{"id":"https://openalex.org/W2804409948","doi":null,"title":"Investigating susceptibility to bipolar disorder, migraine and epilepsy","display_name":"Investigating susceptibility to bipolar disorder, migraine and epilepsy","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2804409948","mag":"2804409948"},"language":"en","primary_location":{"id":"pmh:oai:https://orca.cardiff.ac.uk:108607","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/108607/1/2018KnotS%20PhD.pdf","pdf_url":"https://orca.cardiff.ac.uk/108607/1/2018KnotS%20PhD.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109428178","display_name":"Sarah Knott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sarah Knott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109428178"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9800000190734863},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bipolar-ii-disorder","display_name":"bipolar II disorder","score":0.9800000190734863},{"id":"https://openalex.org/keywords/migraine-with-aura","display_name":"migraine with aura","score":0.9620000123977661},{"id":"https://openalex.org/keywords/suicide-attempts","display_name":"suicide attempts","score":0.890999972820282},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9300000071525574},{"id":"https://openalex.org/keywords/shared-pathophysiology","display_name":"shared pathophysiology","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.886704683303833},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.7774471044540405},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.75687175989151},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.6742256283760071},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.58567214012146},{"id":"https://openalex.org/C2776497919","wikidata":"https://www.wikidata.org/wiki/Q739481","display_name":"Migraine with aura","level":4,"score":0.5504697561264038},{"id":"https://openalex.org/C2777350023","wikidata":"https://www.wikidata.org/wiki/Q1154226","display_name":"Aura","level":3,"score":0.4988076686859131},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.48555633425712585},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4797476530075073},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.44995030760765076},{"id":"https://openalex.org/C2776592573","wikidata":"https://www.wikidata.org/wiki/Q4086956","display_name":"Bipolar II disorder","level":4,"score":0.41649091243743896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38567087054252625},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.12281438708305359}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:https://orca.cardiff.ac.uk:108607","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/108607/1/2018KnotS%20PhD.pdf","pdf_url":"https://orca.cardiff.ac.uk/108607/1/2018KnotS%20PhD.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2804409948","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.732217","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":332,"referenced_works":["https://openalex.org/W160527616","https://openalex.org/W289774075","https://openalex.org/W296941733","https://openalex.org/W300889411","https://openalex.org/W1278569434","https://openalex.org/W1480668309","https://openalex.org/W1500569882","https://openalex.org/W1521535206","https://openalex.org/W1536128866","https://openalex.org/W1540275012","https://openalex.org/W1547704429","https://openalex.org/W1551100748","https://openalex.org/W1563908742","https://openalex.org/W1569006574","https://openalex.org/W1583327662","https://openalex.org/W1634430794","https://openalex.org/W1687266585","https://openalex.org/W1749057191","https://openalex.org/W1830205474","https://openalex.org/W1859478462","https://openalex.org/W1869362176","https://openalex.org/W1879074807","https://openalex.org/W1894180705","https://openalex.org/W1897313079","https://openalex.org/W1905378438","https://openalex.org/W1907155452","https://openalex.org/W1919551764","https://openalex.org/W1920696238","https://openalex.org/W1926175095","https://openalex.org/W1964895417","https://openalex.org/W1965509311","https://openalex.org/W1965661118","https://openalex.org/W1966411707","https://openalex.org/W1966437099","https://openalex.org/W1966547101","https://openalex.org/W1966728711","https://openalex.org/W1967063881","https://openalex.org/W1967982538","https://openalex.org/W1968212169","https://openalex.org/W1968357203","https://openalex.org/W1968700646","https://openalex.org/W1969836710","https://openalex.org/W1970375625","https://openalex.org/W1970