{"id":"https://openalex.org/W2804421760","doi":"https://doi.org/10.1136/ejhpharm-2018-eahpconf.479","title":"5PSQ-126 Assessment of drug-drug interactions in surgical intensive care unit","display_name":"5PSQ-126 Assessment of drug-drug interactions in surgical intensive care unit","publication_year":2018,"publication_date":"2018-03-01","ids":{"openalex":"https://openalex.org/W2804421760","doi":"https://doi.org/10.1136/ejhpharm-2018-eahpconf.479","mag":"2804421760"},"language":"en","primary_location":{"id":"doi:10.1136/ejhpharm-2018-eahpconf.479","doi":"https://doi.org/10.1136/ejhpharm-2018-eahpconf.479","is_oa":false,"landing_page_url":"https://doi.org/10.1136/ejhpharm-2018-eahpconf.479","pdf_url":null,"source":{"id":"https://openalex.org/S3012707348","display_name":"European Journal of Hospital Pharmacy","issn_l":"2047-9956","issn":["2047-9956","2047-9964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Section 5: Patient safety and quality assurance","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7535449","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026113026","display_name":"A Koddous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"A Koddouss","raw_affiliation_strings":["CHU IBN Rochd\u2013University Hassan II, Hospital Pharmacy, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU IBN Rochd\u2013University Hassan II, Hospital Pharmacy, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067875211","display_name":"L Zarayby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"L Zarayby","raw_affiliation_strings":["CHU IBN Rochd\u2013University Hassan II, Hospital Pharmacy, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU IBN Rochd\u2013University Hassan II, Hospital Pharmacy, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027070595","display_name":"Rachid Cherkab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"R Cherkab","raw_affiliation_strings":["CHU IBN Rochd, Surgical Intensive Care Unit, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU IBN Rochd, Surgical Intensive Care Unit, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067005101","display_name":"Lhoucine Barrou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"L Barrou","raw_affiliation_strings":["CHU IBN Rochd, Surgical Intensive Care Unit, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU IBN Rochd, Surgical Intensive Care Unit, Casablanca, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069796192","display_name":"S Derfoufi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"S Derfoufi","raw_affiliation_strings":["CHU IBN Rochd\u2013University Hassan II, Hospital Pharmacy, Casablanca, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU IBN Rochd\u2013University Hassan II, Hospital Pharmacy, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0970971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A222.3","last_page":"A223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surgical-intensive-care-unit","display_name":"surgical intensive care unit","score":0.7870000004768372},{"id":"https://openalex.org/keywords/adverse-drug-interactions","display_name":"adverse drug interactions","score":0.578000009059906},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pharmacodynamic-interactions","display_name":"pharmacodynamic interactions","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.800000011920929},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.7250000238418579},{"id":"https://openalex.org/keywords/anti-infective-agents","display_name":"anti-infective agents","score":0.6309999823570251},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.34299999475479126},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.5799999833106995},{"id":"https://openalex.org/keywords/drug-warnings-and-precautions","display_name":"drug warnings and precautions","score":0.3310000002384186},{"id":"https://openalex.org/keywords/contraindications","display_name":"contraindications","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.81244957447052},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.791379451751709},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.7508533000946045},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6130881309509277},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5894578695297241},{"id":"https://openalex.org/C2778176773","wikidata":"https://www.wikidata.org/wiki/Q2976049","display_name":"Drug class","level":3,"score":0.5091518759727478},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5081076622009277},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.4663597345352173},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.45656973123550415},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.43373340368270874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34128403663635254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3335961103439331},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1136/ejhpharm-2018-eahpconf.479","doi":"https://doi.org/10.1136/ejhpharm-2018-eahpconf.479","is_oa":false,"landing_page_url":"https://doi.org/10.1136/ejhpharm-2018-eahpconf.479","pdf_url":null,"source":{"id":"https://openalex.org/S3012707348","display_name":"European Journal of Hospital Pharmacy","issn_l":"2047-9956","issn":["2047-9956","2047-9964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Section 