{"id":"https://openalex.org/W2804156293","doi":"https://doi.org/10.5958/0975-6892.2018.00016.3","title":"Inhibitory activity of Urena lobata leaf extract on dipeptidyl peptidase-4 (DPP-4): Is it different in vitro and in vivo?","display_name":"Inhibitory activity of Urena lobata leaf extract on dipeptidyl peptidase-4 (DPP-4): Is it different in vitro and in vivo?","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2804156293","doi":"https://doi.org/10.5958/0975-6892.2018.00016.3","mag":"2804156293"},"language":"en","primary_location":{"id":"doi:10.5958/0975-6892.2018.00016.3","doi":"https://doi.org/10.5958/0975-6892.2018.00016.3","is_oa":false,"landing_page_url":"https://doi.org/10.5958/0975-6892.2018.00016.3","pdf_url":null,"source":{"id":"https://openalex.org/S2764880231","display_name":"Medicinal Plants - International Journal of Phytomedicines and Related Industries","issn_l":"0975-4261","issn":["0975-4261","0975-6892"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Plants - International Journal of Phytomedicines and Related Industries","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041875787","display_name":"Yudi Purnomo","orcid":"https://orcid.org/0000-0002-2435-4976","observed_orcids":["https://orcid.org/0000-0002-2435-4976"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yudi Purnomo","raw_affiliation_strings":["Islamic University of Malang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Islamic University of Malang","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024578857","display_name":"Djoko Wahono Soeatmadji","orcid":"https://orcid.org/0000-0003-3475-5172","observed_orcids":["https://orcid.org/0000-0003-3475-5172"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"DjokoW Soeatmadji","raw_affiliation_strings":["Brawijaya University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brawijaya University","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090621571","display_name":"Sutiman Bambang Sumitro","orcid":"https://orcid.org/0000-0001-8001-4338","observed_orcids":["https://orcid.org/0000-0001-8001-4338"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sutiman Bambang Sumitro","raw_affiliation_strings":["Brawijaya University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brawijaya University","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"last","author":{"id":null,"display_name":"Moch Aris Widodo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Moch Aris Widodo","raw_affiliation_strings":["Brawijaya University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brawijaya University","institution_ids":["https://openalex.org/I177055848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1818,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.50844375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"10","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urena-lobata","display_name":"Urena lobata","score":1.0},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dpp-4-inhibition","display_name":"DPP-4 inhibition","score":0.9750000238418579},{"id":"https://openalex.org/keywords/anti-diabetic-effects","display_name":"anti-diabetic effects","score":0.7329999804496765},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.847000002861023},{"id":"https://openalex.org/keywords/in-vivo-versus-in-vitro-comparison","display_name":"in vivo and in vitro comparison","score":0.6370000243186951},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.8029999732971191},{"id":"https://openalex.org/keywords/aqueous-extract","display_name":"aqueous extract","score":0.8809999823570251},{"id":"https://openalex.org/keywords/animal-models-of-diabetes","display_name":"animal models of diabetes","score":0.5979999899864197},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2776704787","wikidata":"https://www.wikidata.org/wiki/Q149121","display_name":"Lobata","level":4,"score":0.903355598449707},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8790044784545898},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.6233202219009399},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5788922905921936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5419110059738159},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.496175616979599},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.47212323546409607},{"id":"https://openalex.org/C2777472216","wikidata":"https://www.wikidata.org/wiki/Q133126","display_name":"Pueraria","level":3,"score":0.378667950630188},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3657796382904053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2616272568702698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2527216076850891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18040159344673157},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06799975037574768},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05303266644477844},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5958/0975-6892.2018.00016.3","doi":"https://doi.org/10.5958/0975-6892.2018.00016.3","is_oa":false,"landing_page_url":"https://doi.org/10.5958/0975-6892.2018.00016.3","pdf_url":null,"source":{"id":"https://openalex.org/S2764880231","display_name":"Medicinal Plants - International Journal of Phytomedicines and Related Industries","issn_l":"0975-4261","issn":["0975-4261","0975-6892"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Plants - International Journal of Phytomedicines and Related Industries","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3140791321","https://openalex.org/W4360776507","https://openalex.org/W2460462533","https://openalex.org/W2333838444","https://openalex.org/W4415649316","https://openalex.org/W4401236853","https://openalex.org/W2520301976","https://openalex.org/W7119523194","https://openalex.org/W4415715522","https://openalex.org/W7122806262"],"abstract_inverted_index":{"This":[0],"study":[1,80,161],"was":[2,28,64,76],"aimed":[3],"to":[4,35,155,195,201],"compare":[5],"the":[6,59,73,130,142,165,185,202],"anti":[7],"diabetic":[8],"effect":[9],"of":[10,42,56,62,85,104,118,121,133,145,167,188,204],"Urena":[11,25],"lobata":[12,26,123,147,190],"leaf":[13,27],"extract":[14,110,120,128,144,157,187,197],"through":[15],"DPP-4":[16,40,57,98,115,151,205],"inhibitory":[17,116],"activity":[18,38,117],"by":[19,66,172,184],"in":[20,23,30,43,46,96,113,159],"vitro":[21,44,49,114],"and":[22,32,45,58,91,102,136,174],"vivo.":[24,47],"extracted":[29],"ethanol":[31],"hot":[33],"water":[34,127,143,186],"evaluate":[36],"its":[37],"on":[39],"both":[41],"In":[48,78],"test":[50,93],"using":[51],"Gly-pro-p-nitroanilide":[52],"(GPPN)":[53],"as":[54,162,164],"substrate":[55],"reactions":[60],"product":[61],"them":[63],"observed":[65],"microplate":[67],"reader":[68],"at":[69],"?=405":[70],"nm":[71],"furthermore":[72],"IC50":[74,131],"value":[75,132],"determined.":[77],"vivo":[79,160],"utilize":[81],"an":[82],"animal":[83],"model":[84],"diabetes":[86],"with":[87,129],"2":[88],"control":[89],"groups":[90,94],"6":[92],"(n=4),":[95],"which":[97],"level,":[99],"GLP-1":[100,178],"level":[101,152,179],"AUC":[103,166],"blood":[105,168],"glucose":[106,169],"were":[107,170],"examined":[108],"after":[109],"administration.":[111],"The":[112],"ethanolic":[119,156,196],"U.":[122,146,189],"is":[124],"higher":[125],"than":[126],"1654,":[134],"64":[135],"6489,":[137],"88":[138],"\u00b5g/ml":[139],"respectively.":[140,176],"However,":[141],"exhibits":[148],"stronger":[149],"decrease":[150],"(60\u201370%)":[153],"compared":[154,194],"(40\u201360%)":[158],"well":[163],"reduced":[171],"50\u201360%":[173],"20\u201350%,":[175],"Meanwhile,":[177],"could":[180],"be":[181],"retained":[182],"more":[183],"administration":[191],"(3\u20137":[192],"fold)":[193,199],"(25":[198],"due":[200],"reducing":[203],"activity.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2018-06-01T00:00:00"}
