{"id":"https://openalex.org/W2803944745","doi":"https://doi.org/10.1016/j.bmc.2018.05.040","title":"Synthesis and biophysical properties of 5\u2032-thio-2\u2032,4\u2032-BNA/LNA oligonucleotide","display_name":"Synthesis and biophysical properties of 5\u2032-thio-2\u2032,4\u2032-BNA/LNA oligonucleotide","publication_year":2018,"publication_date":"2018-05-23","ids":{"openalex":"https://openalex.org/W2803944745","doi":"https://doi.org/10.1016/j.bmc.2018.05.040","mag":"2803944745","pmid":"https://pubmed.ncbi.nlm.nih.gov/29886084"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmc.2018.05.040","doi":"https://doi.org/10.1016/j.bmc.2018.05.040","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2018.05.040","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102018192","display_name":"Md Ariful Islam","orcid":"https://orcid.org/0000-0002-8791-6120","observed_orcids":["https://orcid.org/0000-0002-8791-6120"]},"institutions":[{"id":"https://openalex.org/I315729180","display_name":"Noakhali Science and Technology University","ror":"https://ror.org/05q9we431","country_code":"BD","type":"education","lineage":["https://openalex.org/I315729180"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["BD","JP"],"is_corresponding":false,"raw_author_name":"Md Ariful Islam","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh","Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh","Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8791-6120","affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh","institution_ids":["https://openalex.org/I315729180","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh","institution_ids":["https://openalex.org/I315729180"]},{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021994273","display_name":"Aki Fujisaka","orcid":"https://orcid.org/0009-0000-0475-2187","observed_orcids":["https://orcid.org/0009-0000-0475-2187"]},"institutions":[{"id":"https://openalex.org/I167598709","display_name":"Osaka Ohtani University","ror":"https://ror.org/01jtn9895","country_code":"JP","type":"education","lineage":["https://openalex.org/I167598709"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aki Fujisaka","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Faculty of Pharmacy, Osaka Ohtani University, Nishikiori-Kita 3-11-1, Tondabayashi, Osaka 584-8540, Japan","Faculty of Pharmacy, Osaka Ohtani University, Nishikiori-Kita 3-11-1, Tondabayashi, Osaka 584-8540, Japan","Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Faculty of Pharmacy, Osaka Ohtani University, Nishikiori-Kita 3-11-1, Tondabayashi, Osaka 584-8540, Japan","institution_ids":["https://openalex.org/I167598709","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Faculty of Pharmacy, Osaka Ohtani University, Nishikiori-Kita 3-11-1, Tondabayashi, Osaka 584-8540, Japan","institution_ids":["https://openalex.org/I167598709"]},{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058413798","display_name":"S. Mori","orcid":"https://orcid.org/0000-0001-8472-8055","observed_orcids":["https://orcid.org/0000-0001-8472-8055"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shohei Mori","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078169098","display_name":"Kosuke Ramon Ito","orcid":"https://orcid.org/0000-0001-5161-1301","observed_orcids":["https://orcid.org/0000-0001-5161-1301"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Ramon Ito","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072002940","display_name":"Takao Yamaguchi","orcid":"https://orcid.org/0000-0003-3180-0257","observed_orcids":["https://orcid.org/0000-0003-3180-0257"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Yamaguchi","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3180-0257","affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083003749","display_name":"Satoshi Obika","orcid":"https://orcid.org/0000-0002-6842-6812","observed_orcids":["https://orcid.org/0000-0002-6842-6812"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoshi Obika","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: obika@phs.osaka-u.ac.jp","Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: obika@phs.osaka-u.ac.jp","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083003749"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.6244,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.62421736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"26","issue":"12","first_page":"3634","last_page":"3638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphorothioate-modification","display_name":"phosphorothioate modification","score":0.8360000252723694},{"id":"https://openalex.org/keywords/oligonucleotide-synthesis","display_name":"oligonucleotide synthesis","score":0.828000009059906},{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-methylcytosine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/thymine","display_name":"thymine","score":0.7319999933242798},{"id":"https://openalex.org/keywords/nuclease-resistance","display_name":"nuclease resistance","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dna-binding-affinity","display_name":"DNA binding affinity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/nucleic-acid-therapeutics","display_name":"nucleic acid therapeutics","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.877623438835144},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8625698685646057},{"id":"https://openalex.org/C2781253882","wikidata":"https://www.wikidata.org/wiki/Q770860","display_name":"Thio-","level":2,"score":0.8400425314903259},{"id":"https://openalex.org/C14363569","wikidata":"https://www.wikidata.org/wiki/Q418639","display_name":"Locked nucleic acid","level":4,"score":0.7518711686134338},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.7292569875717163},{"id":"https://openalex.org/C61234307","wikidata":"https://www.wikidata.org/wiki/Q422960","display_name":"Nucleobase","level":3,"score":0.6523464918136597},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5505337119102478},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5209264159202576},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.5204370617866516},{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.4713810384273529},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4695998430252075},{"id":"https://openalex.org/C2778278100","wikidata":"https://www.wikidata.org/wiki/Q6586307","display_name":"Thiophosphate","level":2,"score":0.4455915093421936},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4284391403198242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3577202260494232},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3412700891494751},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14391577243804932},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06322744488716125},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005092","descriptor_name":"Exonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044366","descriptor_name":"Transition Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmc.2018.05.040","doi":"https://doi.org/10.1016/j.bmc.2018.05.040","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2018.05.040","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:29886084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29886084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4529109066","display_name":"\u6bd2\u6027\u30bc\u30ed\u306b\u5411\u3051\u305f\u9769\u65b0\u7684\u6838\u9178\u533b\u85ac\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u69cb\u7bc9\u2212\u30c7\u30e5\u30a2\u30eb\u4fee\u98fe\u578b\u4eba\u5de5\u6838\u9178\u306e\u5275\u88fd\u30fb\u63a2\u7d22\u30fb\u8a55\u4fa1\u2212","funder_award_id":"18am0301004h0005","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1964272339","https://openalex.org/W1972822204","https://openalex.org/W1986939463","https://openalex.org/W1998358440","https://openalex.org/W2001519339","https://openalex.org/W2003248303","https://openalex.org/W2022013776","https://openalex.org/W2072034558","https://openalex.org/W2074539094","https://openalex.org/W2083292951","https://openalex.org/W2087690491","https://openalex.org/W2089512188","https://openalex.org/W2098517499","https://openalex.org/W2104939403","https://openalex.org/W2108185026","https://openalex.org/W2108936334","https://openalex.org/W2118372997","https://openalex.org/W2120439078","https://openalex.org/W2155225853","https://openalex.org/W2184314359","https://openalex.org/W2322950798","https://openalex.org/W2330365892","https://openalex.org/W2335169054","https://openalex.org/W2559280368","https://openalex.org/W2952510860","https://openalex.org/W2953370691"],"related_works":["https://openalex.org/W2559280368","https://openalex.org/W3174441378","https://openalex.org/W7163999188","https://openalex.org/W3159052644","https://openalex.org/W1971377724","https://openalex.org/W2904078385","https://openalex.org/W2077792747","https://openalex.org/W1983297903","https://openalex.org/W2035580712","https://openalex.org/W2905373204"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}