{"id":"https://openalex.org/W2803941007","doi":"https://doi.org/10.1161/circresaha.118.313143","title":"YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6","display_name":"YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6","publication_year":2018,"publication_date":"2018-05-23","ids":{"openalex":"https://openalex.org/W2803941007","doi":"https://doi.org/10.1161/circresaha.118.313143","mag":"2803941007","pmid":"https://pubmed.ncbi.nlm.nih.gov/29794022","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6014930"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.118.313143","doi":"https://doi.org/10.1161/circresaha.118.313143","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circresaha.118.313143","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6014930","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014655181","display_name":"Yang Lv","orcid":"https://orcid.org/0009-0001-7831-3619","observed_orcids":["https://orcid.org/0009-0001-7831-3619","https://orcid.org/0000-0002-7179-4552"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yang Lv","raw_affiliation_strings":["From the Department of Anesthesiology (Y.L., Guochang Hu)","University of Illinois College of Medicine, Chicago; Department of Pharmacology, Nanjing Medical University, Jiangsu, China (Y.L., Gang Hu)","Yang Lv From the Department of Anesthesiology (Y.L., Guochang Hu) University of Illinois College of Medicine, Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anesthesiology (Y.L., Guochang Hu)","institution_ids":[]},{"raw_affiliation_string":"University of Illinois College of Medicine, Chicago; Department of Pharmacology, Nanjing Medical University, Jiangsu, China (Y.L., Gang Hu)","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Yang Lv From the Department of Anesthesiology (Y.L., Guochang Hu) University of Illinois College of Medicine, Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725889","display_name":"Kyungho Kim","orcid":"https://orcid.org/0000-0001-6074-3867","observed_orcids":["https://orcid.org/0000-0001-6074-3867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyungho Kim","raw_affiliation_strings":["Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","Kyungho Kim Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","institution_ids":[]},{"raw_affiliation_string":"Kyungho Kim Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027110921","display_name":"Yue Sheng","orcid":"https://orcid.org/0000-0002-9424-123X","observed_orcids":["https://orcid.org/0000-0002-9424-123X"]},"institutions":[{"id":"https://openalex.org/I4210125096","display_name":"University of Illinois Hospital & Health Sciences System","ror":"https://ror.org/03jhe7195","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210125096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Sheng","raw_affiliation_strings":["Department of Medicine and Cancer Research Center, The University of Illinois Hospital and Health Sciences System, Chicago (Y.S., Z.Q.)","Yue Sheng Department of Medicine and Cancer Research Center, The University of Illinois Hospital and Health Sciences System, Chicago (Y.S., Z.Q.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Cancer Research Center, The University of Illinois Hospital and Health Sciences System, Chicago (Y.S., Z.Q.)","institution_ids":["https://openalex.org/I4210125096"]},{"raw_affiliation_string":"Yue Sheng Department of Medicine and Cancer Research Center, The University of Illinois Hospital and Health Sciences System, Chicago (Y.S., Z.Q.)","institution_ids":["https://openalex.org/I4210125096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055598414","display_name":"Jaehyung Cho","orcid":"https://orcid.org/0000-0003-2404-3446","observed_orcids":["https://orcid.org/0000-0003-2404-3446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaehyung Cho","raw_affiliation_strings":["Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","Jaehyung Cho Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","institution_ids":[]},{"raw_affiliation_string":"Jaehyung Cho Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090313555","display_name":"Zhijian Qian","orcid":"https://orcid.org/0000-0001-5565-7534","observed_orcids":["https://orcid.org/0000-0001-5565-7534"]},"institutions":[{"id":"https://openalex.org/I4210125096","display_name":"University of Illinois Hospital & Health Sciences System","ror":"https://ror.org/03jhe7195","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210125096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhijian Qian","raw_affiliation_strings":["Department of Medicine and Cancer Research Center, The University of Illinois Hospital and Health Sciences System, Chicago (Y.S., Z.Q.)","Zhijian Qian Department of Medicine and Cancer Research Center, The University of Illinois Hospital and Health Sciences System, Chicago (Y.S., Z.Q.