{"id":"https://openalex.org/W2804134539","doi":"https://doi.org/10.1155/2018/9276380","title":"The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health","display_name":"The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2804134539","doi":"https://doi.org/10.1155/2018/9276380","mag":"2804134539","pmid":"https://pubmed.ncbi.nlm.nih.gov/29951549","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5987305"},"language":"en","primary_location":{"id":"doi:10.1155/2018/9276380","doi":"https://doi.org/10.1155/2018/9276380","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/9276380","pdf_url":"http://downloads.hindawi.com/journals/bmri/2018/9276380.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2804134539"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://downloads.hindawi.com/journals/bmri/2018/9276380.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R. A. G. Khammissa","orcid":"https://orcid.org/0000-0002-8599-8249","observed_orcids":["https://orcid.org/0000-0002-8599-8249"]},"institutions":[{"id":"https://openalex.org/I2802393258","display_name":"Sefako Makgatho Health Sciences University","ror":"https://ror.org/003hsr719","country_code":"ZA","type":"education","lineage":["https://openalex.org/I2802393258"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"R. A. G. Khammissa","raw_affiliation_strings":["Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa"],"raw_orcid":"https://orcid.org/0000-0002-8599-8249","affiliations":[{"raw_affiliation_string":"Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa","institution_ids":["https://openalex.org/I2802393258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005298299","display_name":"Jeanine Fourie","orcid":"https://orcid.org/0000-0002-8674-8145","observed_orcids":["https://orcid.org/0000-0002-8674-8145"]},"institutions":[{"id":"https://openalex.org/I2802393258","display_name":"Sefako Makgatho Health Sciences University","ror":"https://ror.org/003hsr719","country_code":"ZA","type":"education","lineage":["https://openalex.org/I2802393258"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"J. Fourie","raw_affiliation_strings":["Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa","institution_ids":["https://openalex.org/I2802393258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003057432","display_name":"Mojakgomo Hendrick Motswaledi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802393258","display_name":"Sefako Makgatho Health Sciences University","ror":"https://ror.org/003hsr719","country_code":"ZA","type":"education","lineage":["https://openalex.org/I2802393258"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"M. H. Motswaledi","raw_affiliation_strings":["Department of Dermatology, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, Medunsa, 0204 Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, Medunsa, 0204 Pretoria, South Africa","institution_ids":["https://openalex.org/I2802393258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001013545","display_name":"Raoul Ballyram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802393258","display_name":"Sefako Makgatho Health Sciences University","ror":"https://ror.org/003hsr719","country_code":"ZA","type":"education","lineage":["https://openalex.org/I2802393258"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"R. Ballyram","raw_affiliation_strings":["Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa","institution_ids":["https://openalex.org/I2802393258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112249632","display_name":"Johan Lemmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802393258","display_name":"Sefako Makgatho Health Sciences University","ror":"https://ror.org/003hsr719","country_code":"ZA","type":"education","lineage":["https://openalex.org/I2802393258"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"J. Lemmer","raw_affiliation_strings":["Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa","institution_ids":["https://openalex.org/I2802393258"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043524804","display_name":"L. Feller","orcid":"https://orcid.org/0000-0001-8209-153X","observed_orcids":["https://orcid.org/0000-0001-8209-153X"]},"institutions":[{"id":"https://openalex.org/I2802393258","display_name":"Sefako Makgatho Health Sciences University","ror":"https://ror.org/003hsr719","country_code":"ZA","type":"education","lineage":["https://openalex.org/I2802393258"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"L. Feller","raw_affiliation_strings":["Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa"],"raw_orcid":"https://orcid.org/0000-0001-8209-153X","affiliations":[{"raw_affiliation_string":"Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, 0204, South Africa","institution_ids":["https://openalex.org/I2802393258"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802393258"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":2.8959,"has_fulltext":true,"cited_by_count":288,"citation_normalized_percentile":{"value":0.9444864,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"2018","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":1.0},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.8709999918937683},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d","display_name":"1,25-dihydroxyvitamin D","score":0.9860000014305115},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6850000023841858},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.753000020980835},{"id":"https://openalex.org/keywords/cardiovascular-system","display_name":"cardiovascular system","score":0.8420000076293945},{"id":"https://openalex.org/keywords/skin-biology","display_name":"skin biology","score":0.75},{"id":"https://openalex.org/keywords/oral-health","display_name":"oral health","score":0.9879999756813049},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.925000011920929},{"id":"https://openalex.org/keywords/vitamin-d-response-element","display_name":"vitamin D response element","score":0.8500000238418579},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.8990383148193359},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.7162488698959351},{"id":"https://openalex.org/C128821507","wikidata":"https://www.wikidata.org/wiki/Q3454518","display_name":"Retinoid X