680","display_name":"Farzin Pourfarzad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Farzin Pourfarzad","raw_affiliation_strings":["Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I3020210244","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028781627","display_name":"Ehsan Habibi","orcid":"https://orcid.org/0000-0002-7208-7999","observed_orcids":["https://orcid.org/0000-0002-7208-7999"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ehsan Habibi","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072937628","display_name":"Kim Berentsen","orcid":"https://orcid.org/0009-0006-7594-5991","observed_orcids":["https://orcid.org/0009-0006-7594-5991"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kim Berentsen","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bowon Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bowon Kim","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059941956","display_name":"Colin Logie","orcid":"https://orcid.org/0000-0002-8534-6582","observed_orcids":["https://orcid.org/0000-0002-8534-6582"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Colin Logie","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091771874","display_name":"Simon Charles Heath","orcid":"https://orcid.org/0000-0002-9550-0897","observed_orcids":["https://orcid.org/0000-0002-9550-0897"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210142206","display_name":"Centro Nacional de An\u00e1lisis Gen\u00f3mico","ror":"https://ror.org/03mynna02","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210142206"]}],"countries":["ES","NL"],"is_corresponding":false,"raw_author_name":"Simon Heath","raw_affiliation_strings":["Centro Nacional de An\u00e1lisis Gen\u00f3mico, Barcelona, Spain","Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de An\u00e1lisis Gen\u00f3mico, Barcelona, Spain","institution_ids":["https://openalex.org/I4210142206"]},{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109852526","display_name":"Albertus T.J. Wierenga","orcid":"https://orcid.org/0000-0002-7464-850X","observed_orcids":["https://orcid.org/0000-0002-7464-850X"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Albertus T.J. Wierenga","raw_affiliation_strings":["Department of Hematology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082531083","display_name":"Laura Clarke","orcid":"https://orcid.org/0000-0002-5989-6898","observed_orcids":["https://orcid.org/0000-0002-5989-6898"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura Clarke","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006816272","display_name":"Paul Flicek","orcid":"https://orcid.org/0000-0002-3897-7955","observed_orcids":["https://orcid.org/0000-0002-3897-7955"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Flicek","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020940867","display_name":"Joop H. Jansen","orcid":"https://orcid.org/0000-0001-9459-568X","observed_orcids":["https://orcid.org/0000-0001-9459-568X"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joop H. Jansen","raw_affiliation_strings":["Department of Laboratory Medicine, Radboud UMC, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Radboud UMC, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012501139","display_name":"Taco Willem Kuijpers","orcid":"https://orcid.org/0000-0002-7421-3370","observed_orcids":["https://orcid.org/0000-0002-7421-3370"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Taco Kuijpers","raw_affiliation_strings":["Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I3020210244","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071739380","display_name":"Marie\u2010Laure Yaspo","orcid":"https://orcid.org/0000-0002-9555-9979","observed_orcids":["https://orcid.org/0000-0002-9555-9979"]},"institutions":[{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marie Laure Yaspo","raw_affiliation_strings":["Max Planck Institute for Molecular Genetics, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Genetics, Berlin, Germany","institution_ids":["https://openalex.org/I4210142260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049393612","display_name":"V\u00e9ronique Della-Valle","orcid":"https://orcid.org/0000-0002-7436-4304","observed_orcids":["https://orcid.org/0000-0002-7436-4304"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Veronique