{"id":"https://openalex.org/W2804454669","doi":"https://doi.org/10.5935/2595-0118.20180033","title":"Ozone therapy as an integrating therapeutic in osteoartrosis treatment: a systematic review","display_name":"Ozone therapy as an integrating therapeutic in osteoartrosis treatment: a systematic review","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2804454669","doi":"https://doi.org/10.5935/2595-0118.20180033","mag":"2804454669"},"language":"en","primary_location":{"id":"doi:10.5935/2595-0118.20180033","doi":"https://doi.org/10.5935/2595-0118.20180033","is_oa":true,"landing_page_url":"https://doi.org/10.5935/2595-0118.20180033","pdf_url":"https://www.scielo.br/j/brjp/a/yMmx8KdmxqkTfjx4f77Xhwx/?lang=en&format=pdf","source":{"id":"https://openalex.org/S4210207983","display_name":"Brazilian Journal Of Pain","issn_l":"2595-0118","issn":["2595-0118","2595-3192"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","scielo"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal Of Pain","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/brjp/a/yMmx8KdmxqkTfjx4f77Xhwx/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009326408","display_name":"Ana Paula Anzolin","orcid":"https://orcid.org/0000-0002-1080-1480","observed_orcids":["https://orcid.org/0000-0002-1080-1480"]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Paula Anzolin","raw_affiliation_strings":["Universidade de Passo Fundo, Programa de Pos-Graduacao em Envelhecimento Humano, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Passo Fundo, Programa de Pos-Graduacao em Envelhecimento Humano, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I16371252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063148096","display_name":"Charise Dallazem Bertol","orcid":"https://orcid.org/0000-0001-7596-315X","observed_orcids":["https://orcid.org/0000-0001-7596-315X"]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Charise Dallazem Bertol","raw_affiliation_strings":["Universidade de Passo Fundo, Programa de Pos-Graduacao em Envelhecimento Humano, Passo Fundo, RS, Brasil.Universidade de Passo Fundo, Curso de Farmacia, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Passo Fundo, Programa de Pos-Graduacao em Envelhecimento Humano, Passo Fundo, RS, Brasil.Universidade de Passo Fundo, Curso de Farmacia, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I16371252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16371252"],"apc_list":null,"apc_paid":null,"fwci":0.2882,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.2326284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"1","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13365","display_name":"Medical and Biological Ozone Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13365","display_name":"Medical and Biological Ozone Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ozone-therapy","display_name":"ozone therapy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.8740000128746033},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2779283356","wikidata":"https://www.wikidata.org/wiki/Q1426433","display_name":"Ozone therapy","level":3,"score":0.6054542064666748},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.5018360614776611},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4191006124019623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4043542444705963},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3578740954399109},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.2053660750389099},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07150143384933472}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5935/2595-0118.20180033","doi":"https://doi.org/10.5935/2595-0118.20180033","is_oa":true,"landing_page_url":"https://doi.org/10.5935/2595-0118.20180033","pdf_url":"https://www.scielo.br/j/brjp/a/yMmx8KdmxqkTfjx4f77Xhwx/?lang=en&format=pdf","source":{"id":"https://openalex.org/S4210207983","display_name":"Brazilian Journal Of Pain","issn_l":"2595-0118","issn":["2595-0118","2595-3192"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","scielo"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal Of Pain","raw_type":"journal-article"},{"id":"pmh:oai:scielo:S2595-31922018000200171","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&amp;pid=S2595-31922018000200171","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BrJP v.1 