{"id":"https://openalex.org/W2803779831","doi":"https://doi.org/10.1158/1538-7445.mousemodels17-a36","title":"Abstract A36: Characterizing the role of Egfr signaling in mediating the exacerbative effect of acute inflammation on tumor development in a mouse model for familial adenomatous polyposis","display_name":"Abstract A36: Characterizing the role of Egfr signaling in mediating the exacerbative effect of acute inflammation on tumor development in a mouse model for familial adenomatous polyposis","publication_year":2018,"publication_date":"2018-05-14","ids":{"openalex":"https://openalex.org/W2803779831","doi":"https://doi.org/10.1158/1538-7445.mousemodels17-a36","mag":"2803779831"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.mousemodels17-a36","doi":"https://doi.org/10.1158/1538-7445.mousemodels17-a36","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.mousemodels17-a36","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019066829","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-9692-9820","observed_orcids":["https://orcid.org/0000-0002-9692-9820"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu-Ping Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Ping Yang","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046249010","display_name":"Robert J. Coffey","orcid":"https://orcid.org/0000-0002-2180-3844","observed_orcids":["https://orcid.org/0000-0002-2180-3844"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Coffey","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"10_Supplement","first_page":"A36","last_page":"A36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.19020000100135803,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.8870000243186951},{"id":"https://openalex.org/keywords/familial-adenomatous-polyposis","display_name":"familial adenomatous polyposis","score":0.921999990940094},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9279999732971191},{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/dextran-sodium-sulfate","display_name":"dextran sodium sulfate","score":0.9649999737739563},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.6549999713897705},{"id":"https://openalex.org/keywords/intestinal-adenoma","display_name":"intestinal adenoma","score":0.45100000500679016},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4729999899864197},{"id":"https://openalex.org/keywords/dysplasia","display_name":"dysplasia","score":0.7300000190734863},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6317616105079651},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.6289780139923096},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5800289511680603},{"id":"https://openalex.org/C2780814781","wikidata":"https://www.wikidata.org/wiki/Q1369011","display_name":"Familial adenomatous polyposis","level":4,"score":0.5534631013870239},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5495617389678955},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5050056576728821},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43430429697036743},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.41492316126823425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36874639987945557},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3546847105026245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33227190375328064},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32717370986938477},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30913493037223816},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.2851376533508301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18802690505981445}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.mousemodels17-a36","doi":"https://doi.org/10.1158/1538-7445.mousemodels17-a36","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.mousemodels17-a36","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077366285","https://openalex.org/W2132349680","https://openalex.org/W2126997649","https://openalex.org/W2034498760","https://openalex.org/W2306727576","https://openalex.org/W1528532402","https://openalex.org/W3083177920","https://openalex.org/W2591782482","https://openalex.org/W2334244159","https://openalex.org/W2104825362"],"abstract_inverted_index":{"Abstract":[0],"Over":[1],"the":[2,20,34,49,56,60,72,78,83,91,98,115,125,129,158,171,182,198,212,227,234,255],"past":[3],"decade":[4],"a":[5,39,110,139,187,244],"number":[6],"of":[7,11,52,55,69,71,85,117,142,149,200,229,237,254],"inducible":[8],"mouse":[9,111,245],"models":[10],"intestinal":[12,63,79],"tumor":[13,155,179,209,241],"formation":[14,84,156,180],"have":[15],"been":[16],"developed":[17,166,189],"to":[18,27,42,67,104,108],"study":[19,43],"genetic":[21],"and":[22,81,136,203,267],"cellular":[23],"changes":[24],"that":[25,113,138],"contribute":[26],"colorectal":[28],"cancer":[29],"(CRC)":[30],"development.":[31],"Among":[32],"them,":[33],"Lrig1-Cre/+;Apcfl/+":[35,99,126,163,184],"mice":[36,100,127,164],"serve":[37],"as":[38,48],"good":[40],"model":[41,112,246],"familial":[44,248],"adenomatous":[45,249],"polyposis":[46,250],"(FAP),":[47],"targeted":[50],"elimination":[51],"one":[53,150],"copy":[54],"Apc":[57,75,151],"gene":[58],"in":[59,77,90,97,120,157,170,181,207,211,232,243,260,263],"Lrig1-expressing":[61],"(Lrig1+)":[62],"progenitor":[64],"cells":[65],"leads":[66],"loss":[68,148],"heterozygosity":[70],"remaining":[73],"wild-type":[74],"allele":[76,152],"epithelium":[80],"eventually":[82],"multiple":[86],"histologically":[87],"advanced":[88],"adenomas":[89,95],"distal":[92,159],"colon.":[93,160],"However,":[94],"formed":[96],"do":[101],"not":[102],"progress":[103],"adenocarcinomas.":[105],"In":[106],"order":[107],"develop":[109],"recapitulates":[114],"process":[116],"CRC":[118],"development":[119,210,242],"its":[121],"entirety,":[122],"we":[123,195],"treated":[124],"with":[128],"proinflammatory":[130],"reagent":[131],"dextran":[132],"sodium":[133],"sulfate":[134],"(DSS)":[135],"found":[137],"single":[140],"cycle":[141],"DSS":[143],"right":[144],"after":[145],"tamoxifen-induced":[146],"initial":[147],"significantly":[153],"exacerbated":[154],"Interestingly,":[161],"DSS-treated":[162,213],"also":[165],"highly":[167],"dysplastic":[168],"tumors":[169],"proximal":[172],"colon,":[173],"which":[174],"is":[175],"normally":[176],"spared":[177],"from":[178],"untreated":[183],"mice.":[185,215],"Using":[186],"newly":[188],"chimeric":[190],"Egfr":[191,205,230],"protein":[192],"reporter":[193],"mouse,":[194],"are":[196],"interrogating":[197],"roles":[199],"dysregulated":[201],"epithelial":[202],"stromal":[204],"signaling":[206,231],"promoting":[208],"Lrig1-Cre/+;Apcfl/+;EgfrEmGFP/+":[214],"Citation":[216],"Format:":[217],"Wei":[218],"Li,":[219],"Yu-Ping":[220],"Yang,":[221],"Robert":[222],"J.":[223],"Coffey,":[224],"Jr.":[225],"Characterizing":[226],"role":[228],"mediating":[233],"exacerbative":[235],"effect":[236],"acute":[238],"inflammation":[239],"on":[240],"for":[247],"[abstract].":[251],"In:":[252],"Proceedings":[253],"AACR":[256],"Special":[257],"Conference:":[258],"Advances":[259],"Modeling":[261],"Cancer":[262,277],"Mice:":[264],"Technology,":[265],"Biology,":[266],"Beyond;":[268],"2017":[269],"Sep":[270],"24-27;":[271],"Orlando,":[272],"Florida.":[273],"Philadelphia":[274],"(PA):":[275],"AACR;":[276],"Res":[278],"2018;78(10":[279],"Suppl):Abstract":[280],"nr":[281],"A36.":[282]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2018-06-01T00:00:00"}