Della Valle","raw_affiliation_strings":["INSERM U1170, Universtit\u00e9 Paris-Saclay, Institut Gustave Roussy, Equipe Labellis\u00e9e Ligue Nationale Contre le Cancer (LNCC), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1170, Universtit\u00e9 Paris-Saclay, Institut Gustave Roussy, Equipe Labellis\u00e9e Ligue Nationale Contre le Cancer (LNCC), Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057065832","display_name":"Olivier Bernard","orcid":"https://orcid.org/0000-0002-0463-9747","observed_orcids":["https://orcid.org/0000-0002-0463-9747"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Bernard","raw_affiliation_strings":["INSERM U1170, Universtit\u00e9 Paris-Saclay, Institut Gustave Roussy, Equipe Labellis\u00e9e Ligue Nationale Contre le Cancer (LNCC), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1170, Universtit\u00e9 Paris-Saclay, Institut Gustave Roussy, Equipe Labellis\u00e9e Ligue Nationale Contre le Cancer (LNCC), Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066760172","display_name":"Ivo Glynne Gut","orcid":"https://orcid.org/0000-0001-7219-632X","observed_orcids":["https://orcid.org/0000-0001-7219-632X"]},"institutions":[{"id":"https://openalex.org/I4210142206","display_name":"Centro Nacional de An\u00e1lisis Gen\u00f3mico","ror":"https://ror.org/03mynna02","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210142206"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ivo Gut","raw_affiliation_strings":["Centro Nacional de An\u00e1lisis Gen\u00f3mico, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de An\u00e1lisis Gen\u00f3mico, Barcelona, Spain","institution_ids":["https://openalex.org/I4210142206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050532707","display_name":"Edo Vellenga","orcid":"https://orcid.org/0000-0002-7741-8697","observed_orcids":["https://orcid.org/0000-0002-7741-8697"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Edo Vellenga","raw_affiliation_strings":["Department of Hematology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036095832","display_name":"Hendrik G. Stunnenberg","orcid":"https://orcid.org/0000-0002-0066-1576","observed_orcids":["https://orcid.org/0000-0002-0066-1576"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hendrik G. Stunnenberg","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012839091","display_name":"Antonello Mai","orcid":"https://orcid.org/0000-0001-9176-2382","observed_orcids":["https://orcid.org/0000-0001-9176-2382"]},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonello Mai","raw_affiliation_strings":["Dipartimento di Chimica e Tecnologie del Farmaco \u2018Sapienza\u2019 Universit\u00e0, Roma, Italy","Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica e Tecnologie del Farmaco \u2018Sapienza\u2019 Universit\u00e0, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Roma, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039682482","display_name":"Lucia Altucci","orcid":"https://orcid.org/0000-0002-7312-5387","observed_orcids":["https://orcid.org/0000-0002-7312-5387"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Altucci","raw_affiliation_strings":["Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014988213","display_name":"Joost H.A. Martens","orcid":"https://orcid.org/0000-0003-2008-6537","observed_orcids":["https://orcid.org/0000-0003-2008-6537"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT","NL"],"is_corresponding":false,"raw_author_name":"Joost H.A. Martens","raw_affiliation_strings":["Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Radboud University, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]},{"raw_affiliation_string":"Dipartimento di Biochimica Biofisica e Patologia Generale, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy","institution_ids":["https://openalex.org/I197809005"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5055976006","https://openalex.org/A5104110147"],"corresponding_institution_ids":["https://openalex.org/I145872427","https://openalex.org/I197809005"],"apc_list":null,"apc_paid":null,"fwci":0.8732,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.70631338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"9","issue":"39","first_page":"25647","last_page":"25660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.49320000410079956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.49320000410079956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.3441999852657318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9279999732971191},{"id":"https://openalex.org/keywords/multi-omics-profiling","display_name":"multi-omics