5: Patient safety and quality assurance","raw_type":"proceedings-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7535449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7535449","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur J Hosp Pharm","raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:ejhpharm:25/Suppl_1/A222-c","doi":null,"is_oa":false,"landing_page_url":"http://ejhp.bmj.com/cgi/content/short/25/Suppl_1/A222-c","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7535449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7535449","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur J Hosp Pharm","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2606143729","https://openalex.org/W4394592742","https://openalex.org/W2925732512","https://openalex.org/W4253582799","https://openalex.org/W7117117446","https://openalex.org/W2898606362","https://openalex.org/W2974117322","https://openalex.org/W3118481999","https://openalex.org/W4361290153","https://openalex.org/W2732212760"],"abstract_inverted_index":{"Background":[0],"Drug-drug":[1],"interactions":[2,15,50,128,221,283,289,309],"of":[3,10,21,37,46,98,107,110,125,136,148,179,196,201,208,218,304,318,322,344],"current":[4],"medications":[5],"could":[6],"increase":[7],"the":[8,17,38,117,134,141,146,302,316,319],"incidence":[9,25],"adverse":[11,48,282],"effects.1":[12],"Adverse":[13],"drug":[14,22,49,95,111,127,220,232,308,323],"are":[16,129,160],"most":[18],"frequent":[19],"causes":[20],"iatrogenicity.":[23],"Their":[24],"is":[26],"proportional":[27],"to":[28,75,116,294,300,311],"drugs":[29,213],"number":[30,45],"and":[31,44,59,78,94,150,168,189,227,248,252,269,284,310],"increases":[32],"with":[33,193],"a":[34,52,68,83,86],"period":[35,71],"extension":[36],"prescription.":[39],"Purpose":[40],"To":[41],"determine":[42],"nature":[43],"potential":[47],"in":[51,82,307,333],"surgical":[53],"intensive":[54,334],"care":[55,335],"unit":[56,336],"(SICU).":[57],"Material":[58],"methods":[60],"The":[61,100,123,205,231,272,287],"pharmaceutical":[62],"analysis":[63],"was":[64,182,222],"carried":[65],"out":[66],"over":[67],"6":[69],"month":[70],"from":[72],"September":[73],"2016":[74],"March":[76],"2017":[77],"involved":[79],"patients":[80,181],"hospitalised":[81],"SICU.":[84],"Using":[85],"written":[87],"document,":[88],"we":[89],"gather":[90],"patients\u2019":[91],"personal":[92],"information":[93],"treatments:":[96],"Number":[97,109],"patients.":[99,337],"epidemiological":[101],"parameters":[102],"(age,":[103],"sex).":[104],"Average":[105,199],"length":[106,200],"stay.":[108],"interactions.":[112],"Drug":[113,137,177],"class":[114],"according":[115],"anatomical":[118],"chemical":[119],"therapeutic":[120],"classification":[121],"(ATC).":[122],"levels":[124,273],"identified":[126],"based":[130],"on":[131,133],"\u2018Guideline":[132],"Investigation":[135],"Interactions\u2019":[138],"edited":[139],"by":[140],"French":[142],"National":[143],"Agency":[144],"for":[145,235],"Safety":[147],"Medicines":[149],"Health":[151],"Products":[152],"(ANSM):":[153],"warnings,":[154,277],"precautions,":[155,279],"possible":[156,281],"adverse,":[157],"contraindications.":[158,286],"Prescriptions":[159],"analysed":[161,210],"using:":[162],"THERIAQUE\u00ae,":[163],"Thesaurus":[164],"ANSM":[165],"2016.":[166],"Averages":[167],"percentages":[169],"were":[170,187,191,275,291],"calculated":[171],"using":[172],"Microsoft":[173],"Excel":[174],"2007.":[175],"Results":[176],"treatment":[178],"131":[180,206],"analysed.":[183],"Forty-seven":[184],"per":[185],"cent":[186],"females":[188],"53%":[190],"males,":[192],"mean":[194],"age":[195],"50.21\u00b117.21":[197],"years.":[198],"stay:":[202],"8.18\u00b114.79":[203],"days":[204],"lines":[207],"prescriptions":[209],"averaged":[211],"11.31\u00b13":[212],"(range:":[214],"3\u201320)":[215],"A":[216],"total":[217],"81":[219],"detected,":[223],"28%":[224],"(n=23)":[225],"pharmacokinetic":[226],"72%":[228],"(n=58)":[229],"pharmacodynamic.":[230],"classes:":[233],"Antiinfectives":[234],"systemic":[236],"use":[237],"23.53%.":[238],"Nervous":[239],"system":[240,244,257,261],"22.55%":[241],"\u2013":[242,259],"cardiovascular":[243],"15.69%.":[245,250],"Alimentary":[246],"tract":[247],"metabolism":[249],"Blood":[251],"blood\u2013forming":[253],"organs":[254],"14.7%.":[255],"Musculo\u2013skeletal":[256],"3.92%":[258],"respiratory":[260],"2.94%.":[262],"Systemic":[263],"hormonal":[264],"preparations,":[265],"excluding":[266],"sex":[267],"hormones":[268],"insulins":[270],"0.98%.":[271],"observed":[274,290],"eight":[276],"34":[278],"35":[280],"four":[285],"actual":[288],"related":[292],"especially":[293],"thrombocytopaenia.":[295],"Conclusion":[296],"It":[297],"seems":[298],"important":[299],"maintain":[301],"vigilance":[303],"healthcare":[305],"professionals":[306],"integrate":[312],"this":[313],"risk":[314],"into":[315],"assessment":[317],"benefit/risk":[320],"balance":[321],"treatments.":[324],"Reference":[325],"and/or":[326],"Acknowledgements":[327],"1.":[328],"Bellmann,":[329],"R.":[330],"Personalised":[331],"pharmacotherapy":[332],"Med.":[338],"Klin.":[339],"Intensivmed.":[340],"Notfallmedizin2017.":[341],"No":[342],"conflict":[343],"interest":[345]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2018-06-01T00:00:00"}