{"id":"https://openalex.org/W2804369396","doi":"https://doi.org/10.1113/jp275937","title":"The relationship between GABA and stress: \u2018it's complicated\u2019","display_name":"The relationship between GABA and stress: \u2018it's complicated\u2019","publication_year":2018,"publication_date":"2018-03-10","ids":{"openalex":"https://openalex.org/W2804369396","doi":"https://doi.org/10.1113/jp275937","mag":"2804369396","pmid":"https://pubmed.ncbi.nlm.nih.gov/29524241","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5978385"},"language":"en","primary_location":{"id":"doi:10.1113/jp275937","doi":"https://doi.org/10.1113/jp275937","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jp275937","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5978385","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023589964","display_name":"Jamie L. Maguire","orcid":"https://orcid.org/0000-0002-4085-8605","observed_orcids":["https://orcid.org/0000-0002-4085-8605"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jamie Maguire","raw_affiliation_strings":["Neuroscience Department, Tufts University School of Medicine, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4085-8605","affiliations":[{"raw_affiliation_string":"Neuroscience Department, Tufts University School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023589964"],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":0.0978,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.36788176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"596","issue":"10","first_page":"1781","last_page":"1782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.4413999915122986,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9399999976158142},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9129999876022339},{"id":"https://openalex.org/keywords/paraventricular-nucleus","display_name":"paraventricular nucleus","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gabaergic-inhibition","display_name":"GABAergic inhibition","score":0.7720000147819519},{"id":"https://openalex.org/keywords/tonic-inhibition","display_name":"tonic inhibition","score":0.8690000176429749},{"id":"https://openalex.org/keywords/phasic-inhibition","display_name":"phasic inhibition","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gabab-receptors","display_name":"GABAB receptors","score":0.7710000276565552},{"id":"https://openalex.org/keywords/gaba-transporters","display_name":"GABA transporters","score":0.9169999957084656},{"id":"https://openalex.org/keywords/extrasynaptic-gaba-receptors","display_name":"extrasynaptic GABA receptors","score":0.8420000076293945},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.7620000243186951},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.6639999747276306},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.44699999690055847},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"negative feedback","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.8969116806983948},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.7211931943893433},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6723970174789429},{"id":"https://openalex.org/C127573956","wikidata":"https://www.wikidata.org/wiki/Q7821376","display_name":"Tonic (physiology)","level":2,"score":0.6177310943603516},{"id":"https://openalex.org/C2778458438","wikidata":"https://www.wikidata.org/wiki/Q386664","display_name":"Corticotropin-releasing hormone","level":3,"score":0.5254570245742798},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.4612978398799896},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4186333417892456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4181840419769287},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.3835896849632263},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3573971390724182},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3535698652267456},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34592610597610474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10039320588111877}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010906","descriptor_name":"Pituitary Hormone-Releasing Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1113/jp275937","doi":"https://doi.org/10.1113/jp275937","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jp275937","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5978385","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5978385","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:29524241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29524241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5978385","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5978385","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000900136","display_name":"CRH Dysregulation of Brainstem Autonomic Circuits Increases SUDEP