profiling","score":0.8100000023841858},{"id":"https://openalex.org/keywords/pml-rara-fusion","display_name":"PML-RARA fusion","score":0.6389999985694885},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.5170000195503235},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.5009999871253967},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.31200000643730164},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.34599998593330383},{"id":"https://openalex.org/keywords/risk-of-relapse","display_name":"relapse risk","score":0.35499998927116394},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5960000157356262},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2991849723","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Molecular cell biology","level":2,"score":0.4530406594276428},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.4317154288291931},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3670198917388916},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.33667707443237305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26714932918548584},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.23876279592514038},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":14,"locations":[{"id":"doi:10.18632/oncotarget.25429","doi":"https://doi.org/10.18632/oncotarget.25429","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25429","pdf_url":"https://www.oncotarget.com/article/25429/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4943418","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986653","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5986653","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986653","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:29876014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29876014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/2831e499-7314-42e0-b6d6-cbf68a121c44","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/2831e499-7314-42e0-b6d6-cbf68a121c44","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unicampania.it:11591/392702","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11591/392702","pdf_url":"https://iris.unicampania.it/bitstream/11591/392702/2/25429-1004893-5-PB.pdf","source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1147239","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1147239","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1147239/1/Singh_Multi-omics_2018.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/197503","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2066/197503","pdf_url":"https://repository.ubn.ru.nl//bitstream/handle/2066/197503/197503.pdf","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/94c71afa-d4d3-4847-9b18-b5a6d932db3a","doi":null,"is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/multiomics-profiling-reveals-a-distinctive-epigenome-signature-for-highrisk-acute-promyelocytic-leukemia(94c71afa-d4d3-4847-9b18-b5a6d932db3a).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, 9(39), 25647 - 25660. Impact Journals","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-01873822v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-01873822","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\\nISSN: \\n1949-2553","raw_type":"\\ninfo:eu-repo/semantics/article\\n"},{"id":"pmh:oai:pure.rug.nl:openaire/d0624f5d-4448-45f6-a48d-c67624e869f1","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/files/62406518/25429_1004893_5_PB.