{"id":"https://openalex.org/W2804414957","doi":null,"title":"Dynamics of Acquisition of Antigen and T Cell Help Influence B Cell Fate in the T-Dependent Humoral Immune Response","display_name":"Dynamics of Acquisition of Antigen and T Cell Help Influence B Cell Fate in the T-Dependent Humoral Immune Response","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2804414957","mag":"2804414957"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/140861","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/140861","pdf_url":"https://hdl.handle.net/2027.42/140861","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/140861","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063694206","display_name":"Jackson S. Turner","orcid":"https://orcid.org/0000-0002-4396-6265","observed_orcids":["https://orcid.org/0000-0002-4396-6265"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jackson S. Turner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4396-6265","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063694206"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-help","display_name":"T cell help","score":0.9409999847412109},{"id":"https://openalex.org/keywords/b-cell-fate","display_name":"B cell fate","score":0.8640000224113464},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.8399999737739563},{"id":"https://openalex.org/keywords/b-cell-proliferation","display_name":"B cell proliferation","score":0.5619999766349792},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/b-cell-anergy","display_name":"B cell anergy","score":0.6880000233650208},{"id":"https://openalex.org/keywords/intravital-imaging","display_name":"intravital imaging","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.650883674621582},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.508239209651947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48632320761680603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45174407958984375},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.431331992149353},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35830920934677124},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2009042501449585},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/140861","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/140861","pdf_url":"https://hdl.handle.net/2027.42/140861","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2804414957","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/140861","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/140861","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/140861","pdf_url":"https://hdl.handle.net/2027.42/140861","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804414957.pdf","grobid_xml":"https://content.openalex.org/works/W2804414957.grobid-xml"},"referenced_works_count":168,"referenced_works":["https://openalex.org/W122104777","https://openalex.org/W1482425583","https://openalex.org/W1489338305","https://openalex.org/W1509793976","https://openalex.org/W1513383992","https://openalex.org/W1570485432","https://openalex.org/W1589053023","https://openalex.org/W1612160402","https://openalex.org/W1652473508","https://openalex.org/W1678411211","https://openalex.org/W1681312898","https://openalex.org/W1780852323","https://openalex.org/W1891705702","https://openalex.org/W1894912312","https://openalex.org/W1901606394","https://openalex.org/W1929236283","https://openalex.org/W1934885234","https://openalex.org/W1953252508","https://openalex.org/W1966057190","https://openalex.org/W1966460557","https://openalex.org/W1966949480","https://openalex.org/W1967994686","https://openalex.org/W1973274031","https://openalex.org/W1976046500","https://openalex.org/W1976750616","https://openalex.org/W1977237743","https://openalex.org/W1978153385","https://openalex.org/W1978790143","https://openalex.org/W1981295756","https://openalex.org/W1981352846","https://openalex.org/W1981525542","https://openalex.org/W1981811803","https://openalex.org/W1982094117","https://openalex.org/W1982289564","https://openalex.org/W1987076250","https://openalex.org/W1988338839","https://openalex.org/W1989134497","https://openalex.org/W1990297263","https://openalex.org/W1991780615","https://openalex.org/W1991988533","https://openalex.org/W1995025510","https://openalex.org/W1996822762","https://openalex.org/W2001039642","https://openalex.org/W2002624767","https://openalex.org/W2005284010","https://openalex.org/W2007886976","https://openalex.org/W2008471218","https://openalex.org/W2009852881","https://openalex.org