Risk","funder_award_id":"R01NS102937","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1523733505","https://openalex.org/W2004846311","https://openalex.org/W2044645058","https://openalex.org/W2061888516","https://openalex.org/W2079578502","https://openalex.org/W2145691687","https://openalex.org/W2154223842","https://openalex.org/W2531903693","https://openalex.org/W2541962673","https://openalex.org/W2792541515"],"related_works":["https://openalex.org/W89585366","https://openalex.org/W2136574888","https://openalex.org/W2189782547","https://openalex.org/W1986556879","https://openalex.org/W2037152702","https://openalex.org/W2127520411","https://openalex.org/W2792541515","https://openalex.org/W2091326035","https://openalex.org/W2495534210","https://openalex.org/W2004846311"],"abstract_inverted_index":{"GABA":[0,98,265,274,570,589,649,863,902,986],"is":[1,177,253,441,511,641,664,764,1002],"well":[2,178],"known":[3],"to":[4,14,61,159,398,471,496,513,534,699,706,750,766,818,833,853,935,949],"be":[5,62,269,299,329,697,733,751,854],"a":[6,389,597,656,718,785,898,974],"critical":[7],"regulator":[8],"of":[9,19,30,42,50,75,82,102,113,129,149,172,183,200,203,214,236,250,273,287,294,322,326,334,340,353,367,379,382,392,402,406,459,530,588,643,648,658,681,702,724,728,741,780,795,799,821,824,837,845,890,924,942,954,962,1008],"the":[10,31,39,43,48,51,94,100,103,110,130,134,147,150,181,184,212,234,285,320,332,338,351,357,377,400,442,457,464,503,516,527,535,541,550,586,631,652,700,725,773,790,796,800,819,825,834,843,887,921,952,959,966,982,993],"body's":[11],"physiological":[12,739],"response":[13],"stress":[15,480,492,521,761,829,846,955],"through":[16,231,257],"tight":[17],"regulation":[18,101,182,366,381,458,889,923,941,961],"hypothalamic\u2013pituitary\u2013adrenal":[20],"(HPA)":[21],"axis":[22,124,136,186,827,878],"function":[23,336,599,640,677,851],"(Cullinan":[24],"et":[25,166,411,436,808,812],"al.":[26,167,412,437,809,813],"2008).":[27],"Nearly":[28],"half":[29],"synapses":[32],"onto":[33,789,910],"corticotropin-releasing":[34],"hormone":[35],"(CRH)":[36],"neurons":[37,57,252,309,355,461,629,748,912,926,964],"in":[38,99,180,197,233,356,384,448,450,520,526,545,553,569,600,610,630,704,776,862,886,900,907,928,939,958,977],"paraventricular":[40],"nucleus":[41],"hypothalamus":[44],"(PVN),":[45],"which":[46,71,267,297,453,663,691,731,868],"govern":[47],"activity":[49,121,352],"HPA":[52,104,123,135,185,465,791,826,877,967],"axis,":[53,105,968],"are":[54,72,310,387,469,620,947],"GABAergic.":[55],"CRH":[56,119,193,221,251,295,308,354,451,460,531,628,729,747,781,891,911,925,943,963],"have":[58,108,137,156,417,499,859,873,882],"been":[59,140,396,418,500],"shown":[60,397,420],"regulated":[63,311],"by":[64,79,205,271,301,312,331,584,736,1004],"both":[65,313],"phasic":[66,316,604],"and":[67,90,116,122,146,239,315,371,428,479,489,494,603,710,721,803,828,904,956,965,987,1011],"tonic":[68,240,291,314,368,581,602,659,693,777],"GABAergic":[69,76,114,218,229,241,248,292,317,348,369,528,574,605,726,778,805,822,888,908,922,940,960],"inhibition,":[70,318,370],"distinct":[73],"types":[74,325],"inhibition":[77,327,582,779,806],"mediated":[78],"specific":[80,407],"subtypes":[81],"GABAA":[83],"receptors":[84,191,619,709],"(GABAARs)":[85],"with":[86,483,866],"unique":[87,598,722],"pharmacological":[88],"properties":[89],"subcellular":[91],"distribution.":[92],"Despite":[93],"well-accepted":[95],"role":[96,820],"for":[97,421,444,543,997],"few":[106,857],"laboratories":[107],"investigated":[109,860],"functional":[111],"contribution":[112],"signalling":[115,230,684,909],"plasticity":[117],"on":[118,162,189,192,216,259,361,623,627,688,840,847,876,920,992],"neuronal":[120],"function.":[125,879],"In":[126,831],"fact,":[127],"many":[128],"synaptic":[131],"mechanisms":[132,219,349,378,416,745],"regulating":[133,220],"only":[138,665],"recently":[139],"elucidated":[141],"(Levy":[142],"&":[143,207,507,558,612,914,930],"Tasker,":[144,915],"2012),":[145],"authors":[148,224,244,653],"article":[151,196],"that":[152,226,247,282,307,515,563,594,616,636,673,768],"this":[153,163,198,278,343,385,473,758,869,970],"Perspective":[154],"highlights":[155],"contributed":[157],"considerably":[158],"our":[160,979],"knowledge":[161,980],"topic":[164],"(Bains":[165],"2015).":[168],"The":[169,195,201,223,243,561,738,917,989,1000],"negative":[170,787],"feedback":[171,788],"glucocorticoids,":[173],"including":[174,425,893],"corticosterone":[175],"(CORT),":[176],"established":[179],"involving":[187],"actions":[188,258,687],"glucocorticoid":[190],"neurons.":[194,222,944],"issue":[199],"Journal":[202],"Physiology":[204],"Colmers":[206,611,929],"Bains":[208,613,931],"(2018)":[209,614,932],"further":[210,734,816],"examines":[211],"effects":[213,836,844,875,919],"CORT":[215,227,536,839,957],"diverse":[217],"demonstrate":[225,306,615,655],"alters":[228],"changes":[232,447,519,525,861,885