{"id":"https://openalex.org/W2804071071","doi":"https://doi.org/10.1159/000489764","title":"Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages","display_name":"Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2804071071","doi":"https://doi.org/10.1159/000489764","mag":"2804071071","pmid":"https://pubmed.ncbi.nlm.nih.gov/29763919"},"language":"en","primary_location":{"id":"doi:10.1159/000489764","doi":"https://doi.org/10.1159/000489764","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000489764","pdf_url":"https://www.karger.com/Article/Pdf/489764","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.karger.com/Article/Pdf/489764","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100683153","display_name":"Xiao Chen","orcid":"https://orcid.org/0000-0003-4517-0508","observed_orcids":["https://orcid.org/0000-0003-4517-0508"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Chen","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jin Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Cui","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","Graduate Management Unit, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Graduate Management Unit, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070801947","display_name":"Xiao Zhai","orcid":"https://orcid.org/0000-0003-4236-2264","observed_orcids":["https://orcid.org/0000-0003-4236-2264"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Zhai","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100742017","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0002-5843-8705","observed_orcids":["https://orcid.org/0000-0002-5843-8705"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084217015","display_name":"Zhengrong Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhengrong Gu","raw_affiliation_strings":["Department of Orthopedics, Jing'an district centre hospital of Shanghai, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Jing'an district centre hospital of Shanghai, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100846080","display_name":"Xin Zhi","orcid":"https://orcid.org/0000-0001-9035-423X","observed_orcids":["https://orcid.org/0000-0001-9035-423X"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zhi","raw_affiliation_strings":["Graduate Management Unit, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Management Unit, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005332938","display_name":"Weizong Weng","orcid":"https://orcid.org/0000-0003-3918-2334","observed_orcids":["https://orcid.org/0000-0003-3918-2334"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weizong Weng","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090900898","display_name":"Panpan Pan","orcid":"https://orcid.org/0000-0002-1601-7283","observed_orcids":["https://orcid.org/0000-0002-1601-7283"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panpan Pan","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059000567","display_name":"Liehu Cao","orcid":"https://orcid.org/0000-0002-0259-9980","observed_orcids":["https://orcid.org/0000-0002-0259-9980"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liehu Cao","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022996582","display_name":"Fang Ji","orcid":"https://orcid.org/0000-0002-7471-0115","observed_orcids":["https://orcid.org/0000-0002-7471-0115"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Ji","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449958","display_name":"Zhiwei Wang","orcid":"https://orcid.org/0000-0002-5421-8887","observed_orcids":["https://orcid.org/0000-0002-5421-8887"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiwei Wang","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108054104","display_name":"Jiacan Su","orcid":"https://orcid.org/0000-0001-7080-263X","observed_orcids":["https://orcid.org/0000-0001-7080-263X"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiacan Su","raw_affiliation_strings":["Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changhai hospital affiliated to the Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1785,"currency":"EUR","value_usd":1925},"apc_paid":{"value":1785,"currency":"EUR","value_usd":1925},"fwci":5.9783,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.96838108,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"47","issue":"1","first_page":"176","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-inhalation","display_name":"hydrogen inhalation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9739999771118164},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7929999828338623},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitochondrial-damage","display_name":"mitochondrial