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Cancer Research Center, The University of Illinois Hospital and Health Sciences System, Chicago (Y.S., Z.Q.)","institution_ids":["https://openalex.org/I4210125096"]},{"raw_affiliation_string":"Zhijian Qian Department of Medicine and Cancer Research Center, The University of Illinois Hospital and Health Sciences System, Chicago (Y.S., Z.Q.)","institution_ids":["https://openalex.org/I4210125096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061188077","display_name":"You\u2010Yang Zhao","orcid":"https://orcid.org/0000-0002-0041-0339","observed_orcids":["https://orcid.org/0000-0002-0041-0339"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"You-Yang Zhao","raw_affiliation_strings":["Departments of Pediatrics and Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.-Y.Z.)","Program for Lung and Vascular Biology, Stanley Manne Children\u2019s Research Institute, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, IL (Y.-Y.Z.)","You-Yang Zhao Program for Lung and Vascular Biology, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, IL (Y.-Y.Z.) Program for Lung and Vascular Biology, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, IL (Y.-Y.Z.) Departments of Pediatrics and Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.-Y.Z.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.-Y.Z.)","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Program for Lung and Vascular Biology, Stanley Manne Children\u2019s Research Institute, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, IL (Y.-Y.Z.)","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"You-Yang Zhao Program for Lung and Vascular Biology, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, IL (Y.-Y.Z.) Program for Lung and Vascular Biology, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, IL (Y.-Y.Z.) Departments of Pediatrics and Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.-Y.Z.)","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065046382","display_name":"Gang Hu","orcid":"https://orcid.org/0000-0002-2864-4372","observed_orcids":["https://orcid.org/0000-0002-2864-4372","https://orcid.org/0000-0002-2598-7548","https://orcid.org/0009-0005-5969-1824"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Gang Hu","raw_affiliation_strings":["Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","From the Department of Anesthesiology (Y.L., Guochang Hu)","University of Illinois College of Medicine, Chicago; Department of Pharmacology, Nanjing Medical University, Jiangsu, China (Y.L., Gang Hu)","Gang Hu  University of Illinois College of Medicine, Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","institution_ids":[]},{"raw_affiliation_string":"From the Department of Anesthesiology (Y.L., Guochang Hu)","institution_ids":[]},{"raw_affiliation_string":"University of Illinois College of Medicine, Chicago; Department of Pharmacology, Nanjing Medical University, Jiangsu, China (Y.L., Gang Hu)","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Gang Hu  University of Illinois College of Medicine, Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087238383","display_name":"Duojia Pan","orcid":"https://orcid.org/0000-0003-2890-4645","observed_orcids":["https://orcid.org/0000-0003-2890-4645"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duojia Pan","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Physiology, UT Southwestern Medical Center, Dallas, TX (D.P.)","Duojia Pan Howard Hughes Medical Institute and Department of Physiology, UT Southwestern Medical Center, Dallas, TX (D.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Physiology, UT Southwestern Medical Center, Dallas, TX (D.P.)","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Duojia Pan Howard Hughes Medical Institute and Department of Physiology, UT Southwestern Medical Center, Dallas, TX (D.P.)","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011756238","display_name":"Asrar B. Malik","orcid":"https://orcid.org/0000-0002-8205-7128","observed_orcids":["https://orcid.org/0000-0002-8205-7128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asrar B. Malik","raw_affiliation_strings":["Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","Asrar B. Malik Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","institution_ids":[]},{"raw_affiliation_string":"Asrar B. Malik Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068315685","display_name":"Guochang Hu","orcid":"https://orcid.org/0000-0002-7054-7867","observed_orcids":["https://orcid.org/0000-0002-7054-7867"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Guochang