{"id":"https://openalex.org/W2804447970","doi":"https://doi.org/10.1158/1541-7786.mcr-18-0178","title":"Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound","display_name":"Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound","publication_year":2018,"publication_date":"2018-05-16","ids":{"openalex":"https://openalex.org/W2804447970","doi":"https://doi.org/10.1158/1541-7786.mcr-18-0178","mag":"2804447970","pmid":"https://pubmed.ncbi.nlm.nih.gov/29769406","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6125173"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-18-0178","doi":"https://doi.org/10.1158/1541-7786.mcr-18-0178","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-18-0178","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6125173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036770225","display_name":"Michael J. Bond","orcid":"https://orcid.org/0000-0001-9552-4525","observed_orcids":["https://orcid.org/0000-0001-9552-4525"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Bond","raw_affiliation_strings":["1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut","2Department of Pharmacology, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"2Department of Pharmacology, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015641099","display_name":"Marina Bleiler","orcid":"https://orcid.org/0000-0003-2256-589X","observed_orcids":["https://orcid.org/0000-0003-2256-589X"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Bleiler","raw_affiliation_strings":["1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut"],"raw_orcid":"https://orcid.org/0000-0003-2256-589X","affiliations":[{"raw_affiliation_string":"1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025896057","display_name":"Lauren E. Harrison","orcid":"https://orcid.org/0000-0002-7727-4873","observed_orcids":["https://orcid.org/0000-0002-7727-4873"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren E. Harrison","raw_affiliation_strings":["1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut"],"raw_orcid":"https://orcid.org/0000-0002-7727-4873","affiliations":[{"raw_affiliation_string":"1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032939790","display_name":"Eric W. Scocchera","orcid":"https://orcid.org/0000-0001-9377-4387","observed_orcids":["https://orcid.org/0000-0001-9377-4387"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric W. Scocchera","raw_affiliation_strings":["3Department of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101822186","display_name":"Masako Nakanishi","orcid":"https://orcid.org/0000-0002-2170-5216","observed_orcids":["https://orcid.org/0000-0002-2170-5216"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masako Nakanishi","raw_affiliation_strings":["4Center for Molecular Oncology, UConn Health, Farmington, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Center for Molecular Oncology, UConn Health, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030067897","display_name":"Narendran G-Dayanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Narendran G-Dayanan","raw_affiliation_strings":["3Department of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002377361","display_name":"Santosh K. Keshipeddy","orcid":"https://orcid.org/0000-0002-9375-2230","observed_orcids":["https://orcid.org/0000-0002-9375-2230"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santosh Keshipeddy","raw_affiliation_strings":["3Department of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066895730","display_name":"Daniel W. Rosenberg","orcid":"https://orcid.org/0000-0003-2897-2613","observed_orcids":["https://orcid.org/0000-0003-2897-2613"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel W. Rosenberg","raw_affiliation_strings":["4Center for Molecular Oncology, UConn Health, Farmington, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Center for Molecular Oncology, UConn Health, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018320671","display_name":"Dennis L. Wright","orcid":"https://orcid.org/0000-0003-4634-3351","observed_orcids":["https://orcid.org/0000-0003-4634-3351"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis L. Wright","raw_affiliation_strings":["3Department of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134109221","display_name":"Charles A. Giardina","orcid":"https://orcid.org/0000-0002-6001-6843","observed_orcids":["https://orcid.org/0000-0002-6001-6843"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles