{"id":"https://openalex.org/W2803654237","doi":"https://doi.org/10.29252/jbrms.5.1.22","title":"Cucurbita maxima (Pumpkin) seeds: Scolicidal activity and preventive efficacy of its extract on experimental hydatidosis in mice","display_name":"Cucurbita maxima (Pumpkin) seeds: Scolicidal activity and preventive efficacy of its extract on experimental hydatidosis in mice","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2803654237","doi":"https://doi.org/10.29252/jbrms.5.1.22","mag":"2803654237"},"language":"en","primary_location":{"id":"doi:10.29252/jbrms.5.1.22","doi":"https://doi.org/10.29252/jbrms.5.1.22","is_oa":true,"landing_page_url":"https://doi.org/10.29252/jbrms.5.1.22","pdf_url":null,"source":{"id":"https://openalex.org/S2764717979","display_name":"Journal of Basic Research in Medical Sciences","issn_l":"2383-0506","issn":["2383-0506","2383-0972"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Basic Research in Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.29252/jbrms.5.1.22","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011805522","display_name":"Arash Babaei","orcid":"https://orcid.org/0000-0002-8018-2451","observed_orcids":["https://orcid.org/0000-0002-8018-2451"]},"institutions":[{"id":"https://openalex.org/I4210146087","display_name":"Malayer University","ror":"https://ror.org/03rk9sq81","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210146087"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Arash Babaei","raw_affiliation_strings":["Department of Biology, Faculty of Sciences, Malayer University, Malayer, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Sciences, Malayer University, Malayer, Iran","institution_ids":["https://openalex.org/I4210146087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103608796","display_name":"Arash Jafari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Arash Jafari","raw_affiliation_strings":["Department of Pathobiology, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohammad Asadpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Asadpour","raw_affiliation_strings":["Department of Pathobiology, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005917035","display_name":"Morteza Shamsi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017965041","display_name":"Medical University of Ilam","ror":"https://ror.org/042hptv04","country_code":"IR","type":"education","lineage":["https://openalex.org/I3017965041"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Morteza Shamsi","raw_affiliation_strings":["Department of Parasitology, Faculty of Paramedical Sciences, Ilam University of Medical Sciences, Ilam, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology, Faculty of Paramedical Sciences, Ilam University of Medical Sciences, Ilam, Iran","institution_ids":["https://openalex.org/I3017965041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4533,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.57350104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"5","issue":"1","first_page":"22","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cucurbita-maxima","display_name":"Cucurbita maxima","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pumpkin-seeds","display_name":"pumpkin seeds","score":0.9639999866485596},{"id":"https://openalex.org/keywords/scolicidal-activity","display_name":"scolicidal activity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/echinococcosis","display_name":"echinococcosis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/echinococcus-granulosus","display_name":"Echinococcus granulosus","score":0.9039999842643738},{"id":"https://openalex.org/keywords/protoscoleces","display_name":"protoscoleces","score":0.8730000257492065},{"id":"https://openalex.org/keywords/methanolic-seed-extract","display_name":"methanolic seed extract","score":0.7620000243186951},{"id":"https://openalex.org/keywords/prophylactic-efficacy","display_name":"prophylaxis efficacy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/albendazole-comparison","display_name":"albendazole comparison","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2781186446","wikidata":"https://www.wikidata.org/wiki/Q161180","display_name":"Cucurbita maxima","level":2,"score":0.980128288269043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7729573845863342},{"id":"https://openalex.org/C2780869770","wikidata":"https://www.wikidata.org/wiki/Q5339301","display_name":"Cucurbita","level":2,"score":0.612680196762085},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5053163170814514},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.24922770261764526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10175666213035583}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.29252/jbrms.5.1.22","doi":"https://doi.org/10.29252/jbrms.5.1.22","is_oa":true,"landing_page_url":"https://doi.org/10.29252/jbrms.5.1.22","pdf_url":null,"source":{"id":"https://openalex.org/S2764717979","display_name":"Journal of Basic Research in Medical Sciences","issn_l":"2383-0506","issn":["2383-0506","2383-0972"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Basic Research in Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:eprints.medilam.ac.ir:1765","doi":null,"is_oa":false,"landing_page_url":"http://eprints.medilam.ac.ir/1765/1/article-1-326-en.pdf","pdf_url":"http://eprints.medilam.ac.ir/1765/1/article-1-326-en.pdf","source":{"id":"https://openalex.org/S4306400609","display_name":"Research Repository Portal (Ilam University of Medical Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I3017965041","host_organization_name":"Medical University of Ilam","host_organization_lineage":["https://openalex.org/I3017965041"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:be0a0247a50d4329b6d99f0af339053c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/be0a0247a50d4329b6d99f0af339053c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Basic Research in Medical Sciences, Vol 5, Iss 1, Pp 22-28 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.29252/jbrms.5.1.22","doi":"https://doi.org/10.29252/jbrms.5.1.22","is_oa":true,"landing_page_url":"https://doi.org/10.29252/jbrms.5.1.22","pdf_url":null,"source":{"id":"https://openalex.org/S2764717979","display_name":"Journal of Basic Research in Medical Sciences","issn_l":"2383-0506","issn":["2383-0506","2383-0972"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Basic Research in Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.5365999937057495,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1969861233","https://openalex.org/W1992946784","https://openalex.org/W1999067093","https://openalex.org/W2020705072","https://openalex.org/W2021032886","https://openalex.org/W2052606614","https://openalex.org/W2059380748","https://openalex.org/W2104993988","https://openalex.org/W2106855406"],"related_works":["https://openalex.org/W1938678831","https://openalex.org/W1994553434","https://openalex.org/W2906524044","https://openalex.org/W2410516334","https://openalex.org/W2001446061","https://openalex.org/W2167657686","https://openalex.org/W2369440291","https://openalex.org/W2430702561","https://openalex.org/W2921350380","https://openalex.org/W2993093339"],"abstract_inverted_index":{"Introduction:":[0],"Hydatid":[1],"Disease":[2],"(HD),":[3],"a":[4,12,173,257],"helminth":[5],"infection":[6],"with":[7,131,168,223],"various":[8,102],"clinical":[9],"complications":[10],"is":[11],"serious":[13],"economic":[14],"and":[15,81,90,110,125,151,185,190,266,281],"public":[16],"health":[17],"concern":[18],"around":[19],"the":[20,40,49,74,78,94,178,195,211,270,284],"world.":[21],"Nowadays,":[22],"different":[23,87],"agents":[24,32],"have":[25,33,206],"been":[26],"broadly":[27],"applied":[28],"as":[29,256],"scolicids;":[30],"these":[31],"several":[34],"side":[35],"effects":[36,76,165],"on":[37,210,277,291],"patients.":[38],"Therefore,":[39],"aims":[41],"of":[42,52,61,77,93,121,146,175,286,289],"this":[43,84],"experimental":[44],"study":[45],"were":[46,99,116,126],"to":[47,72,182,262,269,283],"evaluate":[48],"scolicidal":[50,164,259],"activity":[51],"Cucurbita":[53],"maxima":[54,96,148,159,203,225,250],"seeds":[55,97,149,160,204,226,251],"methanolic":[56],"extract":[57],"(ME)":[58],"against":[59],"protoscolices":[60,124],"hydatid":[62,212,216,234],"cyst":[63,213,217,235],"in-vitro.":[64],"Also,":[65,194],"an":[66,207],"in":[67,101,134,166,198,220,237],"vivo":[68],"assay":[69],"was":[70],"designed":[71],"prove":[73],"preventive":[75],"extract.":[79],"Materials":[80],"methods:":[82],"For":[83],"work,":[85],"Two":[86],"concentrations":[88],"(25":[89],"50":[91,144,176,189],"mg/ml)":[92,229],"C.":[95,147,158,202,224,249],"ME":[98,161,205,227,252],"used":[100],"exposure":[103],"times":[104],"(10,":[105],"20,":[106],"30,":[107],"40,":[108,188],"50,":[109],"60":[111,191],"min).":[112],"Additionally,":[113],"thirty":[114],"mice":[115,133,221],"infected":[117],"intraperitoneally":[118],"by":[119,139],"injection":[120],"1000":[122],"viable":[123],"divided":[127],"into":[128],"three":[129],"groups":[130],"ten":[132],"each":[135],"Group":[136],"I":[137],"(treated":[138],"Albendazole),":[140],"group":[141,152,170,232],"II":[142],"(received":[143],"mg/ml":[145],"ME)":[150],"III":[153],"(untreated":[154],"controls).":[155],"Results:":[156],"Overall,":[157],"exhibited":[162],"signi\ufb01cant":[163],"compared":[167,268],"control":[169,231],"(P<0.05).":[171],"At":[172],"concentration":[174],"mg/ml,":[177],"mortality":[179],"percentage":[180],"increased":[181],"84.7%,":[183],"96.1%":[184],"100%":[186],"after":[187],"minutes,":[192],"respectively.":[193],"obtain":[196],"data":[197],"necropsy":[199],"demonstrated":[200],"that":[201,247],"inhibitory":[208],"effect":[209],"development.":[214],"No":[215],"formation":[218],"observed":[219],"treated":[222],"(50":[228],"versus":[230],"which":[233],"occurred":[236],"6":[238],"(from":[239],"10)":[240],"mice.":[241],"Conclusion:":[242],"The":[243],"current":[244],"investigation":[245],"indicated":[246],"applying":[248],"could":[253],"be":[254],"considered":[255],"potential":[258],"agent":[260],"due":[261],"being":[263],"economical,":[264],"safer":[265],"non-toxic":[267],"reference":[271],"chemical":[272],"drugs.":[273],"However,":[274],"further":[275],"studies":[276],"probably":[278],"active":[279],"compounds":[280],"also":[282],"determination":[285],"its":[287],"mode":[288],"action":[290],"parasites":[292],"are":[293],"required.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-01T00:00:00"}