{"id":"https://openalex.org/W2803979402","doi":null,"title":"Environmental and gene therapy approaches to improve glycemic control and promote healthy aging","display_name":"Environmental and gene therapy approaches to improve glycemic control and promote healthy aging","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2803979402","mag":"2803979402"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1495147592739768","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1495147592739768","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=osu1495147592739768&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1495147592739768","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=osu1495147592739768&disposition=inline","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090063577","display_name":"Travis B. McMurphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Travis McMurphy","raw_affiliation_strings":["the Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090063577"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.4957999885082245,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.4957999885082245,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.3052000105381012,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-36","display_name":"adenovirus 36","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glucose-disposal","display_name":"glucose disposal","score":0.5370000004768372},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8500000238418579},{"id":"https://openalex.org/keywords/insulin-independent-glucose-uptake","display_name":"insulin-independent glucose uptake","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hepatic-gene-therapy","display_name":"hepatic gene therapy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7319999933242798},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.8149999976158142},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.746999979019165},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.7390000224113464},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7789999842643738},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.6780544519424438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5224694013595581},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4461383819580078},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4102843403816223},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.32986125349998474},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18699386715888977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18657147884368896},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1133069097995758}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:osu1495147592739768","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1495147592739768","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=osu1495147592739768&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1495147592739768","raw_type":"text"},{"id":"mag:2803979402","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1495147592739768","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1495147592739768","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1495147592739768","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=osu1495147592739768&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1495147592739768","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803979402.pdf","grobid_xml":"https://content.openalex.org/works/W2803979402.grobid-xml"},"referenced_works_count":204,"referenced_works":["https://openalex.org/W30273463","https://openalex.org/W1495096570","https://openalex.org/W1509983325","https://openalex.org/W1529541248","https://openalex.org/W1535911125","https://openalex.org/W1544413824","https://openalex.org/W1580646470","https://openalex.org/W1734521060","https://openalex.org/W1748636648","https://openalex.org/W1815206142","https://openalex.org/W1818618752","https://openalex.org/W1966132436","https://openalex.org/W1969199439","https://openalex.org/W1970589709","https://openalex.org/W1971834937","https://openalex.org/W1973934213","https://openalex.org/W1977152010","https://openalex.org/W1978281808","https://openalex.org/W1980560408","https://openalex.org/W1981474232","https://openalex.org/W1981583644","https://openalex.org/W1982479748","https://openalex.org/W1982810858","https://openalex.org/W1983469923","https://openalex.org/W1984621921","https://openalex.org/W1988445706","https://openalex.org/W1988769784","https://openalex.org/W1990112639","https://openalex.org/W1990561391","https://openalex.org/W1995890584","https://openalex.org/W1996222881","https://openalex.org/W1996713062","https://openalex.org/W1996846206","https://openalex.org/W1998265194","https://openalex.org/W1998578651","https://openalex.org/W2001649002","https://openalex.org/W2003295985","https://openalex.org/W2003852683","https://openalex.org/W2004342399","https://openalex.org/W2004984537","https://openalex.org/W2005396371","https://openalex.org/W2007302154","https://openalex.org/W2007580094","https://openalex.org/W2007767268","https://openalex.org/W2008008410","https://openalex.org/W2008376603","https://openalex.org/W2008768221","https://openalex.org/W2010763118","https://openalex.org/W2011210301","https://openalex.org/W2012153544","https://openalex.org/W2013604729","https://openalex.org/W2017820712","https://openalex.org/W2018352403","https://openalex.org/W2018373960","https://openalex.org/W2019794937","https://openalex.org/W2022726058","https://openalex.org/W2024123645","https://openalex.org/W2027858580","https://openalex.org/W2028883645","https://openalex.org/W2029732398","https://openalex.org/W2030554335","https://openalex.org/W2031086065","https://openalex.org/W2033735131","https://openalex.org/W2034418213","https://openalex.org/W2041879343","https://openalex.org/W2042444876","https://openalex.org/W2044282983","https://openalex.org/W2044518560","https://openalex.org/W2044528599","https://openalex.org/W2045411634","https://openalex.org/W2045522606","https://openalex.org/W2045577764","https://openalex.org/W2046120487","https://openalex.org/W2047933377","https://openalex.org/W2050321518","https://openalex.org/W2050720508","https://openalex.org/W2054282