{"id":"https://openalex.org/W2803726575","doi":"https://doi.org/10.1111/jnc.14463","title":"The orphan G\u2010protein\u2010coupled receptor 75 signaling is activated by the chemokine CCL 5","display_name":"The orphan G\u2010protein\u2010coupled receptor 75 signaling is activated by the chemokine CCL 5","publication_year":2018,"publication_date":"2018-05-17","ids":{"openalex":"https://openalex.org/W2803726575","doi":"https://doi.org/10.1111/jnc.14463","mag":"2803726575","pmid":"https://pubmed.ncbi.nlm.nih.gov/29772059","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6198807"},"language":"en","primary_location":{"id":"doi:10.1111/jnc.14463","doi":"https://doi.org/10.1111/jnc.14463","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.14463","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6198807","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037638324","display_name":"Simona Dedoni","orcid":"https://orcid.org/0000-0002-7330-2179","observed_orcids":["https://orcid.org/0000-0002-7330-2179"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simona Dedoni","raw_affiliation_strings":["Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040308280","display_name":"Lee Ann Campbell","orcid":"https://orcid.org/0000-0003-4724-1824","observed_orcids":["https://orcid.org/0000-0003-4724-1824"]},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee A. Campbell","raw_affiliation_strings":["Intramural Research Program, National Institute on Drug Abuse, Biochemical Research Center, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Drug Abuse, Biochemical Research Center, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108880617","display_name":"Brandon K. Harvey","orcid":"https://orcid.org/0000-0002-4036-1383","observed_orcids":["https://orcid.org/0000-0002-4036-1383","https://orcid.org/0000-0002-7471-9937"]},"institutions":[{"id":"https://openalex.org/I1327069482","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I1327069482"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon K. Harvey","raw_affiliation_strings":["Intramural Research Program, National Institute on Drug Abuse, Biochemical Research Center, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Drug Abuse, Biochemical Research Center, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I1327069482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039521842","display_name":"Valeria Avdoshina","orcid":"https://orcid.org/0000-0002-5640-3648","observed_orcids":["https://orcid.org/0000-0002-5640-3648"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria Avdoshina","raw_affiliation_strings":["Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA"],"raw_orcid":"https://orcid.org/0000-0002-5640-3648","affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086700125","display_name":"Italo Mocchetti","orcid":"https://orcid.org/0000-0002-5010-636X","observed_orcids":["https://orcid.org/0000-0002-5010-636X"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Italo Mocchetti","raw_affiliation_strings":["Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA"],"raw_orcid":"https://orcid.org/0000-0002-5010-636X","affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA","institution_ids":["https://openalex.org/I2799903593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086700125"],"corresponding_institution_ids":["https://openalex.org/I2799903593"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.3116,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.84010957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"146","issue":"5","first_page":"526","last_page":"539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr75","display_name":"GPR75","score":0.9800000190734863},{"id":"https://openalex.org/keywords/orphan-gpcrs","display_name":"orphan G protein-coupled receptor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.8069999814033508},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8190000057220459},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.6340000033378601},{"id":"https://openalex.org/keywords/ccr3","display_name":"CCR3","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ccr1","display_name":"CCR1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hiv-1-tat","display_name":"HIV-1 Tat protein","score":0.8349999785423279},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.8790000081062317},{"id":"https://openalex.org/keywords/crispr-cas9-knockdown","display_name":"CRISPR/Cas9 knockdown","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.6183846592903137},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5430902242660522},{"id":"https://openalex.org/C2779161069","wikidata":"https://www.wikidata.org/wiki/Q2496179","display_name":"Orphan receptor","level":4,"score":0.5386834144592285},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.45705223083496094},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38578182458877563},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3693110942840576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26917099952697754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19693130254745483},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.06763949990272522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05732259154319763}],"mesh":[{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000076987","descriptor_name":"CRISPR-Associated Protein 