{"id":"https://openalex.org/W2803855997","doi":null,"title":"Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes.","display_name":"Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2803855997","mag":"2803855997","pmid":"https://pubmed.ncbi.nlm.nih.gov/29853770","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5957544"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5957544","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5957544/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5957544/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5957544/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039648599","display_name":"Mariana R. P. Alves","orcid":"https://orcid.org/0000-0002-0796-2101","observed_orcids":["https://orcid.org/0000-0002-0796-2101"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Mariana R P Alves","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002179389","display_name":"Raquel Boia","orcid":"https://orcid.org/0000-0002-0479-3066","observed_orcids":["https://orcid.org/0000-0002-0479-3066"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Raquel Boia","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044883518","display_name":"Elisa Juli\u00e3o Campos","orcid":"https://orcid.org/0000-0002-9601-7696","observed_orcids":["https://orcid.org/0000-0002-9601-7696"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Elisa J Campos","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074419434","display_name":"Jo\u00e3o Martins","orcid":"https://orcid.org/0000-0001-7764-286X","observed_orcids":["https://orcid.org/0000-0001-7764-286X"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Martins","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005781652","display_name":"Sara Nunes","orcid":"https://orcid.org/0000-0002-0240-9059","observed_orcids":["https://orcid.org/0000-0002-0240-9059"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sara Nunes","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080311725","display_name":"Maria Helena Madeira","orcid":"https://orcid.org/0000-0001-6282-3553","observed_orcids":["https://orcid.org/0000-0001-6282-3553"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria H Madeira","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086776275","display_name":"Ana Raquel Santiago","orcid":"https://orcid.org/0000-0002-7541-7041","observed_orcids":["https://orcid.org/0000-0002-7541-7041"]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Raquel Santiago","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","Association for Innovation and Biomedical Research\u00a0on Light (AIBILI), Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Association for Innovation and Biomedical Research\u00a0on Light (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080956531","display_name":"Frederico Costa Pereira","orcid":"https://orcid.org/0000-0002-9381-3320","observed_orcids":["https://orcid.org/0000-0002-9381-3320"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Frederico C Pereira","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034460586","display_name":"Fl\u00e1vio Reis","orcid":"https://orcid.org/0000-0003-3401-9554","observed_orcids":["https://orcid.org/0000-0003-3401-9554"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fl\u00e1vio Reis","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075909802","display_name":"Ant\u00f3nio Francisco Ambr\u00f3sio","orcid":"https://orcid.org/0000-0002-0477-1641","observed_orcids":["https://orcid.org/0000-0002-0477-1641"]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ant\u00f3nio F Ambr\u00f3sio","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","Association for Innovation and Biomedical Research\u00a0on Light (AIBILI), Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Association for Innovation and Biomedical Research\u00a0on Light (AIBILI), Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069451243","display_name":"Filipa I. Baptista","orcid":"https://orcid.org/0000-0001-7972-640X","observed_orcids":["https://orcid.org/0000-0001-7972-640X"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Filipa I Baptista","raw_affiliation_strings":["Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.454,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.87186945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":null,"first_page":"353","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.9240000247955322},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/retinal-thinning","display_name":"retinal thinning","score":0.8899999856948853},{"id":"https://openalex.org/keywords/inner-retina","display_name":"inner retina","score":0.8610000014305115},{"id":"https://openalex.org/keywords/blood-retinal-barrier-permeability","display_name":"blood-retinal barrier permeability","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.9269999861717224},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.7630000114440918},{"id":"https://openalex.org/keywords/brn3a","display_name":"Brn3a","score":0.8299999833106995},{"id":"https://openalex.org/keywords/retinal-neuroinflammation","display_name":"retinal neuroinflammation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/translocator-protein-tspo","display_name":"translocator protein (TSPO)","score":0.8389999866485596},{"id":"https://openalex.org/keywords/high-sucrose-diet","display_name":"high-sucrose diet","score":0.7509999871253967},{"id":"https://openalex.org/keywords/retinal-neurodegeneration","display_name":"retinal