damage","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition-pore","display_name":"mitochondrial permeability transition pore","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cox7a1","display_name":"COX7A1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hspb7","display_name":"HSPB7","score":0.9850000143051147},{"id":"https://openalex.org/keywords/atp2a1","display_name":"ATP2A1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/spinal-neurons","display_name":"spinal cord neurons","score":0.5860000252723694},{"id":"https://openalex.org/keywords/locomotor-function","display_name":"locomotor function","score":0.593999981880188},{"id":"https://openalex.org/keywords/secondary-spinal-cord-injury","display_name":"secondary spinal cord injury","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7630308866500854},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6230098009109497},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6106088161468506},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5599594116210938},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5338802337646484},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.4517703056335449},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4218525290489197},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4100542962551117},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3874779939651489},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3768414556980133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36298221349716187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3324035406112671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2956835627555847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21438753604888916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15882888436317444},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1290004551410675},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09334045648574829}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000489764","doi":"https://doi.org/10.1159/000489764","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000489764","pdf_url":"https://www.karger.com/Article/Pdf/489764","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:29763919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29763919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6db8b9c4f2f74ee9a0f5ed041b1fa18a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6db8b9c4f2f74ee9a0f5ed041b1fa18a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular Physiology and Biochemistry, Vol 47, Iss 1, Pp 176-190 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1159/000489764","doi":"https://doi.org/10.1159/000489764","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000489764","pdf_url":"https://www.karger.com/Article/Pdf/489764","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G618091687","display_name":null,"funder_award_id":"81501052","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8188839121","display_name":null,"funder_award_id":"81671199","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804071071.pdf","grobid_xml":"https://content.openalex.org/works/W2804071071.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1535426243","https://openalex.org/W1552477256","https://openalex.org/W1718179003","https://openalex.org/W1889485241","https://openalex.org/W1964335763","https://openalex.org/W1967544492","https://openalex.org/W1970099785","https://openalex.org/W1983325630","https://openalex.org/W1984710762","https://openalex.org/W1985039688","https://openalex.org/W2003459751","https://openalex.org/W2004900120","https://openalex.org/W2006916686","https://openalex.org/W2008366967","https://openalex.org/W2014882299","https://openalex.org/W2017288304","https://openalex.org/W2045414227","https://openalex.org/W2049579108","https://openalex.org/W2052380760","https://openalex.org/W2069977126","https://openalex.org/W2082884016","https://openalex.org/W2083038107","https://openalex.org/W2087877138","https://openalex.org/W2092146469","https://openalex.org/W2095764747","https://openalex.org/W2104989412","https://openalex.org/W2109157215","https://openalex.org/W2111035623","https://openalex.org/W2113911442","https://openalex.org/W2130109770","https://openalex.org/W2130719735","https://openalex.org/W2131868763","https://openalex.org/W2135376726","https://openalex.org/W2151486024","https://openalex.org/W2152706242","https://openalex.org/W2154431984","https://openalex.org/W2159054927","https://openalex.org/W2169657429","https://openalex.org/W2210041734