Hu","raw_affiliation_strings":["Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","From the Department of Anesthesiology (Y.L., Guochang Hu)","University of Illinois College of Medicine, Chicago; Department of Pharmacology, Nanjing Medical University, Jiangsu, China (Y.L., Gang Hu)","Guochang Hu From the Department of Anesthesiology (Y.L., Guochang Hu) Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","institution_ids":[]},{"raw_affiliation_string":"From the Department of Anesthesiology (Y.L., Guochang Hu)","institution_ids":[]},{"raw_affiliation_string":"University of Illinois College of Medicine, Chicago; Department of Pharmacology, Nanjing Medical University, Jiangsu, China (Y.L., Gang Hu)","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Guochang Hu From the Department of Anesthesiology (Y.L., Guochang Hu) Department of Pharmacology (K.K., J.C., A.B.M., Guochang Hu)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.8331,"has_fulltext":false,"cited_by_count":248,"citation_normalized_percentile":{"value":0.98491511,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"123","issue":"1","first_page":"43","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.08869999647140503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9869999885559082},{"id":"https://openalex.org/keywords/traf6","display_name":"TRAF6","score":0.9179999828338623},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.781000018119812},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7179999947547913},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.8980000019073486},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.7269999980926514},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polymicrobial-sepsis","display_name":"polymicrobial sepsis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.6769999861717224},{"id":"https://openalex.org/keywords/organ-failure","display_name":"organ failure","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7586299180984497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45539775490760803},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4448947310447693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3691631555557251},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35414594411849976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2947511672973633}],"mesh":[{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014657","descriptor_name":"Vasculitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/circresaha.118.313143","doi":"https://doi.org/10.1161/circresaha.118.313143","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circresaha.118.313143","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:29794022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29794022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5554416","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6014930","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6014930","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6014930/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5554416","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6014930","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2761321084","display_name":"Novel mechanisms of obliterative pulmonary vascular remodeling and severe pulmonary arterial hypertension","funder_award_id":"R01HL133951","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2796791747","display_name":"Thiol isomerases in neutrophil recruitment and thromboinflammatory disease","funder_award_id":"R01HL130028","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3409084629","display_name":"Restoration of Lung Vascular Barrier Integrity","funder_award_id":"P01HL060678","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6235693039","display_name":"Mechanisms of Resolution of Lung Injury","funder_award_id":"P01HL077806","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G639620868","display_name":"Role of p120-catenin in sepsis-induced lung injury","funder_award_id":"R01HL104092","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8223216426","display_name":"The role of EVI1-induced DNA hypermethylation in Leukemogenesis","funder_award_id":"R01HL131444","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332697","display_name":"University of Illinois at