{"id":"https://openalex.org/W2803836688","doi":"https://doi.org/10.1016/j.freeradbiomed.2018.04.429","title":"Mitochondrial dysfunction of halimane and labdane diterpenes in human lung cancer cells","display_name":"Mitochondrial dysfunction of halimane and labdane diterpenes in human lung cancer cells","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2803836688","doi":"https://doi.org/10.1016/j.freeradbiomed.2018.04.429","mag":"2803836688"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2018.04.429","doi":"https://doi.org/10.1016/j.freeradbiomed.2018.04.429","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2018.04.429","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069680249","display_name":"Joana M. Andrade","orcid":"https://orcid.org/0000-0002-2088-4451","observed_orcids":["https://orcid.org/0000-0002-2088-4451"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]},{"id":"https://openalex.org/I4405265985","display_name":"Universidade Lus\u00f3fona de Humanidades e Tecnologias","ror":"https://ror.org/03badmv37","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405265985","https://openalex.org/I88596544"]}],"countries":["ES","PT"],"is_corresponding":false,"raw_author_name":"Joana M. Andrade","raw_affiliation_strings":["Center for Research in Biosciences & Health Technologies (CBIOS), Universidade Lus\u00f3fona de Humanidades e Tecnologias, Lisbon, Portugal","Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcal\u00e1, Campus Universitario, Alcal\u00e1 de Henares, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Biosciences & Health Technologies (CBIOS), Universidade Lus\u00f3fona de Humanidades e Tecnologias, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405265985"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcal\u00e1, Campus Universitario, Alcal\u00e1 de Henares, Spain","institution_ids":["https://openalex.org/I189268942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029541493","display_name":"Przemys\u0142aw Sitarek","orcid":"https://orcid.org/0000-0001-5495-3550","observed_orcids":["https://orcid.org/0000-0001-5495-3550"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Przemys\u0142aw Sitarek","raw_affiliation_strings":["Department of Biology and Pharmaceutical Botany, Medical University of Lodz, L\u00f3di, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Pharmaceutical Botany, Medical University of Lodz, L\u00f3di, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006574852","display_name":"Ewa Ska\u0142a","orcid":"https://orcid.org/0000-0003-1139-6840","observed_orcids":["https://orcid.org/0000-0003-1139-6840"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewa Ska\u0142a","raw_affiliation_strings":["Department of Biology and Pharmaceutical Botany, Medical University of Lodz, L\u00f3di, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Pharmaceutical Botany, Medical University of Lodz, L\u00f3di, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067717800","display_name":"Ewelina Synowiec","orcid":"https://orcid.org/0000-0002-0730-4491","observed_orcids":["https://orcid.org/0000-0002-0730-4491"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewelina Synowiec","raw_affiliation_strings":["Laboratory of Medical Genetics, University of Lodz, L\u00f3di, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medical Genetics, University of Lodz, L\u00f3di, Poland","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062647358","display_name":"Tomasz Kowalczyk","orcid":"https://orcid.org/0000-0002-4559-5015","observed_orcids":["https://orcid.org/0000-0002-4559-5015"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Kowalczyk","raw_affiliation_strings":["Department of Genetics and Plant Molecular Biology and Biotechnology, Faculty of Biology and Environmental Protection University of Lodz, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Plant Molecular Biology and Biotechnology, Faculty of Biology and Environmental Protection University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056232692","display_name":"Ana Mar\u00eda D\u00edaz-Lanza","orcid":"https://orcid.org/0000-0002-4216-3997","observed_orcids":["https://orcid.org/0000-0002-4216-3997"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana D\u00edaz-Lanza","raw_affiliation_strings":["Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcal\u00e1, Campus Universitario, Alcal\u00e1 de Henares, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcal\u00e1, Campus Universitario, Alcal\u00e1 de Henares, Spain","institution_ids":["https://openalex.org/I189268942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052706741","display_name":"Catarina Pinto Reis","orcid":"https://orcid.org/0000-0002-1046-4031","observed_orcids":["https://orcid.org/0000-0002-1046-4031"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Catarina Reis","raw_affiliation_strings":["Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Fac. de Farm., Univ. de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Fac. de Farm., Univ. de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012111165","display_name":"Patr\u00edcia  Mendonca Rijo","orcid":"https://orcid.org/0000-0001-7992-8343","observed_orcids":["https://orcid.org/0000-0001-7992-8343"]},"institutions":[{"id":"https://openalex.org/I4405265985","display_name":"Universidade Lus\u00f3fona de Humanidades e Tecnologias","ror":"https://ror.org/03badmv37","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405265985","https://openalex.org/I88596544"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Patr\u00edcia Rijo","raw_affiliation_strings":["Center for Research in Biosciences & Health Technologies (CBIOS), Universidade Lus\u00f3fona de Humanidades e Tecnologias, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Biosciences & Health Technologies (CBIOS), Universidade Lus\u00f3fona de Humanidades e Tecnologias, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405265985"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":null,"first_page":"S130","last_page":"S130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/labdane-diterpenes","display_name":"labdane diterpenes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lung-cancer-cells","display_name":"lung cancer cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9440000057220459},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9959999918937683},{"id":"https://openalex.org/keywords/plectranthus","display_name":"Plectranthus","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.800000011920929},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.5139999985694885},{"id":"https://openalex.org/keywords/forskolin-derivative","display_name":"forskolin derivative","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2778594897","wikidata":"https://www.wikidata.org/wiki/Q8214660","display_name":"Labdane","level":3,"score":0.8479183316230774},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6727380752563477},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6067330837249756},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5229645371437073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45071232318878174},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43101203441619873},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.4134369194507599},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4110000431537628},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4093888998031616},{"id":"https://openalex.org/C2776710815","wikidata":"https://www.wikidata.org/wiki/Q59447","display_name":"Diterpene","level":2,"score":0.3825952708721161},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34056830406188965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2890123724937439},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26646876335144043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24566495418548584},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21624162793159485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16820189356803894}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2018.04.429","doi":"https://doi.org/10.1016/j.freeradbiomed.2018.04.429","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2018.04.429","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399307855","https://openalex.org/W7132045649","https://openalex.org/W2810732924","https://openalex.org/W7131629561","https://openalex.org/W4394710293","https://openalex.org/W1997243387","https://openalex.org/W2520695365","https://openalex.org/W2116663463","https://openalex.org/W2890893807","https://openalex.org/W3107515905"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-01T00:00:00"}