n.2 2018","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2632522","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922018000200171","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BrJP v.1 n.2 2018","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.5935/2595-0118.20180033","doi":"https://doi.org/10.5935/2595-0118.20180033","is_oa":true,"landing_page_url":"https://doi.org/10.5935/2595-0118.20180033","pdf_url":"https://www.scielo.br/j/brjp/a/yMmx8KdmxqkTfjx4f77Xhwx/?lang=en&format=pdf","source":{"id":"https://openalex.org/S4210207983","display_name":"Brazilian Journal Of Pain","issn_l":"2595-0118","issn":["2595-0118","2595-3192"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","scielo"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal Of Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804454669.pdf","grobid_xml":"https://content.openalex.org/works/W2804454669.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2006600627","https://openalex.org/W2155461473","https://openalex.org/W2161825679","https://openalex.org/W2169972412","https://openalex.org/W2327421967","https://openalex.org/W2496759230","https://openalex.org/W2507919150","https://openalex.org/W2557025751","https://openalex.org/W2582012588","https://openalex.org/W2737745629","https://openalex.org/W2765297328"],"related_works":["https://openalex.org/W7214695486","https://openalex.org/W4391967722","https://openalex.org/W2988640356","https://openalex.org/W4401786366","https://openalex.org/W2911645682","https://openalex.org/W2898678046","https://openalex.org/W2996601267","https://openalex.org/W2903186165","https://openalex.org/W4387969680","https://openalex.org/W4405166211"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVES:":[2],"Osteoarthrosis":[3],"affects":[4],"85%":[5],"of":[6,12,54,59,75,81,102,128,134,138,151,160,183,189,222],"the":[7,23,26,29,52,65,73,79,89,118,132,142,172,184,215,220,223],"population":[8],"over":[9],"75":[10],"years":[11],"age.":[13],"It":[14],"is":[15,45],"divided":[16],"into":[17],"primary":[18],"and":[19,48,98,108,155,171],"secondary,":[20],"however":[21],"despite":[22],"knowledge":[24],"at":[25],"molecular":[27],"level":[28],"treatments":[30],"are":[31],"not":[32],"yet":[33],"fully":[34],"effective.":[35],"However,":[36],"ozone":[37,76,123,139,190,200],"therapy":[38,77,124,201],"emerges":[39],"as":[40],"an":[41],"alternative":[42,209],"therapy,":[43],"which":[44],"low":[46],"cost":[47],"seems":[49],"effective":[50],"in":[51,78,125,141,181,195,202,214],"treatment":[53,80,173],"chronic":[55],"pain.":[56],"The":[57,100,136,149,158,187],"objective":[58],"this":[60],"study":[61],"was":[62,104,153,175],"to":[63,68,71,147,166,178],"evaluate":[64],"current":[66],"evidence":[67],"support":[69],"or":[70],"refute":[72],"use":[74,161,188],"patients":[82,196],"with":[83,197],"osteoarthritis.":[84],"CONTENTS:":[85],"Systematic":[86],"review":[87],"using":[88],"keywords":[90],"\u201cozone":[91],"therapy\u201d,":[92],"\u201cozone\u201d,":[93],"\u201costeoarthritis\u201d,":[94],"\u201carthritis\u201d,":[95],"\u201crandomized\u201d,":[96],"\u201ccontrolled\u201d":[97],"\u201cmeta-analysis\u201d.":[99],"selection":[101],"publications":[103],"based":[105],"on":[106,163],"inclusion":[107],"exclusion":[109],"criteria.":[110],"In":[111],"total,":[112],"9":[113,119],"articles":[114,120],"were":[115],"used.":[116],"Among":[117],"found":[121],"regarding":[122],"osteoarthritis,":[126],"7":[127],"them":[129],"clearly":[130],"show":[131],"benefits":[133,194],"ozone.":[135],"concentrations":[137],"used":[140],"studies":[143],"ranged":[144],"from":[145],"20\u00b5g/mL":[146],"15g/mL.":[148],"route":[150],"administration":[152],"intra-articular":[154],"rectal":[156],"insufflation.":[157],"frequency":[159],"was,":[162],"average,":[164],"1":[165],"3":[167,177],"times":[168],"a":[169,205],"week":[170],"time":[174],"between":[176],"4":[179],"months":[180],"most":[182],"studies.":[185],"CONCLUSION:":[186],"produces":[191],"clinically":[192],"relevant":[193],"osteoarthrosis.":[198],"Therefore,":[199],"osteoarthrosis":[203],"represents":[204],"low-cost,":[206],"efficient":[207],"therapeutic":[208],"that":[210],"should":[211],"be":[212],"implemented":[213],"country\u2019s":[216],"Public":[217],"Health,":[218],"considering":[219],"prevalence":[221],"disease.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-01T00:00:00"}