Chicago","ror":"https://ror.org/02mpq6x41"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1504914687","https://openalex.org/W1600472471","https://openalex.org/W1766732272","https://openalex.org/W1905660905","https://openalex.org/W1965971815","https://openalex.org/W1976323469","https://openalex.org/W1977830503","https://openalex.org/W1982270701","https://openalex.org/W1986676916","https://openalex.org/W1992282800","https://openalex.org/W1993143514","https://openalex.org/W2006778392","https://openalex.org/W2008680963","https://openalex.org/W2011112085","https://openalex.org/W2013999310","https://openalex.org/W2017883909","https://openalex.org/W2028593002","https://openalex.org/W2033360354","https://openalex.org/W2037454778","https://openalex.org/W2048472525","https://openalex.org/W2050552243","https://openalex.org/W2056402897","https://openalex.org/W2061626698","https://openalex.org/W2064558057","https://openalex.org/W2078027095","https://openalex.org/W2079828953","https://openalex.org/W2085350376","https://openalex.org/W2086042935","https://openalex.org/W2086332492","https://openalex.org/W2092509739","https://openalex.org/W2093021491","https://openalex.org/W2099709490","https://openalex.org/W2100141065","https://openalex.org/W2111667226","https://openalex.org/W2115339089","https://openalex.org/W2116929481","https://openalex.org/W2119035325","https://openalex.org/W2123723916","https://openalex.org/W2141595533","https://openalex.org/W2157288494","https://openalex.org/W2159376228","https://openalex.org/W2164938105","https://openalex.org/W2266822253","https://openalex.org/W2417318333","https://openalex.org/W2525346244","https://openalex.org/W2560409429","https://openalex.org/W2789588679","https://openalex.org/W7098958697"],"related_works":["https://openalex.org/W2899070238","https://openalex.org/W2116100799","https://openalex.org/W2236920828","https://openalex.org/W3200299058","https://openalex.org/W2073456593","https://openalex.org/W2924596783","https://openalex.org/W2042793659","https://openalex.org/W2538080681","https://openalex.org/W7133846762","https://openalex.org/W4366979768"],"abstract_inverted_index":{"RATIONALE:":[0],"Microvascular":[1],"inflammation":[2,230,246],"and":[3,21,62,67,83,100,124,134,150,162,188,193,227,236,247],"endothelial":[4,34,65,89,120,142,204,214,225],"dysfunction":[5,152],"secondary":[6],"to":[7,127,185],"unchecked":[8],"activation":[9,32,66,223,235],"of":[10,19,33,46,54,64,81,94,110,119,139,198,217,224,244],"endothelium":[11],"play":[12],"a":[13,91,154],"critical":[14],"role":[15,45],"in":[16,58,88,97,104,141,153,196,203,211],"the":[17,43,50,55,60,147,169,207,222,242],"pathophysiology":[18],"sepsis":[20,156],"organ":[22,248],"failure.":[23,249],"The":[24],"intrinsic":[25],"signaling":[26,176],"mechanisms":[27],"responsible":[28],"for":[29,240],"dampening":[30],"excessive":[31],"cells":[35,143,205,226],"are":[36],"not":[37],"completely":[38],"understood.":[39],"OBJECTIVE:":[40],"To":[41],"determine":[42],"central":[44],"YAP":[47,74,140,164,220],"(Yes-associated":[48],"protein),":[49],"major":[51],"transcriptional":[52],"coactivator":[53],"Hippo":[56],"pathway,":[57],"modulating":[59],"strength":[61],"magnitude":[63],"vascular":[68,229],"inflammation.":[69],"METHODS":[70],"AND":[71],"RESULTS:":[72],"Endothelial-specific":[73],"knockout":[75],"mice":[76,112,212],"showed":[77],"increased":[78,101],"basal":[79],"expression":[80,118],"E-selectin":[82],"ICAM":[84],"(intercellular":[85],"adhesion":[86,121,126],"molecule)-1":[87],"cells,":[90],"greater":[92],"number":[93],"adherent":[95],"neutrophils":[96],"postcapillary":[98],"venules":[99],"neutrophil":[102,123,132],"counts":[103],"bronchoalveolar":[105],"lavage":[106],"fluid.":[107],"Lipopolysaccharide":[108],"challenge":[109],"these":[111],"augmented":[113,146,208],"NF-\u03baB":[114,199,234],"(nuclear":[115],"factor-\u03baB)":[116],"activation,":[117],"proteins,":[122],"monocyte":[125],"cremaster":[128],"muscle":[129],"venules,":[130],"transendothelial":[131],"migration,":[133],"lung":[135],"inflammatory":[136,148,209],"injury.":[137],"Deletion":[138],"also":[144],"markedly":[145],"response":[149],"cardiovascular":[151],"polymicrobial":[155],"model":[157],"induced":[158],"by":[159,166],"cecal":[160],"ligation":[161],"puncture.":[163],"functioned":[165],"interacting":[167],"with":[168,213],"E3":[170],"ubiquitin-protein":[171],"ligase":[172],"TLR":[173],"(Toll-like":[174],"receptor)":[175],"adaptor":[177],"TRAF6":[178,191,201],"(tumor":[179],"necrosis":[180],"factor":[181,183],"receptor-associated":[182],"6)":[184],"ubiquitinate":[186],"TRAF6,":[187],"thus":[189],"promoted":[190],"degradation":[192],"modification":[194],"resulting":[195],"inhibition":[197],"activation.":[200],"depletion":[202],"rescued":[206],"phenotype":[210],"cell-specific":[215],"deletion":[216],"YAP.":[218],"CONCLUSIONS:":[219],"modulates":[221],"suppresses":[228],"through":[231],"preventing":[232],"TRAF6-mediated":[233],"is":[237],"hence":[238],"essential":[239],"limiting":[241],"severity":[243],"sepsis-induced":[245]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":45},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":40},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-01T00:00:00"}