/W2010560247","https://openalex.org/W2015177755","https://openalex.org/W2016054852","https://openalex.org/W2017433337","https://openalex.org/W2019206924","https://openalex.org/W2019447967","https://openalex.org/W2021461864","https://openalex.org/W2022012352","https://openalex.org/W2022092564","https://openalex.org/W2023491212","https://openalex.org/W2025036258","https://openalex.org/W2028087680","https://openalex.org/W2029320721","https://openalex.org/W2030707267","https://openalex.org/W2030816309","https://openalex.org/W2033970156","https://openalex.org/W2034360108","https://openalex.org/W2036217549","https://openalex.org/W2038264470","https://openalex.org/W2038976543","https://openalex.org/W2041061869","https://openalex.org/W2041337739","https://openalex.org/W2044512941","https://openalex.org/W2044734125","https://openalex.org/W2046421048","https://openalex.org/W2046517086","https://openalex.org/W2049243675","https://openalex.org/W2049398130","https://openalex.org/W2050600340","https://openalex.org/W2051480457","https://openalex.org/W2051822277","https://openalex.org/W2053095572","https://openalex.org/W2053247044","https://openalex.org/W2054144216","https://openalex.org/W2055138174","https://openalex.org/W2055923182","https://openalex.org/W2056703680","https://openalex.org/W2060324455","https://openalex.org/W2060637301","https://openalex.org/W2063223775","https://openalex.org/W2066444778","https://openalex.org/W2066489069","https://openalex.org/W2067909449","https://openalex.org/W2068064817","https://openalex.org/W2071380288","https://openalex.org/W2071969437","https://openalex.org/W2076274640","https://openalex.org/W2076747220","https://openalex.org/W2078702573","https://openalex.org/W2079574749","https://openalex.org/W2080674820","https://openalex.org/W2084509492","https://openalex.org/W2085465802","https://openalex.org/W2088593344","https://openalex.org/W2091199034","https://openalex.org/W2091229935","https://openalex.org/W2093418362","https://openalex.org/W2093626188","https://openalex.org/W2094993149","https://openalex.org/W2094999215","https://openalex.org/W2095129122","https://openalex.org/W2096084302","https://openalex.org/W2098497060","https://openalex.org/W2099740616","https://openalex.org/W2101827867","https://openalex.org/W2102364213","https://openalex.org/W2103838480","https://openalex.org/W2104067212","https://openalex.org/W2105336865","https://openalex.org/W2106138445","https://openalex.org/W2108312271","https://openalex.org/W2115291391","https://openalex.org/W2121686754","https://openalex.org/W2122016469","https://openalex.org/W2122772587","https://openalex.org/W2123130879","https://openalex.org/W2128203257","https://openalex.org/W2128751441","https://openalex.org/W2131109099","https://openalex.org/W2132838609","https://openalex.org/W2133951067","https://openalex.org/W2134257200","https://openalex.org/W2134544592","https://openalex.org/W2136006589","https://openalex.org/W2136616777","https://openalex.org/W2136877952","https://openalex.org/W2137063023","https://openalex.org/W2137446997","https://openalex.org/W2142174337","https://openalex.org/W2146568771","https://openalex.org/W2146819767","https://openalex.org/W2147450297","https://openalex.org/W2148759300","https://openalex.org/W2149100729","https://openalex.org/W2149140113","https://openalex.org/W2150292882","https://openalex.org/W2155686622","https://openalex.org/W2158500407","https://openalex.org/W2159153399","https://openalex.org/W2159476211","https://openalex.org/W2168628444","https://openalex.org/W2168941586","https://openalex.org/W2171241954","https://openalex.org/W2196700926","https://openalex.org/W2209991137","https://openalex.org/W2239291357","https://openalex.org/W2277351499","https://openalex.org/W2289890884","https://openalex.org/W2338738911","https://openalex.org/W2345778582","https://openalex.org/W2346243632","https://openalex.org/W2365770820","https://openalex.org/W2396908022","https://openalex.org/W2417317977","https://openalex.org/W2507936899","https://openalex.org/W2529255372","https://openalex.org/W2534008997","https://openalex.org/W2597889999","https://openalex.org/W2606391044","https://openalex.org/W2743779163"],"related_works":["https://openalex.org/W4313356207","https://openalex.org/W2606391044","https://openalex.org/W2797625449","https://openalex.org/W103247075","https://openalex.org/W4313359576","https://openalex.org/W2900234070","https://openalex.org/W2726897844","https://openalex.org/W2005038218","https://openalex.org/W2150394130","https://openalex.org/W3029209635"],