,938],"expression":[235,401,548,849],"postsynaptic":[237,373],"GABAARs":[238,383,403,449,690],"inhibition.":[242,606,669,694],"also":[245,280,419,455,654],"expose":[246],"control":[249,293,529,727,823],"constitutively":[254,621],"under":[255],"suppression":[256,647],"presynaptic":[260,362,566,617,624,682,707,901],"GABAB":[261,363,618,683,708],"receptors,":[262,364,592],"thereby":[263,572],"minimizing":[264],"release,":[266,571,903],"can":[268,298],"enhanced":[270],"blockade":[272],"transporters":[275],"(GATs).":[276],"Further,":[277,607],"study":[279,344,870,972],"demonstrates":[281,345],"GATs":[283,564,595,703],"suppress":[284],"activation":[286],"extrasynaptic":[288,579,689,711],"GABAARs,":[289],"limiting":[290,585,645],"neurons,":[296,452,532,730,782,892],"unmasked":[300,666],"blocking":[302],"GATs.":[303],"These":[304,633],"data":[305,608],"although":[319],"magnitude":[321],"these":[323,591,715,742,769,936],"different":[324],"may":[328,454,523,696,732,872,933],"modified":[330],"extent":[333],"GAT":[335,365,639,668,676,848],"and/or":[337,850],"presence":[339],"CORT.":[341],"Thus,":[342,439],"three":[346],"separate":[347],"controlling":[350,746],"PVN:":[358],"GAT-mediated":[359],"influence":[360,760],"CORT-mediated":[372,743,774,918],"GABAAR":[374,408,546,841,895],"regulation.":[375],"Although":[376],"corticosterone-mediated":[380],"context":[386],"unknown,":[388],"neuroactive":[390],"derivative":[391],"corticosterone,":[393],"THDOC,":[394],"has":[395],"regulate":[399],"via":[404],"phosphorylation":[405],"subunits":[409],"(Abramian":[410],"2014).":[413,509,560],"Interestingly,":[414],"similar":[415,533],"other":[422,554],"steroid":[423],"hormones,":[424],"ovarian":[426,445,478,487],"hormones":[427,488],"their":[429],"neurosteroid":[430],"derivatives,":[431],"such":[432,771],"as":[433,772],"allopregnanolone":[434],"(Modgil":[435],"2017).":[438],"there":[440],"potential":[443,474,835],"hormone-mediated":[446],"impact":[456],"and,":[462],"thus,":[463],"axis.":[466,792],"Further":[467],"studies":[468,858,881,946],"required":[470,948],"investigate":[472],"novel":[475,719,786],"mechanism":[476,720,759],"linking":[477],"hormones.":[481],"Consistent":[482],"an":[484],"interaction":[485],"between":[486,985],"stress,":[490,867],"altered":[491,894],"reactivity":[493,522],"vulnerability":[495],"mood":[497],"disorders":[498],"demonstrated":[501,883,927],"over":[502,549],"oestrous":[504,517,551],"cycle":[505,552],"(MacKenzie":[506,557],"Maguire,":[508,559],"It":[510,763],"tempting":[512],"speculate":[514],"cycle-linked":[518],"involve":[524],"observations":[537],"described":[538],"here,":[539],"given":[540],"evidence":[542,562,794],"alterations":[544],"subunit":[547,896],"brain":[555],"regions":[556],"limit":[565],"GABAB-mediated":[567,646],"reduction":[568,899],"facilitating":[573],"signalling,":[575],"whereas,":[576],"they":[577],"prevent":[578],"GABAAR-mediated":[580],"postsynaptically,":[583],"concentration":[587],"reaching":[590],"suggests":[593,871],"perform":[596],"balancing":[601],"presented":[609],"active":[622],"terminals":[625],"impinging":[626],"PVN.":[632],"findings":[634,716],"suggest":[635],"at":[637,661,674],"baseline":[638,675],"incapable":[642],"completely":[644],"release.":[650],"However,":[651,793],"lack":[657],"current":[660],"baseline,":[662],"after":[667],"Therefore,":[670],"it":[671],"appears":[672],"allows":[678],"some":[679],"degree":[680],"but":[685,969],"not":[686],"mediate":[692],"This":[695],"due":[698],"localization":[701],"relation":[705],"GABAARs.":[712],"Either":[713],"way,":[714],"reveal":[717],"tuning":[723],"influenced":[735],"stress.":[737,988],"relevance":[740],"regulatory":[744],"remains":[749,852],"fully":[752,950],"explored.":[753],"For":[754],"example,":[755],"how":[756],"does":[757],"reactivity?":[762],"reasonable":[765],"assume":[767],"changes,":[770],"increase":[775],"would":[783],"provide":[784],"stress-induced":[797,838,884,937],"collapse":[798],"chloride":[801],"gradient":[802],"compromised":[804],"(Hewitt":[807],"2009;":[810],"Sarkar":[811],"2011)":[814],"add":[815],"complexity":[817],"reactivity.":[830],"addition":[832],"regulation,":[842],"determined.":[855],"Very":[856],"uptake":[864],"associated":[865],"profound":[874],"Previous":[880],"expression,":[897],"overall":[905],"impairments":[906],"(Herman":[913],"2016).":[916],"contribute":[934],"Future":[945],"appreciate":[951],"roles":[953],"highlighted":[971],"takes":[973],"huge":[975],"step":[976],"furthering":[978],"regarding":[981],"complicated":[983],"relationship":[984],"author":[990,1001],"serves":[991],"Scientific":[994],"Advisory":[995],"Board":[996],"SAGE":[998],"Therapeutics.":[999],"funded":[1003],"NIH":[1005],"National":[1006],"Institute":[1007],"Neurological":[1009],"Disorders":[1010],"Stroke":[1012],"(NS102937).":[1013]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-06-01T00:00:00"}