{"id":"https://openalex.org/W2804475680","doi":"https://doi.org/10.1002/slct.201800487","title":"Luminescent Anticancer Acenaphtho[1, 2\u2010b]quinoxaline: Green Synthesis, DFT and Molecular Docking Studies, Live\u2010Cell Imaging and Reactivity towards Nucleic Acid and Protein BSA","display_name":"Luminescent Anticancer Acenaphtho[1, 2\u2010b]quinoxaline: Green Synthesis, DFT and Molecular Docking Studies, Live\u2010Cell Imaging and Reactivity towards Nucleic Acid and Protein BSA","publication_year":2018,"publication_date":"2018-05-22","ids":{"openalex":"https://openalex.org/W2804475680","doi":"https://doi.org/10.1002/slct.201800487","mag":"2804475680"},"language":"en","primary_location":{"id":"doi:10.1002/slct.201800487","doi":"https://doi.org/10.1002/slct.201800487","is_oa":false,"landing_page_url":"https://doi.org/10.1002/slct.201800487","pdf_url":null,"source":{"id":"https://openalex.org/S4210221416","display_name":"ChemistrySelect","issn_l":"2365-6549","issn":["2365-6549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemistrySelect","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014229994","display_name":"Sourav De","orcid":"https://orcid.org/0000-0003-4014-7413","observed_orcids":["https://orcid.org/0000-0003-4014-7413"]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sourav De","raw_affiliation_strings":["Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055315615","display_name":"Sunisha Kottukulam Subran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sunisha Kottukulam Subran","raw_affiliation_strings":["Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068710592","display_name":"Selva Kumar Ramasamy","orcid":"https://orcid.org/0000-0003-1899-013X","observed_orcids":["https://orcid.org/0000-0003-1899-013X"]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Selva kumar Ramasamy","raw_affiliation_strings":["Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090326350","display_name":"Subhasis Banerjee","orcid":"https://orcid.org/0000-0003-0716-6508","observed_orcids":["https://orcid.org/0000-0003-0716-6508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Subhasis Banerjee","raw_affiliation_strings":["Department of Pharmaceutical Chemistry Gupta College of Technological Science Asansol - 713301, West Bengal India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry Gupta College of Technological Science Asansol - 713301, West Bengal India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032584630","display_name":"Priyankar Paira","orcid":"https://orcid.org/0000-0003-1698-4895","observed_orcids":["https://orcid.org/0000-0003-1698-4895"]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Priyankar Paira","raw_affiliation_strings":["Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India"],"raw_orcid":"https://orcid.org/0000-0003-1698-4895","affiliations":[{"raw_affiliation_string":"Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030740410","display_name":"Ashok Kumar Somanahalli Kalleshappa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ashok Kumar Somanahalli Kalleshappa","raw_affiliation_strings":["Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry School of Advance Sciences Vellore Institute of Technology Vellore - 632014, Tamil Nadu India","institution_ids":["https://openalex.org/I876193797"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030740410","https://openalex.org/A5032584630"],"corresponding_institution_ids":["https://openalex.org/I876193797"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.4896,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.47873403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"19","first_page":"5421","last_page":"5430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.08739999681711197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/green-synthesis","display_name":"green synthesis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sonication","display_name":"sonication","score":0.6430000066757202},{"id":"https://openalex.org/keywords/dna-cleavage","display_name":"DNA cleavage","score":0.6669999957084656},{"id":"https://openalex.org/keywords/calf-thymus-dna","display_name":"calf thymus DNA","score":0.765999972820282},{"id":"https://openalex.org/keywords/minor-groove-binding","display_name":"minor groove binding","score":0.8610000014305115},{"id":"https://openalex.org/keywords/bovine-serum-albumin-binding","display_name":"bovine serum albumin binding","score":0.8130000233650208},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2780362310","wikidata":"https://www.wikidata.org/wiki/Q419930","display_name":"Quinoxaline","level":2,"score":0.9712582230567932},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6692615747451782},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5705004930496216},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5371582508087158},{"id":"https://openalex.org/C2778370995","wikidata":"https://www.wikidata.org/wiki/Q419781","display_name":"Phenazine","level":2,"score":0.4814012050628662},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4485017657279968},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4415286183357239},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.4287700951099396},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