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositori.upf.edu:10230/43024","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/43024","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/197503","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/197503","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, 9, 25647 - 25660","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/d0624f5d-4448-45f6-a48d-c67624e869f1","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/d0624f5d-4448-45f6-a48d-c67624e869f1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, 9(39), 25647 - 25660. Impact Journals LLC","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.25429","doi":"https://doi.org/10.18632/oncotarget.25429","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25429","pdf_url":"https://www.oncotarget.com/article/25429/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G107044526","display_name":null,"funder_award_id":"AIRC-17217","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G6732411515","display_name":null,"funder_award_id":"17217","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320323705","display_name":"Stichting Kinderen Kankervrij","ror":"https://ror.org/05gxzef39"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804501763.pdf","grobid_xml":"https://content.openalex.org/works/W2804501763.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W96364163","https://openalex.org/W120764409","https://openalex.org/W302408596","https://openalex.org/W1255676896","https://openalex.org/W1486948598","https://openalex.org/W1516721790","https://openalex.org/W1523071718","https://openalex.org/W1550565578","https://openalex.org/W1598192021","https://openalex.org/W1909732837","https://openalex.org/W1965388358","https://openalex.org/W1981044274","https://openalex.org/W1982342754","https://openalex.org/W2023546573","https://openalex.org/W2042056286","https://openalex.org/W2044433401","https://openalex.org/W2060444097","https://openalex.org/W2062828530","https://openalex.org/W2063322714","https://openalex.org/W2075179204","https://openalex.org/W2077187292","https://openalex.org/W2096441981","https://openalex.org/W2098536205","https://openalex.org/W2103728018","https://openalex.org/W2107558453","https://openalex.org/W2130090902","https://openalex.org/W2133237718","https://openalex.org/W2149902033","https://openalex.org/W2153708119","https://openalex.org/W2158958901","https://openalex.org/W2162825670","https://openalex.org/W2164508407","https://openalex.org/W2167769671","https://openalex.org/W2173789978","https://openalex.org/W2256936668","https://openalex.org/W2416059176","https://openalex.org/W2473188297","https://openalex.org/W2553971506","https://openalex.org/W2561859182","https://openalex.org/W2586244967"],"related_works":["https://openalex.org/W1520221249","https://openalex.org/W6950829173","https://openalex.org/W2806969760","https://openalex.org/W3214389889","https://openalex.org/W2590999463","https://openalex.org/W6939359550","https://openalex.org/W2806082254","https://openalex.org/W4360599579","https://openalex.org/W3095037070","https://openalex.org/W7126324554"],"abstract_inverted_index":{"//":[0],"Abhishek":[1],"A.":[2],"Singh":[3],"1,":[4,134],"*":[5,10,286],",":[6,11,15,19,23,27,31,35,39,43,48,52,56,60,64,68,72,77,81,85,90,94,99,104,108,112,116,121,126],"Francesca":[7],"Petraglia":[8],"2,":[9],"Angela":[12],"Nebbioso":[13],"2":[14,34,129,135,145],"Guoqiang":[16],"Yi":[17],"1":[18,30,38,42,47,55,59,63,67,120,136],"Mariarosaria":[20],"Conte":[21],"3":[22,162],"Sergio":[24],"Valente":[25],"4":[26,171],"Amit":[28],"Mandoli":[29],"Lucia":[32,127,301],"Scisciola":[33],"Rik":[36],"Lindeboom":[37],"Hinri":[40],"Kerstens":[41],"Eva":[44],"M.":[45],"Janssen-Megens":[46],"Farzin":[49],"Pourfarzad":[50],"5":[51,93,183],"Ehsan":[53],"Habibi":[54],"Kim":[57,62],"Berentsen":[58],"Bowon":[61],"Colin":[65],"Logie":[66],"Simon":[69],"Heath":[70],"6":[71,111,202],"Albertus":[73],"T.J.":[74],"Wierenga":[75],"7":[76,115,210],"Laura":[78],"Clarke":[79],"8":[80,84,224],"Paul":[82],"Flicek":[83],"Joop":[86],"H.":[87],"Jansen":[88],"9":[89,239],"Taco":[91],"Kuijpers":[92],"Marie":[95],"Laure":[96],"Yaspo":[97],"10":[98,248],"Veronique":[100],"Della":[101],"Valle":[102],"11":[103,107,257],"Olivier":[105],"Bernard":[106],"Ivo":[109],"Gut":[110],"Edo":[113],"Vellenga":[114],"Hendrik":[117],"G.":[118],"Stunnenberg":[119],"Antonello":[122],"Mai":[123],"4,":[124],"12":[125,275],"Altucci":[128],"and":[130,191,217,336,351,402,415,423,453,461,474],"Joost":[131,296],"H.A.":[132,297],"Martens":[133],"Department":[137,184,211,240],"of":[138,185,198,212,215,241,282,338,345,361,380,390,397,420,449,471,477,481],"Molecular":[139,226,253],"Biology,":[140],"Radboud":[141,244],"University,":[142],"Nijmegen,":[143,246],"Netherlands":[144,201,223,247],