296","https://openalex.org/W2054356183","https://openalex.org/W2054593248","https://openalex.org/W2055433448","https://openalex.org/W2056085420","https://openalex.org/W2056305255","https://openalex.org/W2057650127","https://openalex.org/W2058748994","https://openalex.org/W2059061961","https://openalex.org/W2059506809","https://openalex.org/W2061504360","https://openalex.org/W2062073832","https://openalex.org/W2062756228","https://openalex.org/W2066321992","https://openalex.org/W2066805219","https://openalex.org/W2067168283","https://openalex.org/W2067251782","https://openalex.org/W2067440530","https://openalex.org/W2069988949","https://openalex.org/W2070044338","https://openalex.org/W2070172494","https://openalex.org/W2070634275","https://openalex.org/W2070639092","https://openalex.org/W2071641795","https://openalex.org/W2072914828","https://openalex.org/W2075211183","https://openalex.org/W2077018876","https://openalex.org/W2078765043","https://openalex.org/W2079379157","https://openalex.org/W2079395662","https://openalex.org/W2079659159","https://openalex.org/W2079832429","https://openalex.org/W2080094749","https://openalex.org/W2080114671","https://openalex.org/W2080861579","https://openalex.org/W2081397294","https://openalex.org/W2087415885","https://openalex.org/W2087835012","https://openalex.org/W2091602727","https://openalex.org/W2092441434","https://openalex.org/W2094166298","https://openalex.org/W2094352498","https://openalex.org/W2094751859","https://openalex.org/W2094778062","https://openalex.org/W2095304369","https://openalex.org/W2095553811","https://openalex.org/W2095568085","https://openalex.org/W2095822659","https://openalex.org/W2097757382","https://openalex.org/W2098974443","https://openalex.org/W2099110265","https://openalex.org/W2099116960","https://openalex.org/W2099367948","https://openalex.org/W2100397515","https://openalex.org/W2101859467","https://openalex.org/W2101964276","https://openalex.org/W2102992903","https://openalex.org/W2103002807","https://openalex.org/W2103112317","https://openalex.org/W2104338539","https://openalex.org/W2105412616","https://openalex.org/W2105685115","https://openalex.org/W2106989835","https://openalex.org/W2107277218","https://openalex.org/W2108137989","https://openalex.org/W2109617830","https://openalex.org/W2110123927","https://openalex.org/W2113847169","https://openalex.org/W2114041992","https://openalex.org/W2117879192","https://openalex.org/W2118869627","https://openalex.org/W2120852510","https://openalex.org/W2122551774","https://openalex.org/W2130618887","https://openalex.org/W2132924550","https://openalex.org/W2134775482","https://openalex.org/W2134847247","https://openalex.org/W2138235098","https://openalex.org/W2141735000","https://openalex.org/W2142292538","https://openalex.org/W2144590229","https://openalex.org/W2145340989","https://openalex.org/W2146155264","https://openalex.org/W2146544786","https://openalex.org/W2147264139","https://openalex.org/W2147408739","https://openalex.org/W2147465183","https://openalex.org/W2149218172","https://openalex.org/W2149644962","https://openalex.org/W2150249152","https://openalex.org/W2152377123","https://openalex.org/W2153651314","https://openalex.org/W2154486813","https://openalex.org/W2154508866","https://openalex.org/W2155181385","https://openalex.org/W2155726118","https://openalex.org/W2156339883","https://openalex.org/W2157868136","https://openalex.org/W2158082259","https://openalex.org/W2159558071","https://openalex.org/W2159993610","https://openalex.org/W2161704600","https://openalex.org/W2162403028","https://openalex.org/W2163468424","https://openalex.org/W2163710303","https://openalex.org/W2164726383","https://openalex.org/W2165566006","https://openalex.org/W2166016923","https://openalex.org/W2166224820","https://openalex.org/W2166542421","https://openalex.org/W2169721390","https://openalex.org/W2169878192","https://openalex.org/W2170781174","https://openalex.org/W2172051205","https://openalex.org/W2172144699","https://openalex.org/W2176575827","https://openalex.org/W2230222215","https://openalex.org/W2313911142","https://openalex.org/W2323202746","https://openalex.org/W2326516209","https://openalex.org/W2336833178","https://openalex.org/W2343448653","https://openalex.org/W2405465246","https://openalex.org/W2421296032","https://openalex.org/W2466276373","https://openalex.org/W2514954209","https://openalex.org/W4238567307","https://openalex.org/W4244068819"],"related_works":["https://openalex.org/W2558431515","https://openalex.org/W2197317387","https://openalex.org/W2091602727","https://openalex.org/W2148038478","https://openalex.org/W2047933377","https://openalex.org/W7098602096","https://openalex.org/W2754542391","https://openalex.org/W2508276920","https://openalex.org/W2626536946","https://openalex.org/W7097274703"],"abstract_inverted_index":{"Considering":[0],"that":[1,11,24],"impaired":[2],"proximal":[3,50],"insulin":[4,17,51],"signaling":[5,18],"is":[6],"linked":[7],"with":[8,35],"diabetes,":[9],"approaches":[10],"enhance":[12,45],"glucose":[13,46],"disposal":[14],"independent":[15,48],"of":[16,49,54,64,73,90,104],"are":[19],"attractive.In":[20],"vitro":[21],"data":[22],"indicate":[23],"the":[25,61,88],"E4ORF1":[26,72],"peptide":[27],"derived":[28],"from":[29,37],"human":[30],"adenovirus":[31,76],"36":[32],"(Ad36)":[33],"interacts":[34],"cells":[36],"adipose":[38],"tissue,":[39],"skeletal":[40],"muscle":[41],"and":[42],"liver":[43],"to":[44],"disposal,":[47],"signaling.Adipocyte-specific":[52],"expression":[53,103],"Ad36E4ORF1":[55,65],"improved":[56,110],"hyperglycemia":[57],"in":[58,66,87],"mice.To":[59],"determine":[60],"hepatic":[62,102],"interaction":[63],"enhancing":[67],"glycemic":[68,111],"control,":[69],"we":[70],"expressed":[71],"Ad36":[74],"or":[75,78,96],"5,":[77],"fluorescent":[79],"tag":[80],"alone":[81],"using":[82],"recombinant":[83],"adeno-associated":[84],"viral":[85],"vector":[86],"livers":[89],"three":[91],"mouse":[92],"models.In":[93],"diabetic":[94],"db/db":[95],"diet":[97],"induced":[98],"obesity":[99],"(DIO)":[100],"mice,":[101],"Ad36E4ORF1,":[105],"but":[106],"not":[107],"Ad5E4ORF1":[108],"robustly":[109],"control.":[112]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-01T00:00:00"}