{"id":"https://openalex.org/W2803674458","doi":null,"title":"Identification and characterization of a novel microsomal enzyme involved in cardiolipin synthesis and remodeling","display_name":"Identification and characterization of a novel microsomal enzyme involved in cardiolipin synthesis and remodeling","publication_year":2018,"publication_date":"2018-05-17","ids":{"openalex":"https://openalex.org/W2803674458","mag":"2803674458"},"language":"en","primary_location":{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/13312","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/13312","pdf_url":"http://hdl.handle.net/10012/13312","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10012/13312","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109374749","display_name":"Ryan M. Bradley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ryan M. Bradley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109374749"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiolipin","display_name":"cardiolipin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cardiolipin-synthesis","display_name":"cardiolipin synthesis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cardiolipin-remodeling","display_name":"cardiolipin remodeling","score":0.9490000009536743},{"id":"https://openalex.org/keywords/microsomal-enzymes","display_name":"microsomal enzymes","score":0.7570000290870667},{"id":"https://openalex.org/keywords/acyltransferase","display_name":"acyltransferase","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7390000224113464},{"id":"https://openalex.org/keywords/mitochondrial-physiology","display_name":"mitochondrial physiology","score":0.6370000243186951},{"id":"https://openalex.org/keywords/phospholipid-synthesis","display_name":"phospholipid synthesis","score":0.796999990940094},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/barth-syndrome","display_name":"Barth syndrome","score":0.4779999852180481},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5790979862213135},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.5670344829559326},{"id":"https://openalex.org/C2781302388","wikidata":"https://www.wikidata.org/wiki/Q183453","display_name":"Cardiolipin","level":4,"score":0.5596976280212402},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.51632159948349},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4685650169849396},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4221128225326538},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42165321111679077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30187249183654785},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.06986206769943237},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/13312","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/13312","pdf_url":"http://hdl.handle.net/10012/13312","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},{"id":"mag:2803674458","doi":null,"is_oa":false,"landing_page_url":"https://uwspace.uwaterloo.ca/handle/10012/13312?show=full","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/13312","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10012/13312","pdf_url":"http://hdl.handle.net/10012/13312","source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803674458.pdf","grobid_xml":"https://content.openalex.org/works/W2803674458.grobid-xml"},"referenced_works_count":235,"referenced_works":["https://openalex.org/W163644054","https://openalex.org/W181414851","https://openalex.org/W1000006914","https://openalex.org/W1483212282","https://openalex.org/W1487463077","https://openalex.org/W1491197989","https://openalex.org/W1498136138","https://openalex.org/W1507218781","https://openalex.org/W1508025382","https://openalex.org/W1538386443","https://openalex.org/W1552423677","https://openalex.org/W1569856350","https://openalex.org/W1575864823","https://openalex.org/W1600200637","https://openalex.org/W1600980171","https://openalex.org/W1620131620","https://openalex.org/W1658285995","https://openalex.org/W1714259390","https://openalex.org/W1843665006","https://openalex.org/W1851632517","https://openalex.org/W1913881380","https://openalex.org/W1919905560","https://openalex.org/W1925652457","https://openalex.org/W1956063336","https://openalex.org/W1964218515","https://openalex.org/W1965134940","https://openalex.org/W1965280884","https://openalex.org/W1966300077","https://openalex.org/W1966429519","https://openalex.org/W1967752426","https://openalex.org/W1967851488","https://openalex.org/W1968362444","https://openalex.org/W1968366571","https://openalex.org/