Giardina","raw_affiliation_strings":["1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5134109221"],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":null,"apc_paid":null,"fwci":0.6842,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.63492675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"16","issue":"9","first_page":"1361","last_page":"1372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clathrin-heavy-chain","display_name":"clathrin heavy chain","score":0.9089999794960022},{"id":"https://openalex.org/keywords/clathrin","display_name":"clathrin","score":0.6639999747276306},{"id":"https://openalex.org/keywords/mitotic-arrest","display_name":"mitotic arrest","score":0.8090000152587891},{"id":"https://openalex.org/keywords/spindle-assembly","display_name":"spindle assembly","score":0.5220000147819519},{"id":"https://openalex.org/keywords/bipolar-spindle-formation","display_name":"bipolar spindle formation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.621999979019165},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8539999723434448},{"id":"https://openalex.org/keywords/endocytosis-inhibition","display_name":"endocytosis inhibition","score":0.7599999904632568},{"id":"https://openalex.org/keywords/microtubule-organizing-center","display_name":"microtubule organizing center","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.781000018119812},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.859000027179718},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6589999794960022},{"id":"https://openalex.org/keywords/apc-mutant-mice","display_name":"Apc mutant mice","score":0.5720000267028809},{"id":"https://openalex.org/keywords/selective-killing-of-cancer-cells","display_name":"selective cancer cell killing","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.837769627571106},{"id":"https://openalex.org/C2779363559","wikidata":"https://www.wikidata.org/wiki/Q2506092","display_name":"Nocodazole","level":4,"score":0.7103416919708252},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6218551397323608},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6093255281448364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6091098189353943},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5591294765472412},{"id":"https://openalex.org/C3453395","wikidata":"https://www.wikidata.org/wiki/Q6935034","display_name":"Multipolar spindles","level":5,"score":0.5304702520370483},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.49601539969444275},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4659709930419922},{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.4415972828865051},{"id":"https://openalex.org/C186000732","wikidata":"https://www.wikidata.org/wiki/Q6881914","display_name":"Mitotic catastrophe","level":4,"score":0.42305341362953186},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.41772398352622986},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3952395021915436},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3711840510368347},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.3606099784374237},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34289121627807617},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29398196935653687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1773647665977478},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.1031084954738617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.060500919818878174}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D033922","descriptor_name":"Clathrin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033922","descriptor_name":"Clathrin Heavy Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1541-7786.mcr-18-0178","doi":"https://doi.org/10.1158/1541-7786.mcr-18-0178","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-18-0178","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:29769406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29769406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5675665","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6125173","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6125173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6125173","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5675665","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6125173","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G698961998","display_name":"(1) Intestinal Organoid Models for APC