"Dipartimento":[146,172],"di":[147,173],"Biochimica":[148],"Biofisica":[149],"e":[150,175],"Patologia":[151],"Generale,":[152],"Universit\u00e0":[153],"degli":[154],"Studi":[155],"della":[156],"Campania":[157],"Luigi":[158],"Vanvitelli,":[159],"Napoli,":[160,169],"Italy":[161,170,182,285],"IRCCS":[163],"SDN,":[164],"Napoli":[165],"Via":[166],"E.":[167],"Gianturco,":[168],"Chimica":[174],"Tecnologie":[176],"del":[177],"Farmaco":[178],"\u2018Sapienza\u2019":[179],"Universit\u00e0,":[180],"Roma,":[181,284],"Blood":[186],"Cell":[187],"Research,":[188],"Sanquin":[189],"Research":[190],"Landsteiner":[192],"Laboratory,":[193,228],"Academic":[194],"Medical":[195,219],"Center,":[196],"University":[197,214,218,281],"Amsterdam,":[199,200],"Centro":[203],"Nacional":[204],"de":[205],"An\u00e1lisis":[206],"Gen\u00f3mico,":[207],"Barcelona,":[208],"Spain":[209],"Hematology,":[213],"Groningen":[216],"Center":[220],"Groningen,":[221,222],"European":[225,229],"Biology":[227],"Bioinformatics":[230],"Institute,":[231,277],"Wellcome":[232],"Trust":[233],"Genome":[234],"Campus,":[235],"Hinxton,":[236],"United":[237],"Kingdom":[238],"Laboratory":[242],"Medicine,":[243],"UMC,":[245],"Max":[249],"Planck":[250],"Institute":[251],"for":[252,434,479],"Genetics,":[254],"Berlin,":[255],"Germany":[256],"INSERM":[258],"U1170,":[259],"Universtit\u00e9":[260],"Paris-Saclay,":[261],"Institut":[262],"Gustave":[263],"Roussy,":[264],"Equipe":[265],"Labellis\u00e9e":[266],"Ligue":[267],"Nationale":[268],"Contre":[269],"le":[270],"Cancer":[271],"(LNCC),":[272],"Paris,":[273],"France":[274],"Pasteur":[276],"Cenci-Bolognetti":[278],"Foundation,":[279],"Sapienza":[280],"Rome,":[283],"These":[287],"authors":[288],"contributed":[289],"equally":[290],"to":[291,354,485,488],"this":[292],"work":[293],"Correspondence":[294],"to:":[295],"Martens,":[298],"email:":[299,303],"j.martens@ncmls.ru.nl":[300],"Altucci,":[302],"lucia.altucci@unicampania.it":[304],"Keywords:":[305],"epigenome;":[306],"acute":[307],"promyelocytic":[308],"leukemia":[309],"(APL);":[310],"PML-RARA;":[311],"high-risk":[312,347,408,450],"APL;":[313],"epi-drugs":[314],"Received:":[315],"March":[316],"15,":[317],"2018":[318,322,326],"Accepted:":[319],"May":[320,324],"01,":[321],"Published:":[323],"22,":[325],"ABSTRACT":[327],"Epigenomic":[328],"alterations":[329],"have":[330],"been":[331],"associated":[332],"with":[333,373,412],"both":[334,459],"pathogenesis":[335],"progression":[337],"cancer.":[339],"Here,":[340],"we":[341,365],"analyzed":[342],"the":[343,359,398],"epigenome":[344,469,482],"two":[346],"APL":[348,356,451],"(hrAPL)":[349],"patients":[350,372],"compared":[352],"it":[353],"non-high-risk":[355],"cases.":[357],"Despite":[358],"lack":[360],"common":[362,388],"genetic":[363],"signatures,":[364],"found":[366],"that":[367],"human":[368],"hrAPL":[369,472],"blasts":[370,452],"from":[371],"extremely":[374],"poor":[375],"prognosis":[376],"display":[377],"specific":[378],"patterns":[379,419],"histone":[381,421],"H3":[382],"acetylation,":[383],"specifically":[384],"hyperacetylation":[385],"at":[386],"a":[387,441],"set":[389],"enhancer":[391],"regions.":[392],"In":[393],"addition,":[394],"unique":[395],"profiles":[396],"repressive":[399,462],"marks":[400],"H3K27me3":[401],"DNA":[403,424],"methylation":[404],"were":[405],"exposed":[406],"in":[407],"APLs.":[409],"Epigenetic":[410],"comparison":[411],"low/intermediate-risk":[413],"APLs":[414],"AMLs":[416],"revealed":[417],"hrAPL-specific":[418],"acetylation":[422],"methylation,":[425],"suggesting":[426],"these":[427],"could":[428],"be":[429],"further":[430],"developed":[431],"into":[432],"markers":[433],"clinical":[435],"identification.":[436],"The":[437],"epigenetic":[438,486],"drug":[439],"MC2884,":[440],"newly":[442],"generated":[443],"general":[444],"HAT/EZH2":[445],"inhibitor,":[446],"induces":[447],"apoptosis":[448],"reshapes":[454],"their":[455],"epigenomes":[456],"by":[457],"targeting":[458],"active":[460],"marks.":[463],"Together,":[464],"our":[465],"analysis":[466],"uncovers":[467],"distinctive":[468],"signatures":[470],"patients,":[473],"provides":[475],"proof":[476],"concept":[478],"use":[480],"profiling":[483],"coupled":[484],"drugs":[487],"\u2018personalize\u2019":[489],"precision":[490],"medicine.":[491]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}