W1969762460","https://openalex.org/W1971677534","https://openalex.org/W1971922071","https://openalex.org/W1973231345","https://openalex.org/W1973688807","https://openalex.org/W1973709235","https://openalex.org/W1974070493","https://openalex.org/W1974145389","https://openalex.org/W1974396693","https://openalex.org/W1975150752","https://openalex.org/W1976081400","https://openalex.org/W1977222014","https://openalex.org/W1979617203","https://openalex.org/W1979963836","https://openalex.org/W1980690522","https://openalex.org/W1981261838","https://openalex.org/W1981323788","https://openalex.org/W1981377319","https://openalex.org/W1986137232","https://openalex.org/W1986263058","https://openalex.org/W1986783906","https://openalex.org/W1988354683","https://openalex.org/W1988519309","https://openalex.org/W1989073099","https://openalex.org/W1990153284","https://openalex.org/W1990571638","https://openalex.org/W1991186544","https://openalex.org/W1991778481","https://openalex.org/W1992091494","https://openalex.org/W1992973572","https://openalex.org/W1993133323","https://openalex.org/W1994151063","https://openalex.org/W1995793646","https://openalex.org/W1996217052","https://openalex.org/W1996795941","https://openalex.org/W1997128892","https://openalex.org/W1997858198","https://openalex.org/W1998490733","https://openalex.org/W1998638208","https://openalex.org/W1998699136","https://openalex.org/W1999135119","https://openalex.org/W1999169071","https://openalex.org/W2001078159","https://openalex.org/W2001355405","https://openalex.org/W2003594380","https://openalex.org/W2005557466","https://openalex.org/W2006153652","https://openalex.org/W2006966998","https://openalex.org/W2008021748","https://openalex.org/W2009774232","https://openalex.org/W2009970917","https://openalex.org/W2012006993","https://openalex.org/W2012474628","https://openalex.org/W2014222181","https://openalex.org/W2015932693","https://openalex.org/W2016078643","https://openalex.org/W2016699709","https://openalex.org/W2016988333","https://openalex.org/W2017061507","https://openalex.org/W2017550994","https://openalex.org/W2019647204","https://openalex.org/W2019692395","https://openalex.org/W2020929474","https://openalex.org/W2022108138","https://openalex.org/W2022356406","https://openalex.org/W2023695099","https://openalex.org/W2024494886","https://openalex.org/W2024904802","https://openalex.org/W2025155867","https://openalex.org/W2026387596","https://openalex.org/W2028196283","https://openalex.org/W2028823292","https://openalex.org/W2029387236","https://openalex.org/W2029630471","https://openalex.org/W2031227547","https://openalex.org/W2032888644","https://openalex.org/W2033072021","https://openalex.org/W2035187068","https://openalex.org/W2036386995","https://openalex.org/W2037678644","https://openalex.org/W2039547815","https://openalex.org/W2040044089","https://openalex.org/W2042183674","https://openalex.org/W2046733873","https://openalex.org/W2048719661","https://openalex.org/W2048948369","https://openalex.org/W2049411058","https://openalex.org/W2051758651","https://openalex.org/W2052261183","https://openalex.org/W2054062420","https://openalex.org/W2054299455","https://openalex.org/W2055980308","https://openalex.org/W2057723954","https://openalex.org/W2059131067","https://openalex.org/W2060971766","https://openalex.org/W2062897750","https://openalex.org/W2063388729","https://openalex.org/W2065648126","https://openalex.org/W2066458078","https://openalex.org/W2067724628","https://openalex.org/W2068235098","https://openalex.org/W2069787626","https://openalex.org/W2070895853","https://openalex.org/W2072451938","https://openalex.org/W2073704223","https://openalex.org/W2074220154","https://openalex.org/W2074669091","https://openalex.org/W2075006085","https://openalex.org/W2075692785","https://openalex.org/W2077769075","https://openalex.org/W2078416451","https://openalex.org/W2078753143","https://openalex.org/W2079465344","https://openalex.org/W2080222756","https://openalex.org/W2080450157","https://openalex.org/W2080712061","https://openalex.org/W2080944633","https://openalex.org/W2082749665","https://openalex.org/W2083504696","https://openalex.org/W2083681924","https://openalex.org/W2084312389","https://openalex.org/W2084994033","https://openalex.org/W2086275775","https://openalex.org/W2086813762","https://openalex.org/W2087787271","https://openalex.org/W2087981949","https://openalex.org/W2088511433","https://openalex.org/W2091025792","https://openalex.org/W2092070341","https://openalex.org/W2092347071","https://openalex.org/W2093491041","https://openalex.org