{"id":"https://openalex.org/W2803963430","doi":"https://doi.org/10.1016/j.bbrc.2018.05.106","title":"Lysophosphatidic acid receptor, LPA6, regulates endothelial blood-brain barrier function: Implication for hepatic encephalopathy","display_name":"Lysophosphatidic acid receptor, LPA6, regulates endothelial blood-brain barrier function: Implication for hepatic encephalopathy","publication_year":2018,"publication_date":"2018-05-23","ids":{"openalex":"https://openalex.org/W2803963430","doi":"https://doi.org/10.1016/j.bbrc.2018.05.106","mag":"2803963430","pmid":"https://pubmed.ncbi.nlm.nih.gov/29778535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6108890"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2018.05.106","doi":"https://doi.org/10.1016/j.bbrc.2018.05.106","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2018.05.106","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6108890/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011659049","display_name":"Kayo Masago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kayo Masago","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006952722","display_name":"Yasuyuki Kihara","orcid":"https://orcid.org/0000-0001-7462-3006","observed_orcids":["https://orcid.org/0000-0001-7462-3006"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Yasuyuki Kihara","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: kihara-yasuyuki@umin.net","Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"],"raw_orcid":"https://orcid.org/0000-0001-7462-3006","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: kihara-yasuyuki@umin.net","institution_ids":["https://openalex.org/I188891513","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Keisuke Yanagida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Keisuke Yanagida","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan; Vascular Biology Program, Boston Children's Hospital, Boston, MA 20115, USA; Department of Surgery, Harvard Medical School, Boston, MA 20115, USA","Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","Department of Surgery, Harvard Medical School, Boston, MA 20115, USA","Vascular Biology Program, Boston Children's Hospital, Boston, MA 20115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan; Vascular Biology Program, Boston Children's Hospital, Boston, MA 20115, USA; Department of Surgery, Harvard Medical School, Boston, MA 20115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210094012","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","institution_ids":["https://openalex.org/I4210094012"]},{"raw_affiliation_string":"Department of Surgery, Harvard Medical School, Boston, MA 20115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children's Hospital, Boston, MA 20115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030885804","display_name":"Fumie Hamano","orcid":"https://orcid.org/0009-0003-0746-158X","observed_orcids":["https://orcid.org/0009-0003-0746-158X"]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumie Hamano","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","institution_ids":["https://openalex.org/I4210094012","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056863575","display_name":"Shinsuke Nakagawa","orcid":"https://orcid.org/0000-0001-7945-9719","observed_orcids":["https://orcid.org/0000-0001-7945-9719"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinsuke Nakagawa","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7945-9719","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069165211","display_name":"Masami Niwa","orcid":"https://orcid.org/0000-0001-5138-5180","observed_orcids":["https://orcid.org/0000-0001-5138-5180"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]},{"id":"https://openalex.org/I4405263842","display_name":"Pharmaco-Cell Company Ltd. (Japan)","ror":"https://ror.org/007kqa289","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405263842"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami Niwa","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan; PharmaCo-Cell Company Ltd., Nagasaki 852-0862, Japan","Department of Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan","PharmaCo-Cell Company Ltd., Nagasaki 852-0862, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan; PharmaCo-Cell Company Ltd., Nagasaki 852-0862, Japan","institution_ids":["https://openalex.org/I43777268","https://openalex.org/I4405263842"]},{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"PharmaCo-Cell Company Ltd., Nagasaki 852-0862, Japan","institution_ids":["https://openalex.org/I4405263842"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101458079","display_name":"Takao Shimizu","orcid":"https://orcid.org/0000-0002-9079-1357","observed_orcids":["https://orcid.org/0000-0002-9079-1357"]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Shimizu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","institution_ids":["https://openalex.org/I4210094012","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan","institution_ids":["https://openalex.org/I4210094012"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5006952722"],"corresponding_institution_ids":["https://openalex.org/I188891513","https://openalex.org/I74801974"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":2.2932,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.87831995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"501","issue":"4","first_page":"1048","last_page":"1054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"lysophosphatidic acid","score":0.9679999947547913},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.9929999709129333},{"id":"https://openalex.org/keywords/autotaxin","display_name":"autotaxin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.6899999976158142},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.9210000038146973},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/endothelial-cell-contraction","display_name":"endothelial cell contraction","score":0.8640000224113464},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.8740000128746033},{"id":"https://openalex.org/keywords/g12-13-signaling","display_name":"G12/13 signaling","score":0.859000027179718},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2776661833","wikidata":"https://www.wikidata.org/wiki/Q2823281","display_name":"Lysophosphatidic acid","level":3,"score":0.8128148317337036},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7006944417953491},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.6257494688034058},{"id":"https://openalex.org/C2779493303","wikidata":"https://www.wikidata.org/wiki/Q979168","display_name":"Cerebral edema","level":2,"score":0.5526269674301147},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5182526111602783},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.4766327142715454},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.46847429871559143},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43783971667289734},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4083484411239624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3908495306968689},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3652057349681854},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3114861845970154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3065031170845032},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23749372363090515},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16624587774276733},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14740720391273499}],"mesh":[{"descriptor_ui":"D000099189","descriptor_name":"Lysophospholipase D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001397","descriptor_name":"Azoxymethane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006501","descriptor_name":"Hepatic Encephalopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006501","descriptor_name":"Hepatic Encephalopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D049368","descriptor_name":"Receptors, Lysophosphatidic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054460","descriptor_name":"rho-Associated Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbrc.2018.05.106","doi":"https://doi.org/10.1016/j.bbrc.2018.05.106","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2018.05.106","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:29778535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29778535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6108890","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6108890/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem Biophys Res Commun","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6108890","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6108890/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem Biophys Res Commun","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2958020725","display_name":null,"funder_award_id":"07J01750","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4270822146","display_name":null,"funder_award_id":"07J05298","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5996139709","display_name":"S1P signaling machinery in neuroimmune interactions","funder_award_id":"R01NS103940","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7398527253","display_name":null,"funder_award_id":"19002011","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7725674424","display_name":"Development of a novel method to protect cerebrovascular based on the regulation of lysophospholipid","funder_award_id":"17K10838","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1549006420","https://openalex.org/W1594663117","https://openalex.org/W1958139147","https://openalex.org/W1983893444","https://openalex.org/W1985551319","https://openalex.org/W1993410462","https://openalex.org/W2021163309","https://openalex.org/W2025785613","https://openalex.org/W2026827182","https://openalex.org/W2027293462","https://openalex.org/W2045249005","https://openalex.org/W2046695461","https://openalex.org/W2057051750","https://openalex.org/W2073345523","https://openalex.org/W2079878922","https://openalex.org/W2085046768","https://openalex.org/W2088846188","https://openalex.org/W2092530725","https://openalex.org/W2097760799","https://openalex.org/W2118525371","https://openalex.org/W2122027206","https://openalex.org/W2138548521","https://openalex.org/W2148511071","https://openalex.org/W2159821105","https://openalex.org/W2164118729","https://openalex.org/W2745155021","https://openalex.org/W4242966060","https://openalex.org/W6678184113"],"related_works":["https://openalex.org/W2365928779","https://openalex.org/W1983893444","https://openalex.org/W152975451","https://openalex.org/W2025440925","https://openalex.org/W1998703443","https://openalex.org/W2100586833","https://openalex.org/W2120949299","https://openalex.org/W7163245056","https://openalex.org/W1972868549","https://openalex.org/W1982531644"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-01T00:00:00"}