","https://openalex.org/W2292767005","https://openalex.org/W2341341075","https://openalex.org/W2342723950","https://openalex.org/W2350130263","https://openalex.org/W2514711322","https://openalex.org/W2518514540","https://openalex.org/W2598642148","https://openalex.org/W2619868785","https://openalex.org/W2758347652","https://openalex.org/W2761723659","https://openalex.org/W2765387543","https://openalex.org/W2765805717","https://openalex.org/W2797732082","https://openalex.org/W4230916704"],"related_works":["https://openalex.org/W2350130263","https://openalex.org/W3149550335","https://openalex.org/W2118857393","https://openalex.org/W7020826285","https://openalex.org/W2036905187","https://openalex.org/W2085001545","https://openalex.org/W2017288304","https://openalex.org/W2370056969","https://openalex.org/W3158882398","https://openalex.org/W4392895462"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Hydrogen":[1,160,284],"selectively":[2],"neutralizes":[3],"reactive":[4],"oxygen":[5],"species":[6],"(ROS)":[7],"and":[8,26,43,61,81,95,107,120,135,180,189,227,242,261,270,291,298,319,325,329,335],"ameliorates":[9,41],"various":[10],"ROS-induced":[11],"injuries.":[12],"Spinal":[13,206],"cord":[14,68,167,196,207,304],"injury":[15,20,169,216],"(SCI)":[16],"is":[17,29],"a":[18,218,309],"serious":[19],"to":[21,32,51,87,125,144,152,163,185,200],"the":[22,44,52,89,193,228,271],"central":[23],"nervous":[24],"system,":[25],"secondary":[27],"SCI":[28,277,288],"closely":[30],"related":[31,50,96],"excessive":[33],"ROS":[34,94,221,317],"generation.":[35],"We":[36],"hypothesized":[37],"that":[38],"hydrogen":[39,56,76,158,212,237,251,266,281,344],"inhalation":[40,285],"SCI,":[42],"mechanism":[45],"of":[46,55,75,92,157,192,230,256,274,343],"action":[47],"may":[48],"be":[49],"protective":[53,90,300],"effects":[54,91],"against":[57],"oxidative":[58,202,223,320],"stress,":[59,321],"apoptosis,":[60,324],"mitochondrial":[62,136,146,327],"damage.":[63,147],"METHODS:":[64],"Mechanically":[65],"injured":[66,194,246],"spinal":[67,166,195,303],"neurons":[69,208,232,247,305],"were":[70,85,98,123,142,183,209,233,248,263,278,337],"incubated":[71],"with":[72,100,276],"different":[73],"concentrations":[74],"in":[77,217,245,289,296,308],"vitro.":[78],"Immunofluorescence":[79],"staining":[80,191],"transmission":[82],"electron":[83],"microscopy":[84],"used":[86,124,184],"confirm":[88],"hydrogen.":[93],"proteins":[97],"detected":[99],"dihydroethidium":[101],"fluorescence":[102],"staining,":[103,134],"enzyme-linked":[104],"immunosorbent":[105],"assays,":[106,117],"western":[108,121],"blotting.":[109],"Terminal":[110],"deoxynucleotidyl":[111],"transferase":[112],"dUTP":[113],"nick":[114],"end":[115],"labeling":[116],"flow":[118],"cytometry,":[119],"blotting":[122],"detect":[126,201],"neuronal":[127,293,323],"apoptosis.":[128],"ATP":[129,240],"concentrations,":[130],"Janus":[131],"Green":[132],"B":[133],"permeability":[137],"transition":[138],"pore":[139],"(mPTP)":[140],"status":[141],"assessed":[143],"investigate":[145],"RNA":[148],"sequencing":[149],"was":[150,161,170,198,306],"performed":[151,199],"screen":[153],"potential":[154,340],"target":[155,341],"genes":[156,342],"application.":[159],"administered":[162],"mice":[164,275],"after":[165,214,236],"contusion":[168],"established":[171],"for":[172],"42":[173],"days.":[174],"The":[175,239,253,312],"Basso":[176],"Mouse":[177],"Scale":[178],"(BMS)":[179],"footprint":[181,272],"analyses":[182],"assess":[186],"locomotor":[187],"functions,":[188],"immunofluorescence":[190],"segments":[197],"stress":[203,224],"status.":[204],"RESULTS:":[205],"preserved":[210,249],"by":[211,250,265,280],"administration":[213],"mechanical":[215,294],"dose-dependent":[219,310],"manner.":[220,311],"generation,":[222],"injury-related":[225],"markers,":[226],"number":[229],"apoptotic":[231],"significantly":[234],"reduced":[235],"treatment.":[238,267,345],"production":[241],"mPTP":[243],"function":[244],"incubation.":[252],"expression":[254],"levels":[255],"Cox8b,":[257,331],"Cox6a2,":[258,332],"Cox7a1,":[259,333],"Hspb7,":[260,334],"Atp2a1":[262,336],"inhibited":[264],"BMS":[268],"scores":[269],"assessment":[273],"improved":[279],"inhalation.":[282],"CONCLUSIONS:":[283],"(75%)":[286],"ameliorated":[287],"vivo":[290],"attenuated":[292],"injuries":[295],"vitro,":[297],"its":[299],"effect":[301],"on":[302],"exerted":[307],"underlying":[313],"mechanisms":[314],"included":[315],"reducing":[316],"generation":[318],"inhibiting":[322],"restoring":[326],"construction":[328],"function.":[330],"identified":[338],"as":[339]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-01T00:00:00"}