/W2093636989","https://openalex.org/W2093769286","https://openalex.org/W2094336459","https://openalex.org/W2094591121","https://openalex.org/W2094999489","https://openalex.org/W2095720174","https://openalex.org/W2095877372","https://openalex.org/W2098329073","https://openalex.org/W2101641299","https://openalex.org/W2104070301","https://openalex.org/W2104816318","https://openalex.org/W2106351063","https://openalex.org/W2107303221","https://openalex.org/W2109033820","https://openalex.org/W2111410004","https://openalex.org/W2111775116","https://openalex.org/W2112590212","https://openalex.org/W2113920734","https://openalex.org/W2118119775","https://openalex.org/W2120027741","https://openalex.org/W2120549803","https://openalex.org/W2123746079","https://openalex.org/W2124089572","https://openalex.org/W2125024660","https://openalex.org/W2126832105","https://openalex.org/W2127322768","https://openalex.org/W2128635872","https://openalex.org/W2135592618","https://openalex.org/W2136131823","https://openalex.org/W2137100643","https://openalex.org/W2137647403","https://openalex.org/W2139384498","https://openalex.org/W2142397871","https://openalex.org/W2144123285","https://openalex.org/W2144207859","https://openalex.org/W2145750442","https://openalex.org/W2146761165","https://openalex.org/W2148447088","https://openalex.org/W2150503227","https://openalex.org/W2150856099","https://openalex.org/W2152181679","https://openalex.org/W2152243292","https://openalex.org/W2153836184","https://openalex.org/W2154142977","https://openalex.org/W2157888844","https://openalex.org/W2162942828","https://openalex.org/W2164802216","https://openalex.org/W2164876155","https://openalex.org/W2165128851","https://openalex.org/W2168526937","https://openalex.org/W2169006029","https://openalex.org/W2169957088","https://openalex.org/W2187432162","https://openalex.org/W2189711376","https://openalex.org/W2200296684","https://openalex.org/W2305187716","https://openalex.org/W2322402935","https://openalex.org/W2325385842","https://openalex.org/W2397732781","https://openalex.org/W2402884687","https://openalex.org/W2408783417","https://openalex.org/W2410468274","https://openalex.org/W2413006478","https://openalex.org/W2415490480","https://openalex.org/W2469216125","https://openalex.org/W2504689304","https://openalex.org/W2519171974","https://openalex.org/W2522050533","https://openalex.org/W2612325272","https://openalex.org/W2744971743","https://openalex.org/W2745465257"],"related_works":["https://openalex.org/W7017933279","https://openalex.org/W2312749991","https://openalex.org/W2016843555","https://openalex.org/W2275653604","https://openalex.org/W2148037697","https://openalex.org/W1996622107","https://openalex.org/W1979048842","https://openalex.org/W3143124281","https://openalex.org/W2006153652","https://openalex.org/W4211037318"],"abstract_inverted_index":{"Cardiolipin":[0],"(CL)":[1],"is":[2,31,45,55,117,472,649],"a":[3,28,96,103,153,336,403,468,473,484,516,544,576,616,650],"specialized":[4],"dimeric":[5],"phospholipid":[6,183,223,264,366],"predominantly":[7],"found":[8,581,605],"in":[9,14,27,82,106,120,159,187,219,230,251,263,297,323,339,361,369,396,402,413,418,433,482,570,635,657],"the":[10,20,90,107,129,160,173,176,256,307,341,354,363,373,385,390,416,419,423,438,447,496,559,586,636],"inner":[11],"mitochondrial":[12,193,226,234],"membrane":[13],"eukaryotes.":[15],"Following":[16],"de":[17,503],"novo":[18,504],"synthesis,":[19,505],"acyl":[21,53,498],"chains":[22,499],"of":[23,95,111,126,132,162,167,175,178,209,248,259,303,312,345,353,365,379,387,389,405,425,441,449,452,535,539,547,562,593,597,608,615,620,632,638,660,675],"CL":[24,51,210,273,321,342,398,407,432,485,501,511,551,568,640,656,676],"are":[25],"remodeled":[26],"manner":[29],"that":[30,148,241,267,278,294,329,350,442,478,575,582,602,606,625,654],"tissue-":[32],"and":[33,35,70,92,109,122,144,185,189,400,436,524,550,573,642,663],"enzyme-specific,":[34],"can":[36],"also":[37,270,604],"be":[38,359],"regulated":[39],"by":[40],"dietary":[41],"intervention.":[42],"This":[43,283,326,409,553],"process":[44],"important":[46],"for":[47,673],"health.":[48],"An":[49],"incorrect":[50],"fatty":[52,486,497],"profile":[54],"associated":[56],"with":[57,102,305,415,461,507,532],"serious":[58],"disorders":[59,674],"ranging":[60],"from":[61,137,140,459,480,528],"Barth":[62,462],"Syndrome":[63,463],"(BTHS),":[64],"to":[65,171,197,213,289,383,430,491,494,515],"Parkinson\u2019s":[66],"disease,":[67,69],"heart,":[68],"some":[71],"cancers.":[72],"To":[73],"date,":[74],"four":[75],"highly":[76,118],"specific