543745","https://openalex.org/W1970602512","https://openalex.org/W1973174800","https://openalex.org/W1974656257","https://openalex.org/W1975274945","https://openalex.org/W1977437520","https://openalex.org/W1980175371","https://openalex.org/W1980625590","https://openalex.org/W1981978896","https://openalex.org/W1982548901","https://openalex.org/W1984318072","https://openalex.org/W1984344128","https://openalex.org/W1984576035","https://openalex.org/W1985635494","https://openalex.org/W1986653061","https://openalex.org/W1986857614","https://openalex.org/W1987398739","https://openalex.org/W1987494895","https://openalex.org/W1990025103","https://openalex.org/W1993753254","https://openalex.org/W1994514343","https://openalex.org/W1994800580","https://openalex.org/W1995839968","https://openalex.org/W1997868402","https://openalex.org/W1998391728","https://openalex.org/W1999134535","https://openalex.org/W1999948768","https://openalex.org/W2000289247","https://openalex.org/W2001308135","https://openalex.org/W2003307141","https://openalex.org/W2003491970","https://openalex.org/W2004417729","https://openalex.org/W2005038779","https://openalex.org/W2005552296","https://openalex.org/W2007339452","https://openalex.org/W2007895731","https://openalex.org/W2008336545","https://openalex.org/W2008741245","https://openalex.org/W2012149197","https://openalex.org/W2012476442","https://openalex.org/W2013563301","https://openalex.org/W2013791051","https://openalex.org/W2013936484","https://openalex.org/W2014289300","https://openalex.org/W2015396233","https://openalex.org/W2016419728","https://openalex.org/W2017104280","https://openalex.org/W2018131844","https://openalex.org/W2018766133","https://openalex.org/W2019399436","https://openalex.org/W2019884656","https://openalex.org/W2020409577","https://openalex.org/W2020451388","https://openalex.org/W2021176348","https://openalex.org/W2021476447","https://openalex.org/W2022578875","https://openalex.org/W2022661456","https://openalex.org/W2023248706","https://openalex.org/W2023510690","https://openalex.org/W2024404908","https://openalex.org/W2025129891","https://openalex.org/W2025197615","https://openalex.org/W2027062631","https://openalex.org/W2027228969","https://openalex.org/W2027553521","https://openalex.org/W2027759517","https://openalex.org/W2027851686","https://openalex.org/W2028131109","https://openalex.org/W2028281706","https://openalex.org/W2028870364","https://openalex.org/W2031601423","https://openalex.org/W2033276865","https://openalex.org/W2033769577","https://openalex.org/W2034966688","https://openalex.org/W2036380810","https://openalex.org/W2036520094","https://openalex.org/W2037668591","https://openalex.org/W2038051308","https://openalex.org/W2038165308","https://openalex.org/W2038609326","https://openalex.org/W2038903617","https://openalex.org/W2039169515","https://openalex.org/W2040529271","https://openalex.org/W2040863019","https://openalex.org/W2041390878","https://openalex.org/W2043651742","https://openalex.org/W2043882734","https://openalex.org/W2044599947","https://openalex.org/W2045166948","https://openalex.org/W2046048374","https://openalex.org/W2047583978","https://openalex.org/W2048548848","https://openalex.org/W2049239731","https://openalex.org/W2049898930","https://openalex.org/W2050171536","https://openalex.org/W2050272513","https://openalex.org/W2051332182","https://openalex.org/W2051373242","https://openalex.org/W2051525211","https://openalex.org/W2051662206","https://openalex.org/W2051774941","https://openalex.org/W2053014390","https://openalex.org/W2053154970","https://openalex.org/W2056017343","https://openalex.org/W2056206967","https://openalex.org/W2056560811","https://openalex.org/W2056562972","https://openalex.org/W2056797678","https://openalex.org/W2057239478","https://openalex.org/W2057384033","https://openalex.org/W2058938020","https://openalex.org/W2059462619","https://openalex.org/W2059560616","https://openalex.org/W2060564419","https://openalex.org/W2060913012","https://openalex.org/W2061160973","https://openalex.org/W2061889230","https://openalex.org/W2062463079","https://openalex.org/W2062895901","https://openalex.org/W2063913361","https://openalex.org/W2064318755","https://openalex.org/W2064554173","https://openalex.org/W2064582039","https://openalex.org/W2065476766","https://openalex.org/W2067495470","https://openalex.org/W2067768000","https://openalex.org/W2067945598","https://openalex.org/W2068912577","https://openalex.org/W2069078743","https://openalex.org/W2070032514","https://openalex.org/W2070654