{"id":"https://openalex.org/W2804448616","doi":"https://doi.org/10.3892/br.2018.1100","title":"Efficacy of orlistat in non\u2011alcoholic fatty liver disease: A systematic review and meta\u2011analysis","display_name":"Efficacy of orlistat in non\u2011alcoholic fatty liver disease: A systematic review and meta\u2011analysis","publication_year":2018,"publication_date":"2018-05-22","ids":{"openalex":"https://openalex.org/W2804448616","doi":"https://doi.org/10.3892/br.2018.1100","mag":"2804448616","pmid":"https://pubmed.ncbi.nlm.nih.gov/29930810","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6007047"},"language":"en","primary_location":{"id":"doi:10.3892/br.2018.1100","doi":"https://doi.org/10.3892/br.2018.1100","is_oa":true,"landing_page_url":"https://doi.org/10.3892/br.2018.1100","pdf_url":"http://www.spandidos-publications.com/10.3892/br.2018.1100/download","source":{"id":"https://openalex.org/S2754599785","display_name":"Biomedical Reports","issn_l":"2049-9434","issn":["2049-9434","2049-9442"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/br.2018.1100/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100401013","display_name":"Hu Wang","orcid":"https://orcid.org/0000-0001-6132-8788","observed_orcids":["https://orcid.org/0000-0001-6132-8788"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hu Wang","raw_affiliation_strings":["Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100335984","display_name":"Li Wang","orcid":"https://orcid.org/0000-0002-9995-7122","observed_orcids":["https://orcid.org/0000-0002-9995-7122"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":["Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103807896","display_name":"Yujia Cheng","orcid":"https://orcid.org/0009-0006-8688-5269","observed_orcids":["https://orcid.org/0009-0006-8688-5269"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujia Cheng","raw_affiliation_strings":["Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhiqing Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqing Xia","raw_affiliation_strings":["Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076869980","display_name":"Yifeng Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifeng Liao","raw_affiliation_strings":["Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045094860","display_name":"Jiang Cao","orcid":"https://orcid.org/0000-0003-3767-9283","observed_orcids":["https://orcid.org/0000-0003-3767-9283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiang Cao","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7887,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.69711876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"90","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orlistat","display_name":"orlistat","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":1.0},{"id":"https://openalex.org/keywords/lipase-inhibitors","display_name":"lipase inhibitors","score":0.6240000128746033},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7940000295639038},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7620000243186951},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8450000286102295},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/drug-efficacy-and-safety","display_name":"drug safety and efficacy","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2780780548","wikidata":"https://www.wikidata.org/wiki/Q424163","display_name":"Orlistat","level":4,"score":0.836491584777832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7744884490966797},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.7250988483428955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6896549463272095},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6778914928436279},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6476770043373108},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5524616837501526},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4158599376678467},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.41395020484924316},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.30211132764816284},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.25221118330955505},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2035587728023529}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3892/br.2018.1100","doi":"https://doi.org/10.3892/br.2018.1100","is_oa":true,"landing_page_url":"https://doi.org/10.3892/br.2018.1100","pdf_url":"http://www.spandidos-publications.com/10.3892/br.2018.1100/download","source":{"id":"https://openalex.org/S2754599785","display_name":"Biomedical Reports","issn_l":"2049-9434","issn":["2049-9434","2049-9442"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4963517","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6007047","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6007047","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6007047","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Rep","raw_type":"Text"},{"id":"pmid:29930810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29930810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/br.2018.1100","doi":"https://doi.org/10.3892/br.2018.1100","is_oa":true,"landing_page_url":"https://doi.org/10.3892/br.2018.1100","pdf_url":"http://www.spandidos-publications.com/10.3892/br.2018.1100/download","source":{"id":"https://openalex.org/S2754599785","display_name":"Biomedical Reports","issn_l":"2049-9434","issn":["2049-9434","2049-9442"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804448616.pdf","grobid_xml":"https://content.openalex.org/works/W2804448616.