":[77],"enzymes":[78],"have":[79,509],"been":[80,286],"implicated":[81],"this":[83,86,115,149,168,179,202,249,346,380,594,609,630,646,661],"process.":[84],"In":[85,134],"work,":[87],"I":[88],"report":[89],"biochemical":[91],"cellular":[93,182,406],"characterization":[94,579],"novel":[97,374,587,647,670],"25":[98],"kDa":[99],"microsomal":[100,651],"protein":[101,116],"putative":[104],"role":[105,338],"synthesis":[108,161,641],"remodeling":[110,488],"CL.":[112,133,163],"Of":[113,600],"interest,":[114,601],"abundant":[119,310,392,537,618],"cardiac":[121],"neural":[123],"tissue,":[124],"both":[125,639],"which":[127,450,513],"contain":[128],"highest":[130],"concentration":[131],"vitro":[135],"evidence":[136],"crude":[138],"lysates":[139],"HEK-293":[141,199,252,324,370,434,571,583],"overexpressing":[142,201,372,585],"cells,":[143,232,435,572],"reticulocyte":[145],"lysates,":[146],"suggested":[147,327],"enzyme":[150,180,203,250,284,588,611,648,662],"functions":[151],"as":[152,211,467],"phosphatidylcholine":[154],"(PC):":[155],"monolysocardiolipin":[156],"(MLCL)":[157],"transacylase":[158,653],"\\nThe":[164,376],"second":[165,420],"objective":[166,378,421],"thesis":[169,381],"was":[170,228,237,382,411,455,554],"investigate":[172],"effects":[174,191,344],"overexpression":[177,607],"on":[181,192,500],"content":[184,208,236,322,399,569,592],"composition":[186,401],"vivo,":[188],"related":[190],"physiology.":[194],"As":[195],"compared":[196,212],"controls,":[198,214],"cells":[200,253,304,371,584],"had":[204,244,589],"an":[205,536],"~62%":[206],"higher":[207],"but":[215],"no":[216],"significant":[217,337],"increases":[218,655],"any":[220],"other":[221,351],"major":[222],"classes.":[224],"Interestingly,":[225],"respiration":[227],"impaired":[229],"these":[231,306,313,330,426,540],"although":[233],"DNA":[235],"not":[238,245,318,334,445,566],"different,":[239],"indicating":[240],"total":[242],"mitochondria":[243],"decreased.":[246],"Overexpression":[247],"significantly":[254,319,590],"up-regulated":[255],"mRNA":[257],"expression":[258],"multiple":[260],"genes":[261,368],"involved":[262,360],"biosynthesis,":[265],"suggesting":[266,624],"it":[268],"may":[269,358,612,668],"indirectly":[271],"alter":[272,431],"metabolism":[274],"through":[275],"cell":[276],"signaling":[277],"could":[279],"target":[280],"transcriptional":[281],"regulation.":[282],"has":[285],"previously":[287],"demonstrated":[288],"synthesize":[290],"small":[291,314,355,393,427],"bioactive":[292,315,331,356,394,428,453,541,563,598,621,633,666],"molecules":[293,316,332,357,395,429,542,667],"play":[295,335],"roles":[296],"myriad":[298],"biological":[299],"pathways.":[300],"However,":[301],"treatment":[302],"three":[308],"most":[309,391],"species":[311,352,451,538,561,596,619,631],"did":[317,444,565],"increase":[320,567],"cells.":[325,658],"either":[328],"do":[333],"modulating":[340,397],"biosynthetic":[343],"new":[347,610],"enzyme,":[348],"or":[349],"mediating":[362],"induction":[364],"metabolizing":[367],"enzyme.":[375,489],"final":[377,577],"assess":[384],"ability":[386,424],"one":[388],"model":[404],"deficiency.":[408],"work":[410,443],"performed":[412],"parallel":[414],"studies":[417,627],"examining":[422],"therefore,":[437],"negative":[439],"results":[440],"inform":[446],"choice":[448],"molecule":[454,564,634],"tested.":[456],"Cultured":[457],"B-lymphocytes":[458,527],"individuals":[460],"(BTHS)":[464],"were":[465],"utilized":[466],"study":[469,580,603,659],"model.":[470],"BTHS":[471,508,529,643],"rare,":[474],"X-linked":[475],"genetic":[476],"disorder":[477],"stems":[479],"mutations":[481],"Tafazzin,":[483],"acid":[487],"Due":[490],"their":[492],"inability":[493],"remodel":[495],"following":[502],"patients":[506,530],"decreased":[510,591],"content,":[512],"leads":[514],"disease":[517],"state,":[518],"including":[519],"heart":[520],"failure,":[521],"growth":[522,549],"delay,":[523],"cyclic":[525],"neutropenia.":[526],"treated":[531],"1":[533],"\uf06dM":[534],"exhibited":[543],"partial":[545],"rescue":[546],"characteristic":[548],"deficiencies.":[552],"surprising,":[555],"given":[556],"that:":[557],"1)":[558],"same":[560],"2)":[574],"collaborative":[578],"particular":[595],"molecule.":[599],"raise":[613],"levels":[614],"less":[617],"molecule,":[622],"strongly":[623],"future":[626],"should":[628],"examine":[629],"context":[637],"treatment.":[644],"Thus,":[645],"PC:MLCL":[652],"its":[664],"downstream":[665],"provide":[669],"therapeutic":[671],"targets":[672],"metabolism.":[677]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2018-06-01T00:00:00"}
