{"id":"https://openalex.org/W2804268743","doi":"https://doi.org/10.1158/0008-5472.can-18-0056","title":"Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells","display_name":"Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells","publication_year":2018,"publication_date":"2018-05-16","ids":{"openalex":"https://openalex.org/W2804268743","doi":"https://doi.org/10.1158/0008-5472.can-18-0056","mag":"2804268743","pmid":"https://pubmed.ncbi.nlm.nih.gov/29769195","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6050076"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-18-0056","doi":"https://doi.org/10.1158/0008-5472.can-18-0056","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-0056","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6050076","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086895094","display_name":"Shengzhi Liu","orcid":"https://orcid.org/0000-0002-3286-5071","observed_orcids":["https://orcid.org/0000-0002-3286-5071"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Shengzhi Liu","raw_affiliation_strings":["1Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin, China","2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014353709","display_name":"Yao Fan","orcid":"https://orcid.org/0009-0002-8222-6742","observed_orcids":["https://orcid.org/0009-0002-8222-6742","https://orcid.org/0000-0002-4393-7296"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yao Fan","raw_affiliation_strings":["1Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin, China","2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101500415","display_name":"Andy B. Chen","orcid":"https://orcid.org/0000-0001-5960-5483","observed_orcids":["https://orcid.org/0000-0001-5960-5483"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy Chen","raw_affiliation_strings":["2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074904383","display_name":"Aydin Jalali","orcid":"https://orcid.org/0009-0008-8529-3629","observed_orcids":["https://orcid.org/0009-0008-8529-3629"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aydin Jalali","raw_affiliation_strings":["2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045000295","display_name":"Kazumasa Minami","orcid":"https://orcid.org/0000-0002-3864-6478","observed_orcids":["https://orcid.org/0000-0002-3864-6478"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumasa Minami","raw_affiliation_strings":["3Department of Radiation Oncology, Osaka University Graduate School of Medicine Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Radiation Oncology, Osaka University Graduate School of Medicine Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101750702","display_name":"Kazuhiko Ogawa","orcid":"https://orcid.org/0000-0001-8872-7690","observed_orcids":["https://orcid.org/0000-0001-8872-7690"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Ogawa","raw_affiliation_strings":["3Department of Radiation Oncology, Osaka University Graduate School of Medicine Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Radiation Oncology, Osaka University Graduate School of Medicine Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077837457","display_name":"Harikrishna Nakshatri","orcid":"https://orcid.org/0000-0001-8876-0052","observed_orcids":["https://orcid.org/0000-0001-8876-0052"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harikrishna Nakshatri","raw_affiliation_strings":["4Department of Surgery, Simon Cancer Research Center, Indiana University School of Medicine, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Surgery, Simon Cancer Research Center, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101817833","display_name":"Bai\u2010Yan Li","orcid":"https://orcid.org/0000-0002-1853-0216","observed_orcids":["https://orcid.org/0000-0002-1853-0216","https://orcid.org/0000-0002-6837-3220"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bai-Yan Li","raw_affiliation_strings":["1Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin, China"],"raw_orcid":"https://orcid.org/0000-0002-1853-0216","affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081940051","display_name":"Hiroki Yokota","orcid":"https://orcid.org/0000-0002-7881-8959","observed_orcids":["https://orcid.org/0000-0002-7881-8959"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Hiroki Yokota","raw_affiliation_strings":["1Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin, China","2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"2Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5081940051","https://openalex.org/A5101817833"],"corresponding_institution_ids":["https://openalex.org/I156144747","https://openalex.org/I55769427"],"apc_list":null,"apc_paid":null,"fwci":3.0306,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.94579402,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"78","issue":"14","first_page":"3865","last_page":"3876"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0982000008225441,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.06480000168085098,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.6610000133514404},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/fluphenazine","display_name":"fluphenazine","score":0.8619999885559082},{"id":"https://openalex.org/keywords/trifluoperazine","display_name":"trifluoperazine","score":1.0},{"id":"https://openalex.org/keywords/mammary-tumor-cells","display_name":"mammary tumor cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-bone-interaction","display_name":"tumor-bone interaction","score":0.7540000081062317},{"id":"https://openalex.org/keywords/bone-microenvironment","display_name":"bone microenvironment","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nfatc1","display_name":"NFATc1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7910000085830688},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.765999972820282},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.6790000200271606},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.968999981880188},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.7459999918937683},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.7717808485031128},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5754309892654419},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.566645085811615},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5161734223365784},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.5006563663482666},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48806774616241455},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46634596586227417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4188508093357086},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4130024313926697},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39665868878364563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35694363713264465},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3541536033153534},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.2956501841545105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28155744075775146},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.25455060601234436},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.24011415243148804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21658754348754883},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08086153864860535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071250","descriptor_name":"Snail