{"id":"https://openalex.org/W2804034771","doi":"https://doi.org/10.1021/acs.analchem.8b01452","title":"Confocal Raman Microscopy for in Situ Measurement of Phospholipid\u2013Water Partitioning into Model Phospholipid Bilayers within Individual Chromatographic Particles","display_name":"Confocal Raman Microscopy for in Situ Measurement of Phospholipid\u2013Water Partitioning into Model Phospholipid Bilayers within Individual Chromatographic Particles","publication_year":2018,"publication_date":"2018-05-14","ids":{"openalex":"https://openalex.org/W2804034771","doi":"https://doi.org/10.1021/acs.analchem.8b01452","mag":"2804034771","pmid":"https://pubmed.ncbi.nlm.nih.gov/29757613"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.8b01452","doi":"https://doi.org/10.1021/acs.analchem.8b01452","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.8b01452","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.osti.gov/servlets/purl/1437042","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023690125","display_name":"Jay P. Kitt","orcid":"https://orcid.org/0000-0002-1469-3659","observed_orcids":["https://orcid.org/0000-0002-1469-3659"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay P. Kitt","raw_affiliation_strings":["Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850 United States"],"raw_orcid":"https://orcid.org/0000-0002-1469-3659","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850 United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069597223","display_name":"David A. Bryce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Bryce","raw_affiliation_strings":["Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850 United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850 United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060498869","display_name":"Shelley D. Minteer","orcid":"https://orcid.org/0000-0002-5788-2249","observed_orcids":["https://orcid.org/0000-0002-5788-2249"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley D. Minteer","raw_affiliation_strings":["Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850 United States"],"raw_orcid":"https://orcid.org/0000-0002-5788-2249","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850 United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078927573","display_name":"Joel Mark Harris","orcid":"https://orcid.org/0000-0002-7081-8188","observed_orcids":["https://orcid.org/0000-0002-7081-8188"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joel M. Harris","raw_affiliation_strings":["Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850 United States"],"raw_orcid":"https://orcid.org/0000-0002-7081-8188","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850 United States","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078927573"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.622,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.63786053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"90","issue":"11","first_page":"7048","last_page":"7055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.10949999839067459,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.921999990940094},{"id":"https://openalex.org/keywords/supported-lipid-bilayers","display_name":"supported lipid bilayers","score":0.75},{"id":"https://openalex.org/keywords/confocal-raman-microscopy","display_name":"confocal Raman microscopy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/internal-standard","display_name":"internal standard","score":0.47200000286102295},{"id":"https://openalex.org/keywords/bilayer-structure","display_name":"bilayer structure","score":0.6430000066757202},{"id":"https://openalex.org/keywords/membrane-active-compounds","display_name":"membrane-active compounds","score":0.5400000214576721},{"id":"https://openalex.org/keywords/octanol-water-partitioning","display_name":"octanol-water partitioning","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9339962005615234},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.8671417236328125},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.7297351956367493},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.6830570697784424},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.6561749577522278},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.617420494556427},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5665392279624939},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5307122468948364},{"id":"https://openalex.org/C88412794","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal laser scanning microscopy","level":2,"score":0.4581742286682129},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.336486279964447},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3187882900238037},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.27518945932388306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14282259345054626},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08142989873886108},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08136036992073059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.analchem.8b01452","doi":"https://doi.org/10.1021/acs.analchem.8b01452","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.8b01452","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:29757613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29757613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1437042","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1437042","pdf_url":"https://www.osti.gov/servlets/purl/1437042","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:osti.gov:1437042","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1437042","pdf_url":"https://www.osti.gov/servlets/purl/1437042","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G416991182","display_name":null,"funder_award_id":"DE-FG03-93ER14333","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G590953419","display_name":"NEW GRANT -  TIME RESOLVED ANALYTICAL METHODS FOR LIQUID/SOLID INTERFACES  P.I. - JOEL M. HARRIS","funder_award_id":"FG0393ER14333","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804034771.pdf","grobid_xml":"https://content.openalex.org/works/W2804034771.