"abstract_inverted_index":{"The":[0,376],"T-dependent":[1,25,107],"humoral":[2,26,82,108,120,159,318],"immune":[3,27,83,109,121,160,219,319],"response":[4,28,122],"is":[5,47,111,165,303,441,465,480],"critical":[6],"for":[7,338,409],"generation":[8],"of":[9,31,41,74,88,90,105,118,201,242,261,290,311,329,340,349,363,379,388,398,416,431,437,448],"durable":[10],"high-affinity":[11,370],"antibody":[12],"responses":[13,110,161],"and":[14,35,39,43,58,60,66,76,92,131,212,235,239,321,342,359,365,384,391,451,456,459,499],"protection":[15],"from":[16],"many":[17],"pathogenic":[18],"infections.":[19],"B":[20,51,64,97,123,140,150,174,185,232,244,251,270,312,323,335,374,418,427,471,496],"cell":[21,37,45,52,78,94,124,183,203,223,233,301,324,331,344,393,411,428,439,453,472,486],"recruitment":[22,57,253,310],"into":[23,62,158,237,254,314,369,501],"the":[24,71,86,106,115,119,199,258,262,288,291,315,327,385,446],"requires":[29],"acquisition":[30,89,230,248,307,339,390,422,436,450],"both":[32],"antigen":[33],"(Ag)":[34],"T":[36,44,77,93,182,202,222,300,316,330,343,392,410,438,452,485],"help,":[38,184],"reacquisition":[40],"Ag":[42,75,91,127,145,179,190,229,247,306,341,389,421,449],"help":[46,79,95,224,302,345,394,412,440,454,487],"thought":[48],"to":[49,126,173,189,208,215,267,283,468,483],"promote":[50,469,484],"proliferation,":[53],"germinal":[54],"center":[55],"(GC)":[56],"selection,":[59,489],"differentiation":[61,236,500],"memory":[63,243,373],"cells":[65,68,98,151,175,186,271,313,336],"plasma":[67],"(PCs).":[69],"Despite":[70],"central":[72],"role":[73,433],"in":[80,102,137,171,198,217,265,280,285,326,434,457],"driving":[81],"responses,":[84],"how":[85],"dynamics":[87],"by":[96],"affect":[99],"their":[100,281,350],"participation":[101],"different":[103],"stages":[104,117],"poorly":[112],"understood.":[113],"During":[114],"initial":[116],"access":[125],"may":[128,146,493],"be":[129,147,156],"limited,":[130],"intravital":[132],"imaging":[133],"studies":[134,403],"suggest":[135,476],"that":[136,170,176,298,353,407,461,477,491],"some":[138],"cases":[139],"cells'":[141,497],"early":[142],"encounters":[143,164],"with":[144,274],"transient.":[148],"Whether":[149],"are":[152,356,381,395],"tolerized":[153],"or":[154,195,367,372],"can":[155,413,423],"recruited":[157],"following":[162,346],"such":[163],"not":[166,181,192,272,442,466,481],"clear.":[167],"We":[168,444],"found":[169,460],"contrast":[172,266],"continuously":[177],"acquire":[178],"but":[180,490],"transiently":[187],"exposed":[188],"did":[191],"become":[193],"anergic":[194],"undergo":[196,360],"apoptosis":[197],"absence":[200,328],"help;":[204],"rather":[205],"they":[206],"returned":[207],"a":[209],"na\u00efve-like":[210],"state":[211],"were":[213,277],"able":[214],"participate":[216,284],"subsequent":[218],"responses.":[220],"When":[221],"was":[225],"available,":[226,304],"single":[227],"transient":[228,305],"enabled":[231,250],"proliferation":[234],"PCs":[238,371],"various":[240],"subpopulations":[241],"cells.":[245,375],"Transient":[246],"also":[249,424],"cells\u2019":[252],"GCs,":[255,334],"even":[256],"during":[257],"contraction":[259],"phase":[260],"GC":[263,292,417,426,470,495],"response,":[264,320],"newly":[268],"arriving":[269],"preloaded":[273],"Ag,":[275],"which":[276],"severely":[278],"limited":[279],"ability":[282],"GCs":[286],"after":[287],"peak":[289],"response.":[293],"Altogether":[294],"these":[295],"results":[296,475],"indicate":[297],"when":[299],"enables":[308],"efficient":[309],"dependent":[317],"favors":[322],"survival":[325],"help.":[332],"Within":[333],"compete":[337,354],"random":[347],"mutation":[348,364],"BCRs.":[351],"Those":[352],"successfully":[355],"positively":[357],"selected,":[358],"further":[361],"rounds":[362],"selection":[366,380,415,429],"differentiate":[368],"precise":[377],"mechanisms":[378],"still":[382],"unclear":[383],"individual":[386],"roles":[387,447],"an":[396],"area":[397],"active":[399],"investigation.":[400],"While":[401],"recent":[402],"have":[404],"provided":[405],"evidence":[406],"competition":[408],"drive":[414],"cells,":[419],"whether":[420],"support":[425],"independently":[430],"its":[432],"promoting":[435],"known.":[443],"addressed":[445],"separately":[455],"combination":[458],"BCR":[462,478],"cross-linking":[463,479],"alone":[464],"sufficient":[467],"selection.":[473],"Preliminary":[474],"necessary":[482],"based":[488],"it":[492],"enhance":[494],"expansion":[498],"PCs.":[502]},"counts_by_year":[],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2018-06-01T00:00:00"}