4110243022441864},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3789684772491455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26188376545906067},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1513189673423767},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12384703755378723},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1220422089099884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/slct.201800487","doi":"https://doi.org/10.1002/slct.201800487","is_oa":false,"landing_page_url":"https://doi.org/10.1002/slct.201800487","pdf_url":null,"source":{"id":"https://openalex.org/S4210221416","display_name":"ChemistrySelect","issn_l":"2365-6549","issn":["2365-6549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemistrySelect","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1889788822","https://openalex.org/W1924652834","https://openalex.org/W1940643691","https://openalex.org/W1970008331","https://openalex.org/W1975827044","https://openalex.org/W1975937308","https://openalex.org/W1977750472","https://openalex.org/W1979318293","https://openalex.org/W1985175645","https://openalex.org/W1987723396","https://openalex.org/W1989074065","https://openalex.org/W1989534356","https://openalex.org/W1993121895","https://openalex.org/W1993157480","https://openalex.org/W2006055828","https://openalex.org/W2026545311","https://openalex.org/W2031163058","https://openalex.org/W2038852050","https://openalex.org/W2053357042","https://openalex.org/W2054695077","https://openalex.org/W2055532453","https://openalex.org/W2062464868","https://openalex.org/W2082357140","https://openalex.org/W2092310945","https://openalex.org/W2103708366","https://openalex.org/W2120258006","https://openalex.org/W2121518504","https://openalex.org/W2134387977","https://openalex.org/W2137931285","https://openalex.org/W2140446999","https://openalex.org/W2146143233","https://openalex.org/W2155118851","https://openalex.org/W2159292626","https://openalex.org/W2160557315","https://openalex.org/W2167014804","https://openalex.org/W2177206102","https://openalex.org/W2177442635","https://openalex.org/W2467855699","https://openalex.org/W2598018395","https://openalex.org/W2911531103","https://openalex.org/W2949455104","https://openalex.org/W2950382040","https://openalex.org/W2951593240"],"related_works":["https://openalex.org/W2896841991","https://openalex.org/W2920951917","https://openalex.org/W2042043305","https://openalex.org/W2158068056","https://openalex.org/W2528424327","https://openalex.org/W3198234034","https://openalex.org/W4403470028","https://openalex.org/W4210383024","https://openalex.org/W2923143273","https://openalex.org/W4403261296"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"series":[2],"of":[3,18,31,71,77,97,113,155,159],"acenaphtho[1,":[4],"2\u2010b]quinoxaline":[5,34,173,179,188],"derivatives":[6,25,100],"3":[7,10,36,53,78,127,130,161,175,181,184,190,217],"a":[8,128],"\u2010":[9,129],"j":[11,131,191],"were":[12,193],"prepared":[13],"using":[14,46,80],"single":[15],"step":[16],"condensation":[17],"acenaphthoquinone":[19],"with":[20,39,102,209],"different":[21],"o":[22],"\u2010phenylene":[23],"diamine":[24],"on":[26,126,144],"water":[27],"under":[28],"sonication.":[29],"Interaction":[30],"9\u2010fluoro":[32],"acenaptho[1,":[33],"(":[35,174,180,189],"g":[37,54,79,162,185,218],")":[38,192],"calf\u2010thymus":[40],"DNA":[41,56,89,103],"has":[42,66],"been":[43,67],"explored":[44],"by":[45,69,117],"absorption":[47],"and":[48,90,108,186,207,222],"emission":[49,73],"techniques.":[50],"The":[51,62,88,120,167],"compound":[52,160,216],"cleave":[55],"oxidatively":[57],"without":[58],"any":[59],"exogenous":[60],"additives.":[61],"protein":[63,91,115],"binding":[64],"ability":[65],"observed":[68],"quenching":[70],"tryptophan":[72],"in":[74,137,163,199,224],"the":[75,98,105,110,114,138,145,152,226],"presence":[76],"bovine":[81],"serum":[82],"albumin":[83],"(BSA)":[84],"as":[85,205],"model":[86],"protein.":[87],"docking":[92],"study":[93],"suggests":[94],"that":[95,134,171],"most":[96],"quinoxaline":[99,146],"interact":[101],"through":[104],"minor":[106],"groove":[107],"occupies":[109],"active":[111],"site":[112],"favorably":[116],"hydrogen":[118],"bonding.":[119],"density":[121],"functional":[122],"calculations":[123],"carried":[124],"out":[125],"have":[132],"shown":[133],"electron\u2010rich":[135],"regions":[136],"highest":[139],"occupied":[140],"orbital":[141],"are":[142],"localized":[143],"moiety.":[147],"Live\u2010cells":[148],"imaging":[149],"result":[150],"showed":[151],"clear":[153],"evidence":[154],"strong":[156],"cellular":[157],"uptake":[158],"HeLa":[164,208],"cell":[165,202,227],"line.":[166],"MTT":[168],"assay":[169],"concluded":[170],"compounds:9,10\u2010dichloroacenaptho[1,":[172],"d":[176],"),":[177,183],"9\u2010bromoacenaptho[1,":[178],"e":[182],"9\u2010chloro\u201010\u2010fluroacenaptho[1,":[187],"exhibited":[194],"highly":[195],"selective":[196],"cytotoxicity":[197],"profiles":[198],"two":[200],"cancer":[201],"lines":[203],"such":[204],"MCF\u20107":[206],"respect":[210],"to":[211],"normal":[212],"HEK\u2010293.":[213],"Among":[214],"them,":[215],"displayed":[219],"high":[220],"potency":[221],"selectivity":[223],"all":[225],"lines.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}