neurodegeneration","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.7031120657920837},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.620777428150177},{"id":"https://openalex.org/C2778371105","wikidata":"https://www.wikidata.org/wiki/Q1622103","display_name":"Blood\u2013retinal barrier","level":4,"score":0.5555395483970642},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5183709263801575},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.49524155259132385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.459759920835495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45891842246055603},{"id":"https://openalex.org/C2780188069","wikidata":"https://www.wikidata.org/wiki/Q4133186","display_name":"Ganglion cell layer","level":3,"score":0.43826180696487427},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.25973889231681824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25889337062835693},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08361741900444031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07065242528915405}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005070","descriptor_name":"Evans Blue","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050819","descriptor_name":"Transcription Factor Brn-3A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050819","descriptor_name":"Transcription Factor Brn-3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063928","descriptor_name":"Ependymoglial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D063928","descriptor_name":"Ependymoglial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D063928","descriptor_name":"Ependymoglial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5957544","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5957544/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5957544/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:29853770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29853770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:2803855997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29853770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5957544","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5957544/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5957544/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1157252983","display_name":"UNRAVELLING THE INVOLVEMENT OF NEUROINFLAMMATION ON THE IMPAIRMENT OF AXONAL TRANSPORT IN HIPPOCAMPAL NEURONS UNDER DIABETIC CONDITIONS: CONTRIBUTION TO SYNAPTIC CHANGES AND MEMORY IMPAIRMENT","funder_award_id":"SFRH/BPD/86830/2012","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4430581750","display_name":"NEUROPEPTIDE Y SYSTEM: A NEW THERAPEUTIC TARGET IN DIABETIC RETINOPATHY - Development of new tools for the treament of retirnal degenerative diseases:controlled drug release using light-responsive nanoparticles","funder_award_id":"SFRH/BPD/93672/2013","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5258554520","display_name":null,"funder_award_id":"POCI-01-0145-FEDER-007440","funder_id":"https://openalex.org/F4320328601","funder_display_name":"Programa Operacional Regional do Centro"},{"id":"https://openalex.org/G5569247326","display_name":null,"funder_award_id":"POCI-01-0145-FEDER-007440","funder_id":"https://openalex.org/F4320323392","funder_display_name":"Universidade de Coimbra"},{"id":"https://openalex.org/G6276858265","display_name":null,"funder_award_id":"CENTRO-01-0145-FEDER-000008","funder_id":"https://openalex.org/F4320328601","funder_display_name":"Programa Operacional Regional do Centro"},{"id":"https://openalex.org/G7778222860","display_name":null,"funder_award_id":"CENTRO-01-0145-FEDER-000012","funder_id":"https://openalex.org/F4320328601","funder_display_name":"Programa Operacional Regional do Centro"},{"id":"https://openalex.org/G8619143110","display_name":"ROLE OF A2AR MODULATION IN RETINAL NEUROINFLAMMATION: IMPLICATION FOR RGC NEUROPROTECTION IN GLAUCOMA","funder_award_id":"SFRH/BD/75839/2011","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8725392010","display_name":null,"funder_award_id":"CENTRO-01-0145-FEDER-000012","funder_id":"https://openalex.org/F4320323392","funder_display_name":"Universidade de Coimbra"}],"funders":[{"id":"https://openalex.org/F4320323392","display_name":"Universidade de Coimbra","ror":"https://ror.org/04z8k9a98"},{"id":"https://openalex.org/F4320328601","display_name":"Programa Operacional Regional do Centro","ror":null},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803855997.pdf","grobid_xml":"https://content.openalex.org/works/W2803855997.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W127872553","https://openalex.org/W1491931749","https://openalex.org/W1528177085","https://openalex.org/W1583152018","https://openalex.org/W1830827841","https://openalex.org/W1964058722","https://openalex.org/W1967709839","https://openalex.org/W1968352279","https://openalex.org/W1978418030","https://openalex.org/W1983094335","https://openalex.org/W1983786871","https://openalex.org/W1987254708","https://openalex.org/W1987834950","https://openalex.org/W1990644905","https://openalex.org/W1993968665","https://openalex.org/W1996952739","https://openalex.org/W1998471569","https://openalex.org/W2009918956","https://openalex.org/W2011026111","https://openalex.org/W2020477052","https://openalex.org/W2034843310","https://openalex.org/W2037900536","https://openalex.org/W2039127036","https://openalex.org/W2045293119","https://openalex.org/W2047640394","https://openalex.org/W2051066258","https://openalex.org/W2056043330","https://openalex.org/W2061988978","https://openalex.org/W2072778201","https://openalex.org/W2073453384","https://openalex.org/W2092579092","https://openalex.org/W2100730679","https://openalex.org/W2102730253","https://openalex.org/W2105423509","https://openalex.org/W2107277218","https://openalex.org/W2107797783","https://openalex.org/W2108710614","https://openalex.org/W2114360920","https://openalex.org/W2121784482","https://openalex.org/W2121830778","https://openalex.org/W2124011448","https://openalex.org/W2132949972","https://openalex.org/W2134652708","https://openalex.org/W2143288970","https://openalex.org/W2147457499","https://openalex.org/W2151487984","https://openalex.org/W2157997023","https://openalex.org/W2206885504","https://openalex.org/W2520432709","https://openalex.org/W2616524636","https://openalex.org/W2743409708","https://openalex.org/W2763113126","https://openalex.org/W2785933318"],"related_works":["https://openalex.org/W4220878023","https://openalex.org/W4213053976","https://openalex.org/W4410798946","https://openalex.org/W2945862840","https://openalex.org/W2342880967","https://openalex.org/W2012736427","https://openalex.org/W3029794661","https://openalex.org/W4410930322","https://openalex.org/W2909288131","https://openalex.org/W4256686808"],"abstract_inverted_index":{"Purpose:":[0],"Diabetic":[1,27],"retinopathy":[2,28],"is":[3,29,321],"a":[4,30,39,314],"neurovascular":[5],"disease":[6],"characterized":[7],"by":[8,64,172,323],"increased":[9],"permeability":[10,117,269],"of":[11,20,33,38,51,70,90,113,118,132,176,191,231,236,259,270,308,326,342,377],"the":[12,17,21,36,43,68,71,74,88,104,119,125,130,133,155,174,177,185,222,232,237,257,260,268,271,277,283,287,291,297,300,306,318,324,327,343,351,375,387,395],"blood-retinal":[13,72,120,272],"barrier,":[14,73,273],"changes":[15,60,66,249,264,358],"in":[16,61,67,87,250,256,267,296,305,365],"neural":[18,77,138,252],"components":[19],"retina,":[22],"and":[23,79,108,129,137,171,188,201,209,212,225,247,286,333,353,392],"low-grade":[24],"chronic":[25],"inflammation.":[26],"major":[31],"complication":[32],"diabetes;":[34],"however,":[35],"impact":[37],"prediabetic":[40,62,105,315],"state":[41],"on":[42],"retina":[44,298],"remains":[45],"to":[46,55,148,220,394],"be":[47,360,381],"elucidated.":[48],"The":[49,116,229,336],"aim":[50],"this":[52,384],"study":[53,221],"was":[54,122,146,159],"assess":[56,182],"possible":[57],"early":[58,363],"retinal":[59,75,150,183,234,251,309,319],"rats,":[63],"evaluating":[65,173],"integrity":[69],"structure,":[76],"markers,":[78],"inflammatory":[80,292,334,354],"mediators.":[81],"Methods:":[82],"Several":[83],"parameters":[84,293],"were":[85,109,206,218,245,254,265],"analyzed":[86],"retinas":[89,258],"Wistar":[91],"rats":[92,285],"that":[93,346,370],"drank":[94],"high":[95],"sucrose":[96,99],"(HSu;":[97],"35%":[98],"solution":[100],"during":[101],"9":[102],"weeks,":[103],"animal":[106],"model)":[107],"compared":[110],"with":[111,124,140,161],"those":[112],"age-matched":[114],"controls.":[115,288],"barrier":[121],"assessed":[123,160,219],"Evans":[126],"blue":[127],"assay,":[128],"content":[131,281],"tight":[134,278],"junction":[135,279],"proteins":[136],"markers":[139,253],"western":[141],"blotting.":[142],"Optical":[143],"coherence":[144],"tomography":[145],"used":[147],"evaluate":[149],"thickness.":[151],"Cell":[152],"loss":[153],"at":[154,383],"ganglion":[156],"cell":[157],"layer":[158],"terminal":[162],"deoxynucleotidyl":[163],"transferase":[164],"(TdT)":[165],"dUTP":[166],"nick-end":[167],"labeling":[168],"(TUNEL)":[169],"assay":[170],"immunoreactivity":[175,211],"Brn3a":[178],"transcription":[179],"factor.":[180],"To":[181],"neuroinflammation,":[184],"mRNA":[186,216],"expression":[187],"protein":[189,214,280],"levels":[190,217],"inducible":[192],"nitric":[193],"oxide":[194],"synthase":[195],"isoform":[196],"(iNOS),":[197],"interleukin-1":[198],"beta":[199],"(IL-1\u03b2),":[200],"tumor":[202],"necrosis":[203],"factor":[204],"(TNF)":[205],"evaluated.":[207],"Iba1":[208],"MHC-II":[210],"translocator":[213],"(TSPO)":[215],"microglial":[223,310],"number":[224,307],"activation":[226],"state.":[227],"Results:":[228],"thickness":[230],"inner":[233,328,344],"layers":[235],"HSu-treated":[238,261,284],"animals":[239],"decreased.":[240],"Nevertheless,":[241],"no":[242,248],"apoptotic":[243],"cells":[244],"observed,":[246],"detected":[255,266],"animals.":[262],"No":[263],"as":[274,276,362,374],"well":[275],"between":[282],"In":[289,313],"addition,":[290],"remained":[294],"unchanged":[295],"despite":[299],"tendency":[301],"for":[302],"an":[303,366],"increase":[304],"cells.":[311],"Conclusions:":[312],"rat":[316],"model,":[317],"structure":[320],"affected":[322],"thinning":[325],"layers,":[329],"without":[330],"overt":[331],"vascular":[332,352],"alterations.":[335],"results":[337],"suggest":[338],"neuronal":[339],"dysfunction":[340,391],"(thinning":[341],"retina)":[345],"may":[347],"precede":[348],"or":[349],"anticipate":[350],"changes.":[355],"Subtle":[356],"structural":[357],"might":[359],"viewed":[361],"disturbances":[364],"evolving":[367],"disease,":[368],"suggesting":[369],"preventive":[371],"strategies":[372],"(such":[373],"modification":[376],"diet":[378],"habits)":[379],"could":[380],"applied":[382],"stage,":[385],"before":[386],"progression":[388],"toward":[389],"irreversible":[390],"damage":[393],"retina.":[396]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-06-01T00:00:00"}
