{"id":"https://openalex.org/W2804371972","doi":null,"title":"Chromosomal patterns of gene expression in human tumors.","display_name":"Chromosomal patterns of gene expression in human tumors.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2804371972","mag":"2804371972"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/124862","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstreams/688d24b2-8502-4648-a69c-c5ced3c72de7/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087470378","display_name":"Albert M. Levin","orcid":"https://orcid.org/0000-0002-6993-1669","observed_orcids":["https://orcid.org/0000-0002-6993-1669"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Albert M. Levin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6993-1669","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087470378"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.3774000108242035,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-transcriptome","display_name":"tumor transcriptome","score":0.6309999823570251},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.6660000085830688},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.7559999823570251},{"id":"https://openalex.org/keywords/gene-deletion","display_name":"gene deletion","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9200000166893005},{"id":"https://openalex.org/keywords/chromosomal-imbalances","display_name":"chromosomal imbalances","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gene-expression-analysis","display_name":"gene expression analysis","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5811336040496826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5468373894691467},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5171929597854614},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4485694468021393},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43223634362220764}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/124862","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstreams/688d24b2-8502-4648-a69c-c5ced3c72de7/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2804371972","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/124862","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2133969293","https://openalex.org/W7099341631","https://openalex.org/W7097347199","https://openalex.org/W2130951034","https://openalex.org/W2143498954","https://openalex.org/W2505458492","https://openalex.org/W2912156916","https://openalex.org/W2885374792","https://openalex.org/W1981286852","https://openalex.org/W1992693736"],"abstract_inverted_index":{"As":[0],"we":[1,294],"enter":[2],"the":[3,47,56,65,79,110,117,147,162,184,212,224,229,246,250,263,269,286,317],"post-genome":[4],"era":[5],"with":[6,40],"readily":[7],"available":[8],"technologies":[9],"for":[10,30,61,88],"global":[11],"profiling":[12],"of":[13,22,49,52,58,73,82,91,112,119,138,165,171,178,193,206,232,248,266,271,281,320],"gene":[14,33,42,53,83,142,157,179,240,259,272,307],"expression,":[15],"such":[16],"as":[17,85],"microarrays":[18],"and":[19,63,105,140,161,195,249,261,289,301],"Serial":[20],"Analysis":[21],"Gene":[23],"Expression":[24],"(SAGE),":[25],"there":[26],"is":[27,55,76],"great":[28],"potential":[29],"discovering":[31],"underlying":[32],"networks":[34],"that":[35,107],"could":[36],"not":[37],"be":[38],"possible":[39],"single":[41,258],"analyses.":[43],"One":[44],"bottleneck":[45],"in":[46,144,211,239,268,291,316],"investigation":[48],"rich":[50],"datasets":[51],"expression":[54,84,111,143,158,180,225,273,308],"lack":[57],"adequate":[59],"tools":[60],"analyzing":[62,89],"interpreting":[64],"high":[66],"dimensional":[67],"transcriptomic":[68],"data.":[69],"The":[70],"overarching":[71],"goal":[72,118],"this":[74,120,166,243,292],"dissertation":[75,244],"to":[77,135,153,168,190,220,227,285,298,313],"explore":[78],"chromosomal":[80,102,176,264],"organization":[81,265],"a":[86,128,204,257],"framework":[87],"transcriptomes":[90],"human":[92],"tumors.":[93,145],"Cancers":[94],"are":[95,295],"characterized":[96],"by":[97],"regional":[98,230,237],"genetic":[99],"damage":[100],"(e.g.":[101],"imbalances,":[103],"amplifications,":[104],"deletions)":[106],"potentially":[108],"affect":[109],"many":[113],"genes.":[114],"To":[115],"achieve":[116],"dissertation,":[121,293],"three":[122],"specific":[123],"projects":[124],"were":[125,217],"undertaken.":[126],"First,":[127],"model-based":[129,148,185],"scan":[130,149,186],"statistic":[131,150,187],"method":[132,167],"was":[133,151,181,188],"developed":[134,288],"define":[136,191],"regions":[137,170,177,192],"increased":[139,175],"decreased":[141],"Second,":[146],"applied":[152,290],"an":[154],"ovarian":[155,208],"cancer":[156,277],"data":[159,202,226,274],"set,":[160],"predictive":[163],"capacity":[164],"identify":[169],"amplification":[172,194],"based":[173,197,305],"on":[174,198,236,306],"assessed.":[182],"Finally,":[183],"used":[189],"deletion":[196],"genome-wide":[199],"copy":[200,233],"number":[201,234],"from":[203,223,276],"subset":[205],"those":[207,221],"tumors":[209],"analyzed":[210],"previous":[213],"project.":[214],"These":[215],"results":[216],"then":[218],"compared":[219],"obtained":[222,275],"assess":[228],"effect":[231],"alteration":[235],"alterations":[238],"expression.":[241],"Overall,":[242],"demonstrates":[245],"importance":[247],"additional":[251],"information":[252],"gained":[253],"when":[254],"moving":[255],"beyond":[256],"view":[260],"incorporating":[262],"genes":[267],"analysis":[270,283],"studies.":[278],"With":[279],"methods":[280],"genomic":[282,303],"similar":[284],"one":[287],"now":[296],"able":[297],"identify,":[299],"characterize,":[300],"predict":[302],"aberrations":[304],"changes,":[309],"which":[310],"may":[311],"lead":[312],"practical":[314],"advances":[315],"medical":[318],"treatment":[319],"cancers.":[321]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2018-06-01T00:00:00"}