LOH","funder_award_id":"R21CA208638","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1516211547","https://openalex.org/W1585595240","https://openalex.org/W1657157395","https://openalex.org/W1802232529","https://openalex.org/W1966604030","https://openalex.org/W1966936117","https://openalex.org/W1970442105","https://openalex.org/W1974124532","https://openalex.org/W1984507712","https://openalex.org/W1995753459","https://openalex.org/W2001949247","https://openalex.org/W2004928820","https://openalex.org/W2008720155","https://openalex.org/W2009087805","https://openalex.org/W2010636399","https://openalex.org/W2011427175","https://openalex.org/W2018166116","https://openalex.org/W2018845809","https://openalex.org/W2020516698","https://openalex.org/W2026143081","https://openalex.org/W2026412193","https://openalex.org/W2045802318","https://openalex.org/W2053482707","https://openalex.org/W2054224885","https://openalex.org/W2058232728","https://openalex.org/W2061455523","https://openalex.org/W2066265974","https://openalex.org/W2071959428","https://openalex.org/W2082169879","https://openalex.org/W2086368594","https://openalex.org/W2089866954","https://openalex.org/W2104077876","https://openalex.org/W2113754963","https://openalex.org/W2117076903","https://openalex.org/W2120221664","https://openalex.org/W2123820544","https://openalex.org/W2129677038","https://openalex.org/W2137429755","https://openalex.org/W2140306229","https://openalex.org/W2141725799","https://openalex.org/W2142772715","https://openalex.org/W2143106943","https://openalex.org/W2145252755","https://openalex.org/W2148943851","https://openalex.org/W2153192086","https://openalex.org/W2154156417","https://openalex.org/W2166304697","https://openalex.org/W2189225177","https://openalex.org/W2292057342","https://openalex.org/W2325054656","https://openalex.org/W2325994488","https://openalex.org/W2342253360","https://openalex.org/W2344979371","https://openalex.org/W2584611911","https://openalex.org/W2624180692","https://openalex.org/W2767219967","https://openalex.org/W6642124099","https://openalex.org/W6672211948","https://openalex.org/W6679390303"],"related_works":["https://openalex.org/W2416042075","https://openalex.org/W2342253360","https://openalex.org/W2005853241","https://openalex.org/W2129398440","https://openalex.org/W984977030","https://openalex.org/W2791764667","https://openalex.org/W6892717050","https://openalex.org/W2406938992","https://openalex.org/W1988833132","https://openalex.org/W7137739599"],"abstract_inverted_index":{"Abstract":[0],"AK3":[1,25],"compounds":[2],"are":[3],"mitotic":[4,184],"arrest":[5,30,133],"agents":[6],"that":[7,28,143,181],"induce":[8,189],"high":[9],"levels":[10],"of":[11,33,43,54,76,113,118,164,198],"\u03b3H2AX":[12],"during":[13],"mitosis":[14,96,107],"and":[15,31,73,92,97,121,146,157,191],"apoptosis":[16,32,171,190,207],"following":[17],"release":[18],"from":[19,64,131],"arrest.":[20],"We":[21],"synthesized":[22],"a":[23,51,86,201],"potent":[24],"derivative,":[26],"AK306,":[27,77,150,204],"induced":[29],"the":[34,111,183],"HCT116":[35],"colon":[36],"cancer":[37,55,209],"cell":[38,56],"line":[39],"with":[40,58,88,168,200],"an":[41],"EC50":[42],"approximately":[44,65],"50":[45],"nmol/L.":[46],"AK306":[47,94,109,132,169],"was":[48,84],"active":[49],"on":[50],"broad":[52],"spectrum":[53],"lines":[57],"total":[59],"growth":[60],"inhibition":[61],"values":[62],"ranging":[63],"25":[66,69],"nmol/L":[67],"to":[68,79,136],"\u03bcmol/L.":[70],"Using":[71],"biotin":[72],"BODIPY-linked":[74],"derivatives":[75],"binding":[78],"clathrin":[80,199],"heavy":[81],"chain":[82],"(CLTC/CHC)":[83],"observed,":[85],"protein":[87],"roles":[89],"in":[90,106,172,208],"endocytosis":[91],"mitosis.":[93],"inhibited":[95],"endocytosis,":[98],"while":[99],"disrupting":[100,212],"CHC":[101,151,185],"cellular":[102],"localization.":[103],"Cells":[104,129],"arrested":[105],"by":[108,211],"showed":[110],"formation":[112,156],"multiple":[114],"microtubule-organizing":[115],"centers":[116],"consisting":[117],"pericentrin,":[119],"\u03b3-tubulin,":[120],"Aurora":[122],"A":[123,160],"foci,":[124],"without":[125],"apparent":[126],"centrosome":[127],"amplification.":[128],"released":[130],"were":[134],"unable":[135],"form":[137],"bipolar":[138,213],"spindles,":[139],"unlike":[140],"nocodazole-released":[141],"cells":[142,210],"reformed":[144],"spindles":[145],"completed":[147],"division.":[148],"Like":[149],"siRNA":[152],"knockdown":[153],"disrupted":[154],"spindle":[155,214],"activated":[158],"p53.":[159],"short-term":[161],"(3-day)":[162],"treatment":[163],"tumor-bearing":[165],"APC-mutant":[166],"mice":[167],"increased":[170],"tumors,":[173],"but":[174],"not":[175],"normal":[176],"mucosa.":[177],"These":[178],"findings":[179],"indicate":[180],"targeting":[182],"complex":[186],"can":[187],"selectively":[188,205],"may":[192],"have":[193],"therapeutic":[194],"value.":[195],"Implication:":[196],"Disruption":[197],"small-molecule":[202],"inhibitor,":[203],"induces":[206],"formation.":[215],"Mol":[216],"Cancer":[217],"Res;":[218],"16(9);":[219],"1361\u201372.":[220],"\u00a92018":[221],"AACR.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}