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W210395626","https://openalex.org/W221173887","https://openalex.org/W651320805","https://openalex.org/W1482260509","https://openalex.org/W1519509748","https://openalex.org/W1557141846","https://openalex.org/W1966326760","https://openalex.org/W1971874333","https://openalex.org/W1972326413","https://openalex.org/W1972575106","https://openalex.org/W1980844386","https://openalex.org/W1989302050","https://openalex.org/W1994430820","https://openalex.org/W2000070393","https://openalex.org/W2002030120","https://openalex.org/W2006861238","https://openalex.org/W2006893903","https://openalex.org/W2018786385","https://openalex.org/W2019670269","https://openalex.org/W2024050667","https://openalex.org/W2026123751","https://openalex.org/W2035918981","https://openalex.org/W2044894942","https://openalex.org/W2047112187","https://openalex.org/W2062458432","https://openalex.org/W2065790254","https://openalex.org/W2078505365","https://openalex.org/W2080197392","https://openalex.org/W2087601773","https://openalex.org/W2092956113","https://openalex.org/W2094402297","https://openalex.org/W2102632887","https://openalex.org/W2120803401","https://openalex.org/W2158738440","https://openalex.org/W2313521327","https://openalex.org/W2316876055","https://openalex.org/W2320104531","https://openalex.org/W2334683490","https://openalex.org/W2346905224","https://openalex.org/W2475966476","https://openalex.org/W2589916434","https://openalex.org/W2793830102","https://openalex.org/W4205110562","https://openalex.org/W4301194639"],"related_works":["https://openalex.org/W2092956113","https://openalex.org/W2475966476","https://openalex.org/W2945610409","https://openalex.org/W2316876055","https://openalex.org/W2003824216","https://openalex.org/W2089232423","https://openalex.org/W2034435936","https://openalex.org/W7165526170","https://openalex.org/W2106709505","https://openalex.org/W6964750250"],"abstract_inverted_index":{"The":[0,110,130],"phospholipid-water":[1,35],"partition":[2,36],"coefficient":[3],"is":[4,41,174,191,236],"a":[5,86,120,126,135],"commonly":[6],"measured":[7],"parameter":[8],"that":[9,63],"correlates":[10],"with":[11,214,218,245],"drug":[12],"efficacy,":[13],"small-molecule":[14],"toxicity,":[15],"and":[16,98,203,209,217,243],"accumulation":[17],"of":[18,29,46,58,67,85,106,114,119,154,162,171,181,195,198,230,249],"molecules":[19],"in":[20,23,50,76,157],"biological":[21],"systems":[22],"the":[24,27,44,65,83,103,140,151,158,178,182,210,228,246],"environment.":[25],"Despite":[26],"utility":[28],"this":[30,72],"parameter,":[31],"methods":[32],"for":[33,193,238],"measuring":[34],"coefficients":[37],"are":[38,60,212],"limited.":[39],"This":[40,189],"due":[42],"to":[43,81],"difficulty":[45],"making":[47,155],"quantitative":[48],"measurements":[49,156,194],"vesicle":[51,225,252],"membranes":[52,242],"or":[53,93,165],"supported":[54,167],"phospholipid":[55,132,179,224],"bilayers,":[56],"both":[57,96,201,239],"which":[59,149],"small-volume":[61],"phases":[62],"challenge":[64],"sensitivity":[66,152],"many":[68],"analytical":[69],"techniques.":[70],"In":[71],"work,":[73],"we":[74],"employ":[75],"situ":[77],"confocal":[78,136],"Raman":[79],"microscopy":[80],"probe":[82,137],"partitioning":[84,173,197,216,219,232,250],"model":[87,241],"membrane-active":[88],"compound,":[89],"2-(4-isobutylphenyl)":[90],"propionic":[91],"acid":[92],"ibuprofen,":[94],"into":[95,200,220,251],"hybrid-":[97],"supported-phospholipid":[99],"bilayers":[100,205],"deposited":[101],"on":[102,233],"pore":[104],"walls":[105],"individual":[107,221],"chromatographic":[108,115],"particles.":[109],"large":[111],"surface-area-to-volume":[112],"ratio":[113],"silica":[116,207],"allows":[117],"interrogation":[118],"significant":[121],"lipid":[122,253],"bilayer":[123,184,234],"area":[124],"within":[125,134,206],"very":[127],"small":[128],"volume.":[129],"local":[131],"concentration":[133],"volume":[138],"inside":[139],"particle":[141],"can":[142],"be":[143],"as":[144,146,185],"high":[145],"0.5":[147],"M,":[148],"overcomes":[150],"limitations":[153],"limited":[159],"membrane":[160],"areas":[161],"single":[163],"vesicles":[164],"planar":[166],"bilayers.":[168,254],"Quantitative":[169],"determination":[170],"ibuprofen":[172,199,231],"achieved":[175],"by":[176],"using":[177],"acyl-chains":[180],"within-particle":[183,240],"an":[186],"internal":[187],"standard.":[188],"approach":[190],"tested":[192],"pH-dependent":[196],"hybrid-lipid":[202],"supported-lipid":[204],"particles,":[208],"results":[211],"compared":[213,244],"octanol-water":[215],"optically":[222],"trapped":[223],"membranes.":[226],"Additionally,":[227],"impact":[229],"structure":[235],"evaluated":[237],"structural":[247],"impacts":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-01T00:00:00"}