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037342","descriptor_name":"Pertussis Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/jnc.14463","doi":"https://doi.org/10.1111/jnc.14463","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.14463","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:29772059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29772059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5677212","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6198807","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6198807","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6198807","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurochem","raw_type":"Text"},{"id":"pmh:oai:iris.unica.it:11584/246790","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11584/246790","pdf_url":null,"source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5677212","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6198807","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8078330108","display_name":"GPR75: a new CCL5 receptor that mediates neuroprotection against HIV","funder_award_id":"R21NS089446","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1570695002","https://openalex.org/W1590342933","https://openalex.org/W1605885548","https://openalex.org/W1849091229","https://openalex.org/W1974955493","https://openalex.org/W1978040433","https://openalex.org/W2010044815","https://openalex.org/W2016314236","https://openalex.org/W2020771692","https://openalex.org/W2022978872","https://openalex.org/W2037472543","https://openalex.org/W2040909529","https://openalex.org/W2042418839","https://openalex.org/W2052305221","https://openalex.org/W2080127227","https://openalex.org/W2086990722","https://openalex.org/W2087180584","https://openalex.org/W2087527614","https://openalex.org/W2090641122","https://openalex.org/W2105420451","https://openalex.org/W2118526748","https://openalex.org/W2131545168","https://openalex.org/W2131817226","https://openalex.org/W2135319033","https://openalex.org/W2137676142","https://openalex.org/W2144414931","https://openalex.org/W2149410369","https://openalex.org/W2153960708","https://openalex.org/W2154229564","https://openalex.org/W2160807792","https://openalex.org/W2163352150","https://openalex.org/W2165244186","https://openalex.org/W2170391333","https://openalex.org/W2171776741"],"related_works":["https://openalex.org/W2899045176","https://openalex.org/W1985349408","https://openalex.org/W2079470893","https://openalex.org/W2087180584","https://openalex.org/W2145157502","https://openalex.org/W2042937067","https://openalex.org/W3108005585","https://openalex.org/W4319937611","https://openalex.org/W2073244735","https://openalex.org/W2006860685"],"abstract_inverted_index":{"The":[0],"chemokine":[1],"CCL5":[2,25,46,56,90,130,162,170,190,207],"prevents":[3],"neuronal":[4],"cell":[5],"death":[6],"mediated":[7],"both":[8],"by":[9,182],"amyloid":[10],"\u03b2,":[11],"as":[12,14],"well":[13],"the":[15,74,187,213,224,241],"human":[16,84],"immunodeficiency":[17],"virus":[18],"viral":[19],"proteins":[20],"gp120":[21],"and":[22,100,134,146,157],"Tat.":[23],"Because":[24],"binds":[26],"to":[27,59,87,123,191],"CCR5,":[28,113,155],"CCR3":[29,114],"and/or":[30],"CCR1":[31,116,158],"receptors,":[32],"it":[33],"remains":[34],"unclear":[35],"which":[36,65],"of":[37,73,137,154,175,189,212,216,226],"these":[38,54,105],"receptors":[39],"plays":[40],"a":[41,60,68,93,132,172,183,203],"role":[42],"in":[43,51,194,223],"neuroprotection.":[44],"Indeed,":[45],"also":[47],"has":[48],"neuroprotective":[49],"activity":[50],"cells":[52,86,106,119],"lacking":[53],"receptors.":[55,117],"may":[57,221],"bind":[58],"G-protein-coupled":[61],"receptor":[62,72,205],"75":[63],"(GPR75),":[64],"encodes":[66],"for":[67,206],"540":[69],"amino-acid":[70],"orphan":[71],"Gq\u03b1":[75],"family.":[76],"In":[77],"this":[78,217],"study,":[79],"we":[80,198],"have":[81],"used":[82,122],"SH-SY5Y":[83,195],"neuroblastoma":[85],"characterize":[88],"whether":[89],"could":[91,209],"activate":[92,192],"Gq":[94],"signaling":[95],"through":[96],"GPR75.":[97,176],"Both":[98],"qPCR":[99],"flow":[101],"cytometry":[102],"show":[103],"that":[104,129,200,208,231],"express":[107,112],"GPR75":[108,180,201,229],"but":[109],"do":[110],"not":[111,160],"or":[115,167],"SY-SY5Y":[118],"were":[120],"then":[121],"examine":[124],"CCL5-mediated":[125],"signaling.":[126],"We":[127],"report":[128],"promotes":[131,171],"time-":[133],"concentration-dependent":[135],"phosphorylation":[136],"protein":[138],"kinase":[139,144,149],"B":[140],"(AKT),":[141],"glycogen":[142],"synthase":[143],"3\u03b2,":[145],"extracellular":[147],"signal-regulated":[148],"(ERK)":[150],"1/2.":[151],"Specific":[152],"antagonists":[153],"CCR3,":[156],"did":[159],"prevent":[161],"from":[163],"increasing":[164],"phosphorylated":[165],"AKT":[166],"ERK.":[168],"Moreover,":[169],"time-dependent":[173],"internalization":[174],"Lastly,":[177],"knocking":[178],"down":[179],"expression":[181],"CRISPR-Cas9":[184],"approach":[185],"inhibited":[186],"ability":[188],"pERK":[193],"cells.":[196],"Therefore,":[197],"propose":[199],"is":[202],"novel":[204],"explain":[210],"some":[211],"pharmacological":[214],"action":[215],"chemokine.":[218],"These":[219],"findings":[220],"help":[222],"development":[225],"small":[227],"molecule":[228],"agonists":[230],"mimic":[232],"CCL5.":[233],"Open":[234,242],"Science:":[235],"This":[236],"manuscript":[237],"was":[238],"awarded":[239],"with":[240],"Materials":[243],"Badge.":[244],"For":[245],"more":[246],"information":[247],"see:":[248],"https://cos.io/our-services/open-science-badges/.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-01T00:00:00"}