receptor","level":5,"score":0.6389912366867065},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6116889715194702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6036858558654785},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.5189118981361389},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.46956944465637207},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.45589473843574524},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4303472340106964},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.4290018081665039},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3981616795063019},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38979172706604004},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3589473366737366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3541315793991089},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3522546887397766},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.32433027029037476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21586459875106812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1841341257095337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11500737071037292}],"mesh":[{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002320","descriptor_name":"Cardiovascular Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009909","descriptor_name":"Oral Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018167","descriptor_name":"Receptors, Calcitriol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2018/9276380","doi":"https://doi.org/10.1155/2018/9276380","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/9276380","pdf_url":"http://downloads.hindawi.com/journals/bmri/2018/9276380.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4968607","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5987305","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29951549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29951549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed research international","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5987305","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5987305/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Res Int","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2018/9276380","doi":"https://doi.org/10.1155/2018/9276380","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/9276380","pdf_url":"http://downloads.hindawi.com/journals/bmri/2018/9276380.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804134539.pdf","grobid_xml":"https://content.openalex.org/works/W2804134539.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W158524654","https://openalex.org/W1532323817","https://openalex.org/W1568642180","https://openalex.org/W1599765837","https://openalex.org/W1976472175","https://openalex.org/W1994006843","https://openalex.org/W1999720487","https://openalex.org/W2003593645","https://openalex.org/W2005616695","https://openalex.org/W2009307285","https://openalex.org/W2013857309","https://openalex.org/W2016448652","https://openalex.org/W2029299568","https://openalex.org/W2045198418","https://openalex.org/W2063516288","https://openalex.org/W2066403429","https://openalex.org/W2082299940","https://openalex.org/W2085084864","https://openalex.org/W2099427478","https://openalex.org/W2106561353","https://openalex.org/W2113433690","https://openalex.org/W2118540989","https://openalex.org/W2119739932","https://openalex.org/W2122786472","https://openalex.org/W2124070987","https://openalex.org/W2131610958","https://openalex.org/W2137303237","https://openalex.org/W2139260426","https://openalex.org/W2155663446","https://openalex.org/W2160298874","https://openalex.org/W2161361894","https://openalex.org/W2170556033","https://openalex.org/W2254563264","https://openalex.org/W2259501594","https://openalex.org/W2265344969","https://openalex.org/W2335213194","https://openalex.org/W2470895903","https://openalex.org/W2586643098","https://openalex.org/W2609966193","https://openalex.org/W2762467853"],"related_works":["https://openalex.org/W7097985526","https://openalex.org/W2408306070","https://openalex.org/W2041010357","https://openalex.org/W2147907133","https://openalex.org/W2063516288","https://openalex.org/W2476457012","https://openalex.org/W2031177627","https://openalex.org/W2169341159","https://openalex.org/W2401923901","https://openalex.org/W4211039436"],"abstract_inverted_index":{"Vitamin":[0],"D":[1,54,80,126,146],"plays":[2],"an":[3],"important":[4],"role":[5,123],"in":[6,83,127,148],"calcium":[7,171],"homeostasis":[8],"and":[9,18,24,26,31,170,175,183],"bone":[10,169],"metabolism,":[11],"with":[12,65,99],"the":[13,35,48,66,121,141,149,164,181],"capacity":[14],"to":[15,75,91,139,177],"modulate":[16],"innate":[17],"adaptive":[19],"immune":[20,184],"function,":[21,23],"cardiovascular":[22,182],"proliferation":[25],"differentiation":[27],"of":[28,39,44,124,144,153,166],"both":[29],"normal":[30],"malignant":[32],"keratinocytes.":[33],"1,25(OH)2D,":[34,60],"biologically":[36],"active":[37],"form":[38],"vitamin":[40,53,79,125,145],"D,":[41],"exerts":[42,108],"most":[43],"its":[45,93,109,178],"functions":[46],"through":[47],"almost":[49],"universally":[50],"distributed":[51],"nuclear":[52],"receptor":[55,69],"(VDR).":[56],"Upon":[57],"stimulation":[58],"by":[59],"VDR":[61,96],"forms":[62],"a":[63],"heterodimer":[64],"retinoid":[67],"X":[68],"(RXR).":[70],"In":[71,89,104,159],"turn,":[72],"VDR/RXR":[73],"binds":[74],"DNA":[76],"sequences":[77],"termed":[78],"response":[81],"elements":[82],"target":[84],"genes,":[85],"regulating":[86,113],"gene":[87,115],"transcription.":[88],"order":[90],"exert":[92],"biological":[94,110,129],"effects,":[95],"signalling":[97,102],"interacts":[98],"other":[100],"intracellular":[101],"pathways.":[103],"some":[105],"cases":[106],"1,25(OH)2D":[107,167],"effects":[111,165,179],"without":[112],"either":[114],"expression":[116],"or":[117,151,156],"protein":[118],"synthesis.":[119],"Although":[120],"regulatory":[122],"many":[128],"processes":[130],"is":[131,135],"well":[132],"documented,":[133],"there":[134],"not":[136],"enough":[137],"evidence":[138],"support":[140],"therapeutic":[142],"use":[143],"supplementation":[147],"prevention":[150],"treatment":[152],"infectious,":[154],"immunoinflammatory,":[155],"hyperproliferative":[157],"disorders.":[158],"this":[160],"review":[161],"we":[162],"highlight":[163],"on":[168,173,180],"homeostasis,":[172],"cancer,":[174],"refer":[176],"systems.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":45},{"year":2024,"cited_by_count":53},{"year":2023,"cited_by_count":45},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":52},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2018-06-01T00:00:00"}