052","https://openalex.org/W2071335594","https://openalex.org/W2072045297","https://openalex.org/W2072255096","https://openalex.org/W2072448332","https://openalex.org/W2072682020","https://openalex.org/W2072696792","https://openalex.org/W2072821550","https://openalex.org/W2074535951","https://openalex.org/W2075809233","https://openalex.org/W2075851334","https://openalex.org/W2076444692","https://openalex.org/W2077142642","https://openalex.org/W2080659167","https://openalex.org/W2082115432","https://openalex.org/W2083524390","https://openalex.org/W2083567291","https://openalex.org/W2083923855","https://openalex.org/W2084328300","https://openalex.org/W2084937412","https://openalex.org/W2085187330","https://openalex.org/W2085382852","https://openalex.org/W2086056052","https://openalex.org/W2086142190","https://openalex.org/W2086518683","https://openalex.org/W2086904267","https://openalex.org/W2086963093","https://openalex.org/W2087042104","https://openalex.org/W2088438351","https://openalex.org/W2088899386","https://openalex.org/W2089207825","https://openalex.org/W2089489906","https://openalex.org/W2090361336","https://openalex.org/W2090455592","https://openalex.org/W2090967964","https://openalex.org/W2090995094","https://openalex.org/W2091280391","https://openalex.org/W2091925523","https://openalex.org/W2093669734","https://openalex.org/W2094246063","https://openalex.org/W2097051377","https://openalex.org/W2097599164","https://openalex.org/W2098631889","https://openalex.org/W2099478180","https://openalex.org/W2100497330","https://openalex.org/W2102527980","https://openalex.org/W2103634979","https://openalex.org/W2104153167","https://openalex.org/W2104418842","https://openalex.org/W2105137453","https://openalex.org/W2105826342","https://openalex.org/W2106169455","https://openalex.org/W2106277748","https://openalex.org/W2107001839","https://openalex.org/W2107267159","https://openalex.org/W2108722273","https://openalex.org/W2110680655","https://openalex.org/W2112723718","https://openalex.org/W2113784410","https://openalex.org/W2118640105","https://openalex.org/W2119226169","https://openalex.org/W2120023671","https://openalex.org/W2121626412","https://openalex.org/W2121843432","https://openalex.org/W2122708962","https://openalex.org/W2122796918","https://openalex.org/W2122836206","https://openalex.org/W2125439972","https://openalex.org/W2126661869","https://openalex.org/W2126862274","https://openalex.org/W2126876066","https://openalex.org/W2127442418","https://openalex.org/W2128016314","https://openalex.org/W2128211840","https://openalex.org/W2128790645","https://openalex.org/W2129061795","https://openalex.org/W2129559300","https://openalex.org/W2130587165","https://openalex.org/W2131272231","https://openalex.org/W2132576992","https://openalex.org/W2133371501","https://openalex.org/W2133650614","https://openalex.org/W2133752646","https://openalex.org/W2134808298","https://openalex.org/W2136453726","https://openalex.org/W2138515444","https://openalex.org/W2138604344","https://openalex.org/W2139099551","https://openalex.org/W2139392596","https://openalex.org/W2139776066","https://openalex.org/W2139852368","https://openalex.org/W2139870060","https://openalex.org/W2141746153","https://openalex.org/W2142490107","https://openalex.org/W2142961788","https://openalex.org/W2143002682","https://openalex.org/W2143557478","https://openalex.org/W2144042613","https://openalex.org/W2144626458","https://openalex.org/W2145141773","https://openalex.org/W2145664048","https://openalex.org/W2146463107","https://openalex.org/W2147024435","https://openalex.org/W2147082846","https://openalex.org/W2147889774","https://openalex.org/W2147943475","https://openalex.org/W2148437270","https://openalex.org/W2149619804","https://openalex.org/W2150290224","https://openalex.org/W2150473239","https://openalex.org/W2150731420","https://openalex.org/W2151599925","https://openalex.org/W2155654222","https://openalex.org/W2155819581","https://openalex.org/W2156023964","https://openalex.org/W2157702138","https://openalex.org/W2157752701","https://openalex.org/W2157890889","https://openalex.org/W2157943838","https://openalex.org/W2157975334","https://openalex.org/W2158186107","https://openalex.org/W2158949285","https://openalex.org/W2159030144","https://openalex.org/W2159950826","https://openalex.org/W2160772692","https://openalex.org/W2161480846","https://openalex.org/W2161749769","https://openalex.org/W2161963368","https://openalex.org/W2162272146","https://openalex.org/W2163399996","https://openalex.org/W2163434317","