Family Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005476","descriptor_name":"Fluphenazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014268","descriptor_name":"Trifluoperazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015674","descriptor_name":"Mammary Neoplasms, Animal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015674","descriptor_name":"Mammary Neoplasms, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1158/0008-5472.can-18-0056","doi":"https://doi.org/10.1158/0008-5472.can-18-0056","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-0056","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:29769195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29769195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5589203","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6050076","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6050076","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6050076","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/20843","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/20843","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/20843","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1805/20843","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"mag:2980463321","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.iupui.edu/bitstream/1805/20843/1/nihms969000.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306522653","display_name":"PMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5589203","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6050076","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1348640587","display_name":"Mechanical Loading and Bone","funder_award_id":"R01AR052144","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4626858580","display_name":"Novel approach with chemoradiotherapy for bone metastasis on breast cancer","funder_award_id":"18K15318","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W7424893","https://openalex.org/W45776812","https://openalex.org/W192311296","https://openalex.org/W1207983231","https://openalex.org/W1536326448","https://openalex.org/W1964847767","https://openalex.org/W1968335172","https://openalex.org/W1985101172","https://openalex.org/W1988033690","https://openalex.org/W2003213153","https://openalex.org/W2009079495","https://openalex.org/W2011828467","https://openalex.org/W2015963176","https://openalex.org/W2019582558","https://openalex.org/W2026815880","https://openalex.org/W2027560347","https://openalex.org/W2038419308","https://openalex.org/W2043735343","https://openalex.org/W2051926344","https://openalex.org/W2060385016","https://openalex.org/W2060960690","https://openalex.org/W2061177902","https://openalex.org/W2073557556","https://openalex.org/W2097744565","https://openalex.org/W2100235659","https://openalex.org/W2101547995","https://openalex.org/W2102969047","https://openalex.org/W2114715627","https://openalex.org/W2127662432","https://openalex.org/W2152790619","https://openalex.org/W2153272445","https://openalex.org/W2316245666","https://openalex.org/W2409521202","https://openalex.org/W2534152327","https://openalex.org/W2588238973","https://openalex.org/W2604977022","https://openalex.org/W2622329638","https://openalex.org/W2967912579","https://openalex.org/W2978178775","https://openalex.org/W4210530390","https://openalex.org/W4210552414","https://openalex.org/W4237593632"],"related_works":["https://openalex.org/W2604977022","https://openalex.org/W2807204181","https://openalex.org/W2587749267","https://openalex.org/W2610349459","https://openalex.org/W2352044271","https://openalex.org/W1570780042","https://openalex.org/W1483633293","https://openalex.org/W1985331277","https://openalex.org/W2913974430","https://openalex.org/W2038345192"],"abstract_inverted_index":{"Abstract":[0],"While":[1],"bone":[2,65,136,178,192],"is":[3,12],"a":[4,149],"frequent":[5],"target":[6],"of":[7,17,23,31,53,71,103,117,165,172,197],"breast":[8],"cancer\u2013associated":[9],"metastasis,":[10],"little":[11],"known":[13],"about":[14],"the":[15,21,29,114,135,176,187,191,195],"effects":[16,196],"tumor\u2013bone":[18],"interactions":[19,96,125,160],"on":[20,39,121,200],"efficacy":[22],"tumor-suppressing":[24],"agents.":[25],"Here":[26],"we":[27],"examined":[28],"effect":[30],"two":[32],"FDA-approved":[33],"dopamine":[34,60,162,198],"modulators,":[35],"fluphenazine":[36,104,118],"and":[37,45,51,63,91,95,105,109,119,132,141,194,204],"trifluoperazine,":[38],"mammary":[40,54,152,201],"tumor":[41,55,84,122,127,153,166,173,202],"cells,":[42,74],"osteoclasts,":[43],"osteoblasts,":[44],"osteocytes.":[46,205],"These":[47,155,181],"agents":[48],"suppressed":[49,110],"proliferation":[50,128,174],"migration":[52,167],"cells":[56,85,203],"chiefly":[57],"by":[58,67,129],"antagonizing":[59],"receptor":[61],"D2":[62],"reduced":[64],"resorption":[66],"downregulating":[68],"nuclear":[69],"factor":[70],"activated":[72],"T":[73],"cytoplasmic":[75],"1":[76],"(Nfatc1).":[77],"Three-dimensional":[78],"spheroid":[79],"formation":[80],"assays":[81],"revealed":[82],"that":[83,158],"have":[86],"high":[87],"affinity":[88],"to":[89,151],"osteocytes":[90,98,138],"type":[92],"I":[93],"collagen,":[94],"with":[97],"as":[99,101,143,146,148],"well":[100,147],"administration":[102],"trifluoperazine":[106,120],"downregulated":[107,139],"Snail":[108,140],"migratory":[111],"behaviors.":[112],"Unlike":[113],"inhibitory":[115],"action":[116],"growth,":[123],"tumor\u2013osteocyte":[124,159],"stimulated":[126],"upregulating":[130],"NF\u03baB":[131],"Akt.":[133],"In":[134],"microenvironment,":[137],"acted":[142],"an":[144],"attractant":[145],"stimulant":[150],"cells.":[154],"results":[156],"demonstrate":[157],"strengthen":[161],"receptor\u2013mediated":[163],"suppression":[164],"but":[168],"weaken":[169],"its":[170],"inhibition":[171],"in":[175,190],"osteocyte-rich":[177],"microenvironment.":[179],"Significance:":[180],"findings":[182],"provide":[183],"novel":[184],"insight":[185],"into":[186],"cellular":[188],"cross-talk":[189],"microevironment":[193],"modulators":[199],"Cancer":[206],"Res;":[207],"78(14);":[208],"3865\u201376.":[209],"\u00a92018":[210],"AACR.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}