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W98885122","https://openalex.org/W187284916","https://openalex.org/W192756024","https://openalex.org/W359841521","https://openalex.org/W1558646876","https://openalex.org/W1721287869","https://openalex.org/W1988826453","https://openalex.org/W1990168800","https://openalex.org/W2001940599","https://openalex.org/W2007872832","https://openalex.org/W2036047239","https://openalex.org/W2061405430","https://openalex.org/W2065147061","https://openalex.org/W2070070132","https://openalex.org/W2079830534","https://openalex.org/W2085080686","https://openalex.org/W2093616220","https://openalex.org/W2106061083","https://openalex.org/W2112496618","https://openalex.org/W2113109326","https://openalex.org/W2116475791","https://openalex.org/W2152623405","https://openalex.org/W2154075360","https://openalex.org/W2156098321","https://openalex.org/W2169248481","https://openalex.org/W2178246430","https://openalex.org/W2186212048","https://openalex.org/W2328891011","https://openalex.org/W2385748840","https://openalex.org/W2393199492","https://openalex.org/W2417970821","https://openalex.org/W2522261013","https://openalex.org/W2534293284","https://openalex.org/W2590033178","https://openalex.org/W2614799051","https://openalex.org/W4239134602","https://openalex.org/W6717250955"],"related_works":["https://openalex.org/W4394621808","https://openalex.org/W3002534209","https://openalex.org/W2385748840","https://openalex.org/W2154075360","https://openalex.org/W2976995479","https://openalex.org/W2065147061","https://openalex.org/W3134336627","https://openalex.org/W2393199492","https://openalex.org/W2152623405","https://openalex.org/W2590033178"],"abstract_inverted_index":{"In":[0],"the":[1,4,11,26,143,182,196],"present":[2],"meta-analysis,":[3],"efficacy":[5],"and":[6,18,32,57,83,126],"safety":[7],"of":[8,13,30,41,85,93,120,142,173,184,198],"orlistat":[9,42,162],"in":[10,43,79,91,134,152],"treatment":[12,197],"non-alcoholic":[14,19],"fatty":[15],"liver":[16,86,135,174],"(NAFLD)":[17],"steatohepatitis":[20],"(NASH)":[21],"were":[22,36,61,72,89,150],"evaluated.":[23],"PubMed,":[24],"Embase,":[25],"Cochrane":[27],"Library,":[28],"Web":[29],"Science,":[31],"Wan":[33],"Fang":[34],"data":[35],"searched":[37],"for":[38,74,181,195],"controlled":[39,55],"trials":[40,56,60],"patients":[44,153],"with":[45,66,154],"NAFLD":[46,67,185],"or":[47,68,186],"NASH,":[48],"published":[49],"before":[50],"August":[51],"2017.":[52],"Three":[53],"randomized":[54],"four":[58],"single-arm":[59],"included.":[62],"The":[63],"involved":[64],"participants":[65],"NASH":[69],"(330":[70],"patients)":[71],"analyzed":[73],"clinical":[75],"outcomes":[76],"including":[77],"alteration":[78],"hepatic":[80],"histological":[81],"variables":[82],"biomarkers":[84],"function.":[87],"Improvements":[88],"observed":[90,151],"levels":[92],"alanine":[94],"aminotransferase":[95,102],"[standard":[96],"mean":[97],"difference":[98,111],"(SMD)=-1.41;":[99],"P=0.01],":[100,113],"aspartate":[101],"(SMD=-2.06;":[103],"P=0.0005),":[104],"\u03b3-glutamyl":[105],"transpeptidase":[106],"(SMD=-1.91;":[107],"P=0.05),":[108],"glucose":[109],"[mean":[110],"(MD)=-0.51;":[112],"triglycerides":[114],"(MD=-0.93;":[115],"P=0.01),":[116],"homeostasis":[117],"model":[118],"assessment":[119],"insulin":[121],"resistance":[122],"index":[123,129],"(MD=-1.05;":[124],"P=0.04)":[125],"body":[127],"mass":[128],"(MD=-1.97;":[130],"P=0.02),":[131],"but":[132,176],"not":[133,177],"fibrosis":[136],"score":[137],"(SMD=-0.14;":[138],"P=0.71).":[139],"On":[140],"sub-analyses":[141],"different":[144],"patient":[145],"groups,":[146],"no":[147],"significant":[148],"differences":[149],"NASH.":[155],"Taken":[156],"together,":[157],"these":[158],"findings":[159],"demonstrate":[160],"that":[161],"could":[163],"serve":[164],"as":[165,178],"a":[166,190],"therapeutic":[167],"drug":[168,180,193],"to":[169],"improve":[170],"biochemical":[171],"indicators":[172],"damage,":[175],"first-choice":[179],"management":[183],"NASH;":[187],"thus":[188],"suggesting":[189],"novel":[191],"palliative":[192],"only":[194],"NAFLD.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-01T00:00:00"}