https://openalex.org/W2163446367","https://openalex.org/W2163610533","https://openalex.org/W2165070791","https://openalex.org/W2165260077","https://openalex.org/W2165444166","https://openalex.org/W2165540187","https://openalex.org/W2167193785","https://openalex.org/W2167307333","https://openalex.org/W2168953165","https://openalex.org/W2169728426","https://openalex.org/W2171654398","https://openalex.org/W2171954599","https://openalex.org/W2177979388","https://openalex.org/W2286161527","https://openalex.org/W2293962183","https://openalex.org/W2320360611","https://openalex.org/W2333700878","https://openalex.org/W2386118537","https://openalex.org/W2394791624","https://openalex.org/W2400892929","https://openalex.org/W2411878304","https://openalex.org/W2798543501","https://openalex.org/W2906253013","https://openalex.org/W2994408190","https://openalex.org/W3148964027","https://openalex.org/W4246013491","https://openalex.org/W4247496126","https://openalex.org/W4248790175"],"related_works":["https://openalex.org/W2588460371","https://openalex.org/W1978514339","https://openalex.org/W1830205474","https://openalex.org/W2068912577","https://openalex.org/W4206849317","https://openalex.org/W2418022413","https://openalex.org/W2023959982","https://openalex.org/W2012110100","https://openalex.org/W2118193187","https://openalex.org/W1562786221"],"abstract_inverted_index":{"Epidemiological":[0],"and":[1,14,20,47,53,90,98,110,149,192,239,243,247,259,281],"clinical":[2,164,199,279],"studies":[3],"demonstrate":[4],"a":[5,56,74,82,127,133,219,251,272],"high":[6,181],"degree":[7],"of":[8,36,51,60,79,84,88,146,154,166,183,201,209,218,221,236,257,296],"comorbidity":[9,138],"between":[10,18,45],"bipolar":[11,108,118,190,203],"disorder":[12],"(BD)":[13],"migraine.":[15],"A":[16,180],"relationship":[17,44],"BD":[19,46,167],"epilepsy":[21,91,185,226,240],"is":[22],"also":[23,265],"suggested,":[24],"with":[25,62,81,117,123,132,169,174,177,224],"both":[26],"disorders":[27],"displaying":[28],"phenotypically":[29],"similar":[30],"symptom":[31],"profiles.":[32],"The":[33],"overall":[34],"aim":[35],"this":[37,231],"thesis":[38,232,264],"was":[39,103,111,186],"to":[40,113,139,206],"further":[41],"explore":[42],"the":[43,48,68,107,155,163,175,189,198,202,207,234,255,294],"neurological":[49],"conditions":[50],"migraine,":[52],"epilepsy,":[54],"within":[55,94,106,188,227,241],"large,":[57],"well-characterised":[58],"sample":[59,78,109,191],"individuals":[61,80],"BD.":[63,85,228,262],"\\nData":[64],"were":[65,92,171,195],"utilised":[66],"from":[67,230],"Bipolar":[69,121],"Disorder":[70],"Research":[71],"Network":[72],"(BDRN);":[73],"large":[75],"(n>6000)":[76],"UK":[77],"diagnosis":[83],"Lifetime":[86],"history":[87,220],"migraine":[89,125,137,156,170,176,238],"assessed":[93],"BDRN":[95],"using":[96],"questionnaire":[97],"telephone":[99],"interview":[100],"methods.":[101],"\\nMigraine":[102],"highly":[104],"prevalent":[105],"found":[112],"disproportionately":[114],"affect":[115],"those":[116],"II":[119],"disorder.":[120,151],"subjects":[122],"comorbid":[124],"experienced":[126],"relatively":[128],"distinct":[129],"illness":[130,204,258],"profile,":[131],"multivariate":[134],"model":[135],"revealing":[136],"be":[140],"characterised":[141,276],"by":[142,277],"an":[143,215,284],"increased":[144],"risk":[145],"suicide":[147,222],"attempt":[148,223],"anxiety":[150],"Further":[152],"analysis":[153,213],"phenotype":[157],"revealed":[158,196,214],"that":[159,244,267],"observed":[160],"differences":[161,194],"in":[162,197,261],"presentation":[165],"associated":[168,173],"largely":[172],"aura":[178],"subtype.":[179],"rate":[182],"self-reported":[184,210,225],"identified":[187],"group":[193],"course":[200,256],"according":[205],"presence":[208],"epilepsy.":[211],"Multivariate":[212],"independent":[216],"association":[217],"\\nFindings":[229],"highlight":[233],"importance":[235],"identifying":[237],"BD,":[242],"their":[245],"recognition":[246],"treatment":[248],"may":[249,270,282],"have":[250],"beneficial":[252],"impact":[253],"on":[254],"outcome":[260],"This":[263],"suggests":[266],"these":[268],"comorbidities":[269],"represent":[271],"clinically":[273],"useful":[274],"subgroup":[275],"specific":[278],"features,":[280],"provide":[283],"opportunity":[285],"for":[286,288],"subcategorising":[287],"future":[289],"aetiological":[290],"studies,":[291],"potentially":[292],"facilitating":[293],"identification":[295],"shared":[297],"pathophysiological":[298],"mechanisms.":[299]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}